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Articles 601 - 630 of 11981
Full-Text Articles in Medicine and Health Sciences
Problem Solving Skill And Obesity In Children, Caitlin R. Spano
Problem Solving Skill And Obesity In Children, Caitlin R. Spano
The Eleanor Mann School of Nursing Undergraduate Honors Theses
Abstract:
Introduction: Childhood obesity is a problem that leads to many serious health effects including early maturation, decreased quality of life and increased risk for cardiovascular disease. In 2012, over one third of children were considered obese (Childhood Obesity Facts 2015). Efforts have been made to reduce this number but they have not been fully successful (Nutrition Standards for School Meals 2015, Prevalence of Childhood obesity in the United States 2011-2012 2015). What other factors are causing kids to choose foods that lead to weight gain.
Literature Review: In research regarding psychological motivations of overeating, there has been a correlation …
Safe Sleep Education And Staff Compliance, Shayla M. Hadley
Safe Sleep Education And Staff Compliance, Shayla M. Hadley
The Eleanor Mann School of Nursing Undergraduate Honors Theses
The purpose of this project was to evaluate compliance with the teaching and documentation of safe sleep practices within a pediatric unit. The objective was to increase the percentage of the charts of patients one year of age and younger that have documented safe sleep teaching at the level of compliance with the department policy. This change in compliance was measured by determining the percentage of patient charts having documented safe sleep teaching at the level of compliance prior to the implementation of mandatory staff education as compared to the percentage of charts with documented safe sleep teaching at the …
Sustained Isometric Shoulder Contraction On Muscular Strength And Endurance: A Randomized Clinical Trial, Natalie L. Myers, Jenny L. Toonstra, Jacob S. Smith, Cooper A. Padgett, Tim L. Uhl
Sustained Isometric Shoulder Contraction On Muscular Strength And Endurance: A Randomized Clinical Trial, Natalie L. Myers, Jenny L. Toonstra, Jacob S. Smith, Cooper A. Padgett, Tim L. Uhl
Physical Therapy Faculty Publications
BACKGROUND: The Advanced Throwers Ten Exercise Program incorporates sustained isometric contractions in conjunction with dynamic shoulder movements. It has been suggested that incorporating isometric holds may facilitate greater increases in muscular strength and endurance. However, no objective evidence currently exists to support this claim.
HYPOTHESIS/PURPOSE: The purpose of this research was to compare the effects of a sustained muscle contraction resistive training program (Advanced Throwers Ten Program) to a more traditional exercise training protocol to determine if increases in shoulder muscular strength and endurance occur in an otherwise healthy population. It was hypothesized that utilizing a sustained isometric …
Reliability Of 3-Dimensional Measures Of Single-Leg Cross Drop Landing Across 3 Different Institutions: Implications For Multicenter Biomechanical And Epidemiological Research On Acl Injury Prevention, Christopher A. Dicesare, Nathaniel A. Bates, Kim D. Barber Foss, Staci M. Thomas, Samuel C. Wordeman, Dai Sugimoto, Benjamin D. Roewer, Jennifer M. Medina Mckeon, Stephanie Di Stasi, Brian W. Noehren, Kevin R. Ford, Adam W. Kiefer, Timothy E. Hewett, Gregory D. Myer
Reliability Of 3-Dimensional Measures Of Single-Leg Cross Drop Landing Across 3 Different Institutions: Implications For Multicenter Biomechanical And Epidemiological Research On Acl Injury Prevention, Christopher A. Dicesare, Nathaniel A. Bates, Kim D. Barber Foss, Staci M. Thomas, Samuel C. Wordeman, Dai Sugimoto, Benjamin D. Roewer, Jennifer M. Medina Mckeon, Stephanie Di Stasi, Brian W. Noehren, Kevin R. Ford, Adam W. Kiefer, Timothy E. Hewett, Gregory D. Myer
Physical Therapy Faculty Publications
Background: Anterior cruciate ligament (ACL) injuries are physically and financially devastating but affect a relatively small percentage of the population. Prospective identification of risk factors for ACL injury necessitates a large sample size; therefore, study of this injury would benefit from a multicenter approach.
