Medicine and Health Sciences Commons^™

Pfapa: A Periodic Febrile Syndrome Afflicting Children, Jessica Lahti

Physician Assistant Scholarly Project Posters

• Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA).

• Auto-inflammatory disorder occurring in affected children every 3-8 weeks.

• Onset around age 2; lasting into second decade of life.

• A current pathophysiologic theory is PFAPA is a disorder of the innate immune system involving interleukins, chemoattractants, and cytokines that stimulating the inflammatory response causing symptoms associated with PFAPA.

• Early diagnosis of PFAPA may help prevent the unnecessary use of antibiotics.

• Biomarker CD64, galectin-3 and the MPV may be useful in the diagnosis of PFAPA along with other laboratory values during the febrile attack period …

Adolescent Idiopathic Scoliosis: Comparing And Contrasting Operative Versus Non-Operative Treatment Abstract, Ethan Morris

Physician Assistant Scholarly Project Posters

• Adolescent idiopathic scoliosis (AIS) is the most common form of scoliosis. It affects 2-4 percent of adolescents aged 10-16 years. Although most adolescents diagnosed with scoliosis will not develop clinical symptoms, ten percent will progress and require medical intervention due to the potential for rib deformity and respiratory compromise as well as significant emotional distress due to aesthetic changes in appearance. Primary care providers should be prepared to evaluate and recommend treatment when idiopathic scoliosis is discovered or addressed by the patient. Three major factors that determine whether scoliosis will progress are patient gender, magnitude of curve on presentation, …

Implementing Animal Therapy Into Current Medicinal Practices, Jenna Schiefelbein

Physician Assistant Scholarly Project Posters

• The purpose of this study was to explore an unconventional intervention of medicine; specifically the integration of animals into current healthcare practices.

• The review of literature evaluated the implementation of animal therapy in medicine, both in the past and present.

• It was demonstrated that incorporating animal-assistance therapy into modern day medicine had a positive correlation with overall patient health, pain control, and disposition.

Does Pharmacogenetics Play A Role In The Treatment Of Type Ii Diabetes Mellitus?, Lucas N. Vanemelen

Physician Assistant Scholarly Project Posters

• Type 2 diabetes mellitus (T2DM) is a disease commonly presented in the family practice setting. Current therapies include one or multiple medications. Until recently, providers have used algorithms and medical expertise to control T2DM.

• Pharmacogenomics is a branch of pharmacology dealing with genetic variation on a medication response in an individual patient to discover medication compatibility, efficacy or toxicity.

• Analysis of genetic factors are still being discovered; however, this growing field may change the way medications are being prescribed for diabetes. This analysis investigated if pharmacogenetics is a useful tool for prescribing diabetic medications to T2DM patients. …

Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infection Antibiotic Prophylaxis Treatment Compared With Alternative Treatment Options, Heather Watkins

Physician Assistant Scholarly Project Posters

• Pediatric Autoimmune Neuropsychiatric Disorders associated with Streptococcal Infection, known as PANDAS, is a clinical diagnosis made after a child develops Obsessive Compulsive Disorder and/or ticks after a Streptococcal Pharyngitis. Pediatric Autoimmune Neuropsychiatric Disorders associated with Streptococcal Infection is diagnosed in children 3 years of age until 14 years of age. The purpose of this study is to determine if antibiotics versus selective serotonin reuptake inhibitor with cognitive behavior therapy versus prophylaxis with antibiotics should be used in the treatment of children who develops PANDAS. The review of literature will explore studies that compare current treatment options with new research …

The Da Vinci Robotic Surgical Systems In Atrial Septal Defect Repair, Coronary Artery Bypass Graft And Mitral Valve Repair, Randy Yergenson

Physician Assistant Scholarly Project Posters

Historically, these cardiac interventions have been performed using partial or complete open sternotomy.
1. Coronary artery bypass grafting (CABG)
2. Atrial septal defect (ASD) repair,
3. Mitral valve repair and/or replacement

In 2000, the Federal Food and Drug Administration approved the use of the da Vinci Robotic Surgical System. Less invasive surgical option.

