Medicine and Health Sciences Commons^™

The Incidence Of Upper And Lower Extremity Surgery For Rheumatoid Arthritis Among Medicare Beneficiaries, Jeniffer Waljee, Lin Zhong, Onur Baser, Huseyin Yuce, David A. Fox, Kevin C. Chung

Publications and Research

Background: For elderly patients with rheumatoid arthritis, aggressive immunosuppression can be difficult to tolerate, and surgery remains an important treatment option for joint pain and deformity. We sought to examine the epidemiology of surgical reconstruction for rheumatoid arthritis among older individuals who were newly diagnosed with the disorder.

Methods: We identified a 5% random sample of Medicare beneficiaries (sixty-six years of age and older) newly diagnosed with rheumatoid arthritis from 2000 to 2005, and followed these patients longitudinally for a mean of 4.6 years. We used univariate analysis to compare the time from the diagnosis of rheumatoid arthritis to the …

Characteristics Of Clinical Shoulder Research Over The Last Decade: A Review Of Shoulder Articles In The Journal Of Bone & Joint Surgery From 2004 To 2014, Gary M. Gartsman, Brent J. Morris, R. Zackary Unger, Mitzi S. Laughlin, Hussein A. Elkousy, T. Bradley Edwards

Orthopaedic Surgery and Sports Medicine Faculty Publications

Background: The purpose of this study was to determine characteristics and trends in published shoulder research over the last decade in a leading orthopaedic journal.

Methods: We examined all clinical shoulder articles published in The Journal of Bone & Joint Surgery from 2004 to 2014. The number of citations, authorship, academic degrees of the authors, country and institution of origin, topic, level of evidence, positive or nonpositive outcome, and inclusion of validated patient-reported outcome measures were assessed for each article.

Results: Shoulder articles that included an author with an advanced research degree (MD [Doctor of Medicine] with a PhD …

Epidemiology News, Georgia Southern University

Biostatistics, Epidemiology & Environmental Health Sciences: News & Publications (2011-2018)

• Converting Big Data into Public Health
• Evaluation of Diverse Community Asthma Interventions

Health Policy & Management News, Georgia Southern University

Health Policy & Community Health: News & Publications (2011-2018)

• Impact of Emotional Intelligence

Relationship Between Antibody Susceptibility And Lipopolysaccharide O-Antigen Characteristics Of Invasive And Gastrointestinal Nontyphoidal Salmonellae Isolates From Kenya, Robert S. Onsare, Francesca Micoli, Luisa Lanzilao, Renzo Alfini, Chinyere K. Okoro, Anne W. Muigai, Gunturu Revathi, Allan Saul, Samuel Kariuki, Calman A. Maclennan, Simona Rondini

Pathology, East Africa

Background: Nontyphoidal Salmonellae (NTS) cause a large burden of invasive and gastrointestinal disease among young children in sub-Saharan Africa. No vaccine is currently available. Previous reports indicate the importance of the O-antigen of Salmonella lipopolysaccharide for virulence and resistance to antibody-mediated killing. We hypothesised that isolates with more O-antigen have increased resistance to antibody-mediated killing and are more likely to be invasive than gastrointestinal.

Methodology/Principal findings: We studied 192 NTS isolates (114 Typhimurium, 78 Enteritidis) from blood and stools, mostly from paediatric admissions in Kenya 2000-2011. Isolates were tested for susceptibility to antibody-mediated killing, using whole adult serum. O-antigen structural …

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Impact of Emotional Intelligence
• Converting Big Data into Public Health
• Practical Considerations Regarding CBPR For addressing Cancer Health Disparities
• Evaluation of Diverse Community Asthma interventions

Unsilencing The Voice Within: Expressive Writing As A Therapeutic Tool, Karla L. Sapp

National Youth Advocacy & Resilience Conference

Written words are a very powerful tool that is used to facilitate self-healing, awareness, and growth through the communication of one’s deepest thoughts, emotions, and desires. The purpose of this poster session is to provide mental health providers (community, school, criminal justice) with an overview of expressive writing, forms of expressive writing that can be utilized, and implications for professional practice with At-Risk Youth.

