Medicine and Health Sciences Commons^™

Identification Of Functional Single Nucleotide Polymorphisms Associated With Breast Cancer Based On Chromatin Modifications, Laura E. Hayward

CMC Senior Theses

Breast cancer affects 1 in 8 women and can be deadly; yet when detected early enough it is often treatable. Thus, early detection of breast cancer is imperative to save lives. The success of early detection depends, in part, on being able to stratify risk. A new approach to determining risk involves identifying genetic variants that alter an individual’s risk for developing breast cancer. This thesis identified key functional candidates involved in breast cancer development, some of which have been verified by other studies. For a few of the functional candidates, further research needs to be done in order to …

Epidural Hematoma Treated Conservatively: When To Expect The Worst, Julie Lamoureux

All Publications

Background: The Brain Trauma Foundation’s 2006 surgical guidelines have objectively defined the epidural hematoma (EDH) patients who can be treated conservatively. Since then, the literature has not provided adequate clues to identify patients who are at higher risk for EDH progression (EDHP) and conversion to surgical therapy. The goal of our study was to identify those patients.

Methods: We carried a retrospective review over a 5-year period of all EDH who were initially triaged for conservative management. Demographic data, injury severity and history, neurological status, use of anticoagulants or anti-platelets, radiological parameters, conversion to surgery and its timing, and Glasgow …

Is It Time To Adopt A No-Fault Scheme To Compensate Injured Patients?, Elaine Gibson

Articles, Book Chapters, & Popular Press

The tort system is roundly indicted for its inadequacies in providing compensation in response to injury. More egregious is its response to injuries incurred due to negligence in the provision of healthcare services specifically. Despite numerous calls for reform, tort-based compensation has persisted as the norm to date. However, recent developments regarding physician malpractice lead to consideration of the possibility of a move to “no-fault” compensation for healthcare-related injuries. In this paper, I explore these developments, examine programs in various foreign jurisdictions which have adopted no-fault compensation for medical injury, and discuss the wisdom and feasibility of adopting an administratively-based …

Evaluation Of The Dogs, Physical Activity, And Walking (Dogs Paw) Intervention: A Randomized Controlled Trial, Elizabeth Richards, N Ogata, C Cheng

School of Nursing Faculty Publications

Abstract: Background. To facilitate physical activity (PA) adoption and maintenance, promotion of innovative population-level strategies that focus on incorporating moderate intensity, lifestyle PA are needed. Objectives. The purpose of this randomized controlled trial was to evaluate the Dogs, Physical Activity, and Walking intervention (PAW), a 3-month, social cognitive theory (SCT) e-mail based PA intervention. Methods. In a longitudinal, repeated measures design, 49 dog owners were randomly assigned to a control (n=25) or intervention group (n=24). The intervention group received email messages (twice-weekly for four weeks and weekly for eight weeks) designed to influence SCT constructs of self-efficacy, self-regulation, outcome expectations …

Risk Factors In Women For Postpartum Depression Versus Postpartum Psychosis: An Integrative Literature Review, Briana Jamieson

Honors Undergraduate Theses

The purpose of this literature review was to identify differentiating risk factors in women for postpartum depression and postpartum psychosis. By understanding differentiating risk factors health care professionals, and nurses in particular, can be alert to women who are at higher risk for postpartum depression or postpartum psychosis. This information allows for early nursing intervention and the development of appropriate treatment plans. Fifteen peer-reviewed, English language research articles published between 2000 and 2015 were analyzed for the purpose of this literature review. Study results were inconclusive for the intention of this review, but do provide valuable information on independent risk …

Technologies To Enhance Optimal Glycemic Control In Young Adults With Type 1 Diabetes, Shannon L. Hassett

Honors Undergraduate Theses

Background

People with type 1 diabetes make up approximately two million of the American population. Every day, these two million people struggle to fight this lifelong, sometimes life threatening disease. While type 1 diabetes currently has no cure, there are technologies that can make diabetes management more effective. This study surveyed the type 1 diabetes (T1D) young adult population aged 18-30, to evaluate what technologies and tools are most often associated with achieving optimal glycemic control (OGC).

