Medicine and Health Sciences Commons^™

The Efficacy Of Bibliotherapy For Social Anxiety And Depressive Symptomology, Paige Palumbo

Theses and Dissertations

In this study, the efficacy of a self-help treatment was examined. Participants were undergraduates experiencing comorbid social anxiety and depressive symptoms. It is hypothesized that those in the treatment condition (n=5) would experience a significant reduction in social anxiety and depressive symptoms over the course of the nine week treatment. In addition, it is hypothesized that these gains would be greater than the gains experienced by individuals in the wait-list control condition (n=5). The results of this study did support the hypotheses.

Regulation Of Phosphatidylinositol 4-Kinase Iii Alpha Complex Formation In B Cells And Its Role In Autoantibody Production, Michaela M. Sangillo Ms

All Student Scholarship

The plasma membrane protein Efr3b, the Tetratricopeptide domain repeat 7 (Ttc7), and the kinase phosphatidylinositol 4-kinase III alpha (PI4KIIIa) are found to form a complex a the plasma membrane. This complex is thought to play a role regulating the PI4P pools at the plasma membrane, which is imperative to membrane identity and vesicle transport.

Empowerment Model For Nurse Leaders' Participation In Health Policy Development: An East African Perspective, Nilufa Jivraj Shariff

School of Nursing & Midwifery, East Africa

Background: Nurses comprise the largest portion of the health care workforce in most countries; they interact closely with patients and communities, they work throughout the day and within all sectors of health care. Their breath of practice gives them a broad understanding of requirements of the health care system, of how factors in the environment affect the health outcomes of clients and communities. Nurses’ involvement in health policy development ensures that health services are: safe, effective, available and inexpensive.

Methods: A Delphi survey was utilized and included the following criteria: expert panelists, three iterative rounds, qualitative and quantitative analysis, and …

The Sto2 Non-Invasive Tissue Hypoperfusion Monitor As A Screening Tool For Early Sepsis Detection In The Emergency Department, Zachary Kopelman, James Zhou, Alexandra Dattilo, Sandra Schneider, Mary Frances Ward, John D'Angelo, Jason D'Amore

Research Day

Background: Early Recognition of patients with sepsis induced tissue hypoperfusion (SITH) Remains a significant clinical challenge. Non--‐invasive Tissue oxygenation saturation (StO2) Monitors have been developed to provide rapid, low--‐cost, and non--‐invasive bedside assessments of tissue oxygen extraction; they have not been well validated as an initial screening tool for sepsis in the ED. Objectives: To Assess the efficacy of initial bedside StO2 Readings in the early identification of patients with SITH And to compare StO2 Readings with lactate levels. Methods: IRB approved, prospective, observational pilot study of a convenience sample of ED Patients presenting with a sepsis continuum diagnosis. Setting: …

Review Of The Use Of Ceritinib, A Newly Approved Anaplastic Lymphoma Kinase (Alk) Inhibitor, In Crizotinib-Resistant Anaplastic Lymphoma Kinase-Rearranged Non-Small Cell Lung Cancer, Sonia Thomas, Afua Gyapong, Nathan Greenfield

Research Day

Lung cancer is one of the most prevalent cancers in the United States, and is the leading cause of death related to cancer. Non-small cell lung cancer is the most common subtype, with approximately 85% of diagnosed lung cancer being non-small cell lung cancer. Several genetic mutations exist in patients with non-small cell lung cancer, which allows for specialized targeted therapy. One such mutation, EML4-ALK fusion protein abnormalities, represents roughly 5% of non-small cell lung cancer patients, but the patient population in which it is most prevalent is young adults and those that don’t smoke or have a short history …

Evaluation Of Liposomal Bupivacaine Versus Immediate Release Bupivacaine In Post-Operative Pain After Knee Surgery, Nathan Greenfield, Saba Gidey, Dusty Lisi, Cristina Refec

Research Day

Purpose: The use of liposomal bupivacaine, which is formulated to have an extended release, has been associated with a decrease in opiate use after total hip and knee arthroplasty. The aim of this retrospective study is to compare the use of liposomal bupivacaine and immediate release bupivacaine in patients who have undergone knee replacement. The purpose of this study is to determine the effectiveness of using liposomal bupivacaine for patients undergoing total knee arthroplasty in comparison to current practice. Methods This is a single-center, retrospective, cohort study that is being conducted in a 353 bed academic medical center. The electronic …

