Medicine and Health Sciences Commons^™

Glycine Receptor Alpha Subunit (Glyra) Specific Inhibition Contributes To Ganglion Cell Signaling In Mouse Retina., Chi Zhang

Electronic Theses and Dissertations

In the retina, numerous types of neurons are wired together in a highly specific albeit complex pattern. This sophisticated retinal network allows extraction and encoding of more than 20 representations of the visual scene in its output neurons, the retinal ganglion cells (RGCs). Within the inner plexiform layer (IPL) of retina, glycine receptors (GlyRs) are expressed on different cell classes and modulate RGC visual activity to light onset (ON RGCs) and to light offset (OFF RGCs), for example, their temporal precision and gain control. There are four GlyR alpha subunits (GlyRα1-4) with differential expression patterns in IPL. Each mediates spontaneous …

Characterizing The Neuropeptide Pathways Between The Forebrain And The Pons., Ali Al-Magableh

Electronic Theses and Dissertations

Many current health problems including obesity, hypertension, stroke, heart disease, and type 2-diabetes can be attributed to diet. One powerful determinant of food selection is how good or bad a food 'tastes' (e.g. affective value), and is ranked highly by consumers as their top reason for choosing a food (e.g. preference). Learning plays an important role in the establishment and strengthening of food preference and, thus in guiding food choice and calories consumed. The basis of such learning is provided, in part, by limbic system modulation of gustatory neural processing at lower levels in the medulla and pons. I hypothesize …

Exploring The Roles Of Host And Tumor Cell Α4 And Α7 Nicotinic Acetylcholine Receptors In Lung Cancer., John Caleb Greenwell

Electronic Theses and Dissertations

Lung cancer is the leading cause of cancer death in men and women worldwide. Tobacco exposure represents the major risk factor. Nicotine, an addictive plant alkaloid found in tobacco, has been demonstrated to stimulate lung carcinoma cells directly via nicotinic acetylcholine receptors (nAChRs) that trigger downstream signals capable of promoting lung cancer growth and progression. Attention has been given to α7 nAChRs, while less is known about α4 nAChRs. However, most studies evaluating these receptors relied on chemical inhibitors notorious for their off-target effects. Consequently, the true role of α4 and α7 nAChRs in lung cancer remains unclear. To address …

Evaluating The Marginal Integrity Of Lithium Disilicate Veneers Fabricated By Digital Impressions And Cad/Cam Compared To Conventional Techniques., Michael C. Guzelian

Electronic Theses and Dissertations

This in vitro study compared marginal gap size in anterior lithium disilicate veneers produced by conventional and digital impressions. One typodont right central incisor was prepared for an all-ceramic cast. Ten conventional veneers were fabricated using Type IV stone, PVS, and IPS e.max press, while ten digital veneers were fabricated using Lava COS (3M ESPE) and IPS e.max CAD/CAM processing and milling. Samples were divided double-blindly, captured at 45X magnification, evaluated at three images per orientation (B-D-M-P), and measured at three distances (largest, smallest, best fit) per image. Data points were entered into SPSS code for one-way and two-way ANOVA, …

Supporting The Occupational Therapy Student In The Production And Dissemination Of Systematic Reviews: An Interprofessional Collaboration Among Librarians And Occupational Therapy Faculty, Teal W. Benevides, Phd, Otr/L, Paul Hunter, Dmd, Mlis, Gary E. Kaplan, Ms, Ahip, Daniel G. Kipnis, Msi

Department of Occupational Therapy Posters and Presentations

Objectives

This poster describes the outcomes of a curriculum-based collaboration between librarians and OT faculty (‘collaboration’) to enhance graduate student skills for conducting a systematic review (SR); the collaboration included database instruction, bibliographic management software, and culminated in student presentations to healthcare practitioners for continuing education credit. Three outcome areas are discussed: impact of the collaboration on student satisfaction and perceived competence; characteristics of the included literature; and the dissemination of SR findings to healthcare practitioners.