Electromyographic Analysis Of Hip Muscle Activity During Stair Climbing: A Pilot Study, Alexander Barney, Mary Loken, Paige Torgerson, Lyndsey Wunderlich

Physical Therapy Scholarly Projects

Introduction: Prior to this study, little evidence exists for a quality predictive tool correlating maximum velocity contraction (MVC) strength of the hip abductor muscles to walking and stair climbing (ascending/descending, side-stepping) ability. Stair climbing is an important functional activity of daily living and as physical therapists we are involved in training clients to ascend/descend stairs safely, which can be difficult for clients with hip abductor muscle weakness. Subjects: Eleven females voluntarily agreed to participate in this study. All participants were under the age of 30 years old, nonpregnant, physical therapy students without a current musculoskeletal injury. Methods: …

Rehabilitation Following A Distal Fibular Fracture In A 16 Year Old Female Athlete: A Case Report., Brett Morlock

Physical Therapy Scholarly Projects

Background and Purpose: Distal fibular fractures are an uncommon injury in athletes, they are produced by repetitive stress to the fibula often due to overuse. The purpose of this case report is to discuss the rehabilitation following a distal fibular fracture of a young, female athlete and how the rehabilitation prepared the patient to return to her sports.

Case Description: The patient is 16 year old Caucasian female who participated in both cheerleading and gymnastics. She sustained a left distal fibular fracture while performing a stunt in cheerleading. The patient was referred to physical therapy following six weeks …

Outpatient Physical Therapy Interventions For The Cervical Spine: A Case Report, Brandon Szklarski

Physical Therapy Scholarly Projects

There is currently little evidence available to determine which conservative treatment options are best for management of patients with cervical pain and radiculopathy. The purpose of this case report is to describe a cost-effective, non-operative approach for symptom management-with physical therapy interventions in individuals with cervical neck pain and radiculopathy. The patient's diagnosis was determined by the physical signs and symptoms that were presented, as well as classification of the patient's symptoms with the clinical prediction rules used to identify patients with cervical radiculopathy. The results of the examination were consistent with her primary care physician's referral and diagnostic imaging …

Association Of Generalized Joint Hypermobility And Occurrence Of Musculoskeletal Injury In Physical And Occupational Therapy Students, Patricia Bisek, Hannah Owen, Maleeka Rozeboom, Leah Tunseth

Physical Therapy Scholarly Projects

Background: A prior research study showed that the prevalence of hypermobility was higher among Physical and Occupational Therapy students as compared to the general population. The literature shows that certain injury rates are higher among those who are hypermobile. This has led to the question of whether or not hypermobility is directly related to injury and recurrence of injury.

Purpose: The purpose of this study was to assess Physical Therapy (PT) and Occupational Therapy (OT) students for hypermobility as well as survey previous injury history. This study analyzed the prevalence of hypermobility with types of injuries in order …

Evaluation Of Program Satisfaction, Quality Of Life, Strength, And Fall Risk Of Community-Dwelling Older Adults Participating In A Community Exercise Program, Rachel Bothun, Christine Gillespie, Zachariah Kvidt, Krista Moonnan

Physical Therapy Scholarly Projects

Background and Purpose: Exercise programs aimed at prevention of osteoporosis are effective in fall prevention and improving mobility in older adults. This trial examined whether the Bone Builder's community exercise program decreases fall risk and improves mobility in community dwelling females over the age of 60.

Methods: Fifty one females ages 60-90 who currently are participating in the Bone Builder's program volunteered to participate in four different assessments as well as two questionnaires. Tests included: the 4-stage balance, timed up and go, gait speed (measured with the GAITRite system), 30 second sit-to-stand, and grip strength. The Functional Efficacy …

Low Back Pain: A Case Study, Samir Maleki

Physical Therapy Scholarly Projects

Background and Purpose: Low back pain (LBP) is a common complaint in the U.S., and has many possible causes. Multiple physical therapy interventions, including electrotherapy, traction, and lumbar stabilization exercises such as bridging and planking variations, have been shown to be very effective in reducing LBP. The purpose of this case study is to examine the effects of lumbar stabilization exercise and electrotherapy on LBP.

