Medicine and Health Sciences Commons^™

Today - April 17, 2015, Loma Linda University Health

TODAY

Inside this issue:

-- U.S. deputy surgeon general visits Loma Linda University Health to promote veteran inclusion during annual conference
-- PossAbilities members win divisions in 2015 LA Marathon
-- SIMS trip reignites students' passion for health care
-- Fourth-year medical students celebrate Match Day 2015
-- Dietetics students from Japan and LLU prepare Japanese cuisine
-- Loma Linda Guild contributes two large gifts at 22nd annual Foundation Gala
-- Mel Eisele named LLUH vice president for revenue cycle
-- Professor to be a principal speaker at annual World Voice Day in Mexico City
-- Sign up to be part …

Environmental Health News, Georgia Southern University

Biostatistics, Epidemiology & Environmental Health Sciences: News & Publications (2011-2018)

• Persistence of Enteric Markers in Sewage Polluted Water

Research Brief: "Post-Sexual Assault Health Care Utilization Among Oef/Oif Servicewomen", Institute For Veterans And Military Families At Syracuse University

Institute for Veterans and Military Families

This brief is about the use of medical and mental health services by servicewomen after sexual assault that occurred while in the military. In policy and practice, servicewomen who have been sexually assaulted should seek medical and mental healthcare in a timely manner, even if they don't believe it is necessary, to prevent HIV infection and pregnancy; the DoD should continue its use of the DoJ's gold standard of care while ensuring that servicewomen feel that they can reach out for post-assault healthcare. Suggestions for future research include sampling more servicewomen who utilize care, expanding the geographic spread of the …

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Persistence of Enteric Markers in Sewage Polluted Water

Transesophageal Echocardiogram: Accurate Enough To Make Definitive Clinical Decisions Related To Endocarditis, Brian Jackson, Paul Thomas, Tiffany Dehondt, Leanne Swiderski, Rachel Fuller, Amal Raychouni

Clinical Research in Practice: The Journal of Team Hippocrates

A critical appraisal and clinical application of: Daniel WG, Mugge A, Martin RP, et al. Improvement in the diagnosis of abscesses associated with endocarditis by transesophageal echocardiography. N Engl J Med. 1991 Mar 21;324(12):795-800. doi: 10.1056/NEJM199103213241203

Occupational Health Risk Factors For Schistosomiasis: Systematic Review And Analysis, Sarah Grace Sawyer, Amira Roess, Gisela Butera

GW Research Days 2015

Schistosomiasis is a neglected tropical disease caused by a parasitic flatworm which afflicts over 200 million people in the poorest regions of Africa. Carried by snails living in fresh, stagnant water, the parasite penetrates human skin upon contact, causing the victim to suffer a range of symptoms including diarrhea, blood in the urine, and eventual death. Despite its prevalence, schistosomiasis is preventable, treatable, and curable once a control program is implemented. Substantial reduction of schistosomiasis would relieve suffering and produce many socio-economic benefits, including higher productivity and higher school attendance rates. Disease transmission is directly tied to the environment, and …

Irreversible Electroporation Of Malignant Lesions: An Institution Experience, Benjamin Bates, Minia Hellan, Shannon Kauffman, James R. Ouellette

Department of Surgery Faculty Publications

Background: Irreversible electroporation (IRE) is a tumor ablation technique where short, high-voltage pulses are applied to tumors to permeabilize the cell membranes. Since no thermal energy is created, it can be used near vital structures. We report our experience in a wide array of anatomic locations and on diverse oncologic processes.

Methods: We performed a retrospective review of all IRE cases performed at our institution from September 2010 to September 2013. Patients were evaluated for peri-operative morbidity, mortality, and oncologic outcome.

Results: Twenty-seven patients underwent IRE during 16 laparotomies and 12 CT guided percutaneous procedures. Anatomic locations: 9 liver, 7 …

Beyond Silence: Protocol For A Randomized Parallel-Group Trial Comparing Two Approaches To Workplace Mental Health Education For Healthcare Employees, Sandra Moll, Scott Burton Patten, Heather Stuart, Bonnie Kirsh, Joy Christine Macdermid

Bone and Joint Institute

© 2015 Moll et al.; licensee BioMed Central. Background: Mental illness is a significant and growing problem in Canadian healthcare organizations, leading to tremendous personal, social and financial costs for individuals, their colleagues, their employers and their patients. Early and appropriate intervention is needed, but unfortunately, few workers get the help that they need in a timely way due to barriers related to poor mental health literacy, stigma, and inadequate access to mental health services. Workplace education and training is one promising approach to early identification and support for workers who are struggling. Little is known, however, about what approach …

2015 - The Twentieth Annual Symposium Of Student Scholars

Symposium of Student Scholars Program Books

The full program book from the Twentieth Annual Symposium of Student Scholars, held on April 16, 2015. Includes abstracts from the presentations and posters.

