Medicine and Health Sciences Commons^™

Pre-Hospital Tranexamic Acid Use For Trauma, Troy Thompson

Physician Assistant Scholarly Project Posters

• Nearly 40% of deaths after trauma can be attributed to blood loss. It is well known that early surgical interventions, combined with other treatment modalities found in the hospital setting, lead to the decreased morbidity and mortality of trauma patients. However, in an outpatient setting, treatments for hemorrhage control are extremely limited.

• The purpose of this literature review was to explore tranexamic acid (TXA) use as an option for hemorrhage control and to determine its effect on morbidity and mortality in both prehospital and outpatient settings. TXA is an FDA approved antifibrinolytic that has proven efficacy for hemorrhage …

Do Mouth Guards Prevent Concussions In Contact Sports?, Lindsey Siemens

Physician Assistant Scholarly Project Posters

• Concussion is one of the leading cause of traumatic brain injury in 13-22 year olds

• The purpose of this study is to determine whether or not mouth guards provide protection from sports-related concussions in 13-22 year old athletes participating in contact sports

• Which type of mouth guard is the most effective in preventing or reducing the severity of these injuries?

Androgen-Induced Hypertension In Angiotensinogen Deficient Mice: Role Of 20-Hete And Eets, Victor Garcia, Jennifer Cheng, Adam Weidenhammer, Yan Ding, Cheng-Chia Wu, Fan Zhang, Katherine Gotlinger, John R. Falck, Michal L. Schwartzman

NYMC Faculty Publications

20-HETE is a potent inducer of endothelial ACE in vitro and administration of lisinopril or losartan attenuates blood pressure in models of 20-HETE-dependent hypertension. The present study was undertaken to further define the relationship between 20-HETE and the renin-angiotensin system in hypertension using an angiotensinogen-deficient mouse (Agt+/-). Treatment of male AGT+/- with 5α-dihydrotestosterone (DHT) increased systolic BP from 102±2 to 125±3mmHg; in comparison, the same treatment raised BP in wild type (WT) from 110±2 to 138±2mmHg. DHT increased vascular 20-HETE levels in AGT+/- and WT from 1.5±0.7 and 2.1±0.6 to 13.0±2.0 and 15.8±4.0ng/mg, respectively. Concurrent treatment with the 20-HETE antagonist, …

Developing A Health Sciences Information Literacy Assessment For Undergraduates., Carolyn Schubert, Stephanie Baller, Katherine Ott Walter, Lara Sapp, Jessica Jacovidis, Mandalyn Swanson

Libraries

This poster describes the development and pilot of a tailored information literacy assessment tool for undergraduate allied health students. Tool development included collaboration between assessment experts, Health Science faculty, and Health Science librarians. The poster includes results from the tool deployment and next steps in applying results back into revised curriculum.

Workup And Treatment Of Acute Peripheral Nerve Injuries: A Review, Scott D. Evans

UNM Orthopaedic Research Journal

Peripheral nerve injury (PNI) can be a devastating and life-changing condition, normally caused from traumatic and iatrogenic events. Proper treatment of PNI remains difficult, with less than half of surgical procedures resulting in good or excellent outcomes. Subsequently, physicians should be aware of important principles that can help with management of acute PNI. I reviewed studies on PNI involving anatomy and classification schemes; workup such as electrodiagnostic tests, imaging procedures, and surgical indications; and operative treatment options (including nerve repair and use of nerve grafts and conduits, and nerve, muscle, and tendon transfers). Although treatment of these injuries continues to …

Multiple Fracture Following Non-Occupational Fall: A Case Report, Brittany Olson

Physical Therapy Scholarly Projects

Background and Purpose: Falls are prevalent in adults over the age of sixty-five due to lack of balance and decreased lower extremity strength. Non-occupational falls are reported to have an increasing prevalence with age and one-fifth of these types of falls results in hospitalization. The hospitalization of patients who sustain injuries following falls most often results in skeletal fractures. The cost to treat these patients is projected to reach $54.9 billion by the year 2020. The objective of this case report is to demonstrate the outcomes of a patient who sustained multiple fractures following a nonoccupational fall.