Case Description: The patient was a 43 year-old male, who had been experiencing LBP for the past year. He reported falling off of a truck and landing with his hand tucked into the …

Modeling, Optimization, And Sensitivity Analysis Of A Continuous Multi-Segment Crystallizer For Production Of Active Pharmaceutical Ingredients, Bradley James Ridder

Open Access Dissertations

We have investigated the simulation-based, steady-state optimization of a new type of crystallizer for the production of pharmaceuticals. The multi-segment, multi-addition plug-flow crystallizer (MSMA-PFC) offers better control over supersaturation in one dimension compared to a batch or stirred-tank crystallizer. Through use of a population balance framework, we have written the governing model equations of population balance and mass balance on the crystallizer segments. The solution of these equations was accomplished through either the method of moments or the finite volume method. The goal was to optimize the performance of the crystallizer with respect to certain quantities, such as maximizing the …

Mach: A Model For Explaining Molecular And Cellular Mechanisms, Caleb M. Trujillo

Open Access Dissertations

Biologists use mechanistic explanations to understand behaviors of the immense complexity of molecular and cellular systems. In undergraduate biology courses, students are expected to explain molecular and cellular mechanisms, but teaching this skill presents many challenges due to the highly abstract, intangible nature of the cellular world, the influence of everyday language, and the tendency of students to overestimate how much they can explain. Therefore, across three studies this dissertation addresses these obstacles to teach undergraduate biology students to explain molecular and cellular mechanisms. ^ The first step was to model how biology experts explain molecular and cellular mechanisms, and …

Show Horse Welfare, Melissa A. Voigt

Open Access Dissertations

In recent years there has been an increase in the public's attention to situations where trainers, owners, and handlers have compromised the well-being of show horses for the sake of winning. These situations may be due to training negligence or naivety of individuals working with the horse. Either way, due to these incidents, increasing pressure has been placed on the horse industry to address show horse welfare. The purpose of this research was to expound on the welfare of stock-type show horses through the perspective of those directly involved; considering the understanding of welfare, the value placed on welfare, and …

Mdivi-1, A Mitochondrial Division Inhibitor, Exerts Cardioprotective Effects In Myocardial Ischemia/Reperfusion (Mi/R) When Given At Reperfusion, Devon P. Stutzman

PCOM Biomedical Studies Student Scholarship

Acute myocardial infarction (MI) remains a leading cause of morbidity and mortality worldwide. Accompanying MI is myocardial ischemia/reperfusion (MI/R) injury, which results in cardiac contractile dysfunction and additional myocardial cell death. MI/R injury is initiated in part by mitochondrial-derived reactive oxygen species due to mitochondrial membrane potential collapse and uncoupling of the electron transport chain, which may be due to mitochondrial fission in MI/R. Mitochondrial fission is in turn associated with shortening/fragmentation of mitochondria, decreased ATP production, and is thought to promote cardiac contractile dysfunction and post-reperfused cardiomyocyte loss, leading to increased infarct size. Therefore, inhibiting mitochondrial fission may be …

Impact Of Starch Source On Equine Hindgut Microbial Ecology, Brittany Elizabeth Davis Harlow

Theses and Dissertations--Animal and Food Sciences

Grain inclusion in equine diets can allow starch to reach the hindgut where bacteria compete for the substrate. The hypothesis was that starch introduction would cause a source-dependent press disturbance in equine fecal microflora. Fecal cell suspensions were prepared by differential centrifugation and re-suspension in media with ground corn, oats or wheat. At 24 h, corn had more amylolytics and Group D Gram-positive cocci (GPC), and fewer lactate-utilizing (LU) bacteria and lactobacilli than oats, with wheat being intermediate. Predominant amylolytics were identified by their 16S RNA gene sequence as Enterococcus faecalis (corn, wheat) and Streptococcus bovis (oats). In an in …

The Effect Of An Online Coping Skill Application On Relapsing-Remitting Multiple Sclerosis Sufferers, Jennifer H. Garrison

