Medicine and Health Sciences Commons^™

A Novel Codon-Optimized Siv Gag-Pol Immunogen For Genebased Vaccination, Catherine M. Crosby, Eric A. Weaver, Reeti Khare, Michael A. Barry

Nebraska Center for Virology: Faculty Publications

Simian immunodeficiency virus (SIV) is a robust pathogen used in non-human primates to model HIV vaccines. SIV encodes a number of potential vaccine targets. By far the largest and most conserved protein target in SIV is its gag-pol protein that bears many epitopes to drive multivalent immune T cell responses. While gag-pol is an attractive antigen, it is only translated after a frame shift between gag and pol with the effect that gag and pol are expressed at an approximate 10/1 ratio. The codon bias of native lentiviral genes are also mismatched with the abundance of tRNAs in mammalian cells …

From Bibles To Biomarkers: The Future Of The Dsm And Forensic Psychiatric Diagnosis, Teneille R. Brown

Utah Law Faculty Scholarship

Given its importance to the law, it is regrettable that judges and lawyers do not fully understand how the DSM is constructed, and the bedrock of values on which it rests. As evidence of this, lawyers and judges often refer to the DSM as the “psychiatric bible.” This language is both fascinating and perplexing. This Article will attempt to correct the notion that the DSM is a legal “psychiatric bible” by explaining how it is created and used by the medical field. It will also provide a few reasons why the law may have come to view it as a …

Mobile Stroke Unit (Msu): The Future Of Acute Stroke Treatment, Waldo R. Guerrero

Neurosurgery and Brain Repair Faculty Publications

No abstract provided.

Effect Of Harvest Method On In Vitro Digestibility Of Corn Residues, Janessa J. Updike, Jana L. Harding, Terry J. Klopfenstein Klopfenstein, James C. Macdonald

Nebraska Beef Cattle Reports

New corn residue harvesting methods were evaluated to determine the impacts of altering the proportions of plant part that are composed in a round bale. In vitro techniques were used to assess the organic matter digestibility of corn residue bale harvested with different proportions of stalks, leaves, and husk. As husk comprised a greater proportion of the bale, digestibility appeared to increase when compared with a conventional bale of cornstalks.

Sex Differences In The Kinetic Profiles Of D- And L- Methylphenidate In The Brains Of Adult Rats, J. Bentley, F. Snyder, Stacy D. Brown, R. W. Brown, Brooks B. Pond

ETSU Faculty Works

OBJECTIVE: Methylphenidate is commonly used in the treatment of Attention Deficit Hyperactivity Disorder and narcolepsy. Methylphenidate is administered as a racemic mixture of the d- and l- threo enantiomers; however, the d-enantiomer is primarily responsible for the pharmacologic activity. Previous studies of the behavioral effects of methylphenidate have highlighted sex differences in the responsiveness to the drug, namely an increased sensitivity of females to its stimulatory effects. These differences may be due to differences in the uptake, distribution, and elimination of methylphenidate from male and female brains. Therefore, we compared the pharmacokinetics of d- and l- threo methylphenidate in the …

A Qualitative Study Of Adolescent Views Of Sugar Sweetened Beverage Taxes, Claire Krukowski

Master's Theses and Doctoral Dissertations

A qualitative study was used to investigate adolescents’ perceptions of sugar-sweetened beverage taxes using the Theory of Planned Behavior (attitude toward the behavior, subjective norms, perceived behavioral control, and behavioral intentions). A secondary purpose was to explore the role of habit in SSB consumption. Three focus groups were conducted at a suburban Detroit middle school with 22 students. Findings suggest that students understand short-and long-term advantages and disadvantages of sugarsweetened beverages and personal and economic impacts of a sugar-sweetened beverage tax, though the economics of a tax was confusing for them. Students stated various factors that would make reducing sugar-sweetened …

Synthesis And Evaluation Of Substituted Coumarin Derivatives As Inhibitors Of Monoamine Oxidase B, Ian A. Kieffer

