Medicine and Health Sciences Commons^™

Identifying The Critical Domain Of Ll-37 Involved In Mediating Neutrophil Activation In The Presence Of Influenza Virus: Functional And Structural Analysis., Shweta Tripathi, Guangshun Wang, Mitchell White, Michael Rynkiewicz, Barbara Seaton, Kevan Hartshorn

Journal Articles: Pathology and Microbiology

The human cathelicidin LL-37 has been shown to play a role in host defense against influenza A viruses (IAV) through direct antiviral effects and through modulating inflammatory responses to infection. We recently showed that LL-37 increases neutrophil respiratory burst and neutrophil extracellular trap (NET) responses to IAV through engaging formyl peptide receptor 2 (FPR-2). In this paper we show that a fragment of LL-37, GI-20, which is composed of the central helical segment of the peptide, has similar effects as LL-37 on neutrophil activation. In addition to increasing respiratory burst and NET responses of the cells to IAV through an …

Role Of The Dna Sensor Sting In Protection From Lethal Infection Following Corneal And Intracerebral Challenge With Herpes Simplex Virus 1, Zachary M. Parker, Aisling A. Murphy, David. A. Leib

Dartmouth Scholarship

STING is a protein in the cytosolic DNA and cyclic dinucleotide sensor pathway that is critical for the initiation of innate responses to infection by various pathogens. Consistent with this, herpes simplex virus 1 (HSV-1) causes invariable and rapid lethality in STING-deficient (STING(-/-)) mice following intravenous (i.v.) infection. In this study, using real-time bioluminescence imaging and virological assays, as expected, we demonstrated that STING(-/-) mice support greater replication and spread in ocular tissues and the nervous system. In contrast, they did not succumb to challenge via the corneal route even with high titers of a virus that was routinely lethal …

The Human And Environmental Health Impacts Of Food Quality Among Emergency Food Providers, Alexina Cather

Master's Projects and Capstones

Abstract

Human health and environmental health are inextricably entwined, and the ways in which we grow, process, package, transport, market, and consume food are critical factors for both human and environmental health. The current industrial food system in the United States has numerous adverse effects on environmental and human health, which significantly impact the millions of food insecure Americans who receive their nutritional needs from emergency food providers (American Public Health Association, 2007). The widespread food insecurity in the United States and the increasing prevalence of obesity among adults and children have drawn attention to the role that emergency food …

Envisioning A Trauma-Sensitive Public Health Department: Implications For Practice, Policy, And Research, Victoria Lopez

Master's Projects and Capstones

Historically, the concept of trauma and long-term sequelae has rested primarily in the fields of psychology and psychiatry. However, recent attention and research around the health implications of trauma have unmasked this concept as a pervasive public health issue. This has catalyzed a movement to create a paradigm shift that transforms a formerly myopic understanding of trauma towards one that acknowledges the complexity and wide reaching impact trauma. At the core of this paradigm shift is an understanding of the interconnectedness between trauma and socio-ecological constructs at the individual, family, community, and organizational level. Public health departments are well positioned …

The Role Of Public Libraries In Addressing Food Insecurity: A Model For Community Feeding, Monica De La Cruz

Master's Projects and Capstones

Food insecurity is a serious problem in the United States. Not having enough food to eat can negatively impact children more severely than adults. Children who are food insecure are more likely to suffer from a range of physical, mental, and developmental delays in growth. There is prior evidence that the effects of food insecurity in children can be ameliorated through national feeding programs, like the National School Lunch Program (NSLP), which provides daily lunch at school for eligible low-income children. Though these types of programs are considered successful in addressing food insecurity within the community, the lack of these …

Limiting Exposure To Isoflurane In A Veterinary Occupational Setting, Richard A. Votava

Master's Projects and Capstones

This paper characterizes the veterinary occupational health hazards of waste anesthesia gas. A needs assessment was conducted to develop educational materials on hazard and control. Rcommendations were made to HESIS on need for educational products.