Pt/Ot Students Experience Working At Overnight Camp For Children With Disabilities, Audrey L. Zapletal, Ms, Otr/L, David A. Lehman, Phd, Pt

Department of Occupational Therapy Posters and Presentations

Objectives:

• Describe the innovative interprofessional field experience
• Discuss how the camp program enhances the OT/PT students’ skills towards interprofessional practice and discipline specific clinical reasoning
• Examine how this opportunity has influenced OT/PT students’ educational and professional development

Identifying Cases Of Undiagnosed, Clinically Significant Copd In Primary Care: Qualitative Insight From Patients In The Target Population, Nancy K. Leidy, Katherine Kim, Elizabeth D. Bacci, Barbara P. Yawn, David M. Mannino, Byron M. Thomashow, R. Graham Barr, Stephen I. Rennard, Julia F. Houfek, Meilan K. Han, Catherine A. Meldrum, Barry J. Make, Russ P. Bowler, Anna W. Steenrod, Lindsey T. Murray, John W. Walsh, Fernando Martinez

Preventive Medicine and Environmental Health Faculty Publications

BACKGROUND: Many cases of chronic obstructive pulmonary disease (COPD) are diagnosed only after significant loss of lung function or during exacerbations.

AIMS: This study is part of a multi-method approach to develop a new screening instrument for identifying undiagnosed, clinically significant COPD in primary care.

METHODS: Subjects with varied histories of COPD diagnosis, risk factors and history of exacerbations were recruited through five US clinics (four pulmonary, one primary care). Phase I: Eight focus groups and six telephone interviews were conducted to elicit descriptions of risk factors for COPD, recent or historical acute respiratory events, and symptoms to inform the …

Strategies To Improve Medication Adherence In Patients With Schizophrenia: The Role Of Support Services, Peggy El-Mallakh, Jan Findlay

Nursing Faculty Publications

The purpose of this review is to describe research over the past 10 years on the role of support services in promoting medication adherence in mental health consumers diagnosed with schizophrenia. A literature search was conducted using the terms "medication adherence," "schizophrenia," and "support services," using Medline, PubMed, and CINAHL. Reference lists from published studies were also reviewed to identify additional research studies. Twenty-two articles focused on support-service intervention studies, and these were selected for review. Available support-service interventions include adherence therapy, electronic reminders via text messages and telephones, cognitive-behavioral and motivational strategies, and financial incentives. Support-service intervention strategies need …

Unsteady Nasalance Traces Among Sustained Vowels In Typical Adult Speakers: Prevalence & Potential Causes, Catherine Hearit

Honors Theses

Background. Vowels are a commonly used stimulus for evaluating speech resonance because hypernasality is best detected in vowel sounds. It was observed that steady-state sustained vowels show considerable within sample nasalance variance, although nasalance is expected to be stable for this speech target.

Purpose. The purpose of the study was to ascertain the prevalence of variability among normal speakers in steady state vowel nasalance traces and to determine the variables that predict variability.

Methods: Sixty-one participants aged 18 through 30 years were recruited. All participants were lifelong residents of the lower peninsula of Michigan with normal hearing sensitivity and no …

Perceptions Of Neonatal Nurse Practitioner Role Among Nicu Nurses, Michele K. Savin, Msn, Nnp-Bc

College of Nursing Faculty Papers & Presentations

Purpose: The purpose of this project was to examine Neonatal Intensive Care Unit (NICU) nurses’ perceptions of the NNP role and barriers to entering the role.

Background: A shortage of neonatal nurse practitioners (NNPs) exists. Hiring NNPs from outside the current NICU staff has resulted in turnover and additional cost. If current nursing staff prepared as NNPs, the organization would benefit; yet few nurses have done so. Reasons that dissuade nurses from pursuing the NNP role have not been adequately examined. Knowing how nurses perceive the NNP role may help to decrease barriers and inform plans to address the problem.