A Study To Evaluate The Maximal Dose Administration At Two Different Locations In Two Different Vdr4 High Frequency Percussive Ventilator (Hpfv) Circuits, Jeff L. Heltborg, Bethany S. Kobza, Ace Nilson

Student Research Symposium

The purpose of this study was to determine if the positioning of a nebulizer at two different locations in the VDR4, a specialty ventilator, would result in differing dose administrations of a bronchodilator, Albuterol Sulfate. We hypothesized that placement near the endotracheal tube will provide greater dose deposition. The ventilator was set up to mimic the normal adult patient. Administration was done through the nebulizer placed in the ventilator circuit either before the humidifier or between the endotracheal tube and the VDR 4’s Phasitron. Three trials were performed using a standard dose of Albuterol for each trial. The mass of …

My Embodied Multiracial Experience, Catherine C. Miller

Creative Arts Therapies Theses

While there is some research on dance/movement therapy (DMT) and people of Color, there is no research specifically on the use of DMT with multiracial people. This heuristic study explored the embodied experience of being multiracial and how that experience could inform the practice of DMT to better meet the possible needs of multiracial clients. The researcher was a 24 year old multiracial female graduate student. Data collection lasted for 12 weeks and consisted of experiences in which the researcher’s multiracial heritage was highlighted. Data was collected through three self-interviews and artistic journaling. The researcher used Forinash’s adapted form of …

Increased Airway Reactivity And Hyperinsulinemia In Obese Mice Are Linked By Erk Signaling In Brain Stem Cholinergic Neurons, Luiz O. S. Leiria, Fernanda M. Arantes-Costa, Marina C. Calixto, Eduardo C. Alexandre, Rodrigo F. Moura, Franco Folli, Carla M. Prado, Marco Antonio Prado, Vania F. Prado, Licio A. Velloso, Jose Donato Jr., Edson Antunes, Milton A. Martins, Mario J. A. Saad

Anatomy and Cell Biology Publications

Obesity is a major risk factor for asthma, which is characterized by airway hyperreactivity (AHR). In obesity-associated asthma, AHR may be regulated by non-T(H)2 mechanisms. We hypothesized that airway reactivity is regulated by insulin in the CNS, and that the high levels of insulin associated with obesity contribute to AHR. We found that intracerebroventricular (ICV)-injected insulin increases airway reactivity in wild-type, but not in vesicle acetylcholine transporter knockdown (VAChT KDHOM-/-), mice. Either neutralization of central insulin or inhibition of extracellular signal-regulated kinases (ERK) normalized airway reactivity in hyperinsulinemic obese mice. These effects were mediated by insulin in cholinergic nerves located …

Examination Of Lower Limb Ambidextrous Execution Of The Snap Down Technique In Folk Style Wrestling, Nicholas Decastro

Honors Program Theses and Projects

The purpose of this study was to examine the kinematic motions of the lower extremity in the snap down technique. Specifically, the study examined the kinematic differences between execution using the dominant and non-dominant side. Angular displacement, velocity and acceleration of the hip, knee and ankle joint was examined. It was hypothesized that a significant statistical difference would be observed in multiple variables between the dominant and non-dominant limb execution. Five male collegiate wrestlers were recruited for participation in the study. Inclusion into the study was on the basis that each participant was right side dominant and displayed proper foot …

Parents Of Children With Type 1 Diabetes And Their Needs, Janelle M. Neu, Donna Freeborn

Journal of Undergraduate Research

According to the Center for Disease Control and Prevention (CDC) more than 13,000 young people are diagnosed with type 1 diabetes (CDC, 2008b). This autoimmune disease destroys the pancreatic cells that create insulin, a necessary hormone for carbohydrate metabolism. This disease affects every aspect of not only the child’s life, but also of the child’s parents and family (Moreira, H., Frontini, R., Bullinger, M. & Canavarro, M.C., 2013). When a child is diagnosed with type 1 diabetes, parents, alongside their child, must acquire a new repertoire of skills. Parents must become professionals at anticipating their child’s appetite and activity each …

Clustered Regularly Interspaced Short Palindromic Repeat-Dependent, Biofilm-Specific Death Of Pseudomonas Aeruginosa Mediated By Increased Expression Of Phage-Related Genes, Gary E. E. Heussler, Kyle C. Cady, Katja Koeppen, Sabin Bhuju, Bruce A. Stanton, George A. O’Toole