Purpose: To determine the reliability of kinematic and kinetic measures of a single-leg cross drop task across 3 institutions.
Study Design: Controlled laboratory study.
Methods: Twenty-five female high school volleyball players participated in this study. Three-dimensional motion data of each participant performing the single-leg cross drop were collected at 3 institutions over a period of 4 …
Detection And Epidemiology Of Plasmid-Mediated Ampc B-Lactamase Producing Escherichia Coli In Two Irish Tertiary Care Hospitals, Celine Herra
Articles
This study determined the prevalence and distribution of plasmid-mediated AmpC (pAmpC) b-lactamases in Irish Escherichia coli isolates. Clinical E. coli isolates (n = 95) that were intermediate or resistant to cefoxitin and/or flagged by VITEK 2 as potential AmpC-producers underwent confirmation using a MASTDISCST ESBL and AmpC Detection Kit. Multiplex PCR capable of detecting family-specific plasmid ampC genes was performed to detect the presence of these genes. Five PCR- negative isolates were selected for promoter analysis. PFGE and MLST were performed on E. coli isolates that harboured a plasmid ampC gene to determine their clonal relatedness. Plasmid ampC genes were …
Factors Influencing Critical Care Nurses To Speak Up When Patients Are At Risk For Harm: Development Of An Instrument, Deborah Ruth Crumpler
Factors Influencing Critical Care Nurses To Speak Up When Patients Are At Risk For Harm: Development Of An Instrument, Deborah Ruth Crumpler
Nursing Theses and Dissertations
Nurses intervene in situations where patients may be at risk for harm, particularly in critical care units where risk due to severity of illness and complexity of treatment is higher. Although safety improvements have been made, nurses still report barriers to speaking-up. Improvement in skilled communication and true collaboration among health care professionals begins with assessment of the problem. Attitudes and beliefs that influence speaking-up behaviors among critical care nurses have not been well-documented. This research study utilized a mixed-method design framed by the Theory of Planned Behavior to explore factors associated with intention to speak up among critical care …
The Effect Of Neurostimulation On Ischemic Pain And Methods Of Assessing Pain, Kaylee Keck
The Effect Of Neurostimulation On Ischemic Pain And Methods Of Assessing Pain, Kaylee Keck
Biomedical Engineering
Peripheral arterial disease (PAD) impacts approximately eight million people in the United States [1]. Disease progression leads to chronic ischemic pain, hindering quality of life. Pharmaceuticals are a typical treatment for pain associated with PAD; but as few as 30% of patients have a significant reduction of pain (≥50%) [2].
Neurostimulation is commonly used as a treatment for various diseases and injuries, including Parkinson’s disease and sports-related back and knee injuries [2]. The objective of the study was to explore neurostimulation and its effect on pain and paresthesia for a model of acute peripheral ischemia in young college students.
Pain …
Nurses’ Perceptions Of Best Practices To Assess Pediatric Patients And Educate Their Families Experiencing Effects Of Cancer Chemotherapy: “Chemo Brain” A Pilot Study, Jennifer A. Tapping
Nurses’ Perceptions Of Best Practices To Assess Pediatric Patients And Educate Their Families Experiencing Effects Of Cancer Chemotherapy: “Chemo Brain” A Pilot Study, Jennifer A. Tapping
Senior Theses
With more advanced and more aggressive chemotherapy cancer treatment leading to higher survival rates, complications with quality of life are becoming more prominent. Of these complications, delayed cognitive processing, commonly known as “chemo brain,” is becoming a topic of interest. Cognitive changes are some of the most common as well as the most challenging complications associated with central nervous system (CNS) directed treatment, such as chemotherapy. The term “chemo brain” is often used to describe self-reported or observed cognitive processing delays in patients who receive chemotherapy as a form of cancer treatment (Raffa, 2009). Although these cognitive delays have the …
Bed Rest And Its Continued Use In Women With High-Risk Pregnancy: A Review Of Literature, Irene De Los Reyes
Bed Rest And Its Continued Use In Women With High-Risk Pregnancy: A Review Of Literature, Irene De Los Reyes