Health Hub Program Evaluation, Natalie Macias

Master's Projects and Capstones

This paper examines and evaluates the work of LIFT-Levántate a non-profit organization in San Rafael, California on their school-based nutritional education “health hub,” through health promotion interventions with adolescents. The James B. Davidson Middle School health hub educates students on topics related to nutrition and physical activity with the goal of providing access and increasing consumption of fruits and vegetables while lowering students’ intake of high-fat and sugary processed foods. Through research and observations of the students and families in this community, the data seems to indicate apparent disparities which vary by ethnicity, socioeconomic status and access. Underserved populations, including …

Staphylococcus Aureus Biofilms Induce Macrophage Dysfunction Through Leukocidin Ab And Alpha-Toxin., Tyler D. Scherr, Mark L. Hanke, Ouwen Huang, David B.A. James, Alexander R. Horswill, Kenneth W. Bayles, Paul D. Fey, Victor J. Torres, Tammy Kielian

Journal Articles: Pathology and Microbiology

UNLABELLED: The macrophage response to planktonic Staphylococcus aureus involves the induction of proinflammatory microbicidal activity. However, S. aureus biofilms can interfere with these responses in part by polarizing macrophages toward an anti-inflammatory profibrotic phenotype. Here we demonstrate that conditioned medium from mature S. aureus biofilms inhibited macrophage phagocytosis and induced cytotoxicity, suggesting the involvement of a secreted factor(s). Iterative testing found the active factor(s) to be proteinaceous and partially agr-dependent. Quantitative mass spectrometry identified alpha-toxin (Hla) and leukocidin AB (LukAB) as critical molecules secreted by S. aureus biofilms that inhibit murine macrophage phagocytosis and promote cytotoxicity. A role for Hla …

Proton Pump Inhibitors And Corticosteroids As Synergistic Risk Factors For Candida Esophagitis, Nihar Shah Md, Yana Cavanagh, Oleg Shulik, Pooja Patel, Vincent A. Debari, Walid Baddoura

Gastroenterology

Abstract:

Introduction: Inhaled & systemic steroids are one of the well-documented risks factors for Candida esophagitis. However, the role of gastric acid suppression remains controversial.

Methods:

We conducted a retrospective case-control study of 420 patients consisting of 84 cases of Candida esophagitis and 336 matched controls. Our cohort was gathered from subjects evaluated from 2001 to 2012. The diagnosis of Candida esophagitis was based on endoscopic and/or histological criteria.

Results:

On univariate analysis, proton pump inhibitors were associated with higher risk (OR = 2.14; 95 % CI: 1.30 to 3.54); steroid use also increased the risk (OR = 3.55; 95% …

Deletion Of Panx3 Prevents The Development Of Surgically Induced Osteoarthritis, Paxton M. Moon, Silvia Penuela, Kevin Barr, Sami Khan, Christopher L. Pin, Ian Welch, Mukundan Attur, Steven B. Abramson, Dale W. Laird, Frank Beier

Anatomy and Cell Biology Publications

© 2015, Springer-Verlag Berlin Heidelberg. Abstract: Osteoarthritis (OA) is a highly prevalent, disabling joint disease with no existing therapies to slow or halt its progression. Cartilage degeneration hallmarks OA pathogenesis, and pannexin 3 (Panx3), a member of a novel family of channel proteins, is upregulated during this process. The function of Panx3 remains poorly understood, but we consistently observed a strong increase in Panx3 immunostaining in OA lesions in both mice and humans. Here, we developed and characterized the first global and conditional Panx3 knockout mice to investigate the role of Panx3 in OA. Interestingly, global Panx3 deletion produced no …

Macroecology Of North American Suckers (Catostomidae): Tests Of Bergmann's And Rapoport's Rules, Stephen J. Jacquemin, Jason C. Doll

Biological Sciences Faculty Publications

Discerning spatial macroecological patterns in freshwater fishes has broad implications for community assembly, ecosystem dynamics, management, and conservation. This study explores the potential interspecific covariation of geographic range (Rapoport's rule) and body size (Bergmann's rule) with latitude in North American sucker fishes (Cypriniformes: Catostomidae). While numerous tests of Rapoport's and Bergmann's rules are documented in the literature, comparatively few of these studies have specifically tested for these patterns, and none have incorporated information reflecting shared ancestry into analyses of North American freshwater fish through a hierarchical model. This study utilized a hierarchical modeling approach with Bayesian inference to evaluate the …

Upper Body Posture And Pain In Division I Female Volleyball And Softball Athletes, Brittany M. Plunkett Castilla

Dissertations and Theses

Participation in athletics is a popular pastime and form of entertainment. Children often begin to specialize in one sport at a young age in an effort to excel, which increases physical stress and the potential for injuries. Athletes participating in overhead sports are at increased risk of upper body chronic injuries, in part because the shoulder is an unstable hypermobile joint. Posture may also be affected in these athletes because of the demands placed on the upper body. The purpose of this study was to measure the upper body posture in a sample of Division I collegiate volleyball and softball …

Using Research And Roi To Drive Partnerships In Public Health Delivery Systems, Glen P. Mays