Cleveland's Bitter Pill: A Diagnosis Of Injured Title Dreams And Die-Hard Fans, Joseph Congeni, Thomas Bacher

University of Akron Press Publications

This collection of stories examines Cleveland's athletic teams and injuries that have hindered their quests for championships. From rotator cuffs to knee ligaments, from sprained ankles to sprained backs, and from broken legs to broken arms, Cleveland's misery has taken some of its best athletes and immobilized them at inopportune times. Shaq gave fans his inside dominance and his ailing thumb in 2010. Herb Score was a blazing lefthander until he took a line drive to the face in 1957. When the Las Vegas oddsmakers picked the Browns to win the Super Bowl in 1988, Bernie Kosar's arm injury derailed …

Induction Of Autophagy Markers Is Associated With Attenuation Of Mir-133a In Diabetic Heart Failure Patients Undergoing Mechanical Unloading., Shyam Sundar Nandi, Michael J. Duryee, Hamid R. Shahshahan, Geoffrey M. Thiele, Daniel R. Anderson, Paras K. Mishra

Journal Articles: Cellular & Integrative Physiology

Autophagy is ubiquitous in all forms of heart failure and cardioprotective miR-133a is attenuated in human heart failure. Previous reports from heart failure patients undergoing left ventricular assist device (LVAD) implantation demonstrated that autophagy is upregulated in the LV of the failing human heart. Studies in the murine model show that diabetes downregulates miR-133a. However, the role of miR-133a in the regulation of autophagy in diabetic hearts is unclear. We tested the hypothesis that diabetes exacerbates cardiac autophagy by inhibiting miR-133a in heart failure patients undergoing LVAD implantation. The miRNA assay was performed on the LV of 15 diabetic (D) …

Management Of The Hospitalized Transplant Patient., Brian P. Boerner, Vijay Shivaswamy, Whitney Goldner, Jennifer Larsen

Journal Articles: Diabetes, Endocrinology & Metabolism

Significant hyperglycemia is commonly observed immediately after solid organ and bone marrow transplant as well as with subsequent hospitalizations. Surgery and procedures are well known to cause pain and stress leading to secretion of cytokines and other hormones known to aggravate insulin action. Immunosuppression required for transplant and preexisting risk are also major factors. Glucose control improves outcomes for all hospitalized patients, including transplant patients, but is often more challenging to achieve because of frequent and sometimes unpredictable changes in immunosuppression doses, renal function, and nutrition. As a result, risk of hypoglycemia can be greater in this patient group when …

Mustang Ems: Community Emergency Medical Education, Kelly Kiser

Collection of Engaged Learning

While serving as Captain of Mustang EMS, I used Engaged Learning support to develop a series of educational programs designed to make campus a safer place and help Mustang EMS members grow professionally. By designing and implementing Emergency Preparedness Booths at events such as PerunaPalooza, I sought to teach SMU students how to recognize and respond to common medical emergencies such as alcohol poisoning, heart attack, and stroke. Hosting Emergency Response Training Scenarios helped to generate a crew of knowledgeable Mustang EMS officers that will ensure the continuity of this event. Finally, by designing a protocol and hosting a campus-wide …

What Did We Learn About Vads In 2014?, Maya Guglin

The VAD Journal

No abstract provided.

Personal Interviews: Do They Make Sense In 2015?, Larry Boles, Kerry Mandulak

School of Pharmacy Faculty Presentations

No abstract provided.

Recipe For Life - Health Awareness, Courtney Thrower

Collection of Engaged Learning

The design of this project was two-fold; the research component included examination of data from a previous investigation and compared it with data collected in a community service project. In each, the aim was to assess the health habits of underserved Spanish communities and provide information and opportunity for engagement with health education. Data were collected from voluntary participants in Panama and West Dallas. The purpose of the investigation was to learn more about perceptions of health habits and provide hands-on learning regarding what it means to be healthy and practice a wellness lifestyle. Specifically, to help participants in underserved …

Targeting Human Central Nervous System Protein Kinases: An Isoform Selective P38Αmapk Inhibitor That Attenuates Disease Progression In Alzheimer's Disease Mouse Models, Saktimayee M. Roy, Valerie L. Grum-Tokars, James P. Schavocky, Faisal Saeed, Agnieszka Staniszewski, Andrew F. Teich, Ottavio Arancio, Adam D. Bachstetter, Scott J. Webster, Linda J. Van Eldik, George Minasov, Wayne F. Anderson, Jeffrey C. Pelletier, D. Martin Watterson

Spinal Cord and Brain Injury Research Center Faculty Publications

The first kinase inhibitor drug approval in 2001 initiated a remarkable decade of tyrosine kinase inhibitor drugs for oncology indications, but a void exists for serine/threonine protein kinase inhibitor drugs and central nervous system indications. Stress kinases are of special interest in neurological and neuropsychiatric disorders due to their involvement in synaptic dysfunction and complex disease susceptibility. Clinical and preclinical evidence implicates the stress related kinase p38αMAPK as a potential neurotherapeutic target, but isoform selective p38αMAPK inhibitor candidates are lacking and the mixed kinase inhibitor drugs that are promising in peripheral tissue disease indications have limitations for neurologic indications. Therefore, …