Senior Theses
Bed rest is defined as confinement to bed and restriction of activity. In the clinical setting bed rest includes strict bed rest, strict bed rest in Trendelenburg position, bed rest with bathroom privileges, and up ad lib (Irion, Irion, Lewis & Giglio, 2012). Bed rest has been the standard treatment for over the past 30 years in preventing preterm birth and complications arising from high-risk pregnancy despite the lack of evidence to support its safety and effectiveness for the mother and fetus (Maloni, 2010). The purpose of this literature review and critique is to provide information about the adverse physiologic …
Exploring Unintended Pregnancy In The United States Military: A Phenomenological Approach, Mary Kathryn Phillips
Exploring Unintended Pregnancy In The United States Military: A Phenomenological Approach, Mary Kathryn Phillips
Dissertations
Nearly half of the 6.7 million pregnancies in the United States each year are unintended. The U.S. unintended pregnancy rate is significantly higher than the rate in many other developed countries. By age 45, more than half of all American women will have experienced an unintended pregnancy, and three in ten will have had an abortion. Previous empirical research aimed to fix the rate of unintended pregnancy before it was adequately explored. The rationale for this study emanated from the belief that interventions intended to reduce the rate of unintended pregnancy will be more successful if the essence of unintended …
Post Operative Fungal Endopthalmitis Due To Geotrichum Candidum, Thein Myint, Matthew J. Dykhuizen, Carolyn H. Mcdonald, Julie A. Ribes
Post Operative Fungal Endopthalmitis Due To Geotrichum Candidum, Thein Myint, Matthew J. Dykhuizen, Carolyn H. Mcdonald, Julie A. Ribes
Microbiology, Immunology, and Molecular Genetics Faculty Publications
Geotrichum species have been rarely reported as the cause of sepsis, disseminated infection in immunosuppressed patients. The patient we describe developed indolent endophthalmitis four months after her routine right eye cataract surgery. The intraoperative sample from right vitreous fluid grew Geotrichum candidum. The patient underwent vitrectomy, artificial lens explantation and intravitreal injection of amphotericin B followed by oral voriconazole. Despite these interventions, she underwent enucleation. This is the first published case of Geotrichum candidum endophthalmitis.
Best Practices Guidance For Nanomaterial Risk Management In The Workplace, Claude Ostiguy, Maximilien Debia, Brigitte Roberge, André Dufresne
Best Practices Guidance For Nanomaterial Risk Management In The Workplace, Claude Ostiguy, Maximilien Debia, Brigitte Roberge, André Dufresne
Rapports de recherche scientifique
Les nanotechnologies présentent aujourd’hui des enjeux majeurs en termes technologique, économique, éthique, social et environnemental, car elles offrent le potentiel d’améliorer de façon substantielle les propriétés de multiples produits dans tous les secteurs d’activité tant en matière de production de matériaux aux performances inédites que de diagnostic et de traitement médical. Les nanomatériaux favorisent ainsi l’émergence de nouveaux marchés, la création d’emplois, l’amélioration de la qualité de vie et peuvent contribuer à la protection de l’environnement. Du reste, l’impact se fait déjà sentir dans des secteurs aussi diversifiés que l’agroalimentaire, l’aérospatiale, la cosmétique, la construction et la santé. Au Québec, …
A Model For Hospital Discharge Preparation: From Case Management To Care Transition, Marianne E. Weiss, Kathleen Bobay, Sarah J. Bahr, Linda L. Costa, Ronda G. Hughes, Diane E. Holland
A Model For Hospital Discharge Preparation: From Case Management To Care Transition, Marianne E. Weiss, Kathleen Bobay, Sarah J. Bahr, Linda L. Costa, Ronda G. Hughes, Diane E. Holland
College of Nursing Faculty Research and Publications
There has been a proliferation of initiatives to improve discharge processes and outcomes for the transition from hospital to home and community-based care. Operationalization of these processes has varied widely as hospitals have customized discharge care into innovative roles and functions. This article presents a model for conceptualizing the components of hospital discharge preparation to ensure attention to the full range of processes needed for a comprehensive strategy for hospital discharge.