Health Management and Policy Presentations

Stimulating public-private partnerships (PPP) for health and economic development initiatives requires research that can answer key questions: (1) what are the health and economic returns likely to be realized; (2) over what time frames and with what certainty; (3) what investments are required to achieve results; and (4) what are the implementation strategies most likely to succeed. This presentation reviews ongoing research on the PPPs used to deliver public health services in the U.S., and explores the lessons this research offers PPPs in low and middle income countries. We examine how scientific evidence on public health delivery systems and their …

Logarithmic Intensity Compression In Fluorescence Guided Surgery Applications, Alisha V. Dsouza, Huiyun Lin, Jason Gunn, Brian W. Pogue

Dartmouth Scholarship

The use of fluorescence video imaging to guide surgery is rapidly expanding, and improvements in camera readout dynamic range have not matched display capabilities. Logarithmic intensity compression is a fast, single-step mapping technique that can map the useable dynamic range of high-bit fluorescence images onto the typical 8-bit display and potentially be a variable dynamic contrast enhancement tool. We demonstrate a ∼4.6  times improvement in image quality quantified by image entropy and a dynamic range reduction by a factor of ∼380 by the use of log-compression tools in processing in vivo fluorescence images.

Rapid Label-Free Detection Of E. Coli Using Antimicrobial Peptide Assisted Impedance Spectroscopy, Keren Jieng, Hashem Etayash, Sarfuddin Azmi, Selvaraj Naicker, Mahtab Hassanpourfard, Parmiss Mojir Shaibani, Garima Thakur, Kamaljit Kaur, Thomas Thundat

Pharmacy Faculty Articles and Research

There is an increasing demand for rapid detection of waterborne pathogens to monitor drinking water safety. We demonstrate a compact, label-free sensor array for rapid detection of Escherichia coli (E. coli) in contaminated water samples using antimicrobial peptide assisted impedimetric sensor platform. Interdigitated electrode arrays immobilized with the antimicrobial peptide Colicin V (ColV) were used to screen the affinity towards different bacterial strains by monitoring impedance variations in real-time. This ColV assisted impedance biosensor exhibited high selectivity towards Gram-negative strains particularly towards E. coli strains. This selective detection of E. coli from other strains was observed at 10 …

Impaired Regulation Post-Stroke Of Motor Unit Firing Behavior During Volitional Relaxation Of Knee Extensor Torque Assessed Using High Density Surface Emg Decomposition, Spencer A. Murphy, Reivian Berrios, P. Andrew Nelson, Francesco Negro, Dario Farina, Brian D. Schmit, Allison S. Hyngstrom

Physical Therapy Faculty Research and Publications

The purpose of this study was to use high density surface EMG recordings to quantify stroke-related abnormalities in motor unit firing behavior during repeated sub-maximal knee extensor contractions. A high density surface EMG system (sEMG) was used to record and extract single motor unit firing behavior in the vastus lateralis muscle of 6 individuals with chronic stroke and 8 controls during repeated sub-maximal isometric knee extension contractions. Paretic motor unit firing rates were increased with subsequent contractions (6.19±0.35 pps vs 7.89±0.66 pps, P

Genome-Wide Association And Trans-Ethnic Meta-Analysis For Advanced Diabetic Kidney Disease: Family Investigation Of Nephropathy And Diabetes (Find), Sudha K. Iyengar, John R. Sedor, Barry I. Freedman, W. H. Linda Kao, Matthias Kretzler, Benjamin J. Keller, Hanna E. Abboud, Sharon G. Adler, Lyle G. Best, Donald W. Bowden, Allison Burlock, Yii-Der Ida Chen, Shelley A. Cole, Mary E. Comeau, Jeffrey M. Curtis, Jasmin Divers, Christiane Drechsler, Ravi Duggirala, Robert C. Elston, Xiuqing Guo, Huateng Huang, Michael M. Hoffmann, Barbara V. Howard, Eli Ipp, Paul L. Kimmel, Michael J. Klag, William C. Knowler, Orly F. Kohn, Tennille S. Leak, David J. Leehey, Man Li, Alka Malhotra, Winfried Marz, Viji Nair, Robert G. Nelson, Susanne B. Nicholas, Stephen J. O'Brien, Madeleine V. Pahl, Rulan S. Parekh, Marcus G. Pezzolesi, Rebekah S. Rasooly, Charles N. Rotimi, Jerome I. Rotter, Jeffrey R. Schelling, Michael F. Seldin, Vallabh O. Shah, Adam M. Smiles, Michael W. Smith, Kent D. Taylor, Farook Thameem, Denyse P. Thornley-Brown, Barbara J. Truitt, Christoph Wanner, E. Jennifer Weil, Cheryl Winkler, Philip G. Zager, Robert P. Igo Jr., Robert L. Hanson, Carl D. Langefeld, Family Investigation Of Nephropathy And Diabetes (Find) Research Group