Methodology

The instrument is a 35 question, investigator developed survey that is designed to measure how often a participant utilizes the technology identified …

Self-Efficacy And Coping In Transition Of Care After Remission Of Cancer In Adolescents, Leah M. Mcdonnell

Honors Undergraduate Theses

The improvement in cancer remission rates in children and adolescents due to advances in cancer treatment and therapy has led to the development of guidelines that address long-term follow up for survivors of childhood cancers. Adolescents often experience negative emotions related to the fear of uncertainty about long-term survival after cancer remission, yet often report feelings of hope and optimism for the future more than adult cancer survivors. The purpose of this study was to understand the role of self-efficacy and coping in adolescents after remission of cancer. A secondary purpose was to analyze which coping strategies supported long-term survival …

Recognizing Pain Using Novel Simulation Technology, Justin C. Grace

Honors Undergraduate Theses

Effective pain management and time to treatment is essential in patient care. Despite scientific evidence supporting the need to treat pain and an emphasis on addressing pain as a priority, pain management continues to be an unresolved issue. As a member of the health care team, nurses are integral to optimal pain management. Currently, nursing schools have limited innovative or alternative methods for teaching pain assessment and management. Simulation in nursing education provides a unique opportunity to expose students to realistic patient situations and allow them to learn and make mistakes without causing harm. However, modern low- and high-fidelity simulation …

The Synchronicity Of Hope And Enhanced Quality Of Life In Terminal Cancer, Brianna M. Terry

Honors Undergraduate Theses

Cancer is the second leading cause of death in the United States and a leading cause of death worldwide. The rate of mortality is currently approximately 171.2 out of every 100,000 individuals with a terminal cancer diagnosis annually. Individuals with terminal cancer diagnoses facing probable mortality utilize various coping mechanisms or internal resources in an attempt to maintain an internal sense of well-being, commonly referred to as quality of life (QOL). The purpose of this literature review was to investigate themes prevalent in the literature pertaining to internal coping mechanisms and analyze any correlation or causation linking these resources to …

The Efficacy Of Non-Pharmacological Pain Management Methods Amongst Premature Neonates In The Neonatal Intensive Care Unit (Nicu), Hannah R. Martinez

Honors Undergraduate Theses

The purpose of this study was to conduct an integrated review of the literature examining the use of non-pharmacologic pain management strategies in premature neonates and to explore the relationship between health outcomes and time to discharge from the neonatal intensive care unit (NICU). Non-pharmacologic pain management strategies include human touch, facilitated tucking, non-nutritive sucking, and kangaroo care. A systematic review of the literature was conducted from multiple online databases. Peer reviewed, English-language articles containing the keywords ‘pain management’, ‘neonatal intensive care unit’, and ‘non-pharmacologic’ were included for synthesis. Exclusion criteria included articles with a focus on infants not admitted …

Vitamin D Clinical Relevance In The Recovery From Traumatic Brain Injury Among The Military Population, Yuisa M. Colón

Honors Undergraduate Theses

Background: Traumatic brain injury (TBI) still remains a difficult disorder to treat. TBI has been associated to chronic neuroinflammation and a high risk for neurodegenerative disorders. Since 2001 between ten to twenty percent of all deployed military members have suffered a combat-related TBI. Nearly twenty to thirty percent of those will experience chronic cognitive, behavioral and somatic symptoms after suffering a TBI.
Methods: The objective of this review is to evaluate current literature examining vitamin D as a neurosteroid with protective properties and its clinical relevance after traumatic brain injury. Vitamin D is known to participate in neurobiological …

Organizing For Women And Children: Advocating For The ‘Reach Every Mother And Child’ Campaign, Laura E. Leslie

Capstone Collection

Every day families are left without mothers and children. Not only does this affect the family but it can have ramifications on the community. There is a link between the wellbeing of moms and that of their children, yet we lose thousands of women to maternal complications each year. Moreover, each day, thousands of children die before reaching their fifth birthday. The most tragic part is that most of these deaths are preventable. While these deaths have been halved in the last 15 years, there is still a lot of work to be done. There have been several initiatives which …

Assessment Of The Knowledge And Skills Of School Personnel To Respond To Diabetic Emergencies In Georgia Public Schools, Alesha Wright

College of Graduate Studies: Theses & Dissertations

Diabetes is a common chronic disease that affects children in the United States. As children with diabetes attend school, the ability to appropriately manage their diabetes is essential to preventing life-threatening health complications. The purpose of the study was to assess school personnel’s knowledge of diabetes and perceived self-competence in performing diabetes management skills in response to a diabetic emergency. For the present study, a diabetic emergency was operationalized to include hypoglycemia, hyperglycemia, or diabetic ketoacidosis. A cross-sectional survey design, utilizing a fifty-two item self-administered questionnaire that accentuated the causes and symptoms of diabetes, definition of hypoglycemia and hyperglycemia, and …

