Medicine and Health Sciences Commons^™

Differential Expression And Tumorigenic Function Of Neurotensin Receptor 1 In Neuroendocrine Tumor Cells, Ji Tae Kim, Jing Li, Jun Song, Eun Y. Lee, Heidi L. Weiss, Courtney M. Townsend, B. Mark Evers

Markey Cancer Center Faculty Publications

Neurotensin (NTS), localized predominantly to the small bowel, stimulates the growth of a variety of cancers, including neuroendocrine tumors (NETs), mainly through its interaction with the high-affinity NTS receptor 1 (NTSR1). Here, we observed increased expression of NTSR1 in almost all tested clinical NET samples, but not in normal tissues. Through RT-PCR analysis, we found that the expression of NTSR1 and NTSR2 was either variable (NTSR1) or absent (NTSR2) in human NET cell lines. In contrast, NTSR3 and NTS were expressed in all NET cells. Treatment with 5-aza-2'-deoxycytidine, a demethylating agent, increased levels of NTSR1 and NTSR2 suggesting that DNA …

Dual Use Of Va And Non-Va Hospitals By Veterans With Multiple Hospitalizations, Alan N. West, Mary E. Charlton, Mary Vaughan-Sarrazin

Dartmouth Scholarship

Background: Veterans who are hospitalized in both VA and non-VA hospitals within a short timespan may be at risk for fragmented or conflicting care. To determine the characteristics of these “dual users,” we analyzed administrative hospital discharge data for VA-enrolled veterans of any age in seven states, including any VA or non-VA hospitalizations they had in 2004 – 2007. Method: For VA enrollees in Arizona, Iowa, Louisiana, Florida, South Carolina, Pennsylvania, or New York in 2007, we merged 2004 – 2007 discharge data for all VA hospitalizations and all non-VA hospitalizations listed in state health department or hospital association databases. …

Missed Opportunities: Public Health Disaster Management In Canada, Lisa Gorman, Christopher Stoney

Journal of Public Management & Social Policy

Three recent Canadian public health crises present an illustration of both the opportunities for reform and the challenges that may impede progress and public health renewal in federalist nations. While the three crises examined exposed serious flaws in emergency preparedness and fuelled demands for vital public health reform, evidence indicates that fundamental challenges have not been addressed and may have even heightened over the last decade given a move to “open federalism” and the significant fiscal impacts of ongoing austerity measures. With future pandemics inevitable, we identify the missed opportunities to optimize Canada’s emergency response capacity and procedures and examine …

Water And Sanitation Hygiene Knowledge, Attitude, And Practices Among Household Members Living In Rural Setting Of India, Anjana Kuberan, Awnish Kumar Singh, Jyoti Bala Kasav, Satish Prasad, Krishna Mohan Surapaneni, Vandana Upadhyay, Ashish Joshi

Publications and Research

Background: Rural population in developing countries face water, sanitation, and hygiene-related health issues. To objectively highlight these issues, we studied the knowledge, attitude, and practices-related to drinking water and sanitation facilities among the rural population of Chennai, India.

Materials and Methods: A cross-sectional study was designed involving individuals over 18 years of age living in Thandalam village, Chennai, India. Basic information about sociodemographic profile and existing drinking water and sanitation related knowledge, attitude, and practices was collected using a modified version of previously validated questionnaire and analyzed.

Results: Forty-five percent of the participants were not following any methods of water …

What's Happening: September 28, 2015, Maine Medical Center

What's Happening

No abstract provided.

The Hippo/Yap Pathway Interacts With Egfr Signaling And Hpv Oncoproteins To Regulate Cervical Cancer Progression., Chunbo He, Dagan Mao, Guohua Hua, Xiangmin Lv, Xingcheng Chen, Peter C. Angeletti, Jixin Dong, Steven W. Remmenga, Kerry J. Rodabaugh, Jin Zhou, Paul F. Lambert, Peixin Yang, John S. Davis, Cheng Wang

Journal Articles: Obstetrics & Gynecology

The Hippo signaling pathway controls organ size and tumorigenesis through a kinase cascade that inactivates Yes-associated protein (YAP). Here, we show that YAP plays a central role in controlling the progression of cervical cancer. Our results suggest that YAP expression is associated with a poor prognosis for cervical cancer. TGF-α and amphiregulin (AREG), via EGFR, inhibit the Hippo signaling pathway and activate YAP to induce cervical cancer cell proliferation and migration. Activated YAP allows for up-regulation of TGF-α, AREG, and EGFR, forming a positive signaling loop to drive cervical cancer cell proliferation. HPV E6 protein, a major etiological molecule of …