Chemistry Theses

Monoamine oxidase B (MAO B) is of clinical importance due to its perceived role in neurodegenerative diseases such as Parkinson’s, making inhibitors of MAO B popular candidates for drug design. A series of coumarin derivatives have been prepared and assayed, revealing that the synthesized inhibitors act through a competitive mode of inhibition. In addition, these inhibitors are potent with Ki values in the nanomolar range. Overall, substitution at the 3- position of the coumarin was found to be important to inhibitor potency and further study of 3-aryl coumarin substitution computationally led to the prediction of 3-(3-aminophenyl)-6-hydroxycoumarin as a lead compound …

Justifying The Implementation Of A Collaborative Drug Therapy Management (Cdtm) Protocol In An Outpatient Psychiatric Clinic: A Retrospective Chart Review, Kevin Michael Bozymski

Undergraduate Honors Thesis Collection

Objective

To identify opportunities where pharmacists could intervene and justify the benefits of outpatient clinical pharmacy services through a CDTM protocol within Gallahue Mental Health Center by assessing current antipsychotic monitoring

Methods

A retrospective chart review was performed of patients visiting an outpatient psychiatric clinic over 14 months. A review was also completed of patients followed at two primary care clinics within Community Health Network. Patients were at least 18 years old and had at least one active antipsychotic prescription. A standardized data collection sheet was used to document monitoring frequency and appropriateness as recommended by the 2004 American Diabetes …

Financing Early Childhood Education: An Investment Into The Future, Shelina Bhamani

Department of Obstetrics & Gynaecology

No abstract provided.

Urine Neutrophil Gelatinase-Associated Lipocalin In Asphyxiated Neonates: A Prospective Cohort Study, Farida Essajee, Fred Were, Bashir Admani

Paediatrics and Child Health, East Africa

Background: Acute kidney injury (AKI) is the most common complication of perinatal asphyxia. Recent research indicates that urine neutrophil gelatinase-associated lipocalin (NGAL) is an early marker for AKI; yet, there is a paucity of data about its use in term neonates with perinatal asphyxia.

Methods: A prospective cohort study was conducted on 108 term babies in the new-born unit of Pumwani Maternity Hospital and Kenyatta National Hospital. Urine NGAL and serum creatinine were measured in 108 term asphyxiated neonates on days 1 and 3 of life.

Results: One-hundred and eight patients were recruited (male:female 1.4:1). At a cut-off of 250 …

Parenting Skills And Emotional Availability: An Rct, Aisha K. Yousafzai, Muneera A. Rasheed, Arjumand Rizvi, Robert Armstrong, Zulfiqar A. Bhutta

Paediatrics and Child Health, East Africa

Objective: To investigate whether a responsive stimulation intervention delivered to caregivers of young children either alone or integrated with nutrition interventions would benefit parenting skills and emotional availability to promote children’s development and growth compared with either a nutrition intervention alone or the usual standard of care.

Methods: A cluster randomized factorial effectiveness trial was implemented in an impoverished community in Pakistan. The 4 trial arms were control (usual standard of care), responsive stimulation (responsive care and stimulation), enhanced nutrition (education and multiple micronutrients), and a combination of both enriched interventions. The 4 intervention packages were delivered by community health …

World Allergy Organization-Mcmaster University Guidelines For Allergic Disease Prevention (Glad-P): Probiotics, Alessandro Fiocchi, Ruby Pawankar, Carlos Cuello-Garcia, Kangmo Ahn, Suleiman Al-Hammadi, Arnav Agarwal, Kirsten Beyer, Wesley Burks, Giorgio W. Canonica, Motohiro Ebisawa, Shreyas Gandhi, Rose Kamenwa, Bee Wah Lee, Haiqi Li, Susan Prescott, John J. Riva, Lanny Rosenwasser, Hugh Sampson, Michael Spigler, Luigi Terracciano, Andrea Vereda-Ortiz, Susan Waserman, Juan José Yepes-Nuñez, Jan L. Brożek, Holger J. Schünemann

Paediatrics and Child Health, East Africa

Background: Prevalence of allergic diseases in infants, whose parents and siblings do not have allergy, is approximately 10% and reaches 20–30% in those with an allergic first-degree relative. Intestinal microbiota may modulate immunologic and inflammatory systemic responses and, thus, influence development of sensitization and allergy. Probiotics have been reported to modulate immune responses and their supplementation has been proposed as a preventive intervention.

