Medicine and Health Sciences Commons^™

Profil Rujukan Kasus Nonspesifik Pada Fasilitas Kesehatan Tingkat Primer, Elda Nazriati, Nuzelly Husnedi

Kesmas

Salah satu indikator kualitas fasilitas kesehatan tingkat primer (FKTP) adalah rendahnya rujukan nonspesialistik. Rujukan nonspesialistik adalah rujukan dari 144 penyakit yang seharusnya dapat diatur di FKTP. Kenyataannya, masih banyak kasus nonspesialistik yang dirujuk ke fasilitas kesehatan sekunder. Penelitian deskriptif dengan metode campuran kuantitatif dan kualitatif ini bertujuan untuk mengetahui pola dan penyebab kasus penyakit nonspesialistik yang dirujuk ke fasilitas kesehatan tingkat sekunder di Kota Pekanbaru. Gambaran kasus penyakit nonspesialistik dikumpulkan dari data Badan Penyelenggara Jaminan Sosial Kesehatan Kota Pekanbaru periode Desember 2014 - April 2015, sedangkan faktor penyebab rujukan diperoleh dari focus group discussion yang diikuti oleh 40 dokter berdasarkan …

Stigma Masyarakat Terhadap Orang Dengan Hiv/Aids, Zahroh Shaluhiyah, Syamsulhuda Budi Musthofa, Bagoes Widjanarko

Kesmas

Kabupaten Grobogan merupakan kabupaten dengan peningkatan kasus HIV/AIDS cukup tajam dibandingkan kabupaten lain di Jawa Tengah. Penelitian ini bertujuan untuk mengidentifikasi stigma masyarakat terhadap orang dengan HIV/AIDS (ODHA) dan faktor yang memengaruhinya. Penelitian explanatory ini dilakukan melalui pendekatan studi potong lintang dengan sampel berjumlah 300 kepala keluarga yang dipilih menggunakan sampel acak proporsional pada tiga kelurahan dengan kasus HIV tertinggi selama Agustus - September 2014. Pengumpulan data dilakukan melalui wawancara tatap muka menggunakan kuesioner terstruktur. Sedangkan analisis data dilakukan secara univariat, bivariat menggunakan kai kuadrat, dan multivariat menggunakan regresi logistik. Sebagian besar responden adalah laki-laki dengan tingkat pendidikan terbanyak sekolah …

Perilaku Seksual Berisiko Pengguna Narkotika, Rico Januar Sitorus, Merry Natalia

Kesmas

Penyalahgunaan narkotika yang melakukan hubungan seksual sebelum menikah, dan berganti-ganti mitra seksual merupakan perilaku berisiko. Masalah yang diakibatkan penyalahgunaan narkotika sangat kompleks, seperti masalah sosial dan kesehatan. Kecenderungan pengguna narkotika melakukan perilaku seksual dini dan tidak aman semakin memperparah kondisi kualitas hidup pecandu dan tentunya berdampak besar pada kelangsungan hidup di masa depan. Tujuan penelitian ini adalah mengetahui determinan perilaku seksual berisiko di kalangan pengguna narkotika. Metode penelitian adalah potong lintang menggunakan data sekunder kajian rekam medis di instalasi Medical Psikiatric Evaluation di rumah sakit ketergantungan obat (RSKO) Jakarta tahun 2013. Populasi penelitian adalah pasien ketergantungan narkotika yang dirawat inap …

Ketidaktepatan Sasaran Jamkesmas Berdasarkan Kriteria Miskin Pendataan Program Perlindungan Sosial, Umi Luthfiah, Ery Setiawan, Sindu Setia Lucia