Week Of September 28, 2015, New York Medical College

InTouch

• NYMC Celebrates Wellness Week
• NYMC Welcomes Claudette Killian, M.B.A., as Purchasing Specialist
• Be Part of the Farm-to-Campus Initiative

The Nutrition And Dietetics Workforce Needs Skills And Expertise In The New York Metropolitan Area, Ann Gaba, Apoorva Srivastava, Chioma Amadi, Ashish Joshi

Publications and Research

Background: There is an increased demand in the Nutrition and Dietetics field which has fostered credentialing to ensure competent graduates. The objective of this study is to conduct an exploratory analysis to identify nutrition/dietetics workforce needs, skills and expertise in the New York metropolitan area as exemplified in position announcements over a 4 year period.

Methods: We recorded position announcements for jobs in nutrition and dietetics from the New York State Registered Dietitian Yahoo group, and the Hunter College Nutrition and Food Sciences student and alumni listserv (NFS-L) over a 4 year period. Keywords were identified using job categories defined …

College Undergraduate Students’ Self-Rating Of Their Physical Activity Involvement Over A 7-Day Period, Wycliffe W. Njororai Simiyu, Fletcher J. Njororai

Health & Kinesiology Faculty Publications and Presentations

Purpose: To establish the college undergraduate students’ self-rated physical activity involvement over a 7-day period. Methodology: The study utilized the survey method using the International Physical Activity Short Version of the Questionnaire (IPAQ). The purpose of the questionnaires is to provide a common instrument that can be used to obtain internationally comparable data on health-related physical activity. The study was undertaken at a medium sized campus in the South Western part of U.S.A., with respondents drawn from the College of Nursing and Health Sciences. Results: A total of 220 students responded to the questionnaire. Most of the respondents, 182 (82.73%) …

Endoscopic Management Of Idiopathic Subglottic Stenosis In Twenty-Five Patients, Katherine Mckee-Cole, Md, Ethan C. Bassett, Md, Maurits Boon, Md, Joseph Spiegel, Md

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

Introduction

While multiple causes exist for the development of subglottic stenosis, the mechanism responsible for idiopathic subglottic stenosis (ISS) remains unknown. Proposed etiologies include gastro-esophageal reflux (GERD) related exposure, telescoping of the first tracheal ring under the cricoid cartilage, a hormonal cause, and the possibility of an unidentified autoimmune process (1,3,6,8,12,18,19).

As ISS represents a rare disease of yet unknown etiology, the optimal management remains to be defined. The treatment options range from endoscopic management, which is less invasive but tends to show recurrence to open tracheal resection with anastomosis for those patients in whom endoscopic techniques are ineffective or …

The Controversy Of Vaccinations, Nicholas G. Aboreden

The Kabod

Recently vaccination has become a controversial topic. There is a growing number of people who believe that vaccines carry great health risks to patients and therefore refuse to be vaccinated or to vaccinate their children. This ill-informed view of immunizations is beginning to cause serious problems in the United States as growing numbers of disease cases are being seen. A closer look into the science of vaccines and the benefits they have brought, clearly show that not only do vaccines carry very little risk to patients, but they are responsible for the eradication and reduction of multiple debilitating diseases.

Medical School Watercooler Newsletter - September 27, 2015, Lindsey Lyle

Watercooler Newsletter

This is the September 27, 2015 edition of the Frederick P. Whiddon College of Medicine's Newsletter - Watercooler.

Contents Include:

Dr. Brooks Cash Publishes Review Article on IBS

Retirement Reception Honors Dr. Charles Hamm

First-Year Medical Students Take Class of 2019 Oath

USA Welcomes Dr. Spencer Liles

The Lsu Department Of Otolaryngology – Head And Neck Surgery: A Decade In Review And A Vision For Our Future, Department Of Otolaryngology

LSUHSC Hurricane Katrina Archive: Reports & Presentations

"The LSU Department of Otolaryngology – Head and Neck Surgery: A Decade in review and a vision for our future" is a 10 page document extracted from a publication created the LSU Health Department of Laryngology on September 27, 2015.

The selected pages from this publication detail the forced temporary closure and relocation of LSU Health Sciences Center due to the impact of Hurricane Katrina, and the ways the Department of Otolaryngology continued their academic programming.