The Knowledge, Attitude, And Self-Reported Behaviors Of Psychiatric Nurses Towards Obese Psychiatric Patients On Atypical Anti-Psychotic Medications, Marcia D. Williams-Hailey
The Knowledge, Attitude, And Self-Reported Behaviors Of Psychiatric Nurses Towards Obese Psychiatric Patients On Atypical Anti-Psychotic Medications, Marcia D. Williams-Hailey
Theses & Dissertations
Background/Purpose: Obesity has continued to increase over the years with increase in morbidity and mortality. The advancement of psychiatric treatment has resulted in a higher prevalence of obesity among the psychiatric population related to the side-effects of the newer atypical anti-psychotics. This study addresses nurses’ attitudes towards obesity and people who are obese, focusing on psychiatric patients. Negative attitudes and low knowledge about psychiatric patients on atypical anti-psychotics can interfere with psychiatric nurses’ therapeutic potential to support patients with health promotion behaviors. The purpose of this study was to develop an instrument to measure the knowledge, attitudes, and self-reported behavior …
Himmelfarb Library Liaison Letter - December 2015, George Washington University, Himmelfarb Health Sciences Library
Himmelfarb Library Liaison Letter - December 2015, George Washington University, Himmelfarb Health Sciences Library
Himmelfarb Library Liaison Letters
No abstract provided.
The Relationship Between New Nurses Who Volunteer And The Caring Behavior New Nurses Exhibit In The Practice Setting, One Year Post Graduation, Nicolette Fiore-Lopez
The Relationship Between New Nurses Who Volunteer And The Caring Behavior New Nurses Exhibit In The Practice Setting, One Year Post Graduation, Nicolette Fiore-Lopez
Theses & Dissertations
Volunteering is engaged in by millions world-wide and nurses comprise a significant portion of those who provide their professional talents, unpaid, to the underserved in local, national and international efforts. Nurses who have engaged in volunteer activities anecdotally describe personally transforming experiences gained through their efforts and for many nurses volunteering becomes part of their professional mandate. Although many social disciplines have studied volunteering, to date there has been a paucity of research on nurses who volunteer. The purpose of this study was to describe the characteristics of novice nurses who volunteer and determine the influence of volunteering and associated …
Transcriptomics In Type 2 Diabetes: Bridging The Gap Between Genotype And Phenotype, Christopher Jenkinson, Harald H. H. Goring, Rector Arya, John Blangero, Ravindranath Duggirala, Ralph A. Defronzo
Transcriptomics In Type 2 Diabetes: Bridging The Gap Between Genotype And Phenotype, Christopher Jenkinson, Harald H. H. Goring, Rector Arya, John Blangero, Ravindranath Duggirala, Ralph A. Defronzo
School of Medicine Publications
Type 2 diabetes (T2D) is a common,multifactorial disease that is influenced by genetic and environmental factors and their interactions. However, common variants identified by genome wide association studies (GWAS) explain only about 10% of the total trait variance for T2D and less than 5% of the variance for obesity, indicating that a large proportion of heritability is still unexplained. The transcriptomic approach described here uses quantitative gene expression and disease-related physiological data (deep phenotyping) to measure the direct correlation between the expression of specific genes and physiological traits. Transcriptomic analysis bridges the gulf between GWAS and physiological studies. Recent GWAS …
Statin Action Favors Normalization Of The Plasma Lipidome In The Atherogenic Mixed Dyslipidemia Of Mets: Potential Relevance To Statin-Associated Dysglycemia, Peter J. Meikle, Gerard Wong, Ricardo Tan, Philippe Giral, Paul Robillard, Alexina Orsoni, Neil Hounslow, Dianna J. Magliano, Jonathan E. Shaw, Joanne E. Curran, John Blangero
