Medicine and Health Sciences Commons^™

The Creative Process Of Choreography And Performance: The Brain Injury Rehabilitation Within Dance/Movement Therapy, Chih-Hsien Lin

Creative Arts Therapies Theses

The underlying creative process in the acts of choreography and performance has not yet been fully researched for use in clinical practices. It is rarely addressed for adults with brain injury in rehabilitation. This study investigated the perceived effects of the creative process within the performance as therapy (PAT) framework on the brain injury population. In a collaborative process engaging the participants as co-researchers and as co-performers in a final dance performance at a public venue, the role of PAT in brain injury rehabilitation was explored. By using artistic inquiry methodology through participatory action research (PAR) paradigm, the study addressed …

Medical School Watercooler Newsletter - May 10, 2015, Lindsey Lyle

Watercooler Newsletter

This is the May 10, 2015 edition of the Frederick P. Whiddon College of Medicine's Newsletter - Watercooler.

Contents Include:

Dr. Alexeyev Interviewed in Science Magazine

May Med School Café – 'Civil War Medicine'

ASGE Updates Guidelines on Colonoscopy Prep

Medical School Graduates Participate in Honors Convocation Ceremony

USA Medicine Magazine - Mailing Now

Deciphering Signals From Huntington’S Disease Brains In The Search For Treatments, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

A Novel Role For Drebrin In Regulating Progranulin Bioactivity In Bladder Cancer., Shi-Qiong Xu, Simone Buraschi, Alaide Morcavallo, Marco Genua, Tomoaki Shirao, Stephen C Peiper, Leonard G Gomella, Ruth Birbe, Antonino Belfiore, Renato V Iozzo, Andrea Morrione

Department of Urology Faculty Papers

We recently established a critical role for the growth factor progranulin in bladder cancer insofar as progranulin promotes urothelial cancer cell motility and contributes, as an autocrine growth factor, to the transformed phenotype by modulating invasion and anchorage-independent growth. In addition, progranulin expression is upregulated in invasive bladder cancer tissues compared to normal controls. However, the molecular mechanisms of progranulin action in bladder cancer have not been fully elucidated. In this study, we searched for novel progranulin-interacting proteins using pull-down assays with recombinant progranulin and proteomics. We discovered that drebrin, an F-actin binding protein, bound progranulin in urothelial cancer cells. …

Postoperative Pain Management, Taylor H. Schuler

Senior Honors Projects, 2010-2019

This literature review examined two pharmacological forms of postoperative pain

management and one nonpharmacological intervention to help reduce pain (See

Appendix A). Sources were gathered from the nursing research databases of

Cumulative Index to Nursing & Allied Health Literature (CINAHL) and PubMed.

Articles and studies between 2004 and 2015 were analyzed to write the review. The

focus was to look at postoperative patients and determine if epidural or patient

controlled analgesia (PCA) provided the same satisfaction for individuals who

underwent surgery. In addition, music therapy was researched to explore the effects

of listening to a pleasurable sound and how it …

The First Year: The Relationship Between Loneliness & Wellness Among College Freshmen, Isabel M. Jimenez-Bush

Senior Honors Projects, 2010-2019

Loneliness is common in the majority of first-semester college students, but if left unaddressed, long-term loneliness may cause physical health problems. The purpose of this study was to investigate the relationship between perceived loneliness and physical health among college freshmen at James Madison University using a Qualtrics survey. The relationship between loneliness and health was assessed using the Behavioral Risk Factor Surveillance Survey (BRFSS) to gauge physical health and the UCLA Loneliness Survey (UCLA-LS) to gauge perceived loneliness. Contrary to the hypothesis, results indicated there was no relationship between loneliness and physical health. It was thought the BRFSS was a …

The Effect Of Auditory Stimuli On Visual Time-To-Contact Perception, Chelsea L. Rugel