Walden Dissertations and Doctoral Studies

Many individuals with multiple sclerosis (MS) are classified as having relapsing-remitting MS (RRMS), a form of the illness that requires constant symptom management for suffers to achieve optimum outcomes. There are only a few community-based educational programs that exist to help RRMS sufferers cope with their illness; the effectiveness of those that have been fielded has not yet been adequately assessed. The research questions of this study were to determine if an online training development module would increase the coping skills of those affected by RRMS and if the online educational module would be more effective at improving the coping …

The Predictors Of Physician-Patient Discussions Of Sexual Health With Older Adults, Dana Marie Werner

Walden Dissertations and Doctoral Studies

The number of adults aged 65 years and over has been rising quickly, as has the rate of new onset sexually transmitted diseases within this population. Discussions of sexual health between physicians and older adults are currently lacking in frequency and effectiveness. Using the foundation of stereotype embodiment theory, the purpose of this study was to identify the factors that predict frequency of discussing sexual health with older adult patients. A comparative sample of geriatric physicians and family practitioners completed 2 researcher-developed questions and the Sexual Health Care Scale-Attitude tool that assessed their stereotype beliefs toward discussing sexual health with …

Program For Healthcare Personnel To Improve Anti-Hypertensive Medication Adherence In Black Adults, Verena D. Johnson

Walden Dissertations and Doctoral Studies

Medication nonadherence is a healthcare problem that costs the United States billions of dollars annually. The purpose of this project was to propose an evidence-based program for healthcare personnel to increase the rate of medication adherence in hypertensive Black adults who require daily, oral medication. The transtheoretical model of change was used to explain the process of change and to identify approaches to changing non-adherent behaviors related to medications. Motivational interviewing was used to explain the process that nurse-educators would use to guide patients through the stages of change. In the initial step of this quality improvement program, a convenience …

How Spiritual Values Correlate With Hospice Use For African Americans, Latrina Dion Frazier

Walden Dissertations and Doctoral Studies

End of life hospice services have consistently been underused by African Americans. This disproportionate use of hospice has contributed to poor quality of life and a lack of cost-effective care for patients with terminal illness. Driven by the theory of reasoned action, the purpose of this quantitative study was to test associations between African Americans' perceptions of hospice, decisions to use hospice, and religiosity. A convenience sample of 154 African American adults was surveyed online. The survey instrument combined the AARP End of Life survey, Perception of Hospice survey, and the Religiousness Measure survey. The results of a multiple linear …

Improving The Quality Of Care In An Acute Care Facility Through Reeducating Nurses About Managing Central Lines, Jacqueline Raffaele

Walden Dissertations and Doctoral Studies

Central line-associated bloodstream infections continue to be some of the most deadly hospital-associated infections in the United States. Guided by Lewin's change theory which focuses on prior learning, rejection, and replacement, the purpose of this study was to improve the quality of care patients receive in an acute care facility by reducing life threatening central line infections. The research question examined whether additional education using Venous Access Nurse (VAN) customized newsletters and manager coaching of nurses in an acute care setting would improve the quality of care for patients with central lines. This was a quantitative nonexperimental descriptive retrospective study …

Automated Medication Dispensing Cabinet And Medication Errors, Marie Helen Walsh

Walden Dissertations and Doctoral Studies

The number of deaths due to medical errors in hospitals ranges from 44,000 to 98,000 yearly. More than 7,000 of these deaths have taken place due to medication errors. This project evaluated the implementation of an automated medication dispensing cabinet or PYXIS machine in a 25-bed upper Midwestern critical access hospital. Lewin's stage theory of organizational change and Roger's diffusion of innovations theory supported the project. Nursing staff members were asked to complete an anonymous, qualitative survey approximately 1 month after the implementation of the PYXIS and again 1 year later. Questions were focused on the device and its use …

Teachers' Perceptions Of Multimodal Literacies In Middle School Health Literacy Programs, Cynthia Darlene Jackson-Howard