Dartmouth Scholarship

The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated (CRISPR/Cas) system is an adaptive immune system present in many archaea and bacteria. CRISPR/Cas systems are incredibly diverse, and there is increasing evidence of CRISPR/Cas systems playing a role in cellular functions distinct from phage immunity. Previously, our laboratory reported one such alternate function in which the type 1-F CRISPR/Cas system of the opportunistic pathogen Pseudomonas aeruginosa strain UCBPP-PA14 (abbreviated as P. aeruginosa PA14) inhibits both biofilm formation and swarming motility when the bacterium is lysogenized by the bacteriophage DMS3. In this study, we demonstrated that the presence of just the DMS3 …

Programming Macrophage Inflammation Resolution: The Role Of Omega-3 Polyunsaturated Fatty Acids, Boris Krasnov, Mathew Lombardozzi, Maria Caraballo, Ramil Sapinoro

Pharmacy Faculty/Staff Publications

It was previously thought that resolution of inflammation was a passive process, but recent emerging research has identified that resolution is an active process and that dual acting lipid mediators derived from essential omega-3 polyunsaturated fatty acids (PUFAs) have both anti-inflammatory (reducing neutrophil access to the inflamed tissue) and pro-resolving (removal of apoptotic cells by macrophages in the inflamed site) actions. The objective of our study was to determine the role of omega-3 PUFAs in programming phenotypic changes in treated macrophages. The polarization of macrophages during inflammatory responses to functionally distinct phenotypes may play a role in both inflammation and …

Caring For Dying Children: A Systematic Review Of The Literature, Megan Watts, Debra Mills

Journal of Undergraduate Research

The death of a child is experienced with great resistance because it is understood as an interruption in the life cycle—often seen as untimely and unfair. Pediatric nurses care for children in high-mortality environments, such as the pediatric intensive care and oncology units and, as a result, are directly affected by childhood death (Papadatou, 2000). Caring for a dying child and their family is an emotionally charged situation (American Academy of Pediatrics, 2000; Catlin and Carter, 2001; Stutts and Schloemann, 2002). Nurses spend much time caring for their patients but forget to look after themselves. Caring for the nurse is …

A National Study Of Nursing Students’ Recommendations Regarding End Of Life Content In Nursing Education Curricula, Danielle Shkapich, Barbara Heise

Journal of Undergraduate Research

The purpose of this qualitative study was to analyze the recommendations of nursing students nationwide who have experienced a patient death while in nursing school regarding end-of-life (EOL) curricula. Many nursing students are not adequately instructed on how to perceive and react to death. For registered nurses, dealing with death is an evitable part of their careers. Without adequate instruction, student nurses are less prepared to deal with such circumstances in their future practice. While many studies regarding the benefits of EOL training have been published, this study takes the next step in determining, on a national basis, what students …

The Evaluation Of Creative Passages: A Dance/Movement Therapy And Rits Of Passage Pilot Program For Adolescent Girls, Monimia Macbeth

Creative Arts Therapies Theses

The purpose of this evaluation project was to assess the Creative Passages Program; a dance/movement therapy pilot program incorporating rites of passage rituals that was developed by the principle investigator. The evaluation included comprehensive assessment evaluation methods to assess the programs performance and its ability to achieve its specified outcomes. Creative Passages was constructed around a rites of passage framework, applying a ritual based experience similar to ceremonies performed for female adolescents in many cultures around the world. The program was developed around the idea that a dance/movement therapy program that incorporates rites of passage ritual for adolescent girls will …

Evaluation Of Teamstepps Integration Across A Curriculum Regarding Team Attitudes: A Longitudinal Study, Mary Beth R. Maguire, Marie N. Bremner, David N. Bennett, Lewis Vanbrackle

Faculty Articles

Introduction: The ability to function as an effective member of the healthcare team is essential for graduate nurses upon entry into practice. Team training is therefore, an important element of nursing education. A convenient and cost-effective approach to providing team training to nursing students is through the TeamSTEPPS® curriculum. The purpose of the study was to determine if an intentional integration of TeamSTEPPS® principles into simulation-based team training modules would improve attitudes toward teamwork in a cohort of undergraduate nursing students. Methods: A quasi–experimental time series nonequivalent control group design was used. A convenience sample of 115 first semester students …