Methods

Three librarians participated in the instruction and the institutional repository (Jefferson Digital Commons; JDC) deposits. A total of 132 students over a period …

Evaluation Of A Pharmacist-Led Medication Assessment Used To Identify Prevalence Of And Associations With Polypharmacy And Potentially Inappropriate Medication Use Among Ambulatory Senior Adults With Cancer., Ginah Nightingale, Emily Hajjar, Kristine Swartz, Jocelyn Andrel-Sendecki, Andrew Chapman

College of Pharmacy Faculty Papers

PURPOSE: The use of multiple and/or inappropriate medications in seniors is a significant public health problem, and cancer treatment escalates its prevalence and complexity. Existing studies are limited by patient self-report and medical record extraction compared with a pharmacist-led comprehensive medication assessment.

PATIENTS AND METHODS: We retrospectively examined medication use in ambulatory senior adults with cancer to determine the prevalence of polypharmacy (PP) and potentially inappropriate medication (PIM) use and associated factors. PP was defined as concurrent use of five or more and less than 10 medications, and excessive polypharmacy (EPP) was defined as 10 or more medications. PIMs were …

Consequence Of The Tumor-Associated Conversion To Cyclin D1b., Michael A Augello, Lisa D Berman-Booty, Richard Carr, Akihiro Yoshida, Jeffry L Dean, M J Schiewer, Felix Y Feng, Scott A Tomlins, Erhe Gao, Walter J Koch, Jeffrey L Benovic, John Alan Diehl, Karen E Knudsen

Department of Cancer Biology Faculty Papers

Clinical evidence suggests that cyclin D1b, a variant of cyclin D1, is associated with tumor progression and poor outcome. However, the underlying molecular basis was unknown. Here, novel models were created to generate a genetic switch from cyclin D1 to cyclin D1b. Extensive analyses uncovered overlapping but non-redundant functions of cyclin D1b compared to cyclin D1 on developmental phenotypes, and illustrated the importance of the transcriptional regulatory functions of cyclin D1b in vivo. Data obtained identify cyclin D1b as an oncogene, wherein cyclin D1b expression under the endogenous promoter induced cellular transformation and further cooperated with known oncogenes to promote …

Plasminogen Activator Inhibitor-1 In Cigarette Smoke Exposure And Influenza A Virus Infection-Induced Lung Injury, Yashodhar P. Bhandary, Shwetha K. Shetty, Amarnath S. Marudamuthu, Krishna K. Midde, Hong-Long Ji, Homoyoun Shams, Renuka Subramaniam, Jian Fu, Steven Idell, Sreerama Shetty

Center for Research on Environmental Disease Faculty Publications

Parenchymal lung inflammation and airway and alveolar epithelial cell apoptosis are associated with cigarette smoke exposure (CSE), which contributes to chronic obstructive pulmonary disease (COPD). Epidemiological studies indicate that people exposed to chronic cigarette smoke with or without COPD are more susceptible to influenza A virus (IAV) infection. We found increased p53, PAI-1 and apoptosis in AECs, with accumulation of macrophages and neutrophils in the lungs of patients with COPD. In Wild-type (WT) mice with passive CSE (PCSE), p53 and PAI-1 expression and apoptosis were increased in AECs as was lung inflammation, while those lacking p53 or PAI-1 resisted AEC …

University Of New England’S College Of Osteopathic Medicine 2015 Peter Morgane Research Fellowship Recipients, University Of New England College Of Osteopathic Medicine

Peter Morgane Research Fellowships

2015 recipients of the University of New England College of Osteopathic Medicine's Peter Morgane Research Fellowship.

Family-Centered Pediatric Radiation Therapy: A Nurse-Led Quality Improvement Collaboration Model, Elizabeth A. Austin

Doctoral Projects

Problem: Parents of children diagnosed with cancer face a number of physical, emotional, and social hurdles in the race for a cure. Family schedules shift dramatically to accommodate daily radiation therapy treatment appointments. Ambulatory procedure unit nursing staff attempt to teach and interpret the process without the benefit of a family-centered intradepartmental structured communication process to promote safe care with these families.

Methods: Implementation of a structured family-centered interprofessional standard work model to promote interdepartmental collaboration. The project implemented a structured family-centered interview and standard work algorithms to improve the radiation therapy family experience.