Kesmas

Peserta Jaminan Kesehatan Masyarakat (Jamkesmas) hingga tahun 2010 mencapai 76,4 juta jiwa mencakup masyarakat miskin dan tidak mampu, sedangkan peserta Jaminan Kesehatan Daerah (Jamkesda) mencapai 31,6 juta jiwa. Secara prinsip, program Jamkesda dibentuk untuk memfasilitasi masyarakat miskin dan kurang mampu di luar kuota Jamkesmas yang dibiayai oleh pemerintah daerah. Penelitian ini bertujuan untuk meninjau ketepatan sasaran peserta program Jamkesmas berdasarkan kriteria miskin Pendataan Program Perlindungan Sosial (PPLS). Sumber data yang digunakan adalah data Survei Sosial Ekonomi Nasional (Susenas) tahun 2012. Populasi dari penelitian ini adalah seluruh rumah tangga di Indonesia tahun 2012. Sampel penelitian adalah rumah tangga terpilih dari masing-masing …

Studi Intervensi Klaster Kawasan Tanpa Rokok Pada Tingkat Rumah Tangga, Najmah Najmah, Fenny Etrawati, Yeni Yeni, Feranita Utama

Kesmas

Perilaku merokok memberikan dampak negatif, baik bagi perokok aktif maupun pasif, ditinjau dari sudut pandang kesehatan maupun ekonomi. Regulasi mengenai Kawasan Tanpa Rokok (KTR) yang telah diterbitkan belum ada yang mengatur mengenai penerapan KTR di tingkat rumah tangga. Penelitian ini bertujuan untuk mengidentifikasi perubahan perilaku melalui intervensi terpadu KTR pada tingkat rumah tangga. Penelitian dilakukan pada bulan Juli - September 2014 menggunakan desain cluster trial pada empat desa di Kabupaten Ogan Ilir, Sumatera Selatan. Selanjutnya, 200 sampel kepala keluarga dipilih melalui metode cluster random sampling. Intervensi yang dilakukan meliputi konseling terpadu, pemberian permen pengganti rokok, dan tabungan sehat. Hasil penelitian …

Efektivitas Collaborative Governance Dalam Pelayanan Komprehensif Berkesinambungan Untuk Menanggulangi Hiv/Aids, Argyo Demartoto

Kesmas

Di tingkat nasional dan daerah telah terdapat kebijakan publik, program dan kegiatan untuk menanggulangi HIV/AIDS, namun jumlah kasus HIV/AIDS meningkat setiap tahun. Tujuan penelitian ini untuk mengetahui efektivitas collaborative governance antarpemangku kepentingan dalam pelayanan komprehensif berkesinambungan untuk menanggulangi HIV/AIDS di Kota Surakarta. Penelitian ini merupakan studi kasus jenis exploratory. Informan ditentukan dengan menggunakan purposive sampling. Pengumpulan data dilakukan pada 2 Juli – 2 September 2013 dengan wawancara mendalam, observasi, focus group discussion, dan dokumentasi. Teknik analisis data dengan model analisis interaktif. Hasil penelitian menunjukkan bahwa pemberi dan penerima layanan berperan dalam penanggulangan HIV/AIDS sesuai tugas dan fungsinya masing-masing. Program pencegahan …

Experimental Determination Of Solids Suspension With Angled Impeller In A Pharmaceutical Mixing Vessel, Yingxi Tang

Theses

Angled-mounted impellers are commonly used in a number of pharmaceutical industry applications, from laboratory reactors to full-scale tanks. In these systems, the impeller is not centrally and vertically mounted, as in most stirred vessels, but it enters the vessel, and is therefore immersed in the fluid, at an angle from the vertical. This arrangement provides some baffling effects that would not otherwise exist if the impeller was centrally mounted.