Statin Action Favors Normalization Of The Plasma Lipidome In The Atherogenic Mixed Dyslipidemia Of Mets: Potential Relevance To Statin-Associated Dysglycemia, Peter J. Meikle, Gerard Wong, Ricardo Tan, Philippe Giral, Paul Robillard, Alexina Orsoni, Neil Hounslow, Dianna J. Magliano, Jonathan E. Shaw, Joanne E. Curran, John Blangero
School of Medicine Publications
The impact of statin treatment on the abnormal plasma lipidome of mixed dyslipidemic patients with metabolic syndrome (MetS), a group at increased risk of developing diabetes, was evaluated. Insulin-resistant hypertriglyceridemic hypertensive obese males (n = 12) displaying MetS were treated with pitavastatin (4 mg/day) for 180 days; healthy normolipidemic age-matched nonobese males (n = 12) acted as controls. Statin treatment substantially normalized triglyceride ( ô 41%), remnant cholesterol ( ô 55%), and LDLcholesterol ( ô 39%), with minor effect on HDL-cholesterol (+4%). Lipidomic analysis, normalized to nonHDL-cholesterol in order to probe statin-induced differences in molecular composition independently of reduction in …
Individual Responses For Muscle Activation, Repetitions, And Volume During Three Sets To Failure Of High- (80% 1rm) Versus Low-Load (30% 1rm) Forearm Flexion Resistance Exercise, Nathaniel D. M. Jenkins, Terry J. Housh, Samuel L. Buckner, Haley C. Bergstrom, Kristen C. Cochrane, Cory M. Smith, Ethan C. Hill, Richard J. Schmidt, Joel T. Cramer
Individual Responses For Muscle Activation, Repetitions, And Volume During Three Sets To Failure Of High- (80% 1rm) Versus Low-Load (30% 1rm) Forearm Flexion Resistance Exercise, Nathaniel D. M. Jenkins, Terry J. Housh, Samuel L. Buckner, Haley C. Bergstrom, Kristen C. Cochrane, Cory M. Smith, Ethan C. Hill, Richard J. Schmidt, Joel T. Cramer
Kinesiology and Health Promotion Faculty Publications
This study compared electromyographic (EMG) amplitude, the number of repetitions completed, and exercise volume during three sets to failure of high- (80% 1RM) versus low-load (30% 1RM) forearm flexion resistance exercise on a subject-by-subject basis. Fifteen men were familiarized, completed forearm flexion 1RM testing. Forty-eight to 72 h later, the subjects completed three sets to failure of dumbbell forearm flexion resistance exercise with 80% (n = 8) or 30% (n = 7) 1RM. EMG amplitude was calculated for every repetition, and the number of repetitions performed and exercise volume were recorded. During sets 1, 2, and 3, one …
Effects Of Eccentric Exercise On Tendon Loading And Ankle Power During A Single-Leg Heel Rise And Lowering Tank, Derek Palmer, Jordan Visser, Jason Beilstein
Effects Of Eccentric Exercise On Tendon Loading And Ankle Power During A Single-Leg Heel Rise And Lowering Tank, Derek Palmer, Jordan Visser, Jason Beilstein
Student-Faculty Research - College of Physical Therapy
No abstract provided.
What Are The Effects Of Wearing Shoes On Foot Pressure?, David Moran, Drew Stewart, Josh Farrester, Ryan Wiser
What Are The Effects Of Wearing Shoes On Foot Pressure?, David Moran, Drew Stewart, Josh Farrester, Ryan Wiser
Student-Faculty Research - College of Physical Therapy
No abstract provided.
Reliability And Validity Of The Modified Vestibular Disorders Activities Of Daily Living Scale In Older Adult Balance Examination, Ashley Berry, Jammie Hoberg, Tiffany Stevens, Kayla Taylor, Melissa Vetter
Reliability And Validity Of The Modified Vestibular Disorders Activities Of Daily Living Scale In Older Adult Balance Examination, Ashley Berry, Jammie Hoberg, Tiffany Stevens, Kayla Taylor, Melissa Vetter
Student-Faculty Research - College of Physical Therapy
No abstract provided.