Urine Proteomics Identifies Preeclampsia Subphenotypes, Michelle R. Axe

Undergraduate Honors Thesis Projects

Preeclampsia is a perinatal complication of unknown etiology, resulting in 76,000 maternal deaths and 500,000 infant deaths annually₁. The Nationwide Children’s Center for Perinatal Research was the first cohort to propose that preeclampsia is rooted in protein misfolding. We aimed to characterize the misfolded protein components of maternal urine samples and to determine if distinct molecular profiles exist for clinical preeclampsia phenotypes. A total of 86 maternal urine samples from Yale-New Haven Hospital were analyzed for this study, from six clinical preeclampsia subphenotypes- pregnant control (n=10), idiopathic proteinuria (n=15), mild preeclampsia (n=14), superimposed preeclampsia (n=12), typical severe preeclampsia …

Is Work The Forgotten Occupation?, Holly Ehrenfried Otr/L, Cht

Department of Medicine

No abstract provided.

A Descriptive Study Of Non Traditional School Health Delivery; Funding Sources, Outcomes And Staff Configurations, Sherri Becker, Msn, Mba, Rn, Erin D. Maughan, Phd, Ms, Rn, Aphn-Bc, June Horowitz, Phd, Rn, Faan

College of Nursing Faculty Papers & Presentations

Background:

1) The traditional funding for school nursing has been educational dollars.

2) As school district budgets tighten, the number of students with health needs continues to rise and the Affordable Care Act (ACA) puts increased emphasis on community care, new school health delivery models are emerging.

3) There is limited study in this area. Anecdotal stories of wide variability exist.

Antimicrobial Activity Of Thymoquinone, Alya A. Almatrafi

MSMLS Capstone Projects

Abstract

With the increase in resistance to traditional antibiotics displayed by microbial agents, efforts have been devoted to the explorations of naturally derived antimicrobial compounds.

One such compound is thymoquinone (TQ), derived from Nigella Sativa (black seeds). This compound has been known for its anti-inflammatory and antioxidant properties (Ahmad et al., 2013); however, other healing properties may also be attributed to this compound. Nigella Sativa (NS), an herb, is a member of the Ranunculaceae family. Nigella Sativa has been used to treat different diseases since the ancient era. Extracts from the seeds have been used to treat bacterial infections such …

Managing High-Risk Patients: Community Care Team Outcomes, Kay Werhun Dnp, Mba, Rn, Ne- Bc

Patient Care Services / Nursing

No abstract provided.

Translating Research Findings Into Practice: An Investigation Of Missed Nursing Care., Tricia Bernecker Phd, Msn, Rn, Acns-Bc, Mae Ann Pasquale Phd, Msn, Rn, Kathy Baker Mph, Rn, Carol A. Foltz Phd

Patient Care Services / Nursing

No abstract provided.

Chaperone Hsp47 Drives Malignant Growth And Invasion By Modulating An Ecm Gene Network, Jieqing Zhu, Gaofeng Xiong, Hanjiang Fu, B. Mark Evers, Binhua P. Zhou, Ren Xu

Markey Cancer Center Faculty Publications

The extracellular matrix (ECM) is a determining factor in the tumor microenvironment that restrains or promotes malignant growth. In this report, we show how the molecular chaperone protein Hsp47 functions as a nodal hub in regulating an ECM gene transcription network. A transcription network analysis showed that Hsp47 expression was activated during breast cancer development and progression. Hsp47 silencing reprogrammed human breast cancer cells to form growth-arrested and/or noninvasive structures in 3D cultures, and to limit tumor growth in xenograft assays by reducing deposition of collagen and fibronectin. Coexpression network analysis also showed that levels of microRNA(miR)-29b and -29c were …

Synergistic Trigeminal Pain Molecules In A Model Of Traumatic Brain Injury: Implications For Post-Traumatic Headache, Brittany V. Daiutolo, Ashley L. Tyburski, Shannon W. Clark, Md, Melanie B. Elliott, Phd.

Department of Neurosurgery Faculty Papers

Introduction

Headache following traumatic brain injury (TBI) is highly prevalent, and also the most common and persistent symptom of post-concussion syndrome [1,2]. It could also arise de novo or as a pre-existing headache disorder, in which migraine was the most frequent headache phenotype in both civilian and military patients with mild TBI [1,2]. Most post-traumatic headaches will resolve within a couple of weeks following injury; however, headache in a substantial subset of patients it may last more than three months and contribute to a prolonged recovery from injury, disability, and a poor quality of living [2]. Headaches can persist well …