Biology Faculty Articles

Diabetic kidney disease (DKD) is the most common etiology of chronic kidney disease (CKD) in the industrialized world and accounts for much of the excess mortality in patients with diabetes mellitus. Approximately 45% of U.S. patients with incident end-stage kidney disease (ESKD) have DKD. Independent of glycemic control, DKD aggregates in families and has higher incidence rates in African, Mexican, and American Indian ancestral groups relative to European populations. The Family Investigation of Nephropathy and Diabetes (FIND) performed a genome-wide association study (GWAS) contrasting 6,197 unrelated individuals with advanced DKD with healthy and diabetic individuals lacking nephropathy of European American, …

Early Mortality And Functional Outcome After Acute Stroke In Uganda: Prospective Study With 30 Day Follow-Up, Martha Sajatovic

Faculty Scholarship

Identification of early outcomes post stroke and their predictors is important in stroke management strategies. We prospectively analysed 30-day outcomes (mortality and functional ability) after stroke and their predictors among patients admitted within 7 days post event to a national referral hospital in Uganda. This was a prospective study of acute stroke patients consecutively enrolled between February and July 2014. Social demographics, clinical, laboratory, imaging characteristics, outcomes (all through 30 days), time of death were assessed using standardised questionnaires. Multiple regression was used to analyse the independent influence of factors on outcomes. Of 127 patients, 88 (69.3 %) had ischemic …

Eliciting Preferences For Waterpipe Tobacco Smoking Using A Discrete Choice Experiment: Implications For Product Regulation, Ramzi G. Salloum, Wasim Maziak, David Hammond, Rima Nakkash, Farahnaz Islam, Xi Cheng, Jim Thrasher

Faculty Publications

Objectives Waterpipe smoking is highly prevalent among university students, and has been increasing in popularity despite mounting evidence showing it is harmful to health. The aim of this study was to measure preferences for waterpipe smoking and determine which product characteristics are most important to smokers.

Setting A large university in the Southeastern USA.

Participants Adult waterpipe smokers attending the university (N=367).

Design Participants completed an Internet-based discrete choice experiment to reveal their preferences for, and trade-offs between, the attributes of hypothetical waterpipe smoking sessions. Participants were presented with waterpipe lounge menus, each with three fruit-flavoured options and one tobacco …

Maternal Psychiatric Disease And Epigenetic Evidence Suggest A Common Biology For Poor Fetal Growth, Timothy H. Ciesielski, Carmen J. Marsit, Scott M. Williams

Dartmouth Scholarship

We sought to identify and characterize predictors of poor fetal growth among variables extracted from perinatal medical records to gain insight into potential etiologic mechanisms. In this process we reevaluated a previously observed association between poor fetal growth and maternal psychiatric disease. We evaluated 449 deliveries of >36 weeks gestation that occurred between 9/2008 and 9/2010 at the Women and Infants Hospital in Providence Rhode Island. This study group was oversampled for Small-for-Gestational-Age (SGA) infants and excluded Large-for-Gestational-Age (LGA) infants. We assessed the associations between recorded clinical variables and impaired fetal growth: SGA or Intrauterine Growth Restriction (IUGR) diagnosis. After …

What's Happening: August 24, 2015, Maine Medical Center

What's Happening

No abstract provided.

Mental Health Screening Of Veterans Diagnosed With Cancer: Analyzing Psychological Distress And Attitudes Towards Seeking Professional Psychological Help, Jessica Jean Baptiste

Seton Hall University Dissertations and Theses (ETDs)

Studies analyzing mental health care utilization in veterans with a co-occurrence of a medical and psychological diagnosis are still underrepresented in the literature. The primary purpose of this study is to examine psychological screening methods of veterans diagnosed with cancer and determining when these veterans are more likely to endorse psychological symptoms. This information can contribute to the discussion of effective ways of integrating mental health screening in specialty care settings. A correlational, causal-comparative research design is employed to answer the study research questions and hypotheses. The participants include Vietnam, Korean, and World War II veterans seeking oncology services at …

Perspective From Two Professions: Two Professionals Making Meaning Of The Clinical Educator Role, Tara Payor