Results: A structured, streamlined, interdepartmental interview, …

Redesigning The Use Of Electronic Health Records In The Exam Room: A Multidisciplinary Approach, Quinton Dean Fletchall

Theses - ALL

Utilizing video-recordings and transcriptions of actual clinical interactions, as well as interviews with patients and physicians, this thesis analyzes how the use of electronic health records, and the information found within them, impact doctor-patient interaction and, in effect, notions of patient-centered care. ‘Patient centered care,’ a major area of focus in doctor-patient communication literature, is a style of interaction where the patient is put first and their concerns and feelings are given priority over the ‘biomedical agenda’ by the doctor. Using a multidisciplinary approach between language and social interaction and industrial and interaction design, this thesis proposes possible changes to …

Visceral Space: Dissection And Michelangelo's Architecture, Chloe Costello

Architecture Undergraduate Honors Theses

This thesis focuses on the architectural work of Renaissance master Michelangelo Buonarroti, who, perhaps, is better known for his painting and sculpture than for his architecture. Nevertheless, his buildings are revered by architectural historians, such as James Ackerman, for their mimicry of bodily motion and emotion. Under the influence of Renaissance humanism, it was not uncommon for architects to validate their designs by reference to the human body, for example, basing the dimensions of a basilica on ideal bodily proportions. But, Michelangelo's approach in his earliest architectural designs, such as the Medici Chapel (1521-1524) and the Laurentian Library (1523-1525) in …

Developing A Bilingual, Computer-Tailored, Hpv Vaccination Promotion Intervention Targeting Latino Parents, Angela Chia-Chen Chen, Ashish Amresh

Publications

In this paper we present an innovative, computer-tailored application aimed at increasing Latino parents' intention to vaccinate their adolescent children against Human Papilloma Virus (HPV). HPV infection is the most common sexually transmitted infection in the United States. Latinas have the highest age-adjusted incidence rate for HPV-associated cervical cancer compared with their counterparts in other racial/ethnic groups. HPV vaccines offer hope against HPV-associated diseases. Because parental consent is required for children under age 18 to receive t h e HPV vaccination in most U. S. states, parents' attitudes and intention to have their children vaccinated are keys for promoting HPV …

C-Train - The Care Transitions Innovation - Analysis Of Program Impacts, Bill J. Wright, Keri B Vartanian, Megan Holtorf, Nicole Olson, Leif Rustvold, Honora Englander (C-Train Program Contact)

Articles, Abstracts, and Reports

No abstract provided.

Increasing Adipocyte Lipoprotein Lipase Improves Glucose Metabolism In High Fat Diet-Induced Obesity, R. Grace Walton, Beibei Zhu, Resat Unal, Michael Spencer, Manjula Sunkara, Andrew J. Morris, Richard Charnigo, Wendy Katz, Alan Daugherty, Deborah A. Howatt, Philip A. Kern, Brian S. Finlin

Clinical and Translational Science Faculty Publications

Background: Lipoprotein lipase regulates fat uptake into adipose tissue.

Results: A mouse model with increased adipose tissue lipoprotein lipase has improved glucose metabolism when challenged with a high fat diet.

Conclusion: Increasing adipose tissue lipoprotein lipase improves adipose tissue function.

Significance: Adipose tissue lipoprotein lipase protects against obesity-induced glucose and insulin intolerance.

Flight Physician - May, 2015, Civil Aviation Medical Association

Browse all Civil Aviation Medical Association Newsletters

A seventeen page newsletter of the Civil Aviation Medical Association. The newsletter provided news about civil aviation medicine and information related to the organization.