Senior Honors Projects, 2010-2019

Previous research has demonstrated that auditory and visual stimuli have individual effects on the accuracy of a person’s estimation of time-to-contact (TTC), the time at which two objects collide. Prior findings also suggest that there is cross-modal interference between vision and audition; however, this phenomenon has never been studied in a TTC situation. (Driver & Spence, 1998; Ichikawa & Masskura, 2006; Roseboom, Kawabe, & Nishida, 2013) In this study we attempted to fill in this research gap by examining the effect of auditory speed cues over visual speed cues in a two-dimensional TTC scenario, and by determining if an object’s …

The Effect Of Communication Type On Knowledge Retention Of Brain Injuries, Alyson Cregger

Senior Honors Projects, 2010-2019

Misconceptions about traumatic brain injuries have been seen in the general population since 1988. Previous research has demonstrated that the misconceptions are not limited to geographical area and have been seen in health care professionals. A possible explanation for these misconceptions could be the ineffective transmission of knowledge. The current study examined the effect of an educational intervention on eight misconceptions and their ‘real life’ applications, as well as the general knowledge surrounding traumatic brain injuries. Comparative and absolute risk were also examined. Thirty undergraduate students were given a pre-test consisting of four surveys (misconceptions, application of misconception, general knowledge, …

Critical Analysis Of The Confounding Of Clinical Trials, Eleanor L. Jordan

Senior Honors Projects, 2010-2019

To provide a comprehensive overview of issues confounding clinical trials, Chapter 2 will discuss the parties involved in the research and development of medications and detail the individual responsibilities of each. However, the ambition of these individual entities often produces a conflict of interest especially when profits are involved [9]. Organizations and individuals such as insurance corporations, pharmaceutical companies (sponsors), pharmacy benefit managers, investigators (doctors/medical professionals) and most importantly patients, are all involved in carrying out clinical research and have definitive responsibilities they are required to follow for unbiased results. However, many rules are overlooked and biases go unrecorded causing …

A Portfolio Of Experiences In Communications Sciences And Disorders, Dakota Michael Sharp

Senior Honors Projects, 2010-2019

N/A

Mouth Asymmetries During Infant Babbling: A Brain Lateralization Study, Cecilia Breazile

Senior Honors Projects, 2010-2019

Although babbling is both prevalent and important in the process of language development, it could be argued that we still do not understand the basic nature of babbling. To further our understanding of the nature of babbling we attempted to find evidence for brain lateralization typical of adult speech acts during early babbling. This study examined infant mouth asymmetries during babbling sequences in search of evidence that babbling is an inherently linguistic act as indicated by the lateralization of the brain. Previously recorded videos of 12 infants, all 9 months of age, were examined, 29 images were captured, and a …

Evidence-Based Practices In Selecting Standardized Assessments Of Child Language, Darielle Cooper

Senior Honors Projects, 2010-2019

From the results of a survey given to 1,399 speech-language pathologists, 11 frequently used language assessment tools for preschool and school age children were selected to undergo a systematic review. The examiner’s manual of each assessment was examined to determine whether the test reported adequate psychometric properties and acceptable levels of diagnostic accuracy. Results indicated that all reviewed assessments met at least 60% of McCauley and Swisher’s (1984) psychometric criteria for evaluating norm-referenced tests. Six of the 11 assessments provided information on diagnostic accuracy in the examiner’s manual or in the literature. Four tests published acceptable levels of diagnostic accuracy, …

The Effects Of Narrative Elicitation Task On The Verb Morphological Patterns Of Younger Adolescents With And Without Specific Language Impairment, Megan T. Taliaferro

Senior Honors Projects, 2010-2019

Specific language impairment (SLI) is one of the most commonly occurring communication disorders (Castrogiovanni (2008)). SLI is an impairment in the language of children, adolescents and adults who show no other impairment such as mental, emotional or physical problems. Individuals with SLI demonstrate normal intelligence as shown by nonverbal Intelligence Quotient (IQ) scores; however, their language skills appear to be worse than their normally achieving (NA) peers. There has been an issue in identifying individuals with SLI. One factor contributing to the identification issues of SLI is the lack of a clinical marker. Although no clinical marker currently …