Clinical Characteristics Of Active Individuals With Chronic Ankle Instability, Mary Elizabeth Winningham

College of Graduate Studies: Theses & Dissertations

Ankle sprains, specifically to the lateral ligament complex, are one of the most common injuries seen during athletic participation and may lead to chronic ankle instability (CAI).¹ Residual symptoms of CAI can include feelings of giving way and instability as well as, persistent weakness, pain during activity, and self-reported disability, which may affect postural control and functional performance.² The purpose of this study was to determine if there was a relationship between perceived kinesiophobia and dorsiflexion range of motion (DROM), measures of dynamic postural control, and measures of functional performance, within active individuals with CAI. Thirty-seven physically active …

A Feasibility Study Of A Lqts-Specific Workshop: Childrens' Problem-Solving Skills, Coping, Self-Efficacy, And Locus Of Control, Katherine L. Corvi

PCOM Psychology Dissertations

Living with a chronic medical condition in childhood and adolescence requires many critical lifestyle changes and restrictions, which may compromise psychosocial development. Social problem-solving skills have been shown to enhance the ability to cope with both minor and major daily stressors and to minimize psychological problems associated with physical health problems. The research is part of a larger study with children with long QT syndrome (LQTS) and their parents; the present study focuses on the children. This study was developed to examine the feasibility and efficacy of a problem-solving workshop to increase problem solving, self-efficacy, coping, and locus of control …

Medical Interns', Residents' And Attending Physicians' Attitudes Towards Integrative Medicine And Recommended Treatments For Patients With Psoriasis, Jennifer L. Pacyon

PCOM Psychology Dissertations

Background: Psoriasis is a multifactorial disease that effect approximately 7.5 million Americans. There are a variety of traditional treatments for psoriasis (e.g. topical medications, biologics) that for many, are effective in combating the disease. However, traditional treatments often have aversive side effects and may not be appropriate for every patient (e.g. pregnant women). Additionally, the efficacy of these medications are variable leaving some looking for adjunctive treatment options. There is increasing evidence to support the use of adjunctive treatments for psoriatic patients (e.g. psychotherapy, mindfulness). However, research is variable in regards to medical professionals’ attitudes towards integrative medicine (IM) as …

Type 2 Diabetes In Offspring Of Diabetic African American Women, Toby Valentino Yak

Walden Dissertations and Doctoral Studies

The prevalence of Type 2 diabetes is greater among African American women and their offspring than it is among Caucasian women and their offspring. In Iowa, there has been a gap in public health knowledge regarding risk factors associated with Type 2 diabetes in African American women and their offspring. The behavioral change wheel model was used to guide this study. This research study was a quantitative, retrospective cohort using primary data to investigate the association between a sample of diabetic African American and the occurrence of diabetes in their offspring. The sample included 105 diabetic African American women between …

Interrelationships In The Variability Of Root Canal Anatomy Among The Permanent Teeth: A Full-Mouth Approach By Cone-Beam Ct., Paul Monsarrat, Bertrand Arcaute, Ove A. Peters, Elisabeth Maury, Norbert Telmon, Marie Georgelin-Gurgel, Delphine Maret

All Dugoni School of Dentistry Faculty Articles

OBJECTIVES: In endodontic practice, clinicians should be aware of possible root canal anatomic variations. The aim of this study was to assess using CBCT acquisitions regarding whether one root canal anatomy of a tooth is associated with a specific anatomy of another tooth.

METHODS: A total of 106 CBCT acquisitions were obtained using a CBCT scanner with 200μm voxel size. Numbers of roots and canals of the entire dentition were described. Bivariate analyses and logistic regressions were conducted to explore root canal anatomy on one tooth according to age, gender, jaw, side and the others teeth. Multiple correspondence analysis (MCA) …

Food Labeling And Consumer Associations With Health, Safety, And Environment, Joanna K. Sax, Neal Doran

Faculty Scholarship

The food supply is complicated and consumers are increasingly calling for labeling on food to be more informative. In particular, consumers are asking for the labeling of genetically modified organisms (GMO) food based on health, safety and environmental concerns. At issue is whether the labels that are sought would accurately provide the information desired. The present study examined consumer (n = 181) perceptions of health, safety and the environment for foods labeled organic, natural, fat free or low fat, GMO, or non-GMO. Findings indicated that respondents consistently believed that foods labeled GMO are less healthy, safe and environmentally-friendly compared to …

The Ability Of Hepascore To Predict Liver Fibrosis In Chronic Liver Disease: A Meta-Analysis, Yi Huang, Leon A. Adams, John Joseph, Max Bulsara, Gary P. Jeffrey

Health Sciences Papers and Journal Articles

Background & Aims: Hepascore is a serum model that was developed to assess the severity of liver fibrosis. It has been well validated in common causes of chronic liver disease. This study performed a meta-analysis to evaluate the pooled diagnostic performance of Hepascore and to compare it for different aetiologies of chronic liver disease.