Walden Dissertations and Doctoral Studies

Health literacy, defined as the ability to understand and use health information to make informed decisions, is critical to maintaining health; however, not all U.S. states mandate strategies to improve adolescents' health literacy. Moreover, many middle school teachers are often unaware of how their roles could improve the health literacy of their students. Multimodal literacies help students to create meaning through viewing print-based resources and using digital technologies. The purpose of this study was to investigate teachers' perceptions of the effectiveness of multimodal literacies on adolescents' overall health literacy via the introduction of health literacy programs into the curriculum. This …

Mcm2 And Chromogranin Are Markers Of Serrated Polyp Progression, Danielle Fortuna, Md, Bruce M. Boman, Md, Phd, Juan P. Palazzo, Md

Department of Pathology, Anatomy, and Cell Biology Resident's Posters

Objectives:

Using immunohistochemistry for MCMs and CGA:

Examine the proliferative compartment of SPs

Assess neuroendocrine cell population in SPs

Goal: Identify potential trends in the proliferative and the neuroendocrine cell compartments in SP progression compared to the background normal mucosa

Current Intimate Partner Violence Screening Practices Of Maternity Nurses In A Hospital Setting, Lina Garrard

Summer Community of Scholars Posters (RCEU and HCR Combined Programs)

No abstract provided.

Intrinsically Disordered Proteins And Their (Disordered) Proteomes In Neurodegenerative Disorders, Vladimir N. Uversky

Molecular Medicine Faculty Publications

No abstract provided.

Beyond The Excluded Volume Effects: Mechanistic Complexity Of The Crowded Milieu, Irina M. Kuznetsova, Boris Y. Zaslavsky, Leonid Breydo, Konstantin K. Turoverov, Vladimir N. Uversky

Molecular Medicine Faculty Publications

Macromolecular crowding is known to affect protein folding, binding of small molecules, interaction with nucleic acids, enzymatic activity, protein-protein interactions, and protein aggregation. Although for a long time it was believed that the major mechanism of the action of crowded environments on structure, folding, thermodynamics, and function of a protein can be described in terms of the excluded volume effects, it is getting clear now that other factors originating from the presence of high concentrations of “inert” macromolecules in crowded solution should definitely be taken into account to draw a more complete picture of a protein in a crowded milieu. …

Structure And Stability Of Recombinant Bovine Odorant-Binding Protein: Ii. Unfolding Of The Monomeric Forms, Olga V. Stepanenko, Denis O. Roginskii, Olesya V. Stepanenko, Irina M. Kuznetsova, Vladimir N. Uversky, Konstantin K. Turoverov

Molecular Medicine Faculty Publications

In a family of monomeric odorant-binding proteins (OBPs), bovine OBP (bOBP), that lacks conserved disulfide bond found in other OBPs, occupies unique niche because of its ability to form domain-swapped dimers. In this study, we analyzed conformational stabilities of the recombinant bOBP and its monomeric variants, the bOBP-Gly121+ mutant containing an additional glycine residue after the residue 121 of the bOBP, and the GCC-bOBP mutant obtained from the bOBP-Gly121+ form by introduction of the Trp64Cys/His155Cys double mutation to restore the canonical disulfide bond. We also analyzed the effect of the natural ligand binding on the conformational stabilities of these bOBP …

Intrinsically Disordered Caldesmon Binds Calmodulin Via The “Buttons On A String” Mechanism, Sergei E. Permyakov, Eugene A. Permyakov, Vladimir N. Uversky

Molecular Medicine Faculty Publications

We show here that chicken gizzard caldesmon (CaD) and its C-terminal domain (residues 636–771, CaD136) are intrinsically disordered proteins. The computational and experimental analyses of the wild type CaD136 and series of its single tryptophan mutants (W674A, W707A, and W737A) and a double tryptophan mutant (W674A/W707A) suggested that although the interaction of CaD136 with calmodulin (CaM) can be driven by the non-specific electrostatic attraction between these oppositely charged molecules, the specificity of CaD136-CaM binding is likely to be determined by the specific packing of important CaD136 tryptophan residues at the CaD136-CaM interface. It is suggested that this interaction can be …