One common requirement for such systems is that they are capable of suspending small solids dispersed in the liquid. Therefore, it is critical to know the value of the minimum agitation …

Effect Of Impeller Submergence On Power Dissipation And Solids Suspension In Mixing Systems Equipped With Pitch-Blade Turbines, Yufeng Song

Theses

Mixing and dispersion of solids in a liquid is a process frequently encountered in the pharmaceutical industry and often conducted in cylindrical baffled tanks stirred by mechanical impellers. In operations where the liquid level is decreased (as often which emptying the tank) the process must be stopped when the solids are no longer suspended. In this work, the minimum agitation to suspend solids (Njs) when the liquid level was lowered, and the impeller submergence S_b changed as a result were determined for the case of a six-blade, pitch-blade turbine (6-PBT) impeller. The power consumed by the impeller …

Experimental Determination Of The Agitation Requirements For Solids Suspension In Dissolution Systems Using A Mini Paddle Apparatus, Yang Song

Theses

Dissolution testing is a critical step in quality control of manufactured final products in the pharmaceutical industry. The United State Pharmacopeia (USP) Dissolution Testing Apparatus 2 (paddle) is the most widely used dissolution test devices in the pharmaceutical industry to formulate solid drug dosage forms and to develop quality control specifications for its manufacturing process.

Mini vessels and mini paddle dissolution testing systems are smaller versions of the USP 2 Apparatus. The concept of the mini paddle apparatus is similar to that of the USP 2 setup but it is scaled down about to 1/5 of the volume and 40% …

Effects Of Onsite Stretching Exercise On Employee Musculoskeletal Discomfort And Wellbeing, Kellie L. Caldwell

Theses

To fight high incidence of musculoskeletal pain and discomfort complaints among the maintenance workers in a large transportation company, this pilot intervention study of an on-site stretch and flex exercise program was implemented. The participants (n=62) were maintenance workers; whose age ranged from 26 to 69 years.

A 4½-minute video was created which included still images of human figures performing stretches, while a voice recording instructed how to perform each stretch. Exercises targeted the neck, shoulders, triceps, hamstrings, and quadriceps. The exercise program was conducted 5 days a week for 5 consecutive weeks, during daily shift meetings.

The results of …

Serum Vitamin D Status Is Associated With The Presence But Not The Severity Of Primary Open Angle Glaucoma., Aurélien Goncalves, Dan Milea, Philippe Gohier, Ghislaine Jallet, Stéphanie Leruez, Mani Baskaran, Tin Aung, Cédric Annweiler

Medical Biophysics Publications

OBJECTIVES: Vitamin D is involved in visual health and function. Our objective was to determine whether age-related vitamin D insufficiency was associated with the presence and the severity of primary open angle glaucoma (POAG) in a case-control study of older adults.

STUDY DESIGN: Case-control study.

MAIN OUTCOME MEASURES: One hundred fifty cases diagnosed with moderate-to-severe POAG (mean, 75.1±8.5 years; 42.0% female) and 164 healthy controls (mean, 73.0±7.9 years; 59.8% female) were included. POAG diagnosis was based on classical diagnostic criteria of optic nerve cupping and/or RNFL thinning, measured with optical coherence tomography. Severe POAG was defined as Humphrey visual field …

Identification Of Novel Genes That Regulate Androgen Receptor Signaling And Growth Of Androgen-Deprived Prostate Cancer Cells, Elina Levina, Hao Ji, Mengqiang Chen, Mirza Baig, David Oliver, Patrice Ohouo, Chang-Uk Lim, Garry Schools, Steven Carmack, Ye Ding, Eugenia Broude, Igor Roninson, Ralph Buttyan, Michael Shtutman

Faculty Publications

Prostate cancer progression to castration refractory disease is associated with anomalous transcriptional activity of the androgen receptor (AR) in an androgen-depleted milieu. To identify novel gene products whose downregulation transactivates AR in prostate cancer cells, we performed a screen of enzymatically-generated shRNA lenti-libraries selecting for transduced LNCaP cells with elevated expression of a fluorescent reporter gene under the control of an AR-responsive promoter. The shRNAs present in selected populations were analyzed using high-throughput sequencing to identify target genes. Highly enriched gene targets were then validated with siRNAs against selected genes, testing first for increased expression of luciferase from an AR-responsive …

Implementation Of A Student Development Workshop Series To Supplement A Traditional Curriculum, Melinda E. Lull, Jennifer Mathews

Pharmacy Faculty/Staff Publications

Preparing students to be successful in the classroom and as professionals requires more than didactic education. Academic programs primarily address the academic needs of students based on curricular and assessment goals but often fail to fully prepare students to successfully face the challenges they experience in school and after graduation. To truly prepare students, teachers must address their needs in domains outside the classroom. This session explores student development programs aimed at improving students’ academic, personal, and future professional success as a supplement to the traditional didactic education.