Novel Targeted Sirna-Loaded Hybrid Nanoparticles: Preparation, Characterization And In Vitro Evaluation., Nneka Dim, Maryna Perepelyuk, Olukayode Gomes, Chellappagounder Thangavel, Yi Liu, Robert Den, Ashakumary Lakshmikuttyamma, Sunday A Shoyele

Department of Radiation Oncology Faculty Papers

BACKGROUND: siRNAs have a high potential for silencing critical molecular pathways that are pathogenic. Nevertheless, their clinical application has been limited by a lack of effective and safe nanotechnology-based delivery system that allows a controlled and safe transfection to cytosol of targeted cells without the associated adverse effects. Our group recently reported a very effective and safe hybrid nanoparticle delivery system composing human IgG and poloxamer-188 for siRNA delivery to cancer cells. However, these nanoparticles need to be optimized in terms of particle size, loading capacity and encapsulation efficiency. In the present study, we explored the effects of certain production …

Rural Emergency Nurses’ End-Of-Life Care Obstacle Experiences: Stories From The Last Frontier, Renea L. Beckstrand, Jonathan Rohwer, Karlen E. Luthy, Janelle L. B. Macintosh, Ryan J. Rasmussen

Faculty Publications

Introduction: Rural emergency nurses face unique obstacles to providing quality end-of-life (EOL) care. Stories provided by emergency nurses embody their most difficult EOL care obstacles.

Methods: A questionnaire was sent to 53 rural hospitals. Respondents were asked to share stories that epitomized the obstacles faced while providing EOL care in the rural emergency setting.

Results: The lack of an ideal death (eg, the nurse personally knows the patient, issues with family members, and unknown patient wishes) was the top obstacle. Other reported obstacles were insufficient ED staff and power struggles between nurses and physicians.

Discussion: Rural emergency nurses often provide …

Think Inside The Blocks: Health Literacy Outreach To Disadvantaged People In Their Own Environment, Nancy Patterson

Georgia International Conference on Information Literacy

This bilingual (Spanish/English) poster highlights six creative health literacy outreach projects that have proven to be successful in increasing participation in health-related events in their communities and in boosting health literacy in the process.

For example, in Georgetown, South Carolina, a beauty salon owner, concerned about her clients’ frequent frustration with trying to decipher medical information, partners with her local public library and is grant funded to provide a Wellness Workstation in her salon. Years later, her clients research health information between services using the workstation, evening health literacy classes are regularly conducted for community members and continued funding has …

Health Literacy 101: Increasing Literacy Reduces Health Disparities, Nancy Patterson

Georgia International Conference on Information Literacy

According to the Center for Disease Control and Prevention (CDC), health disparities are “preventable differences in the burden of disease, injury, violence, or opportunities to achieve optimal health that are experienced by socially disadvantaged populations”. The American Medical Association (AMA) has identified literacy as the number one social determinant of an individual’s health, above education, income and race.

Learn about health literacy as a tool in the fight against health disparities from this poster as well as methods of effective health communication between health information providers and information seekers. Self-advocacy, plain language cultural competence, and the teach-back technique are …

Behavioural Charactertics Of Patients Vulnerable For Repeated Hospitalisation, Amresh Srivastava, Coralee Berlmont, Miky Kaushal, Avinash Desouza, Robbie Campbell, Larry Stitt

Data and Test Instruments

Background Re-hospitalization which takes place in about 30 to 50% postdischarge patienst, leads to poor outcome, increased rate of mortality and consumes more than 2/3 of budgetary allocations. Inability to identify vulnerable candidates for repeated admissions limits our options for strategic treatment. Methods In this prospective study conducted at Regional Mental Health Care ( Presently Parkwood Institute) 101 patienst ( 51 feamles, mean age 43 years), were examined using standard psychometric tools on parameters of clinical, psychopathological, suicide behaviour and resiliency for their risk and preventive characerstics. Results We assessed 101 subjects (51 females) with mean age of 42 years. …

Brain Maturation, Poverty And Social Exclusion: Shifting Paradigms Of Psychopathology, Amresh Srivastava

Psychiatry Presentations

Abstract for lecture

Poverty is a major risk factor for mental disorders. Neuroimaging studies show path are breaking findings to explain why ppeople living in poverty suffer from improper development and maturation of brain due to neuronal loss. It sets in much before the child is born and leads to increased vulnerability for mental disorders.

Recent findings show that changes in brain structure and function due to lack of brain maturation is directly related to poverty. A number of these changes are end result of neuronal survival in the most fundamental neuronal matrix. These findings along with other biological correlates …

A Single Baseline Ultrasound Assessment Of Fibroid Presence And Size Is Strongly Predictive Of Future Uterine Procedure: 8-Year Follow-Up Of Randomly Sampled Premenopausal Women Aged 35-49 Years., Donna D. Baird, T M Saldana, D L Shore, Michael C. Hill, J M Schectman

Radiology Faculty Publications

STUDY QUESTION: How well can a single baseline ultrasound assessment of fibroid burden (presence or absence of fibroids and size of largest, if present) predict future probability of having a major uterine procedure?