The Correlation Of Childhood Obesity And Dental Caries In South Central Kentucky, Christina Guthrie

Mahurin Honors College Capstone Experience/Thesis Projects

Does obesity have an effect on dental caries in South Central Kentucky Previous research has presented information stating a high prevalence of tooth decay found within the state of Kentucky. In addition, studies have indicated an elevated rate of childhood obesity found within the region. As a future dental hygienist in Kentucky, it is important to understand if a correlation exists between tooth decay and childhood obesity to better educate both patients and caregivers. The investigation will utilize a sample of patient records through a retrospective collection process. A correlation of dental caries and childhood obesity is expected to be …

The Effect Of Cheese On The Ph Levels In The Oral Cavity, Madison R. Hayden

Mahurin Honors College Capstone Experience/Thesis Projects

In the Fall of 2014, research was conducted with 20 participants on the campus of Western Kentucky University. Participants were given two ounces of Coca Cola^® to drink and the pH level in their mouth was tested one minute later. After waiting a minute, the participants were given a one ounce square of mild cheddar cheese to eat and the pH level was tested again one minute later. For further study, this project will be expanded to include more subjects as well as an increased exposure time to Coca Cola^®. This research is conducted to help support …

Identification Of Risk Factors For Suicide Amongst Psychiatric Patients: Can Structured Measurement Tools Be More Specific?, Amresh Shrivastava, Robbie Campbell, Megan Johnston, Coralee Berlmont, Miky Kaushal, Avinash Desousa, Larry Stitt, Charles Nelson

Data and Test Instruments

Background One of the main challenges in suicide prevention is that it cannot be predicted. Significant number of patients attempt suicide while being under psychiatric treatment. Lethality and intent of each risk factor varies and remains inconsistent. Though structured instruments have also been useful with limited success search for newer methods remains an urgent clinical need. We believe risk is multifactorial and a scale based upon fundamental domains of biological, psychological, social, environmental, spiritual and clinical origin can elucidate more specific factors. Scale for impact of suicidality- Management, Assessment and Planning of care-brief screener (SISMAP-bcs) is 23 item scale which …

Endothelin-1 Promotes Bovine Corneal Endothelial Cell Proliferation Via A Mapk Pathway: Implications For Keratopathy And Deturgescence, Brandon C. Farmer

Mahurin Honors College Capstone Experience/Thesis Projects

The corneal endothelium is vital in maintaining the functions of the cornea, namely hydration, thickness, and transparency. Diseases that impair the corneal endothelium are currently remedied solely via surgery. These surgeries present obstacles to patients of underserved areas due to cost, ineffectiveness, and lack of access. Trachoma, an infection which can cause corneal opacities, is the leading cause of infectious blindness in the world. In order to eradicate trachoma, epidemiological data is needed. Three villages in Kasigau, Kenya were studied to quantify the occurrence of trachoma in the region. The three villages were found to have adequate access to antibiotics …

A Model For A Structured Clinical Development Program For First-Year Residents: Utilizing The Entrance Osce, Individualized Learning Plans (Ilps), And Peer Clinical Coaching, Jill M. Krapf, Sameer Aggarwal, Larrie Greenberg, Benjamin Blatt

E-Learning Modules

Identification of incoming residents’ unique strengths and weaknesses in a clinical setting is important for developing an individualized educational curriculum and ultimately addressing specific needs. This resource presents and describes materials for a clinical development program for first year residents. The program is structured around three educational elements: an entrance Objective Structured Clinical Examination (OSCE), Individualized Learning Plan (ILP), and peer clinical coaching. The included files, which describe these three elements, are intended to serve as a resource for residency directors and/or graduate medical education faculty interested in constructing a similar program.

In the described clinical development program, first-year Obstetrics …

What's Happening: May 11, 2015, Maine Medical Center

What's Happening

No abstract provided.