The Importance Of A Pictorial Medical History In Assisting Medical Diagnosis Of Individuals With Intellectual Disabilities: A Telemedicine Approach, Grace Bonanno

CCAC Theses and Dissertations

When face-to-face physical medical exams are not possible, virtual physical exams, in the form of a pictorial medical exam/history, can be substituted, and telemedicine can be the means to deliver these virtual exams. The goal of this work was to determine if presence in the form of a visual and/or pictorial medical history can be of benefit to clinicians in the diagnosis of medical conditions of individuals with developmental disabilities (DDs) and/or intellectual disabilities (IDs), in particular those who cannot, because of their cognitive and/or physical disabilities, verbally relate their illness to a clinician. Virtual exams can also be useful …

387. Gene Delivery Of Apoe2 Reduces Amyloid Pathology In Transgenic Mouse Models Of Alzheimer's Disease, Lingzhi Zhao, Andrew J. Gottesdiener, Mayur S. Parmar, Christine Grevstad, David Havlicek, Jonathan Rosenberg, Stephen Kaminsky, Maria Chiuchiolo, Dolan Sondhi, Ronald G. Crystal, Steven M. Paul

HPD Articles

The deposition of amyloid β-peptides (Aβ), cleavage products of the amyloid precursor protein (APP) by β- and γ-secretases, in brain represents a pathological hallmark of Alzheimer's disease (AD). Apolipoprotein E (APOE) ε4 allele carriers have an increased risk to develop AD and an earlier age of onset, whereas carriers of the ε2 allele have reduced risk and a delayed age of onset. APOE is also a major determinant of brain Aβ and amyloid burden in humans and in several transgenic mouse models of AD (E4>E3>E2). We have previously reported that lentivirus-mediated intraparenchymal gene delivery of APOE2 significantly reduces …

Roles Of Albumin In Patients With Chronic Liver Disease: Evidence-Based Medicine, Akarawut Juntrapirat, Sombat Treeprasertsuk

Chulalongkorn Medical Journal

This article details the roles of albumin in patients with chronic liver disease especially cirrhosis according to evidence-based information. In addition, this review includes the summary of several guidelines for albumin use in patients with chronic liver disease including those who are undergoing large volume paracentesis (more than 5 litre), those with spontaneous bacterial peritonitis (SBP), and those with hepatorenal syndrome (HRS), which occurred mainly in decompensated cirrhotic patients and acute liver failure. The physiologic functions of albumin and the other potential indications of albumin in cirrhotic patients are also mentioned.

Pediapp Finder: Creating A Pediatric Application Database, Sara Pro, Adrianne Leblanc, April Wasjutin, Robert Williams

Dissertations, Masters Theses, Capstones, and Culminating Projects

It is estimated that of the 85% of Americans that own cell phones, over half of these cell phone owners use apps on their phone (Fox & Duggan, 2012; Purcell, 2011). According to the U.S. Food and Drug Administration (2013), by 2015, 500 million mobile device users will be using mobile health, or “m-Health” apps. Healthcare professionals are increasingly adopting mobile technology as an innovative, cost-efficient, and timesaving tool that may promote patient wellness and disease prevention (Kumar, 2013; mHealth Bible, 2013). Although mobile technology is a natural fit to the field of occupational therapy, research demonstrates that few resources …

Efficient In Vitro Development Of Photoreceptors From Human Pluripotent Stem Cells, Joseph C. Reynolds

Dissertations, Masters Theses, Capstones, and Culminating Projects

Degeneration of the rod and cone photoreceptors in the human retina is among the most common causes of blindness. Replacing these damaged photoreceptors may help to restore vision. Repairing the damaged retina relies on the insertion of new, healthy cells. Embryonic stem (ES) cells and induced pluripotent stem (iPS) cells are two possible sources of photoreceptors to restore vision. Previous data shows that human ES cells and iPS cells can be differentiated into photoreceptors and transplanted into the eye to restore some vision. However, this process is inefficient, and costly. Here, we show a new method for inducing photoreceptor production …

Correlates Of Male Involvement In Maternal And Newborn Health: A Cross-Sectional Study Of Men In A Peri-Urban Region Of Myanmar, Frances Ampt, Myo Myo Mon, Kyu Kyu Than, May May Khin, Paul A. Agius, Christopher Morgan, Jessica Davis, Stanley Luchters

Population Health, East Africa

Background: Evidence suggests that increasing male involvement in maternal and newborn health (MNH) may improve MNH outcomes. However, male involvement is difficult to measure, and further research is necessary to understand the barriers and enablers for men to engage in MNH, and to define target groups for interventions. Using data from a peri-urban township in Myanmar, this study aimed to construct appropriate indicators of male involvement in MNH, and assess sociodemographic, knowledge and attitude correlates of involvement.