Objective: The World Allergy Organization (WAO) convened a guideline panel to develop evidence-based recommendations about the use of probiotics in the prevention of allergy.

Methods: We identified the most relevant clinical questions and performed a systematic review …

A Comparison Of Self-Acceptance Of Disability Between Thai Buddhists And American Christians, Roy K. Chen, Wilaiporn Kotbungkair, Alicia D. Brown

School of Rehabilitation Services & Counseling Faculty Publications

Having a disability can significantly change a person’s life in many aspects. Research has shown that people with disabilities collectively have diminished access and fewer opportunities to pursue education, find gainful employment, and engage in intimate relationships. Self-acceptance of disability is, therefore, critical to help build resilience, confidence, and psychological well-being in this population. The purpose of the study was to compare the self-acceptance of disability in international settings, specifically in the context of religions. The sample of the study included 98 Thai Buddhists and 95 American Christians with neuromuscular disorders. Constructs used for the study included demographic characteristics, Hope …

Benchmarking Hospital Performance Using Health Analytics, Viju Raghupathi, Wullianallur Raghupathi

Publications and Research

Background: The objective of this study is to investigate hospital performance using an emerging analytics approach. Given that hospital care accounts for a large segment of healthcare spending, it is essential that hospital performance be measured over time to determine whether and where there is room for improvement in some of its critical success factors, and if there are savings to be found.

Methods: Employing indicators such as hospital cost, in-hospital death rate, length of hospital stay, and the number of discharges from the hospital, we look at the trends for these indicators over a 10-year period. Data was extracted …

A Neural Network Analysis Of Treatment Quality And Efficiency Of Hospitals, Viju Raghupathi, Wullianallur Raghupathi

Publications and Research

Objectives: Due to the escalating healthcare expenditure and the number of hospitalizations, it is becoming increasingly important for healthcare organizations to evaluate the cost and improve the quality and efficiency of treatment.

Method: We deploy neural networks to examine the strategic association between hospitalization experience and treatment results. The healthcare data for the years 2009-2012 are downloaded from the Statewide Planning and Research Cooperative System (SPARCS) of the New York State Department of Health (NYSDOH). We operationalize the hospitalization experience using the indicators facility ID, procedure description, type of admission, patient disposition upon discharge, APR severity of illness, source of …

The Impact Of Population, Health, And Environment Projects: A Synthesis Of Evidence, Rachel Winnik Yavinsky, Carolyn Lamere, Kristen P. Patterson, Jason Bremner

Reproductive Health

This working paper synthesizes the existing research and results from projects that integrate family planning with environment, livelihoods, natural-resource management, and other non-health development sectors. The report synthesizes the published and gray literature on current and past integrated projects and the experiences of implementers to generate a summary of the state of knowledge on integrated family planning and environment projects. Specifically, this synthesis documents what is being measured by integrated projects, the proven benefits of integration, and gaps in the evidence base. Based on this analysis, the synthesis highlights and discusses successes and challenges for documenting the impact of integrating …

Low Use And High Discontinuation Of Modern Contraceptives In Pakistan: Reasons And Policy Recommendations, Population Council

Reproductive Health

According to the latest Pakistan Demographic and Health Survey, 20 percent of married women of reproductive age have unmet need for contraception. Moreover, the country’s contraceptive prevalence rate (CPR), for modern and traditional methods combined, is only 35 percent—one of the lowest CPRs in the region. In addition to the problem of nonuse, the country is finding it difficult to keep current contraceptive users onboard: compared to other developing countries, Pakistan has the highest rate of discontinuation of contraceptive use. Thus, while there has been an overall increase in the use of contraceptives—modern and traditional—there is a large difference between …

The Effect Of Integrating Hiv Services On Quality Of Postnatal Care, Integra Initiative

Reproductive Health

Addressing the postnatal needs of new mothers is a neglected area of care throughout sub-Saharan Africa. Unintended pregnancies during the first 12 months following delivery, and vertical transmission of HIV during labor and delivery, are some of the challenges faced by women during the extended postpartum period. Many women want to delay or avoid another pregnancy, but are not using a modern contraceptive method. Few developing countries ensure that mothers and newborns are assessed early and monitored during the initial six-week period as recommended by WHO, which contributes to discontinuity of services received during pregnancy and delivery and limits linkages …