Providing The Teen Outreach Program In School Settings, Phillippia Faust, Tina Thomas, Greg Johnson

National Youth Advocacy & Resilience Conference

MTCI will share the experiences of providing the Teen Outreach Program (TOP). The challenges of providing a year long program within school systems where most students change classes each semester will be addressed, along with effective strategies. The presenters will offer instruction regarding successful program activities for the youth service professional working with high school populations.

2015 March 3 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

Ms-Squared Focus Group Questions And Probes: V1.4, Philip J. Kroth

MS-Squared

This document contains the MS-Squared Study's focus group questions and probes.

Reply To Kjartansdóttir Et Al.: Chlorovirus Atcv-1 Findings Not Explained By Contamination, Robert H. Yolken, Lorraine Jones-Brando, David Dunigan, Geetha Kannan, Faith Dickerson, Emily Severance, Sarven Sabunciyan, C. Conover Talbot Jr., Emese Prandovszky, James Gurnon, Irina Agarkova, Flora Leister, Kristin L. Gressitt, Ou Chen, Bryan Deuber, Fangrui Ma, Mikhail V. Pletnikov, James L. Van Etten

James Van Etten Publications

We agree with Kjartansdóttir et al. (1) that extreme caution must be used when interpreting high-throughput sequencing results in new hosts. The situation demands thorough investigation and validation beyond the identification of a few sequencing reads. However, we believe it is unlikely that random laboratory contamination explains the results reported in Yolken et al. (2) for the following reasons. ...

Therefore, the conclusions in our report are based not only on “a few sequence reads” (1), but on confirmatory assays, as well as a highly controlled animal model of oral exposure and subsequent measurement of immune response and behavior. We …

The Journey Toward Voluntary Public Health Accreditation Readiness In Local Health Departments: Leadership And Followership Theories In Action, Angela L. Carman

Health Management and Policy Faculty Publications

Local health department directors’ intent on getting their organizations ready for accreditation must embrace the blurring of leader/follower lines and create an accreditation readiness team fueled not by traditional leader or follower roles but by teamship.

Unlocking The Mysteries Of Tdp-43, Keith A. Josephs, Peter T. Nelson

Sanders-Brown Center on Aging Faculty Publications

No abstract provided.

Metabolic Reprogramming Of Cancer-Associated Fibroblasts By Idh3Α Downregulation, Daoxiang Zhang, Yongbin Wang, Zhimin Shi, Jingyi Liu, Pan Sun, Xiaodan Hou, Jian Zhang, Shimin Zhao, Binhua P. Zhou, Jun Mi

Markey Cancer Center Faculty Publications

Cancer-associated fibroblasts (CAFs) provide critical metabolites for tumor growth and undergo metabolic reprogramming to support glycolysis. However, the molecular mechanisms responsible for this change remain unclear. Here, we report that TGF-β1- or PDGF-induced CAFs switch from oxidative phosphorylation to aerobic glycolysis. We identify downregulation of isocitrate dehydrogenase 3α (IDH3α) as a marker for this switch. Furthermore, miR-424 downregulates IDH3α during CAF formation. Downregulation of IDH3α decreases the effective level of α-ketoglutarate (α-KG) by reducing the ratio of α-KG to fumarate and succinate, resulting in PHD2 inhibition and HIF-1α protein stabilization. The accumulation of HIF-1α, in turn, promotes glycolysis by increasing …

Identification Of A Family Of Fatty Acid-Speciated Sonic Hedgehog Proteins, Whose Members Display Differential Biological Properties, Jun Long, Robert Tokhunts, William M. Old, Stephane Houel, Jezabel Rodgriguez-Blanco, Samer Singh, Neal Schilling, Anthony J. Capobianco, Natalie G. Ahn, David J. Robbins