Case Description …

Mobility Device For Injured Us Army Corp Engineer, Jessica Jones, Robert Whittaker

Physical Therapy Scholarly Projects

Background and Purpose: Low back pain affects 70-85% of American adults at some point in their life. Back pain can have a negative impact on a person's quality of life. A group of three engineering students and two physical therapy students collaborated on designing a mobility device for a US Army veteran to aid him in transfers and pain management. The purpose of this research proposal would be to assess how our client would respond to an individualized mobility device.

Case Description: Our client suffered lumbar disc injuries as a result of lifting and twisting a heavy object resulting in …

The Effectiveness Of Traction In A Patient With Recurring Neck Pain: A Case Report, Kassandra Kertz

Physical Therapy Scholarly Projects

Background and Purpose: According to Hoya et aI, neck pain is a common problem throughout the world, affecting 10.4-21.3% of the population each year. 50-85% of people with a new episode of neck pain will have a recurrence of neck pain 1-5 years later. Mechanical traction is an intervention commonly used to treat neck disorders; however, there is little current research supporting or refuting the effectiveness of the use of mechanical traction for neck pain. The purpose of this case report is to discuss the effectiveness of using mechanical traction in one patient with a recurring incidence of neck, shoulder, …

Benign Paroxysmal Positional Vertigo (Bppv): A Case Report, Kylie J. Palmiscno

Physical Therapy Scholarly Projects

BACKGROUND AND PURPOSE: Benign paroxysmal positional vertigo (BPPV) is the most common vestibular disorder. Of the vestibular disorders diagnosed in the general population, BPPV accounts for one third and may be successfully diagnosed and treated by a physical therapist in as little as one visit.

METHODS/CASE DESCRIPTION: This is a single case report of a 36-year-old female who was 5 months pregnant and diagnosed by her physician with vertigo. She was referred to physical therapy for further evaluation and treatment.

FINDINGS/INTERVENTION: With use of the Dix-Hallpike Maneuver the patient's diagnosis was confirmed and specified to be BPPV of the right …

A Case Report: Diabetic Amputee, Kip H. Thorstenson

Physical Therapy Scholarly Projects

Background and Purpose: The purpose of this case study is to present the reader with a detailed description of the physical therapy provided for a diabetic lower extremity amputee. As the number of amputations across America steadily increase, there is an elevated importance of understanding the prevalence, causes, and reasons for amputations and which interventions are most effective in increasing a patient's quality of life.

Case Description: The patient is a 77 year old male with significant past medical history of type I diabetes mellitus, hypertension, and osteoarthritis. This patient has significant gross muscle weakness in both his …

Distal Femoral Osteotomy With Reflex Sympathetic Dystrophy: A Multifaceted Therapeutic Approach, Mark Laraway

Physical Therapy Scholarly Projects

Background and Purpose: The surgical procedure known as a distal femoral osteotomy has been shown to be effective in treating valgus deformities of the knee with osteoarthritis in younger, active patients. But with any procedure, unsuspected complications such as Complex Regional Pain Syndrome (CRPS) can make rehabilitation for the patients and their therapists challenging. This study focuses on taking a multifaceted approach to treating all of the underlying impairments of a patient with recurring knee pathologies and an underlying secondary diagnosis of CRPS.

Case Description: The patient is a 38-year-old female who has had multiple surgeries on her …

Progressive Cognitive Deficit, Motor Impairment And Striatal Pathology In A Transgenic Huntington Disease Monkey Model From Infancy To Adulthood, Anthony W. S. Chan, Jie Jiang, Yiju Chen, Chunxia Li, Melinda S. Prucha, Yijuan Hu, Tim Chi, Sean Moran, Tayeb Rahim, Shihua Li, Xiaojiang Li, Stuart M. Zola, Claudia M. Testa, Hui Mao, Rosa Villalba, Yoland Smith, Xiaodong Zhang, Jocelyne Bachevalier