Expanding Young People's Access To Integrated Services In Malawi, Integra Initiative

Reproductive Health

In sub-Saharan Africa, uptake of sexual and reproductive health (SRH) services among young people remains low, placing millions of young people at risk of poor reproductive health outcomes and sexually transmitted infections, including HIV. The “Steps to Integration” series provides a guide on how to integrate HIV and SRH services based on findings from the Integra Initiative, managed by the International Planned Parenthood Federation in partnership with the London School of Hygiene & Tropical Medicine and the Population Council. Issue 7 of the series focuses on expanding young people’s access to integrated services in Malawi. Conclusions include: improving the quality …

Reducing Maternal And Child Mortality In Punjab: The Untapped Potential Of Family Planning, Zeba Sathar, Maqsood Sadiq, Seemin Ashfaq

Reproductive Health

Family planning (FP) is recognized as a necessary tool for faster fertility decline leading to accelerated economic development. However, its unique and potent role in preserving mother and child health is less well understood. This Population Council/Evidence Project policy brief explains why FP must be prioritized in Punjab’s health strategy as a key intervention for reducing maternal, infant, and under-five mortality in the province. By fulfilling the existing unmet need for birth spacing and limiting, it is possible to prevent 45 percent of maternal deaths, 26 percent of infant deaths, and 76 percent of young child deaths. FP’s wider health …

Sheep Updates 2015 - Moora, Bruce Mullen, Kate Pritchett, Kimbal Curtis, Daniel Real, Jaq Pearson, Lynne Bradshaw, Geoff Lindon, Katherine Davies, Kevin Hepworth, Stephen Lee, Dawson Bradford, Lucy Anderton, Jackie Jarvis, Ben Patrick

Sheep Updates

This session covers thirteen papers from different authors:

1. The Sheep Industry Business Innovation project, Bruce Mullan, Sheep Industry Development Director, Department of Agriculture and Food, Western Australia

2. Western Australian sheep stocktake, Kate Pritchett and Kimbal Curtis, Research Officers, Department of Agriculture and Food, Western Australia

3. Tedera - a perenial forage legume to reduce your supplementary feeding in summer and autumn, Dr. Daniel Real, Senior Plant Breeder, Department of Agriculture and Food, Western Australia

4. National Livestock Identification System (NLIS) for sheep and goats - what is the NLIS database? Jac Pearson, Biosecurity Officer, Department of Agriculture and …

Treatment Of Exophytic Renal Cancer Smaller Than 3 Cm: Surgery Versus Active Surveillance., Costas D. Lallas, Edouard J. Trabulsi, Samuel D. Kaffenberger, Karim A Touijer

Department of Urology Faculty Papers

No abstract provided.

Anti-Nmda Receptor Encephalitis In A Patient With Previous Psychosis And Neurological Abnormalities: A Diagnostic Challenge, R. David Heekin, Maria C. Catalano, Alfred T. Frontera, Glenn Catalano

Neurology Faculty Publications

Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is an autoimmune disorder characterized by IgG autoantibodies directed against the NR1 subunit of the NMDA glutamate receptor. Psychiatric symptoms are common and include psychosis, mania, depressed mood, aggression, and speech abnormalities. Neurological symptoms such as seizures, decreased responsiveness, dyskinesias, and other movement abnormalities and/or autonomic instability are frequently seen as well. We present the case of a woman who was followed up at our facility for over 14 years for the treatment of multiple neuropsychiatric symptoms. Initially, she presented with paresthesias, memory loss, and manic symptoms. Nine years later, she presented to our facility again, …

Use Of A Novel Imaging Technology For Remote Autism Diagnosis: A Reflection On Experience Of Stakeholders, Uwe Reischl