The Nursing Documentation Dilemma In Uganda: Neglected But Necessary. A Case Study At Mulago National Referral Hospital, Grace Nakate, Diane Dahl, Pammla Petrucka, Karen B. Drake, Ruby Dunlap
The Nursing Documentation Dilemma In Uganda: Neglected But Necessary. A Case Study At Mulago National Referral Hospital, Grace Nakate, Diane Dahl, Pammla Petrucka, Karen B. Drake, Ruby Dunlap
School of Nursing & Midwifery, East Africa
In Uganda, nursing documentation still remains a challenge, in most of the government hospitals and some private hospitals, it remains at a manual (non-technology driven) level and omissions have been observed. Nurses continue to capture standard elements in their documentation. A mixed methods intervention study was conducted to determine knowledge and attitudes of nurses towards documentation, including an evaluation of nurses’ response to a designed nursing documentation form. Forty participants were selected through convenience sampling from six wards of a Ugandan health institution. The study intervention involved teaching nurses the importance of documentation and using of the trial documentation tool. …
A Synthetic Lethality Screen Using A Focused Sirna Library To Identify Sensitizers To Dasatinib Therapy For The Treatment Of Epithelial Ovarian Cancer., Harsh B Pathak, Yan Zhou, Geetika Sethi, Jeff Hirst, Russell J Schilder, Erica A Golemis, Andrew K Godwin
A Synthetic Lethality Screen Using A Focused Sirna Library To Identify Sensitizers To Dasatinib Therapy For The Treatment Of Epithelial Ovarian Cancer., Harsh B Pathak, Yan Zhou, Geetika Sethi, Jeff Hirst, Russell J Schilder, Erica A Golemis, Andrew K Godwin
Department of Medicine Faculty Papers
Molecular targeted therapies have been the focus of recent clinical trials for the treatment of patients with recurrent epithelial ovarian cancer (EOC). The majority have not fared well as monotherapies for improving survival of these patients. Poor bioavailability, lack of predictive biomarkers, and the presence of multiple survival pathways can all diminish the success of a targeted agent. Dasatinib is a tyrosine kinase inhibitor of the Src-family kinases (SFK) and in preclinical studies shown to have substantial activity in EOC. However, when evaluated in a phase 2 clinical trial for patients with recurrent or persistent EOC, it was found to …
The Effect Of The Patient Protection And Affordable Care Act On The Medicare Part D Coverage Gap As Reflected In Diabetes Medication Adherence., Jennifer A. Forristal
The Effect Of The Patient Protection And Affordable Care Act On The Medicare Part D Coverage Gap As Reflected In Diabetes Medication Adherence., Jennifer A. Forristal
Electronic Theses and Dissertations
This dissertation involves an evaluation of the effect of the Patient Protection and Affordable Care Act (ACA) on diabetic medication adherence for mail order utilizers over 6 years as the Medicare Part D coverage gap begins to close. The study had 3 objectives: 1) to evaluate diabetes medication adherence of health plan members before they reach the coverage gap and then while they are in the coverage gap, 2) to compare diabetes medication adherence between two similar groups with differing benefit structures, one group with a gap in coverage as opposed to a group with no benefit changes within the …
Mechanisms And Intervention Strategies For Alcohol And Hiv-Antiretroviral Therapy-Induced Liver Injury., Hridgandh Donde
Mechanisms And Intervention Strategies For Alcohol And Hiv-Antiretroviral Therapy-Induced Liver Injury., Hridgandh Donde
Electronic Theses and Dissertations
Chronic alcohol consumption is a leading cause of liver disease and liver-related death worldwide. Alcoholic liver disease includes, hepatic steatosis, steatohepatitis and ultimately fibrosis and cirrhosis. Emerging evidence has established the important role of the “gut-liver” axis in the development of alcoholic liver disease (ALD). Our recent work indicated that chronic alcohol induced perturbations in the gut microbiome and consequent changes in fatty acids have a major impact on the development of intestinal barrier dysfunction and ALD. The aim of this study was to investigate whether treatment with tributyrin - a butyrate prodrug results in protection against ALD in terms …