Learning goals:

• Reflect on current teaching and advising methods.

• Use …

Development Of A Guide By Postgraduate Residents On Receiving Feedback From Faculty In The Operating Theatre At Aga Khan University Hospital, David Karuri Maina

Master of Medicine in General Surgery

Background: Direct observation of residents in clinical encounters by faculty and assessment for learning has now become a key component of postgraduate training programs. DOPS, a workplace-based assessment form, was designed to provide formative assessment and feedback about a trainee’s procedural skills. Interactions between residents and faculty are central to this learning process and are influenced by multiple factors both at faculty and resident levels as well as contextual factors. The feedback may be used by the receiver to contemplate behaviour change. The receptivity of the resident to the feedback is a key determinant as to whether the process to …

Comparison Of Cardiovascular Risk Profiles Amongst Newly Diagnosed Cancer Patients And Non-Cancer Patients At The Aga Khan University Hospital Nairobi, Majid Lingani-Ncube Sikosana

Master of Medicine in Internal Medicine

Background: Non-Communicable Diseases (NCDs) are fast becoming the leading causes of morbidity and mortality in Low and Middle-income countries (LMIC) with cancers and cardiovascular diseases (CVDs) becoming the most prominent. CVD can be prevented if appropriate measures of screening and treatment of modifiable risk factors are addressed. This may translate to reduced risk of CVDs and some cancers in the long term. Increasing evidence exhibits common risk factors for both CVDs and cancer and that CVDs and their risk factors when present in cancer patients may worsen the overall outcome. Objectives: The primary objective was to determine and compare the …

A General Framework For Diagnosing Confounding Of Time-Varying And Other Joint Exposures, John W. Jackson

Harvard University Biostatistics Working Paper Series

No abstract provided.

The First Shared Online Curriculum Resources For Veterinary Undergraduate Learning And Teaching In Animal Welfare And Ethics In Australia And New Zealand, Jane Johnson, Teresa Collins, Chris Degeling, Anne Fawcett, Andrew D. Fisher, Rafael Freire, Susan J. Hazel, Jennifer Hood, Jennifer K.F. Lloyd, Clive J.C. Phillips, Kevin J. Stafford

Professional Veterinary Ethics Collection

The need for undergraduate teaching of Animal Welfare and Ethics (AWE) in Australian and New Zealand veterinary courses reflects increasing community concerns and expectations about AWE; global pressures regarding food security and sustainability; the demands of veterinary accreditation; and fears that, unless students encounter AWE as part of their formal education, as veterinarians they will be relatively unaware of the discipline of animal welfare science. To address this need we are developing online resources to ensure Australian and New Zealand veterinary graduates have the knowledge, and the research, communication and critical reasoning skills, to fulfill the AWE role demanded of …

Expanding The Role Of Peer Tutors Through The Use Of Online Quizzes, Melinda E. Lull, Jennifer Mathews

Pharmacy Faculty/Staff Publications

Peer tutors are commonly used in higher education as a way to provide additional resources for student learning. Self‐testing, a type of formative assessment tool, provides students with a study tool that can help identify areas of weakness that require focus. Despite their usefulness, this type of additional learning resource can often be time consuming for faculty members, limiting its successful use across multiple courses. The use of peer tutors has been investigated and shown to provide advantages to both students utilizing tutoring services and tutors alike. Educating peer tutors to be involved in the academic process by preparing study …

Disruption Of Columnar And Laminar Cognitive Processing In Primate Prefrontal Cortex Following Cocaine Exposure, Ioan Opris, Greg A. Gerhardt, Robert E. Hampson, Sam A. Deadwyler