A Comparison Of The Effects Of A Web-Based Education Program About The Icu Environment And A Standard Education Program On Anxiety, Depression, And Acute Stress Experienced Among Family Members Of Icu Patients, Chrystal Leigh Lewis

Dissertations

Family members of ICU patients may experience anxiety, depression, and acute stress disorder symptoms. A need identified by the multi-society task for critical care research was to study the usefulness of interventions to quantify and treat anxiety, depression, and stress symptoms experienced by family members of ICU patients (Deutschman et al., 2012). This task force encouraged investigating using technology to address this need. (Deutschman et al.). The purpose of this prospective, quasi-experimental nonequivalent control group (pretest/posttest) design study was to compare the effect of standard ICU education and a web-based education program about the ICU environment on the level of …

Week Of May 11, 2015, New York Medical College

InTouch

• Office of the Registrar Rolls Out Self-Service Portal for Students
• Peer to Peer Committee Recognizes Role Models at NYMC
• NYMC Unveils Historic Letter by Charles Darwin
• Four Faculty Members are 2015 Healthcare Heroes

Specialty Selection In The Face Of An Aging Demographic In Taiwan, Ian Christensen, Michael Barnes

Journal of Undergraduate Research

As of the end of August, 2013, senior citizens accounted for 11 percent of Taiwan’s population¹. According to a report published by Taiwan’s Ministry of the Interior earlier this year, Taiwan’s population is predicted to be “hyper-aged”,with 20% of the population 65 or over, by 2025. With the world’s lowest birth rate (less than 0.9 children per woman)² and a universal health care system, the aging of Taiwan’s population constitutes a massive challenge for the Taiwan health care system. Such a challenge is not, however, unique to Taiwan. Many populations, especially in developed nations such as those …

Qualitatively Assessing The Expression Of Kynurenine Pathway Metabolic Enzymes In Human Glioma Tissue, Kaushik Varadarajan

Honors College Theses

Gliomas are the most common brain tumor and glioblastoma multiforme (GBM) is the most common type of glioma observed in patients. Prognosis with late stage glioma and GBM is very poor even with recent advances in treatment. Along with treating the tumor, manners of bypassing the blood brain barrier and ensuring the tumor uptakes the treatment is necessary. Because the treatments can harm regular brain cells there is concern about the viability and toxic side effects of many treatments. With all of these challenges posed it is important to understand how glial tumors can be so recurring and difficult to …

A Novel Caspase 8 Selective Small Molecule Potentiates Trail-Induced Cell Death, Octavian Bucur, Gabriel Gaidos, Achani Yatawara, Bodvael Pennarun, Chamila Rupasinghe, Jérémie Roux, Stefan Andrei, Bingqian Guo, Alexandra Panaitiu, Maria Pellegrini, Dale Mierke, Roya Khosravi-Far

Dartmouth Scholarship

Recombinant soluble TRAIL and agonistic antibodies against TRAIL receptors (DR4 and DR5) are currently being created for clinical cancer therapy, due to their selective killing of cancer cells and high safety characteristics. However, resistance to TRAIL and other targeted therapies is an important issue facing current cancer research field. An attractive strategy to sensitize resistant malignancies to TRAIL-induced cell death is the design of small molecules that target and promote caspase 8 activation. For the first time, we describe the discovery and characterization of a small molecule that directly binds caspase 8 and enhances its activation when combined with TRAIL, …

Triceps Activation Amplitudes During Functional Activities, Srinath Kamineni, Corey Gildea, Arthur J. Nitz, Timothy L. Uhl

Orthopaedic Surgery and Sports Medicine Faculty Publications

Objective: To investigate the muscular activation amplitudes of three regions of triceps musculature during functional activities. We hypothesized that the medial and lateral triceps would be greatest in the terminal 30° arc of extension activities.

Design: Cross sectional.

Setting: Musculoskeletal Clinical Laboratory.

Participants: 20 healthy subjects recruited from a sample of convenience.

Intervention: Fine wire electromyograhical (EMG) electrodes were placed into the medial, central, and lateral triceps to measure muscular activation amplitude and two dimensional electrogoniometric kinematic activity was recorded during functional activities associated with activities of daily living.

Main Outcome Measure(s): Root mean squared amplitudes of triceps muscles normalized …

Impact Of Hospice Nurse Education On After-Hours Calls And Visits, Cheryl Slack

Evidence-Based Practice Project Reports

Medicare-certified hospice home care agencies must provide a 24/7 on call system for after business hours patient concerns. An agency identified a problem with a high volume of after-hours hospice calls for symptom management. How these calls are handled impact patient and family outcomes and satisfaction. A literature review provided evidence that hospice nurse education and appropriate telephone support improves symptom management, enhances family support, provides a sense of security, reduces anxiety, and promotes comfort. Providing hospice nurse education on symptom management supported the goal of this evidence based practice (EBP) project to reduce the family/caregiver need for frequent on-call …