Methods: A cross-sectional study of married men with one or more children aged up to one year was conducted in 2012. Structured questionnaires …

Isolation Housing Exacerbates Alzheimer's Disease-Like Pathophysiology In Aged App/Ps1 Mice, Huang Huang, Linmei Wang, Min Cao, Charles Marshall, Junying Gao, Na Xiao, Gang Hu, Ming Xiao

Center of Excellence in Rural Health Faculty Publications

BACKGROUND: Alzheimer's disease is a neurodegenerative disease characterized by gradual declines in social, cognitive, and emotional functions, leading to a loss of expected social behavior. Social isolation has been shown to have adverse effects on individual development and growth as well as health and aging. Previous experiments have shown that social isolation causes an early onset of Alzheimer's disease-like phenotypes in young APP695/PS1-dE9 transgenic mice. However, the interactions between social isolation and Alzheimer's disease still remain unknown.

METHODS: Seventeen-month-old male APP695/PS1-dE9 transgenic mice were either singly housed or continued group housing for 3 months. Then, Alzheimer's disease-like pathophysiological changes were …

Improving Use Of The Confusion Assessment Method (Cam) In The Intensive Care Unit: A Quality Improvement Project To Reduce Delirium, Anne Smith

The Eleanor Mann School of Nursing Undergraduate Honors Theses

The purpose of this project was to implement an educational intervention to enhance the use of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) tool at an intensive care unit at a Northwest Arkansas hospital. The goal was for earlier diagnosis and treatment of delirium which research has indicated can impact more favorable patient outcomes. Delirium is an acute mental disturbance, which may have a fluctuating course (van Ejik et al., 2011). Delirium is common in the intensive care unit (ICU) but often goes unidentified causing delayed treatment (van Ejik et al., 2011). The Confusion Assessment Method (CAM) …

Long-Term Paracetamol Treatment Induces Interleukin-1Β Expression In Human Microglial Cells, Benjawan Wongprom, Supang Maneesri-Le, Thananya Thongtan

Chulalongkorn Medical Journal

Background Paracetamol or acetaminophen (N-acetyl-p-aminophenol; APAP) is a widely used as an analgesic and antipyretic drug. This drug has long time been considered as a safe drug, when used in the therapeutic levels. However, the adverse effects concerning long-term APAP usage at the non-hepatotoxicity dosage regarding the human central nervous system, in particular microglia, remains unclear. Objective To investigate the effect of short-term (6, 12 and 24 hr.) and long-term APAP treatments (1, 2, 3 and 4 weeks) on the expression of the pro-inflammatory cytokine IL-1β in human microglia. Design Experimental research Setting Department of Biochemistry and Department of Pathology …

Volume Assessment Of Normal Adrenal Gland From Computed Tomography: A Pilot Study, Kewalee Sasiwimonphan, Phornanong Ariyajinda

Chulalongkorn Medical Journal

Background : In clinical practice, it is quite difficult to differentiate pathologic adrenal hyperplasia from normal adrenal gland enlargement especially in the elderly. CT scan is so far the best technique to detect and measure the size of the glands. We, hereby, try to evaluate the volume of the adrenal gland through CT scan in several age groups of Thai people to identify its normal range. Objective : To establish age-specific ranges of the volume of a normal adrenal gland in adult patients by using CT scan. Setting : Department of Radiology, Faculty of Medicine, Chulalongkorn University. Research Design : …

Mechanisms Of Enhanced Pulmonary Vasoconstriction And Calcium Sensitization Following Chronic Hypoxia, Charles Elbert Norton Iii