Methods: Two reviewers searched electronic databases from October 2005 to September 2015 for studies that evaluated the diagnostic performance of Hepascore for liver fibrosis in chronic liver disease.

Results: 21 studies were included. The AUROC was adjusted according to the distribution of fibrosis stages. The mean …

A Preliminary Investigation Of Trunk And Wrist Kinematics When Using Drivers With Different Shaft Properties, C Joyce, A Burnett, J Cochrane, A Reyes

Health Sciences Papers and Journal Articles

It is unknown whether skilled golfers will modify their kinematics when using drivers of different shaft properties. This study aimed to firstly, determine if golf swing kinematics and swing parameters and related launch conditions differed when using modified drivers, then secondly, determine which kinematics were associated with clubhead speed. Twenty high level amateur male golfers (Mean ± SD: handicap = 1.9 ± 1.9 score) had their three-dimensional trunk and wrist kinematics collected for two driver trials. Swing parameters and related launch conditions were collected using a launch monitor. A one-way repeated measures ANOVA revealed significant (p ≤ 0.003) between-driver differences; …

Preferential Mobilization And Egress Of Type 1 And Type 3 Innate Lymphocytes In Response To Exercise And Hypoxia, I Ng, T Fairchild, W Greene, G Hoyne

Health Sciences Papers and Journal Articles

The study examined the effect of exercise and hypoxia on the mobilization and egress of innate lymphocytes (ILCs) and adaptive T cell populations in the blood. The ILCs have emerged as a critical population of cells in immune regulation at mucosal surfaces in animals and humans. Eleven healthy male subjects performed (i) 45 min of exercise at 50% VO2 peak on a cycle ergometer under normoxia and (ii) hypoxia, or (iii) while resting in hypoxia. Blood samples were obtained pre-exercise, immediately post-exercise and 60 min post-exercise and were analyzed by flow cytometry to examine the type 1 and type 3 …

Male Or Nurse What Comes First? Challenges Men Face On Their Journey To Nurse Registration, D Juliff, K Russell, C Bulsara

Health Sciences Papers and Journal Articles

Objective: This paper aims to provide an account of the first phase of a qualitative longitudinal study that explored the initial challenges men in nursing face to become registered. What is known is that men, a minority group within nursing, face the usual challenges of all new nurses in their quest to register as nurses. In addition, they have added pressures that hinder their quest due to being male.

Primary Argument: An Australian nursing shortage is looming due to nurses retiring from this female-dominate profession. Hence, the retention of men in nursing is an area requiring attention in order to …

Plasmodium Falciparum Hep1 Is Required To Prevent The Self Aggregation Of Pfhsp70-3, D Nyakundi, L Vuko, S Bentley, H Hoppe, G Blatch, A Boshoff

Health Sciences Papers and Journal Articles

The majority of mitochondrial proteins are encoded in the nucleus and need to be imported from the cytosol into the mitochondria, and molecular chaperones play a key role in the efficient translocation and proper folding of these proteins in the matrix. One such molecular chaperone is the eukaryotic mitochondrial heat shock protein 70 (Hsp70); however, it is prone to self-aggregation and requires the presence of an essential zinc-finger protein, Hsp70-escort protein 1 (Hep1), to maintain its structure and function. PfHsp70-3, the only Hsp70 predicted to localize in the mitochondria of P. falciparum, may also rely on a Hep1 orthologue to …

Structural And Functional Characterization Of Enzymes Of A Novel Group Of Tryptophylquinone Cofactor Containing Oxidases, Esha Sehanobish