Comparison Of Digital Scanning And Polyvinyl Siloxane Impression Techniques By Dmd Students : Instructional Efficiency And Attitudes Toward Technology., Alexander M. Marti
Comparison Of Digital Scanning And Polyvinyl Siloxane Impression Techniques By Dmd Students : Instructional Efficiency And Attitudes Toward Technology., Alexander M. Marti
Electronic Theses and Dissertations
The aim of this research was compare the ability of dental students to learn an digital scanner (3M LAVA) and material-based (PVS) impression techniques and to determine attitudes and preferences towards each. D2 dental students (n=25) were recruited and instructed on the use of 3M LAVA and PVS techniques using three pedagogic methods: 1) video lecture (P1), 2) investigator-led demonstration (P2), and 3) independent clinical exercise (P3). The amount of time for each pedagogic method was measured, averaged (± s.d.) and compared using Wilcoxon Signed-Ranks tests. A pre- and post-test was administered assessing their attitudes towards both techniques using a …
Nutrinews, Volume 12, December 2015, Department Of Nutrition And Dietetics, University Of North Florida
Nutrinews, Volume 12, December 2015, Department Of Nutrition And Dietetics, University Of North Florida
NutriNews
This issue features Mixify, UNF DND 2014-2015 Highlights, and Recipes from Jessica's Table
Hybrid Diffuse Optical Techniques For Continuous Hemodynamic Measurement In Gastrocnemius During Plantar Flexion Exercise, Brad Henry, Mingjun Zhao, Yu Shang, Tim L. Uhl, D. Travis Thomas, Eleftherios S. Xenos, Sibu P. Saha, Guoqiang Yu
Hybrid Diffuse Optical Techniques For Continuous Hemodynamic Measurement In Gastrocnemius During Plantar Flexion Exercise, Brad Henry, Mingjun Zhao, Yu Shang, Tim L. Uhl, D. Travis Thomas, Eleftherios S. Xenos, Sibu P. Saha, Guoqiang Yu
Physical Therapy Faculty Publications
Occlusion calibrations and gating techniques have been recently applied by our laboratory for continuous and absolute diffuse optical measurements of foreann muscle hemodynamics during handgrip exercises. The translation of these techniques from the foreann to the lower limb is the goal of this study as various diseases preferentially affect muscles in the lower extremity. This study adapted a hybrid near-infrared spectroscopy and diffuse correlation spectroscopy system with a gating algorithm to continuously quantify hemodynamic responses of medial gastrocnemius during plantar flexion exercises in 10 healthy subjects. The outcomes from optical measurement include oxy-, deoxy-, and total hemoglobin poncentrations, blood oxygen …
Associations Of Perfluoroalkyl Substances (Pfass) With Lower Birth Weight: An Evaluation Of Potential Confounding By Glomerular Filtration Rate Using A Physiologically Based Pharmacokinetic Model (Pbpk), Marc-André Verner, Anne E. Loccisano, Nils-Halvdan Morken, Miyoung Yoon, Huali Wu, Robin Mcdougall, Mildred Maisonet, Michele Marcus, Reiko Kishi, Chihiro Miyashita, Mei-Huei Chen, Wu-Shiun Hsieh, Melvin E. Andersen, Harvey J. Clewell Iii, Matthew P. Longnecker
Associations Of Perfluoroalkyl Substances (Pfass) With Lower Birth Weight: An Evaluation Of Potential Confounding By Glomerular Filtration Rate Using A Physiologically Based Pharmacokinetic Model (Pbpk), Marc-André Verner, Anne E. Loccisano, Nils-Halvdan Morken, Miyoung Yoon, Huali Wu, Robin Mcdougall, Mildred Maisonet, Michele Marcus, Reiko Kishi, Chihiro Miyashita, Mei-Huei Chen, Wu-Shiun Hsieh, Melvin E. Andersen, Harvey J. Clewell Iii, Matthew P. Longnecker
ETSU Faculty Works
Background: Prenatal exposure to perfluoroalkyl substances (PFAS) has been associated with lower birth weight in epidemiologic studies. This association could be attributable to glomerular filtration rate (GFR), which is related to PFAS concentration and birth weight.
Objectives: We used a physiologically based pharmacokinetic (PBPK) model of pregnancy to assess how much of the PFAS–birth weight association observed in epidemiologic studies might be attributable to GFR.
Methods: We modified a PBPK model to reflect the association of GFR with birth weight (estimated from three studies of GFR and birth weight) and used it to simulate PFAS concentrations in maternal and cord …