Neurology Publications

One of the roadblocks to developing effective therapeutics for Huntington disease (HD) is the lack of animal models that develop progressive clinical traits comparable to those seen in patients. Here we report a longitudinal study that encompasses cognitive and motor assessment, and neuroimaging of a group of transgenic HD and control monkeys from infancy to adulthood. Along with progressive cognitive and motor impairment, neuroimaging revealed a progressive reduction in striatal volume. Magnetic resonance spectroscopy at 48 months of age revealed a decrease of N-acetylaspartate (NAA), further suggesting neuronal damage/loss in the striatum. Postmortem neuropathological analyses revealed significant neuronal loss in …

Virginia Dental Journal (Vol. 92, No. 4, 2015)

Virginia Dental Journal

No abstract provided.

We Happy Few: Accomplishments In Calendar 2014, Edward F. Ansello

Director's Editorials from Age in Action

The Virginia Center on Aging recognizes strides its staff has made in confronting elder abuse and domestic violence in later life; building and improving lifelong learning opportunities across the Commonwealth for mid-life and older adults; delivering interprofessional geriatrics training for health care providers and measuring the impacts of this training upon the patients they care for; training clinical students to partner across professions to improve geriatrics care; developing and delivering education and training programs to audiences in state, regional, and national conferences and webinars on topics ranging from gerontological education to aging with lifelong disabilities, community health to interdisciplinary teamwork; …

Culture-Centered Approaches: The Relevance Of Assessing Emotional Health For Latinos With Type 2 Diabetes, Jeannie Belinda Concha, Brianna Mezuk, Bonnie Duran

Family Medicine and Population Health Publications

Objective

Within Latino culture, there is a belief that strong emotions can cause diabetes. Because of this belief and evidence regarding the bi-directional relationship between depression and diabetes, the objectives of this study were to determine if medical doctors are asking Latinos with diabetes about emotional problems and to assess attitudes toward professional help for emotional problems.

Research design and methods

Data come from the nationally representative National Latino and Asian American Study and the National Comorbidity Survey Replication study. Only Latino subsamples were included (n=3076). A smaller subsample with complete data (n=2568) was used for the inquiry outcome variable. …

Comparison Of Effectiveness Of Cefovecin, Doxycycline, And Amoxicillin For The Treatment Of Experimentally Induced Early Lyme Borreliosis In Dogs, Bettina Wagner, John Johnson, David Garcia-Tapia, Nicole Honsberger, Vickie King, Catherine Strietzel, John M. Hardham, Thomas J. Heinz, Richard T. Marconi, Patrick F.M. Meeus

Microbiology and Immunology Publications

Background

While Koch’s postulates have been fulfilled for Lyme disease; causing transient fever, anorexia and arthritis in young dogs; treatment of sero-positive dogs, especially asymptomatic animals, remains a topic of debate. To complicate this matter the currently recommended antibiotic treatments of Lyme Disease in dogs caused by Borrelia burgdorferi require daily oral administrations for 31 days or longer, which makes non-compliance a concern. Additionally, there is no approved veterinary antimicrobial for the treatment of Lyme Disease in dogs in the USA and few recommended treatments have been robustly tested.

In vitro testing of cefovecin, a novel extended-spectrum cephalosporin, demonstrated inhibition …

Identification Of Small-Molecule Inhibitors Against Meso-2, 6-Diaminopimelate Dehydrogenase From Porphyromonas Gingivalis, Victoria N. Stone, Hardik I. Parikh, Fadi El-Rami, Xiuchun Ge, Weihau Chen, Yan Zhang, Glen E. Kellogg, Ping Xu

Microbiology and Immunology Publications

Species-specific antimicrobial therapy has the potential to combat the increasing threat of antibiotic resistance and alteration of the human microbiome. We therefore set out to demonstrate the beginning of a pathogen-selective drug discovery method using the periodontal pathogen Porphyromonas gingivalis as a model. Through our knowledge of metabolic networks and essential genes we identified a “druggable” essential target, meso-diaminopimelate dehydrogenase, which is found in a limited number of species. We adopted a highthroughput virtual screen method on the ZINC chemical library to select a group of potential small-molecule inhibitors. Meso-diaminopimelate dehydrogenase from P. gingivalis was first expressed and purified in …