Dartmouth Scholarship

Hedgehog (HH) proteins are proteolytically processed into a biologically active form that is covalently modified by cholesterol and palmitate. However, most studies of HH biogenesis have characterized protein from cells in which HH is overexpressed. We purified Sonic Hedgehog (SHH) from cells expressing physiologically relevant levels and showed that it was more potent than SHH isolated from overexpressing cells. Furthermore, the SHH in our preparations was modified with a diverse spectrum of fatty acids on its amino termini, and this spectrum of fatty acids varied dramatically depending on the growth conditions of the cells. The fatty acid composition of SHH …

Spectral Gene Set Enrichment (Sgse), H Robert Frost, Zhigang Li, Jason H. Moore

Dartmouth Scholarship

Gene set testing is typically performed in a supervised context to quantify the association between groups of genes and a clinical phenotype. In many cases, however, a gene set-based interpretation of genomic data is desired in the absence of a phenotype variable. Although methods exist for unsupervised gene set testing, they predominantly compute enrichment relative to clusters of the genomic variables with performance strongly dependent on the clustering algorithm and number of clusters. We propose a novel method, spectral gene set enrichment (SGSE), for unsupervised competitive testing of the association between gene sets and empirical data sources. SGSE first computes …

An Interdisciplinary Approach To Reducing Pressure Ulcers In The Geriatric Trauma Population, Kai L. Bortz Rn

Patient Care Services / Nursing

No abstract provided.

Is Metabolic Syndrome Predictive Of Prevalence, Extent, And Risk Of Coronary Artery Disease Beyond Its Components? Results From The Multinational Coronary Ct Angiography Evaluation For Clinical Outcome: An International Multicenter Registry (Confirm), Ricardo Cury

All Publications

No abstract provided.

Choices: A Family-Based Childhood Obesity Intervention For Low Income Minority Children, Cynthia Williams Brown, Claudia Warren, Marian Booker

National Youth Advocacy & Resilience Conference

The objective of this presentation is to discuss the effectiveness of a 6-week summer childhood obesity intervention for low-income minority children ages 10-12. Topics will include strategies and best practices for effective summer programming for youth. The target audience includes practitioners, educators, and researchers interested in childhood obesity interventions involving families and communities.

Reaching Vs. Teaching: How To Connect With Youth In A Way That Changes Behavior, Jackie Brewton

National Youth Advocacy & Resilience Conference

Jackie Brewton’s “Reaching vs. Teaching” workshop will equip attendees with tried and true techniques that have helped her to empower thousands of girls, as well as guys, to choose to delay sexual activity as the “best choice” option for their future. Attendees will learn effective approaches to connect with youth for long-term behavioral change Including: the importance of knowing their world and using culturally relevant examples; teaching students towards something not away from something; and how to help students think, not tell them how to think.

Ada News - 03/02/2015, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

What's Happening: March 2, 2015, Maine Medical Center

What's Happening

No abstract provided.

Guidelines For Pre-Clinical Assessment Of The Acetylcholine Receptor-Specific Passive Transfer Myasthenia Gravis Model - Recommendations For Methods And Experimental Designs., Linda L. Kusner, Mario Losen, Angela Vincent, Jon Lindstrom, Socrates Tzartos, Konstantinos Lazaridis, Pilar Martinez-Martinez

Pharmacology and Physiology Faculty Publications

Antibodies against the muscle acetylcholine receptor (AChR) are the most common cause of myasthenia gravis (MG). Passive transfer of AChR antibodies from MG patients into animals reproduces key features of human disease, including antigenic modulation of the AChR, complement-mediated damage of the neuromuscular junction, and muscle weakness. Similarly, AChR antibodies generated by active immunization in experimental autoimmune MG models can subsequently be passively transferred to other animals and induce weakness. The passive transfer model is useful to test therapeutic strategies aimed at the effector mechanism of the autoantibodies. Here we summarize published and unpublished experience using the AChR passive transfer …