Does Vestibular Sensory Stimulation, In The Form Of Slow, Linear Swinging, Change The Modes Of Communication Among Children With Autism?, Katherine A. Gallaher

Senior Honors Projects, 2010-2019

The purpose of this study was to determine if children with autism receiving vestibular sensory stimulation (VSS) in the form of slow, linear swinging, had any change or progression in their modes of communication when compared to children with autism who received a free-play period (nVSS) during speech-language (SL) therapy. Over the course of therapy, each child’s response mode was recorded as a gesture, vocalization, gesture + vocalization, or an utterance, and each mode was a dependent variable (DV) in this study. Participants who received VSS treatment were expected to have a greater improvement on the progression of modes, such …

Quality Of Life Indices In Brain Injury: A Pilot Investigation, Lauren Kristine Maher

Senior Honors Projects, 2010-2019

This IRB approved study explores the scope of acquired brain injury (ABI) as it affects an individual’s perceived quality of life and how measurement informs clinical decisions. Quality of life is an important consideration for persons with ABI, since research indicates acquired brain injury can lead to personality changes such as depression, anxiety, and aggression not previously exhibited (Greve et al., 2001). When treating persons with ABI, healthcare professionals must be able to reliably measure and track their client’s perceived quality of life. This pilot study included 35 clients receiving community-based intervention at Crossroads to Brain Injury Recovery, Inc. (Crossroads) …

Pre-Pulse Inhibition Assessment Of Sound Localization In Mice, Kathryn C. Brooks

Senior Honors Projects, 2010-2019

The purpose of my Honors Research Project was to assist Dr. Megan

Klingenberg in completing part of the research in her final dissertation project. Dr.

Klingenberg’s project was based off of a study done by Allen and Ison in 2010.

This study tested the auditory spatial acuity of mice using pre-pulse inhibition of

the startle reflex as the response for detecting the sound stimulus. The goal of

Dr. Klingenberg’s AuD project was “to explore the methodological, functional, and

genetic influences on sound localization using pre-pulse inhibition of the acoustic

startle response in mice”. Dr. Klingenberg’s project was broken into three …

Identification Of The Staphylococcal Cassette Chromosome Mec (Sccmec) Element In Viral Fractions From Environmental Samples, Emily M. Pelto

Senior Honors Projects, 2010-2019

Antibiotic resistance attributed to methicillin-resistant Staphylococcus aureus (MRSA) has become a growing concern over the last decade in both the healthcare and agricultural environment. This resistance is encoded by the gene mecA that is located on a mosaic, mobile genetic element called the Staphylococcal Cassette Chromosome mec (SCCmec) element. It is proposed that the transfer of the SCCmec element and resulting spread of resistance occur by transduction, the transfer of genetic material from bacterium to bacterium by a bacteriophage. Specifically, it is hypothesized that the transduction of this resistance is occurring in the agricultural setting. To test …

The Effectiveness Of Social Stories On Children With Autism Spectrum Disorder: A Literature Review, Caroline E. Johnson

Senior Honors Projects, 2010-2019

The primary goal of Social Stories is to address debilitating difficulties and are written with the goal of objectively sharing important social information with individuals with ASD (Gray, 1998). The purpose of this literature review was to look at the effectiveness of Social Stories on children with autism.