Redox Regulation Of Nlrp3 Inflammasomes: Ros As Trigger Or Effector?, Justine M. Abais, Min Xia, Yang Zhang, Krishna M. Boini, Pin-Lan Li

Pharmacology and Toxicology Publications

Significance: Inflammasomes are multiprotein complexes localized within the cytoplasm of the cell that are responsible for the maturation of proinflammatory cytokines such as interleukin-1β (IL-1β) and IL-18, and the activation of a highly inflammatory form of cell death, pyroptosis. In response to infection or cellular stress, inflammasomes are assembled, activated, and involved in host defense and pathophysiology of diseases. Clarification of the molecular mechanisms leading to the activation of this intracellular inflammatory machinery may provide new insights into the concept of inflammation as the root of and route to human diseases. Recent Advances: The activation of inflammasomes, specifically the most …

Use Of Prescription Drugs And Future Delinquency Among Adolescent Offenders, Tess K. Drazdowski, Lena Jäggi, Alicia Borre, Wendy L. Kliewer

Psychology Publications

Non-medical use of prescription drugs (NMUPD) by adolescents is a significant public health concern. The present study investigated the profile of NMUPD in 1349 adolescent offenders from the Pathways to Desistance project, and whether NMUPD predicted future delinquency using longitudinal data. Results indicated that increased frequency and recency of NMUPD in adolescent offenders are related to some demographic factors, as well as increased risk for violence exposure, mental health diagnoses, other drug use, and previous delinquency, suggesting that severity of NMUPD is important to consider. However, ANCOVA analyses found that NMUPD was not a significant predictor of drug-related, non-aggressive, or …

Integrating Mrna And Mirna Weighted Gene Co-Expression Networks With Eqtls In The Nucleus Accumbens Of Subjects With Alcohol Dependence, Mohammed Mamdani, Vernell Williamson, Gowon O. Mcmichael, Tana Blevins, Fazil Aliev, Amy Adkins, Laura Hack, Tim Bigdeli, Andrew D. Van Der Vaart, Bradley Todd Webb, Silviu-Alin Bacanu, Gursharan Kalsi, Coga Consortium, Kenneth S. Kendler, Michael F. Miles, Danielle Dick, Brien P. Riley, Catherine Dumur, Vladimir I. Vladimirov

Psychology Publications

Alcohol consumption is known to lead to gene expression changes in the brain. After performing weighted gene co-expression network analyses (WGCNA) on genome-wide mRNA and microRNA (miRNA) expression in Nucleus Accumbens (NAc) of subjects with alcohol dependence (AD; N = 18) and of matched controls (N = 18), six mRNA and three miRNA modules significantly correlated with AD were identified (Bonferoni-adj. p≤ 0.05). Cell-type-specific transcriptome analyses revealed two of the mRNA modules to be enriched for neuronal specific marker genes and downregulated in AD, whereas the remaining four mRNA modules were enriched for astrocyte and microglial specific marker genes and …

Developmental Changes In Genetic And Shared Environmental Contributions To Smoking Initiation And Subsequent Smoking Quantity In Adolescence And Young Adulthood, Cristina B. Bares, Kenneth S. Kendler, Hermine H. Maes

Psychiatry Publications

Background

Few studies examining the genetic architecture of cigarette smoking have focused on adolescents or examined developmental changes in additive genetic, shared environment and unique environmental influences on liability to initiate cigarette smoking and quantity of cigarettes smoked. The aim of this study is to add to the literature on liability to initiate and use cigarettes during adolescence using a nationally representative sample.

