Medicine and Health Sciences Commons^™

Alternating Magnetic Field-Induced Hyperthermia Increases Iron Oxide Nanoparticle Cell Association/Uptake And Flux In Blood-Brain Barrier Models, Mo Dan, Younsoo Bae, Thomas A. Pittman, Robert A. Yokel

Pharmaceutical Sciences Faculty Publications

PURPOSE: Superparamagnetic iron oxide nanoparticles (IONPs) are being investigated for brain cancer therapy because alternating magnetic field (AMF) activates them to produce hyperthermia. For central nervous system applications, brain entry of diagnostic and therapeutic agents is usually essential. We hypothesized that AMF-induced hyperthermia significantly increases IONP blood-brain barrier (BBB) association/uptake and flux.

METHODS: Cross-linked nanoassemblies loaded with IONPs (CNA-IONPs) and conventional citrate-coated IONPs (citrate-IONPs) were synthesized and characterized in house. CNA-IONP and citrate-IONP BBB cell association/uptake and flux were studied using two BBB Transwell^® models (bEnd.3 and MDCKII cells) after conventional and AMF-induced hyperthermia exposure.

RESULTS: …

Raman Micro Spectroscopy For In Vitro Drug Screening: Subcellular Localisation And Interactions Of Doxorubicin, Zeineb Farhane, Franck Bonnier, Alan Casey, Hugh Byrne

Articles

Vibrational spectroscopy, including Raman spectroscopy, has been widely used over the last few years to explore potential biomedical applications. Indeed, Raman spectroscopy has been demonstrated to be a powerful non-invasive tool in cancer diagnosis and monitoring. In confocal microscopic mode, the technique is also a molecularly specific analytical tool with optical resolution which has potential applications in subcellular analysis of biochemical processes, and therefore as an in vitro screening tool of the efficacy and mode of action of, for example, chemotherapeutic agents.

In order to demonstrate and explore the potential in this field, established, model chemotherapeutic agents can be valuable. …

Examining The Role Of Consciousness And The Absurd In Suicide, Alexandra R. Azevedo

Senior Honors Projects

In order to emphasize the significance of suicide as a subjective experience, this research project explores suicide through a philosophical lens, primarily focusing on the absurdist school of thought that gained prominence with the twentieth century French philosopher and writer Albert Camus. Despite recent advances in the scientific study of suicide, I argue that many of the historically divisive questions surrounding suicide are rooted in philosophy. My original work attempts to rectify the current disconnect between suicidality and philosophy through the analysis and application of Camus’ chief work on the subjects, The Myth of Sisyphus. Recognizing the efficacy of …

Internship Impact In Early Intervention, Morgan E. Anderson

Senior Honors Projects

Early childhood intervention programs were introduced in the 1960s, and professionals have recognized the benefits of intensive therapy and education starting when the child is an infant up to the age of three. Working with a child in a comfortable environment, such as their own home, preschool, child care center or even the community has many benefits. Conducting sessions in a more everyday environment encourages family interaction and support. When a family member, caretaker, or even teacher is present to witness the therapy session, they are more likely to be comfortable carrying these techniques over into the everyday routine. Working …

An Information Privacy Examination Of The Practices Of Pharmaceutical Companies Regarding Use Of Information Collected Through Their Websites, Shonda Dellena Brown

CCAC Theses and Dissertations

Consumers have begun to take a more proactive approach to their healthcare by accessing pharmaceutical companies Websites to obtain health and drug information, support groups, rebates, coupons, as well as free drug trials. In exchange for these benefits, companies require consumers to voluntarily disclose information. However, research has shown that consumers continue to be concerned about how their information is managed, used, and distributed by companies, especially if accessed via the Web. To date, there has been limited empirical research to examine the actual online practices of companies when it comes to privacy, especially those of pharmaceutical companies. Using Delphi …

Persister Cell Control Mechanisms In Uropathogenic Escherichia Coli, William H. Law Iii

Senior Honors Projects

Persister cells are a subpopulation of bacteria that demonstrate high tolerance to antibiotics, but revert to sensitivity after antibiotics are removed. The mechanism for induction of the persister cell state and antibiotic tolerance is not completely understood but likely occurs through the establishment of dormancy. Some of the suggested mechanisms for persister cell formation in Escherichia coli include: toxin­-antitoxin systems, starvation, gene regulation by (p)ppGpp, and stochastic formation. In our study we examine the mechanisms behind persistence in the E. coli strain CFT073, a uropathogenic isolate, which forms elevated levels of persisters compared to the laboratory strain MG1655. However, CFT073 …