Improving Nurses Knowledge Of Delirium And Implementation Of The R.A.D.A.R. Screening Tool At Two Post Acute Care Facilities In The United States, Kanah Lewallen

DNP Projects

Delirium in post acute care patients is under-recognized and linked to poor patient outcomes. Nurses in the post acute care setting are currently not using a standardized tool for assessing delirium, but the literature suggests they should do this routinely. The purposes of this study were to evaluate methods for improving the management of delirium in post acute care and to evaluate the implementation of a new screening tool for delirium (Recognizing Active Delirium As Routine or R.A.D.A.R.). This quasi-experimental study was conducted at two post acute care facilities in an urban location. The study included the implementation of a …

Learning Language In Autism: Maternal Linguistic Input Contributes To Later Vocabulary, Janet Bang, Aparna Nadig

Faculty Research, Scholarly, and Creative Activity

It is well established that children with typical development (TYP) exposed to more maternal linguistic input develop larger vocabularies. We know relatively little about the linguistic environment available to children with autism spectrum disorders (ASD), and whether input contributes to their later vocabulary. Children with ASD or TYP and their mothers from English and French-speaking families engaged in a 10 min free-play interaction. To compare input, children were matched on language ability, sex, and maternal education (ASD n = 20, TYP n = 20). Input was transcribed, and the number of word tokens and types, lexical diversity (D), mean length …

How Far Will They Go?: Assessing The Travel Distance Of Current And Former Drug Users To Access Harm Reduction Services, Sean Allen, Monica S. Ruiz, Allison O'Rourke

Prevention and Community Health Faculty Publications

Background

Prior research has explored spatial access to syringe exchange programs (SEPs) among people who inject drugs (PWID), but little is known about service utilization by former PWID who continue to access services (e.g., HIV screenings and referrals for social services) at harm reduction providers. The purpose of this research is to examine differences in access to SEPs between current and former PWID seeking services at a mobile SEP in Washington, DC.

Findings

A geometric point distance estimation technique was applied to data collected as part of a PWID population estimation study that took place in Washington, DC, in March …

Refractory Angiosarcoma Of The Breast With Vegfr2 Upregulation Successfully Treated With Sunitinib., Edibaldo Silva, Zoran Gatalica, Semir Vranic, Gargi Basu, Sandeep K. Reddy, Andreas Voss

Journal Articles: Surgery

No abstract provided.

Medical School Watercooler Newsletter- March 1, 2015, Lindsey Lyle

Watercooler Newsletter

This is the March 1, 2015 edition of the Frederick P. Whiddon College of Medicine's Newsletter - Watercooler.

Contents Include:

USA College of Medicine Division of Medical Education Publishes CURRents Newsletter

COM Alum Dr. David Adkison Presents Lecture

USA Mourns Loss of Dr. Nathan Aronson

Mark Your Calendar: Match Day 2015

The Association Between Critical Thinking And Scholastic Aptitude On First-Time Pass Rate Of The National Physical Therapy Examination, Daniel W. Suckow, C. Jayne Brahler, Betsy Donahoe-Fillmore, Mary Insana Fisher, Philip A. Anloague

Physical Therapy Faculty Publications

Objectives: 1) To investigate the relationships among critical thinking (CT) abilities, overall academic performance in the Doctorate of Physical Therapy (DPT) program as measured by cumulative grade point average (GPA), and National Physical Therapy Examination (NPTE) licensure scores, and 2) To determine if NPTE scores were significantly different between groups of students who were classified as having low, moderate or high CT abilities.

Background: It is well-established that physical therapy practice requires good clinical reasoning skills. Passage of the NPTE is required for licensure. Research to date has been mixed as to whether CT abilities or GPA can predict success …

Brain Blast 2015 Speakers Poster, Annie Leslie

Brain Blast

Poster from UNE's Brain Blast 2015 listing the expected presenters at this event.*