Method

Data for this study came from adolescent and young adult twin pairs (ages 14-33) from the National Longitudinal Study of Adolescent to Adult Health. We ran a series of developmental causal-contingent-common pathway models to examine whether …

Genetic Network Properties Of The Human Cortex Based On Regional Thickness And Surface Area Measures, Anna R. Docherty, Chelsea K. Sawyers, Matthew S. Panizzon, Michael C. Neale, Lisa T. Eyler, Christine Fennema-Notestine, Carol E. Franz, Chi-Hua Chen, Linda K. Mcevoy, Brad Verhulst, Ming T. Tsuang, William S. Kremen

Psychiatry Publications

We examined network properties of genetic covariance between average cortical thickness (CT) and surface area (SA) within genetically-identified cortical parcellations that we previously derived from human cortical genetic maps using vertex-wise fuzzy clustering analysis with high spatial resolution. There were 24 hierarchical parcellations based on vertex-wise CT and 24 based on vertex-wise SA expansion/contraction; in both cases the 12 parcellations per hemisphere were largely symmetrical. We utilized three techniques—biometrical genetic modeling, cluster analysis, and graph theory—to examine genetic relationships and network properties within and between the 48 parcellation measures. Biometrical modeling indicated significant shared genetic covariance between size of several …

Political Attitudes Develop Independently Of Personality Traits, Peter K. Hatemi, Brad Verhulst

Psychiatry Publications

The primary assumption within the recent personality and political orientations literature is that personality traits cause people to develop political attitudes. In contrast, research relying on traditional psychological and developmental theories suggests the relationship between most personality dimensions and political orientations are either not significant or weak. Research from behavioral genetics suggests the covariance between personality and political preferences is not causal, but due to a common, latent genetic factor that mutually influences both. The contradictory assumptions and findings from these research streams have yet to be resolved. This is in part due to the reliance on cross-sectional data and …

Genome-Wide Association Data Suggest Abcb1 And Immune-Related Gene Sets May Be Involved In Adult Antisocial Behavior, J E. Salvatore, A C. Edwards, J N. Mcclintick, T B. Bidgeli, A Adkins, F Aliev, H J. Edenberg, T Foround, V Hesselbrock, J Kramer, J I. Nurnberger, M Schuckit, J A. Tischfield, X Xuei, D Dick

Psychiatry Publications

Adult antisocial behavior (AAB) is moderately heritable, relatively common and has adverse consequences for individuals and society. We examined the molecular genetic basis of AAB in 1379 participants from a case–control study in which the cases met criteria for alcohol dependence. We also examined whether genes of interest were expressed in human brain. AAB was measured using a count of the number of Antisocial Personality Disorder criteria endorsed under criterion A from the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV). Participants were genotyped on the Illumina Human 1M BeadChip. In total, all single-nucleotide polymorphisms (SNPs) accounted for …

Who Are Those “Risk-Taking Adolescents”? Individual Differences In Developmental Neuroimaging Research, James M. Bjork, Dustin A. Pardini

Psychiatry Publications

Functional magnetic resonance imaging (fMRI) has illuminated the development of human brain function. Some of this work in typically-developing youth has ostensibly captured neural underpinnings of adolescent behavior which is characterized by risk-seeking propensity, according to psychometric questionnaires and a wealth of anecdote. Notably, cross-sectional comparisons have revealed age-dependent differences between adolescents and other age groups in regional brain responsiveness to prospective or experienced rewards (usually greater in adolescents) or penalties (usually diminished in adolescents). These differences have been interpreted as reflecting an imbalance between motivational drive and behavioral control mechanisms, especially in mid-adolescence, thus promoting greater risk-taking. While intriguing, …

Respiratory Motion Variability Of Primary Tumors And Lymph Nodes During Radiotherapy Of Locally Advanced Non-Small-Cell Lung Cancers, Nuzhat Jan, Geoffrey D. Hugo, Nitai Mukhopadhyay, Elisabeth Weiss

Radiation Oncology Publications

Background and purpose

The need for target adjustment due to respiratory motion variation and the value of carina as a motion surrogate is evaluated for locally advanced non-small-cell lung cancer.

Material and methods

Using weekly 4D CTs (with audio-visual biofeedback) of 12 patients, respiratory motion variation of primary tumors (PT), lymph nodes (LN) and carina (C) were determined.