Dysarthria: A Study Of Effects On Communication, Casey Johnsen

Senior Honors Projects

Dysarthria is an impairment characterized by slow, weak, and imprecise muscle movements that affect one’s speech and communication. The specific characteristics of dysarthria vary depending on the site and extent of the lesion. Some general examples include articulatory-resonatory incompetence, imprecise consonants, distorted vowels, hypernasality, low pitch, harshness, strained-strangled voice and prosodic disturbances including slow rate. Dysarthria can be found in both children and adults, and is caused by neurologic disorders such as stroke, Down syndrome, cerebral palsy, Parkinson’s disease, or muscular dystrophy. Dysarthria can negatively impact one’s social participation. The extra effort it takes to speak and the frustration of …

Impact Of Prior Healthcare Experience On Self-Reported Confidence And Competency Among Third Year Clinical Nursing Students, Conrad N. Bukoski, Jennifer Fuvich

Senior Honors Projects

There is a long-running debate amongst nurse educators if prior healthcare experience facilitates or encumbers a nursing student’s clinical training and education. Nursing students with prior healthcare experience have often worked as home health aids (HHAs), certified nursing assistants (CNAs), patient care technicians (PCTs), emergency medical technicians (EMTs), electrocardiogram technicians (EKG tech), student nurse associates (SNAs), and paramedics. The psychomotor and cognitive nursing skills utilized in these healthcare positions vary and some overlap with nursing skills. All of these positions interact with other healthcare positions to deliver patient care.

Some educators feel that inadequate skills and training may be acquired …

Human: A Cat Dissection Tutorial, Sean P. Pierel

Senior Honors Projects

HuMan: A Cat Dissection Tutorial

Human anatomy is a topic that many important scientific studies depend on, such as the study of medicine or the research of cultural gender identities and their respective anatomical characteristics. It is logical to expect those who want to work with and study the human body to have a greater understanding of what makes us what we are. Unfortunately this topic is typically considered difficult to learn as there is a very large amount of material to memorize and even more material to comprehend in order to truly achieve an understanding of the human body. …

Periodontal Disease: Molecular Visualization Through Computer Modeling And 3d Printing, Catherine Chatowsky

Senior Honors Projects

Periodontal disease is a common infection that damages gingival tissue and creates jawbone destruction that can lead to the loosening or loss of teeth. Hundreds of diverse bacterial species reside in the harsh environment of the oral cavity. The creation of plaque and biofilms serve to allow the bacteria to avoid immune-mediated destruction. This project analyzed periodontal disease pathogens using molecular printing 3D visualization. Two bacterial species (T. denticola and P. gingivalis) were chosen from the public resource: Research Collaboratory for Structural Bioinformatics: Protein Data Bank. T. denticola was a bacteria found to have a binding protein (FhbB) …

Associations Between Family Functioning And Adolescent Health Behaviors, Megan S. Fleming

Senior Honors Projects

Background: The obesity epidemic has been a concern across the globe, affecting about 20% of adolescents in the U.S. Physical activity and nutrition-related behaviors that develop during adolescence carry through into adulthood. Adolescents’ perceptions of how their family functions may be associated with health behaviors, including physical activity and diet.

Objective: To determine whether there is an association between perceived family functioning and adolescent health behaviors among a national sample of adolescents aged 11 to 16 who participated in the 2009-2010 Health Behaviors of School-Aged Children survey.

Methods: Participants reported on demographics and measures of family function, which included …

Effects Of Inositol-6-Phosphate (Phytate) On Mucin 3 Of The Gastrointestinal Tract, Jesse Lawson

Undergraduate Honors Theses

Mucins are heavily glycosylated epithelial proteins. Under or overexpression of mucins may lead to several different types of dysfunctions. Mucins are under investigation as possible diagnostic markers for malignancies and other disease. This study examined the over/under expression of Mucin-3 in the presence of IP6. Three groups of six mice were fed varying levels of phytate (inositol 6-phosphate, IP6) for six days before being subjected to carbon dioxide asphyxiation. Sections of the duodenum, jejunum, ileum, stomach, and colon were collected, lysed, and the tissue proteins were prepared and analyzed by Western Blot to determine Mucin-3 expression. The hypothesis was that …

Comparing Access To Medical Homes For Children Aged 6-17 Years With Add/Adhd And Autism In Arkansas, Marie Mackenzie Plum