Public and Population Health Faculty Publications and Presentations

Timely diagnosis and early interventions are critical to improving the long term functioning of a child with ASD. However, a major challenge facing parents is difficulty in obtaining on-time access to appropriate diagnostic services. To address this need, an imaging technology, NODA® (Naturalistic Observation Diagnostic Assessment), has been successfully developed and field-tested. NODA® includes 1) NODA SmartCapture; a smart-phone based recording system for parents to capture and share inhome video evidence of their child behavior and 2) NODA Connect; a HIPPA compliant web-platform for diagnosticians to conduct remote autism diagnostic assessments based on in-home video evidence of behavior, developmental history …

Relationships1 Among Applications Of Tacit Knowledge And Transformational/Transactional Leader Styles: An Exploratory Comparison Of The Mlq And Tkml, Teresa Z. Taylor, Joseph Psotka, Peter Legree

Psychological Sciences Faculty Publications and Presentations

Purpose: The purpose of this research is to examine intercorrelational relations among the self-report behavioral construct Multifactor Leadership Questionnaire (MLQ) 5X transformational and transactional subscales and the Tacit Knowledge for Military Leaders Inventory (TKML) leader-level specific situational judgment test scenarios.

Design/methodology/approach: Two leadership measures, the behavioral construct Multifactor Leadership Questionnaire (MLQ) and the cognitive construct Tacit Knowledge for Military Leaders Inventory (TKML) assess different aspects of how a leader functions and were administered to 125 active US Army officers representing three leader levels: platoon, company, and battalion. We examine the intercorrelational relationship between these two measures.

Findings: Results show a …

Oral Health And The Elderly Talking Points, American Dental Association

Action for Dental Health

No abstract provided.

Impact Of The Global Strategy For Infant And Young Child Feeding On Nutrition And Child Survival Indicators As Illustrated By The World Breastfeeding Trends Initiative Tool, Charles Ituka Mosimah

Master of Public Health Program Student Publications

Background: Non-optimal infant and young child feeding (IYCF) practices are associated with malnutrition, infant mortality and under-five mortality, especially in Sub-Saharan Africa, where the risk of under-five mortality is 15 times higher than developed countries.

Objective: To determine implementation effects of the Global Strategy for Infant and Young Child Feeding before and after WBTi tool assessment using infant/child health data collected between 2000 and 2013 in Cameroon.

Methods: A descriptive analysis of Cameroon’s policies, programmes and practices was conducted using the WBTi tool. Child survival and nutrition indicators before (2003-2008) and after (2009-2013) WBTi assessment were analyzed using data from …

Association Of Maternal Demographics With Breastfeeding Of Low Birth Weight Infants In Ohio In 2012, Raymond I. Okeke Jr.

Master of Public Health Program Student Publications

Background: Breastfeeding (BF) is an important feeding practice for newborns, especially the low birth weight (LBW) infant population and during emergencies. Association of maternal demographics with BF in LBW infants in Ohio, especially during emergencies is not fully characterized. This study aims to fill that data gap.

Methods: The data for this study were the 2012 Ohio Vital Statistics Birth Data compiled by the Ohio Department of Health and obtained from Public Health – Dayton & Montgomery County. It included all 11,805 LBW, 8.5% of the total births in Ohio in 2012. IBM SPSS version 22 was used for the …

The Implications Of Hiv Treatment On The Hiv-Malaria Coinfection Dynamics: A Modeling Perspective, F. Nyabadza, B. T. Bekele, Megan A. Rúa, D. M. Malonza, N. Chiduku, M. Kgosimore

Biological Sciences Faculty Publications

Most hosts harbor multiple pathogens at the same time in disease epidemiology. Multiple pathogens have the potential for interaction resulting in negative impacts on host fitness or alterations in pathogen transmission dynamics. In this paper we develop a mathematical model describing the dynamics of HIV-malaria coinfection. Additionally, we extended our model to examine the role treatment (of malaria and HIV) plays in altering populations’ dynamics. Our model consists of 13 interlinked equations which allow us to explore multiple aspects of HIV-malaria transmission and treatment. We perform qualitative analysis of the model that includes positivity and boundedness of solutions. Furthermore, we …

Vital Signs, Winter 2015, Boonshoft School Of Medicine

Vital Signs

A sixty page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, a research spotlight, alumni notes, and more.