Results

Mean (SD) 3D respiratory motion ranges of PT, LN and C were 4 (3), 5 (3) and 5 (3) mm. PT and LN (p = 0.003), and LN and C motion range were correlated (p = 0.03). Only 20 …

Spag17 Deficiency Results In Skeletal Malformations And Bone Abnormalities, Maria Eugenia Teves, Gobalakrishnan Sundaresan, David J. Cohen, Sharon L. Hyzy, Illya Kajan, Melissa Maczis, Zhibing Zhang, Richard M. Costanzo, Jamal Zweit, Zvi Schwartz, Barbara` D. Boyan, Jerome F. Strauss Iii

Obstetrics and Gynecology Publications

Height is the result of many growth and development processes. Most of the genes associated with height are known to play a role in skeletal development. Single-nucleotide polymorphisms in the SPAG17 gene have been associated with human height. However, it is not clear how this gene influences linear growth. Here we show that a targeted mutation in Spag17 leads to skeletal malformations. Hind limb length in mutants was significantly shorter than in wild-type mice. Studies revealed differences in maturation of femur and tibia suggesting alterations in limb patterning. Morphometric studies showed increased bone formation evidenced by increased trabecular bone area …

Sperm Associated Antigen 6 (Spag6) Regulates Fibroblast Cell Growth, Morphology, Migration And Ciliogenesis, Wei Li, Abir Mukherjee, Jinhua Wu, Ling Zhang, Maria E. Teves, Hongfei Li, Shanti Nambiar, Scott C. Henderson, Alan R. Horwitz, Jerome F. Strauss Iii, Xianjun Fang, Zhibing Zhang

Obstetrics and Gynecology Publications

Mammalian Spag6 is the orthologue of Chlamydomonas PF16, which encodes a protein localized in the axoneme central apparatus, and regulates flagella/cilia motility. Most Spag6-deficient mice are smaller in size than their littermates. Because SPAG6 decorates microtubules, we hypothesized that SPAG6 has other roles related to microtubule function besides regulating flagellar/cilia motility. Mouse embryonic fibroblasts (MEFs) were isolated from Spag6-deficient and wild-type embryos for these studies. Both primary and immortalizedSpag6-deficient MEFs proliferated at a much slower rate than the wild-type MEFs, and they had a larger surface area. Re-expression of SPAG6 in the Spag6-deficient MEFs …

Screening And Surveillance Ct Abdomen/Pelvis For Metastases In Patients With Soft-Tissue Sarcoma Of The Extremity, M. J. Thompson, J. Ross, G. Domson, W. Foster

Orthopaedic Surgery Publications

Objectives The clinical utility of routine cross sectional imaging of the abdomen and pelvis in the screening and surveillance of patients with primary soft-tissue sarcoma of the extremities for metastatic disease is controversial, based on its questionable yield paired with concerns regarding the risks of radiation exposure, cost, and morbidity resulting from false positive findings.

Methods Through retrospective review of 140 patients of all ages (mean 53 years; 2 to 88) diagnosed with soft-tissue sarcoma of the extremity with a mean follow-up of 33 months (0 to 291), we sought to determine the overall incidence of isolated abdominopelvic metastases, their …

Quality Control Material For The Detection Of Somatic Mutations In Fixed Clinical Specimens By Next-Generation Sequencing, Catherine I. Dumur, Jorge A. Almenara, Celeste N. Powers, Andrea Ferreira-Gonzalez

Pathology Publications

Background

Targeted next generation sequencing (NGS) technology to assess the mutational status of multiple genes on formalin-fixed, paraffin embedded (FFPE) tumors is rapidly being adopted in clinical settings, where quality control (QC) practices are required. Establishing reliable FFPE QC materials for NGS can be challenging and/or expensive. Here, we established a reliable and cost-effective FFPE QC material for routine utilization in the Ion AmpliSeq™ Cancer Hotspot Panel v2 (CHP2) assay.

Methods

The performance characteristics of the CHP2 assay were determined by sequencing various cell line mixtures and 55 different FFPE tumors on the Ion Torrent PGM platform. A FFPE QC …