The Eleanor Mann School of Nursing Undergraduate Honors Theses

A growing number of children are being diagnosed with attention deficit disorder and hyperactivity (ADD/ADHD) and autism in Arkansas. These developmental disorders necessitate comprehensive, holistic, effective and well-coordinated care, and require a complex treatment regimen. Lack of access to coordinated care creates a real impediment for these children as they are in constant need for medical services. Pediatric care provided within a medical home has been suggested to improve health outcomes of children with special health care needs. OBJECTIVE: The purpose of this study was to determine access to a medical home among children aged 6-17 years with ADD/ADHD, autism, …

Implementing Dysphagia Assessment In Stroke Patients: Hospital-Based Education Quality Improvement Project, Renee Kortlynn Cristy

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Dysphagia is a prevalent manifestation of stroke. An evidence-based dysphagia assessment is needed to provide quality care to stroke patients. Aims: To provide a descriptive analysis of the patient’s admitted to the hospital with the primary diagnosis of stroke; to evaluate three dysphagia screening tools; and to develop an education program to address training and implementation of the chosen dysphagia assessment tool on pilot units. Design: Descriptive analysis, and an educational program. Setting: Local hospital in Northwest Arkansas. Patients: Pre-data included patients with the primary diagnosis of stroke, over the age of 18, excluding those identified with cognitive impairment, admitted …

A Quantitative Study Of The Effectiveness Of The Nurse-Led Delirium Protocol On Hospitalized Older Adults Utilizing The Confusion Assessment Method (Cam), Marie Claire Roca

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Delirium presents as a reversible, fluctuating, altered state of consciousness that leads to an increase in length of hospital stay, a decline in the functional and cognitive status, and increased mortality rates. There are many risk factors and predisposing conditions, and the onset of delirium is thought to be multifactorial. Delirium remains the most common complication of hospitalized older adults. The Confusion Assessment Method (CAM) is one of the assessment tools available to diagnose delirium, and has been implemented at the study hospital. The goal of this quality improvement project is to determine the effectiveness of interventions set forth in …

Rush To Judgment: The Sti-Treatment Trials And Hiv In Sub-Saharan Africa, Eileen Stillwaggon, Larry Sawers

Economics Faculty Publications

Introduction: The extraordinarily high incidence of HIV in sub-Saharan Africa led to the search for cofactor infections that could explain the high rates of transmission in the region. Genital inflammation and lesions caused by sexually transmitted infections (STIs) were a probable mechanism, and numerous observational studies indicated several STI cofactors. Nine out of the ten randomized controlled trials (RCTs), however, failed to demonstrate that treating STIs could lower HIV incidence. We evaluate all 10 trials to determine if their design permits the conclusion, widely believed, that STI treatment is ineffective in reducing HIV incidence.

Discussion: Examination of the …

Oncolog, Volume 60, Number 05, May 2015, Sarah Bronson, Bryan Tutt, U. Arizor

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Algorithm for Treating Advanced Ovarian Cancer Increases Complete Resection Rate: Most ovarian cancers have spread beyond the ovary by the time they are diagnosed, and they often recur even after responding to primary treatment. Researchers at The University of Texas MD Anderson Cancer Center aim to improve patient outcomes by changing the standard approach to newly diagnosed advanced ovarian cancer.
• Clinical Trials Explore Systemic Treatments for Brain Metastases from Breast Cancer: Brain metastases from breast cancer are difficult to treat because many of the systemic drugs that are effective against breast cancer cannot cross the blood-brain barrier. But researchers at …

A Comparison Study Of Diagnostic Outcomes Between The Music Therapy Assessment Tool For Awareness In Disorders Of Consciousness (Matadoc) And The Coma Recovery Scale-Revised (Crs-R), Caitlyn E. Bodine

Masters Theses

The purpose of this study was to explore preliminary external validation of a standardized music therapy assessment tool used in the detection of awareness with the DOC patient population with an external reference standard. Eight subjects were administered both the MATADOC and the CRS-R within five days of one another, and results were compared on the levels of overall diagnosis, analogous domain subscales, and intra-assessment relationships between individual domains and overall diagnosis. Results indicated a very strong level of agreement for overall diagnosis (r_s = .85, p < .01), very strong relationships between the auditory and visual components of the two assessments (r_s = .76, p < .05, and r_s = .81, p < .05, respectively), and a strong, but non-significant relationship between arousal scores on the two assessments (r …