Electronic Theses and Dissertations

Protein-derived cofactors are redox and catalytic centers that are generally formed by the posttranslational modifications of one or more amino acids. An important class of these cofactors are the quinones derived from tyrosine and tryptophan. Amongst redox proteins, it has been known till now that oxidases either contain a flavin or a tyrosylquinone cofactor, whereas tryptophylquinone ones are present within the dehydrogenases. In recent times, oxidases from a marine bacterium, Marinomonas mediterranea, have been shown to possess the latter. This study involves the characterization of two such proteins, lysine-?-oxidase (LodA) and glycine oxidase (GoxA). They have been reported to contain …

Disaster Preparedness And Response: A Survey Of U.S. Dental Hygienists, Brenda T. Bradshaw, Ann P. Bruhn, Tara L. Newcomb, Bridget T. Giles, Kathryn Simms

Dental Hygiene Faculty Publications

Purpose: The purpose of this study was to assess dental hygienists’ interests, current involvement, formal education, views, comfort levels, and intentions for involvement with disaster preparedness and response.

Methods: Dental hygienists (n=400) were asked to respond to a 21-item online survey. Data was analyzed using descriptive statistics, chi-square goodness-of-fit tests, and a paired-samples t-test. Common themes were identified and categorized from open-ended questions.

Results: A response rate of 84% (n=334) was obtained. Most respondents (97%) reported no involvement with disaster preparedness and response; however, a majority (86%) reported interest. Of those who indicated an interest in disaster preparedness and response, …

Diaphragm Training And Evaluation As A Therapeutic Tool By Athletic Trainers In Orthopedic Rehabilition, Marisa Rashel Foltz

Graduate Theses/Dissertations

Athletic trainers (AT) incorporate diaphragm training techniques into treatment protocols; however, further understanding of the techniques’ purpose and application is needed. An investigation of clinical reasoning for use of diaphragm training and evaluation as therapeutic tools in rehabilitation was conducted. Research questions sought to identify AT perspectives and rationale for incorporating these techniques, explore how ATs gain knowledge, and identify evaluation and educational methods utilized in rehabilitation. A qualitative investigation employing a phenomenological approach was used to address the research questions. Procedures included convenience sampling, one-on-one semi structured interviews, transcription, and coding that led to overall theme development. Thirteen ATs …

Identification And Characterization Of Dna Repair Snf2/Swi2 Atpases In Tetrahymena Thermophila, Andrew Francis Morin

Graduate Theses/Dissertations

The Snf2/Swi2 ATPases Rad5 and Rad16 have been shown to play vital roles in a number of DNA repair pathways. In both Saccharomyces cerevisiae and human cell lines, Rad5 homologs (SHPRH, HLTF) have been shown to function in DNA double strand break (DSB) repair along with pathways that repair damage after replication. The function of Rad16, unlike Rad5, has been found only in lower eukaryotes such as Saccharomyces, despite the fact that it plays an essential role in nucleotide excision repair (NER), and more specifically in the repair of silenced areas of the genome. In order to more fully understand …

Differences In Patient Outcomes Of Prevalence, Interval, And Screen-Detected Lung Cancers In The Ct Arm Of The National Lung Screening Trial, Matthew B. Schabath, Pierre P. Massion, Zachary J. Thompson, Steven A. Eschrich, Yoganand Balagurunathan, Dmitry Goldof, Denise R. Aberle, Robert J. Gillies

Computer Science and Engineering Faculty Publications

Lung cancer screening identifies cancers with heterogeneous behaviors. Some lung cancers will be identified among patients who had prior negative CT screens and upon follow-up scans develop a de novo nodule that was determined to be cancerous. Other lung cancers will be identified among patients who had one or more prior stable positive scans that were not determined to be lung cancer (indeterminate pulmonary nodules), but in follow-up scans was diagnosed with an incidence lung cancer. Using data from the CT arm of the National Lung Screening Trial, this analysis investigated differences in patient characteristics and survival endpoints between prevalence-, …

Fundamental Frequency Characteristics Of Modal And Vocal Fry Registers, Heidi Brubaker, Jason Albertson Whitfield Ph.D., Jane Schoonmaker Rodgers D.M.A.

Honors Projects

This study examined the distribution of fundamental frequencies in the connected speech of 14 healthy young adults. Acoustic analysis of fundamental frequency was performed on previously collected speech samples of a phonetically balanced reading passage. For the first three sentences of the reading passage, fundamental frequency contours were extracted using PRAAT, a speech analysis software package. The accuracy of these contours were visually verified and manually corrected when needed. The distribution of the fundamental frequency histories for each sample were then analyzed using Gaussian Mixture Model analyses in MATLAB. For most speakers, four statistical modes were identified in the data …