Neuroscience Faculty Publications

Prefrontal cortical activity in primate brain plays a critical role in cognitive processes involving working memory and the executive control of behavior. Groups of prefrontal cortical neurons within specified cortical layers along cortical minicolumns differentially generate inter- and intra-laminar firing to process relevant information for goal oriented behavior. However, it is not yet understood how cocaine modulates such differential firing in prefrontal cortical layers. Rhesus macaque nonhuman primates (NHPs) were trained in a visual delayed match-to-sample (DMS) task while the activity of prefrontal cortical neurons (areas 46, 8 and 6) was recorded simultaneously with a custom multielectrode array in cell …

Patient Access To Electronic Health Records: Strengths, Weaknesses And What’S Needed To Move Forward, Alicia V. Zuniga

School of Information Student Research Journal

Electronic health records (EHRs) are desired by both physicians and patients, but the transition to and acceptance of sensitive health information online has been slow. This paper reviews the current literature on EHR adoption and outlines barriers, advantages and explicit steps for moving toward the EHR ubiquity. Potential benefits of EHRs to patients and physicians include reduced costs for patients, hospitals and insurance providers, patient empowerment, less errors in records and better health outcomes, but security and privacy concerns, cost of implementation and poor electronic records management system design have proved barriers to adoption.

The Biosynthesis Of Capuramycin-Type Antibiotics: Identification Of The A-102395 Biosynthetic Gene Cluster, Mechanism Of Self-Resistence, And Formation Of Uridine-5'-Carboxamide, Wenlong Cai, Anwesha Goswami, Zhaoyong Yang, Xiaodong Liu, Keith D. Green, Sandra Barnard-Britson, Satoshi Baba, Masanori Funabashi, Koichi Nonaka, Manjula Sunkara, Andrew J. Morris, Anatol P. Spork, Christian Ducho, Sylvie Garneau-Tsodikova, Jon S. Thorson, Steven Van Lanen

Pharmaceutical Sciences Faculty Publications

A-500359s, A-503083s, and A-102395 are capuramycin-type nucleoside antibiotics that were discovered using a screen to identify inhibitors of bacterial translocase I, an essential enzyme in peptidoglycan cell wall biosynthesis. Like the parent capuramycin, A-500359s and A-503083s consist of three structural components: a uridine-5'-carboxamide (CarU), a rare unsaturated hexuronic acid, and an aminocaprolactam, the last of which is substituted by an unusual arylamine-containing polyamide in A-102395. The biosynthetic gene clusters for A-500359s and A-503083s have been reported, and two genes encoding a putative non-heme Fe(II)-dependent α-ketoglutarate:UMP dioxygenase and an l-Thr:uridine-5'-aldehyde transaldolase were uncovered, suggesting that C-C bond formation during assembly of …

Cellular And Deafness Mechanisms Underlying Connexin Mutation-Induced Hearing Loss - A Common Hereditary Deafness, Jeffrey C. Wingard, Hong-Bo Zhao

Otolaryngology--Head & Neck Surgery Faculty Publications

Hearing loss due to mutations in the connexin gene family, which encodes gap junctional proteins, is a common form of hereditary deafness. In particular, connexin 26 (Cx26, GJB2) mutations are responsible for ~50% of non-syndromic hearing loss, which is the highest incidence of genetic disease. In the clinic, Cx26 mutations cause various auditory phenotypes ranging from profound congenital deafness at birth to mild, progressive hearing loss in late childhood. Recent experiments demonstrate that congenital deafness mainly results from cochlear developmental disorders rather than hair cell degeneration and endocochlear potential reduction, while late-onset hearing loss results from reduction of active …

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Georgia Southern Researchers Use CBPR to Extend Prostate Cancer Education, Counseling and Screening to Inner-City Men
• Georgia Southern Assesses Call to Integrate Healthcare and Public Health
• Georgia Southern Assistant Professor Implements a Community Empowerment Center
• Georgia Southern Investigates Perfomance of Stratified biviraite Ranked Set Sampling