Family And Child Development Education For Harrisonburg Adolescents, Mollie M. Moran, Jennifer E. Corser, Julia M. Glauber

Senior Honors Projects, 2010-2019

The pregnancy rate among 15- to 17-year-old women in Harrisonburg is double Virginia's state rate (Townsend, 2008). While meeting administers and guidance counselors of Harrisonburg High School we learned that Harrisonburg High School views this issue as one that cannot be addressed by teaching abstinence in their public school. They have found that because of cultural beliefs, abstinence is not an effective tool for preventing teenage pregnancy. Instead, HHS teaches their students about safe sexual practices and how to have a healthy pregnancy in the event they were to become pregnant. The high school offers a class called “Child and …

An Investigation Of On-Campus Composting Among Undergraduate College Students, Ashleigh Beben

Senior Honors Projects, 2010-2019

Composting among college students can promote a healthy environment and encourage the appropriate disposal method for generated organic wastes. The purpose of this study was to observe composting behaviors and attitudes among students and foster an increase in knowledge of suitable composting behavior in on-campus dining halls. Questionnaires containing questions related to composting behavior and knowledge, demographics, and place of residence were distributed to 140 James Madison University (JMU) undergraduate students. Of those students 26.4% were males and 73.6% were females. Freshmen made up 77.9% of the sample followed by sophomores making up 14.3% of respondents. The sample was made …

Vaccine Education And Compliance Statistics In The Greater Indianapolis Area, Matthew Brennan Budi

Undergraduate Honors Thesis Collection

Background: Recently, rates of certain vaccine-preventable diseases have increased and outbreaks have occurred. For example, in 2014, the incidence of measles in the United States reached a record high since 2000, with 644 total cases reported to the Centers for Disease Control and Prevention's (CDC's) National Center for Immunization and Respiratory Diseases. Increases such as this may likely be due to widespread public fears that vaccines can cause serious adverse events.Therefore, due to their accessibility, pharmacists can play a crucial role in lessenning these public fears through proper education.

Study objective: The primary objective of this study was to dispel …

The Impact Of Peptide Nucleic Acid Fluorescence In Situ Hybridization (Pna Fish®) Rapid Diagnostic Testing On The Initiation Of Appropriate Antifungal Therapy In Patients With Candida Species Bloodstream Infections, Jenna Lee Ksiazkiewicz

Undergraduate Honors Thesis Collection

Background: Traditional methods for detecting positive blood cultures include the use of broth bottles with sensitive indicators for growth. These techniques can take 24-48 hours to signal a positive test. Another 24 hours are often required to determine the species of the organism. The use of rapid diagnostic testing for Candida species bloodstream infections provides accurate species identification in less than two hours.

Objective: Evaluate the time to appropriate antifungal therapy in patients in which rapid diagnostic testing was utilized.

Methods: This study was a retrospective, observational cohort of patients who had positive blood cultures for Candida species and had …

The Medical Response To The Black Death, Joseph A. Legan

Senior Honors Projects, 2010-2019

This paper discusses the medical response to the Black Death in both Europe and the Middle East. The Black Death was caused by a series of bacterial strands collectively known as Yersinia pestis. The Plague originated in the Mongolian Steppes. It was spread westward by the east-west trading system. Once it arrived in the Crimea in 1346, Italian merchants helped spread it throughout the Mediterranean. Medicine in Europe and the Middle East were centered on Galen’s theory of humors. There were many religious explanations for the Plague, but the main medical explanation was the spread of bad air, or …

Effectiveness Of Nutrition Diagnosis And Intervention, Olivia R. Massa

Senior Honors Projects, 2010-2019

This study is designed to investigate whether the current system of administering fluid to enteral nutrition patients in a mid-sized community hospital is effective based on the enteral feeding order, outcomes recorded by the dietitian in the medical record, or comparison to widely- accepted standards for estimating fluid needs. Data of this retrospective chart review came from 566 medical records that were pulled based on admission date within a one year time span and an order for enteral nutrition (EN) during the patient’s stay. Out of these, 107 records were used due to incomplete chart documentation and inaccessibility of medical …

The Nonmedical Use Of Prescription Stimulants Among Students With High Academic Standing, Megan L. Dwyer

Senior Honors Projects, 2010-2019

College students report one of the highest rates of the nonmedical use of prescription stimulants (NPS). Research has shown that use is more common among students who have high levels of perceived stress, such as honors students. The purpose of this study was to determine whether honors students reported higher rates of NPS than their non-honors peers with high academic standing. It was hypothesized that honors students would report higher rates of use. The instrument used in this study was an email survey that was administered electronically through the online Qualtrics Survey system. The survey request was sent to 3,530 …