Biomedical Sciences ETDs

CH results in pressure dependent basal tone and enhanced depolarization- and endothelin-1 (ET-1)-induced vasoconstriction in the pulmonary circulation through Rho kinase (ROK)-dependent Ca2+ sensitization, responses that may contribute to the development of pulmonary hypertension (PH) in this setting. The free radical superoxide (O2-) has been implicated in these responses. Because NADPH oxidases (NOX) play a role in the development of PH, we hypothesized that membrane depolarization, increases in intraluminal pressure, and ET-1 signaling lead to pulmonary vascular smooth muscle (VSM) myofilament Ca2+ sensitization and augmented vasoconstrictor reactivity following CH through NOX-derived O2- production. As epidermal growth factor receptor (EGFR) and …

Gcn5l1 Functions As A Mitochondrial Acetyltransferase That Regulates Mitophagy, Bradley Roy Webster

Biomedical Sciences ETDs

Caloric restriction (CR) increases lifespan and promotes both longevity and €˜healthy-aging. CR's benefits are dependent in part on NAD-dependent deacetylases known as sirtuins. NAD levels increase with CR promoting sirtuin-mediated deacetylation of lysine residues. Humans express seven sirtuin isoforms that localize to specific sub-cellular compartments. Sirtuins and acetylation affect numerous cellular processes including mitochondrial function. Sirt3 is the major mitochondrial deacetylase and regulates mitochondrial function namely ATP levels, oxidative stress and metabolism. Given the importance of mitochondrial acetylation and Sirt3, we hypothesized the existence of a mitochondrial-localized acetyltransferase that 1) localizes to the mitochondria; 2) has an acetyltransferase domain; and …

Sex-Specific Parental Effects On Offspring Lipid Levels, Irene M. Predazzi, Rafal S. Sobota, Serena Sanna, William S. Bush, Jacquelaine Bartlett, Jessica S. Lilley, Macrae F. Linton, David Schlessinger, Francesco Cucca, Sergio Fazio, Scott M. Williams

Dartmouth Scholarship

Background:

Plasma lipid levels are highly heritable traits, but known genetic loci can only explain a small portion of their heritability.

Methods and Results:

In this study, we analyzed the role of parental levels of total cholesterol (TC), low‐density lipoprotein cholesterol (LDL‐C), high‐density lipoprotein cholesterol (HDL‐C), and triglycerides (TGs) in explaining the values of the corresponding traits in adult offspring. We also evaluated the contribution of nongenetic factors that influence lipid traits (age, body mass index, smoking, medications, and menopause) alone and in combination with variability at the genetic loci known to associate with TC, LDL‐C, HDL‐C, and TG levels. …

Medical Crises In Older People: Cohort Study Of Older People Attending Acute Medical Units, Developmental Work And Randomised Controlled Trial Of A Specialist Geriatric Medical Intervention For High-Risk Older People; Cohort Study Of Older People With Mental Health Problems Admitted To Hospital, Developmental Work And Randomised Controlled Trial Of A Specialist Medical And Mental Health Unit For General Hospital Patients With Delirium And Dementia; And Cohort Study Of Residents Of Care Homes And Interview Study Of Health-Care Provision To Residents Of Care Homes, John Gladman, Rowan Harwood, Simon Conroy, Pip Logan, Rachel Elliot, Rob Jones, Sarah Lewis, Jane Dyas, Justine Schneider, Davina Porock, Kristian Pollock, Sarah Goldberg, Judi Edmans, Adam Gordon, Lucy Bradshaw, Matthew Franklin, Katherine Whittamore, Isabella Robbins, Aidan Dunphy, Karen Spencer, Janet Darby, Lukasz Tanajewski, Vladislav Berdunov, Georgios Gkountouras, Pippa Foster, Nadia Frowd

Publications and Research

Background: This programme of research addressed shortcomings in the care of three groups of older patients: patients discharged from acute medical units (AMUs), patients with dementia and delirium admitted to general hospitals, and care home residents.

Methods: In the AMU workstream we undertook literature reviews, performed a cohort study of older people discharged from AMU (Acute Medical Unit Outcome Study; AMOS), developed an intervention (interface geriatricians) and evaluated the intervention in a randomised controlled trial (Acute Medical Unit Comprehensive Geriatric Assessment Intervention Study; AMIGOS). In the second workstream we undertook a cohort study of older people with mental health problems …