Intramembranous Bone Healing Process Subsequent To Tooth Extraction In Mice: Micro-Computed Tomography, Histomorphometric And Molecular Characterization, Andreia Espindola Vieira, Carlos Eduardo Repeke, Samuel De Barros Ferreira Junior, Priscila Maria Colavite, Cláudia Cristina Biguetti, Rodrigo Cardoso Oliveira, Gerson Francisco Assis, Rumio Taga, Ana Paula Favaro Trombone, Gustavo P. Garlet

School of Podiatric Medicine Publications

Bone tissue has a significant potential for healing, which involves a significant the interplay between bone and immune cells. While fracture healing represents a useful model to investigate endochondral bone healing, intramembranous bone healing models are yet to be developed and characterized. In this study, a micro-computed tomography, histomorphometric and molecular (RealTimePCRarray) characterization of post tooth-extraction alveolar bone healing was performed on C57Bl/6 WT mice. After the initial clot dominance (0 h), the development of a provisional immature granulation tissue is evident (7 d), characterized by marked cell proliferation, angiogenesis and inflammatory cells infiltration; associated with peaks of growth factors …

An Innovative Approach To Decreasing Concussions In Adolescent Female Soccer Athletes: 2370 Board #117 May 29, 9, A. Lynn Millar, Brent A. Harper, Jared Casazza, Cameron Lephew, Meredith Moore, Timothy Schmidt

Faculty Publications

Concussion is a public health issue, fundamental to health promotion and injury prevention. Concussions are prevalent in adolescent athletic competition, in high-collision and non-collision sports. A history of previous concussion increases risk by a factor of three, female gender increases it 1.5 to 2.5 times, and female middle-school soccer players have 22.9 times increased risk during games. Non-collision concussions (indirect) may be primed by altered movement patterns from previous injuries, disruption of cervical proprioception, or musculoskeletal pain. Assessment of dynamic balance and functional movement allows identification of poor movement patterns or control.

PURPOSE: To assess a preventative movement-based warm-up routine …

Research Brief: "Alcohol Use And Craving Among Veterans With Mental Health Disorders And Mild Traumatic Brain Injury", Institute For Veterans And Military Families At Syracuse University

Institute for Veterans and Military Families

This brief is about the relation between alcohol craving and mental health disorders among veterans, and how mental health disorders impact alcohol cravings. For policy and practices, the research shows that alcohol cravings and mental health disorders among veterans could be a sign for risk of alcohol use disorder. It also shows that the VA should assess veterans for alcohol use disorder, and also research more ties between mental health disorders and alcohol use. Suggestions for future research include conducting the study in a larger, more representative population, as well as involving families in measuring alcohol use/cravings to ensure less …

Community Health News, Georgia Southern University

Health Policy & Community Health: News & Publications (2011-2018)

• Georgia Southern Researchers Use CBPR to Extend Prostate Cancer Education, Counseling and Screening to Inner-City Men
• Georgia Southern Assistant Professor Implements a Community Empowerment Center

Health Policy & Management News, Georgia Southern University

Health Policy & Community Health: News & Publications (2011-2018)

• Georgia Southern Assesses Call to Integrate Healthcare and Public Health

Overcoming The Fear Of The Lion: A Courageous Film About Genetic Testing And Huntington's Disease, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Generation And Assessment Of Muscular Mutations In Caenorhabditis Elegans, Katie N. Reget

DePaul Discoveries

A study of egg laying muscular mutations in C. elegans was conducted over a span of ten weeks. Parent (EGL-19) and wild type (N2) were exposed to mutagenesis and integration mutation techniques to generate genetic and physical different mutants. Overall, four genetic, physical and phenotypically unique worms were generated for the process of mutagenesis. The worms used in the process of integration were found to have shortened life spans, reduced size and decrease numbers of progeny.