Knowledge, Attitudes, And Behaviors Related To Emergency Contraception Among College Students, Sarah Donohue

Senior Honors Projects, 2010-2019

More than 50% of pregnancies in the United States are unplanned. Though recent regulations have expanded access to EC, the numerous policy changes, lack of knowledge, and unreliable sources of information regarding EC prevent women from utilizing the benefits that EC can offer.

The purpose of this study was to assess students’ knowledge and attitudes about emergency contraception (EC) and to determine if there is a relationship between sexual behaviors and the use of EC. Two hundred and twelve undergraduate students from James Madison University completed an anonymous 29-question survey regarding EC.

Results indicated that students were reasonably knowledgeable regarding …

A Study Of The Relationship Between Self-Esteem And High-Risk Sexual Behaviors In College- Aged Black Women, Deborah P. Cameron

Senior Honors Projects, 2010-2019

The purpose of this research study was to examine the relationship between self- esteem and high-risk sexual behaviors. This project aimed to determine if there was a significant difference in this relationship in Black females and non-Black females. Exploring self-esteem and high-risk sexual behaviors could enhance sexual health programs. A pilot survey was developed to measure high-risk behaviors, self-esteem and intentions of practicing safe sex. The survey was distributed via email to all female undergraduate students attending James Madison University during the Spring 2015 semester. SPSS was used to analyze the data collected. The participants of the study (n=268) were …

The Synthesis And Study Of The Biological And Colloidal Properties Of Bolaamphiphiles, Louis M. Damiano

Senior Honors Projects, 2010-2019

Over the past decade, antibiotic resistant bacteria have caused infections in patients throughout the world.^[1] The rise in antibiotic resistance is primarily due to the misuse and overuse of antibiotics. ^[1] To counter the increase in antibiotic resistance, infection control mechanisms have been aggressively researched in recent years. In particular, drug delivery has become a focal point to fight antibiotic resistant infections.^[2] Amphiphiles have a wide range of applications in the clinical setting, including the ability to inhibit bacterial transference because of their bactericidal activity. ^[3] Bolaamphiphiles are a subclass of amphiphiles that possess two or more hydrophilic …

Structural Studies Of The Ig58 Domain Of The Giant Muscle Protein Obscurin, Matthew C. Oehler

Senior Honors Projects, 2010-2019

Obscurin (720-900 kD) is a giant sarcomeric signaling protein that is the only known link

between the cytoskeleton and the surrounding membrane structure. Mutations to obscurin

and to obscurin binding partners have been linked to human muscle diseases such as

hypertrophic cardiomyopathies and muscular dystrophy. These diseases likely occur due

to the abrogation of specific molecular interactions necessary for suitable function. To

more fully understand how specific mutations lead to disease, here we solve the highresolution

structure of obscurin Ig58. The literature shows that an Arg8Gln mutation to

the Ig58 domain of obscurin is associated with hypertrophic cardiomyopathy (HCM).

Chemical …

Comparative Analysis Of Anti-Bd Bacteria From Six Malagasy Frog Species Of Ranomafana National Park, Kelsey Savage

Senior Honors Projects, 2010-2019

As Malagasy amphibians are facing an impending extinction crisis from the lethal skin fungus Batrachochytrium dendrobatidis (Bd), it has become imperative to proactively mitigate the threat. Bd sporangia develop in the skin of infected amphibians and cause the skin to thicken, leading to ionic imbalance and eventual heart failure. It has been shown that certain bacterial species are able to inhibit Bd growth on amphibians by producing antifungal metabolites. Community-based probiotics are one approach used to combat chytridomycosis by inoculating an environment with Bd-inhibitory bacteria so that many amphibian species are treated at once. With this method, it is important …