USF Tampa Graduate Theses and Dissertations

The purpose of this phenomenological study was to describe how professional educators make sense of their role in helping novice practitioners make meaning from authentic clinical practice. Simultaneously studying a clinical educator from teacher and graduate medical education, and subsequently setting their stories side by side, speaks to the interest both professions have in learning from the other. Both clinical educators were Board certified in their respective area of practice. In-depth phenomenological interviewing was used as the study’s methodology, and the professional formation construct served as the study’s conceptual framework. Data corroborate findings in the literature that there is a …

Week Of August 24, 2015, New York Medical College

InTouch

• School of Medicine Class of 2019 Embarks on their Journey to Medicine at the White Coat Ceremony
• NYMC Celebrates Walkway Ribbon Cutting
• NYMC Celebrates Faculty Authorship
• D.P.T. Class of 2015 Achieves 100 Percent First-Time Passing Rate on the National Licensure Exam
• GSBMS Welcomes New Cohort of Ph.D. Candidates

Medical School Watercooler Newsletter - August 23, 2015, Lindsey Lyle

Watercooler Newsletter

This is the August 23, 2015 edition of the Frederick P. Whiddon College of Medicine's Newsletter - Watercooler.

Contents Include:

Dr. Susana Figarola Named Chair of Radiology

Basic Medical Sciences Graduate Program Student Receives Edwin R. Hughes Award

Mark Your Calendar: Lions Club Run for Sight

USA Welcomes Dr. Ashleigh Butts-Wilkerson

Clinical Psychology Students’ Perceived Training In Working With Transgender Clients: An Exploratory Study, Vanessa Zimmerman

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

Literature on appropriate psychological care for the transgender population has been sparse (American Psychological Association [APA], 2009; Carroll, Gilroy, & Ryan, 2002; Israel, Gorcheva, Walther, Sulzner, & Cohen, 2008; Korell & Lorah, 2007; Maguen, Shipherd, Harris, & Welch, 2007; Walker & Prince, 2010). Historically, the focus of research has been on medical care for transgender individuals, and this literature has tended to pathologize the population (APA, 2009). More recently, individuals who identify as transgender have been included under the umbrella of lesbian, gay, bisexual, and transgender (LGBT) studies, where their unique needs are often overlooked or ignored (APA, 2009; Carroll …

Living With Dignity: A Pilot Study Implementing Dignity Therapy With Allogeneic Blood Or Marrow Transplant Recipients, Emily Newman

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

Dignity Therapy is a relatively novel therapeutic intervention designed to address psychosocial and existential distress among those facing life threatening circumstances. This narrative psychotherapy approach invites patients to reflect and speak about issues that are most important to them and hopes to elicit feelings of purposefulness and autonomy, characteristics that are typically waning when nearing end of life. Dignity Therapy consists of a ten question semi-structured interview designed to integrate themes of accomplishments and sources of pride, things that may feel unsaid, and/or particular lessons or wisdom that the patient hopes to pass on to loved ones. The interview is …

Apples And Oranges: An Argument For Psychopathy As A Formal Diagnosis, Katherine K. Mcmann

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

When one thinks of the psychopath, an image of one of the notorious serial killers of the 1980s generally pops in their head- Ted Bundy, Jeffrey Dahmer, or the Green River Killer. While still rare, psychopaths encompass much more than just serial killers, and they have a unique presentation that lies outside the confines of any current diagnosis. Characteristics such as lack of empathy, impulsivity, grandiosity, and poor behavioral controls are included in various personality disorders. The Narcissist will show lack of empathy and grandiosity while the Borderline will have poor behavioral controls and impulsivity, for example. However, the construct …

Visual Hallucinations Differential Diagnosis Annotated Decision Tree, Shelly D. Davis

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

Differential diagnosis of the etiology of visual hallucinations is challenging. Although visual hallucinations can be symptomatic of psychiatric disorder, they more commonly indicate neurological or medical disorders, sensory impairment, or substance intoxication or withdrawal. Accurate diagnosis and treatment is crucial given that misdiagnosis and incorrect treatment intervention can have profound consequences. The purpose of this paper is to summarize the most prevalent causes of visual hallucinations, review the DSM-5 hallucination decision tree, and provide an annotated visual hallucination differential diagnosis decision tree.

Therapeutic Assessment In Sport Psychology, Fernando Frias

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

This paper outlines the history of assessment in sport psychology and provides a summary of controversies and criticisms of psychological testing in athletics that have persisted throughout the development of the field. Such concerns include the use of personality inventories and tests for talent identification, the misuse of tests and related ethical concerns, cultural sensitivity of tests, and debates about the validity and reliability of assessment measures. In spite of these concerns, interest and demand for psychological assessment in sport remains. Therapeutic Assessment, an emerging but not yet well-known model of collaborative psychological assessment, addresses many of these criticisms and …