SUMMARY ANSWER: During an 8-year follow-up period, the risk of having a major uterine procedure was 2% for those without fibroids and increased with fibroid size for those with fibroids, reaching 47% for those with fibroids ≥4 cm in diameter at baseline.

WHAT IS KNOWN ALREADY: Uterine fibroids are a leading indication for hysterectomy. However, when fibroids are found, there are few available data to help clinicians …

Coaching Future Physicians: The Select Program's Unique 4-Year Medical School Model, Margaret A. Hadinger Edd, Ms, Dionne Ferguson Phd, Jd, Joann Quinn Phd, Suzette Sookdeo Msed, Suzanne J. Templer Do

Department of Education

No abstract provided.

Involvement Of The Right Hemisphere In Reading Comprehension: A Dti Study, Tzipi Horowitz-Kraus, Yingying Wang, Elena Plante, Scott K. Holland

Center for Brain, Biology, and Behavior: Faculty Publications

The Simple View of reading emphasizes the critical role of two factors in normal reading skills: word recognition and reading comprehension. The current study aims to identify the anatomical support for aspects of reading performance that fall within these two components. Fractional anisotropy (FA) values were obtained from Diffusion Tensor images in twenty-one typical adolescents and young adults using the Tract Based Spatial Statistics (TBSS) method. We focused on the Arcuate Fasciculus (AF) and Inferior Longitudinal Fasciculus (ILF) as fiber tracts that connect regions already implicated in the distributed cortical network for reading. Our results demonstrate dissociation between word-level and …

Lipin1 Regulates Skeletal Muscle Differentiation Through Extracellular Signal-Regulated Kinase (Erk) Activation And Cyclin D Complex-Regulated Cell Cycle Withdrawal, Weihua Jiang, Jing Zhu, Xun Zhuang, Xiping Zhang, Tao Luo, Karyn Esser, Hongmei Ren

Saha Cardiovascular Research Center Faculty Publications

Lipin1, an intracellular protein, plays critical roles in controlling lipid synthesis and energy metabolism through its enzymatic activity and nuclear transcriptional functions. Several mouse models of skeletal muscle wasting are associated with lipin1 mutation or altered expression. Recent human studies have suggested that children with homozygous null mutations in the LPIN1 gene suffer from rhabdomyolysis. However, the underlying pathophysiologic mechanism is still poorly understood. In the present study we examined whether lipin1 contributes to regulating muscle regeneration. We characterized the time course of skeletal muscle regeneration in lipin1-deficient fld mice after injury. We found that fld mice exhibited smaller regenerated …

Successes, Challenges And Needs Regarding Rural Health Medical Education In Continental Central America: A Literature Review And Narrative Synthesis, Maria C. Colon-Gonzalez, F. El Rayess, S. Guevara, G. Anandarajah

School of Medicine Publications

Introduction: Central American countries, like many others, face a shortage of rural health physicians. Most medical schools in this region are located in urban areas and focus on tertiary care training rather than on community health or primary care, which are better suited for rural practice. However, many countries require young physicians to do community service in rural communities to address healthcare provider shortages. This study aimed to: (a) synthesize what is known about the current state of medical education preparing physicians for rural practice in this region, and (b) identify common needs, challenges and opportunities for improving medical education …

Isoform-Specific Dynamic Translocation Of Pkc By Α1-Adrenoceptor Stimulation In Live Cells., Jin O-Uchi, Jaime Sorenson, Bong Sook Jhun, Jyotsna Mishra, Stephen Hurst, Kaleef Williams, Shey-Shing Sheu, Coeli M.B. Lopes

Center for Translational Medicine Faculty Papers

Protein kinase C (PKC) plays key roles in the regulation of signal transduction and cellular function in various cell types. At least ten PKC isoforms have been identified and intracellular localization and trafficking of these individual isoforms are important for regulation of enzyme activity and substrate specificity. PKC can be activated downstream of Gq-protein coupled receptor (GqPCR) signaling and translocate to various cellular compartments including plasma membrane (PM). Recent reports suggested that different types of GqPCRs would activate different PKC isoforms (classic, novel and atypical PKCs) with different trafficking patterns. However, the knowledge of isoform-specific activation of PKC by each …

Risk Factors For Hemorrhoids On Screening Colonoscopy, Anne F. Peery, Robert S. Sandler, Joseph A. Galanko, Robert S. Bresalier, Jane C. Figueiredo, Dennis J. Ahnen, Elizabeth L. L. Barry, John A. Baron

Dartmouth Scholarship

Background: Constipation, a low fiber diet, sedentary lifestyle and gravidity are commonly assumed to increase the risk of hemorrhoids. However, evidence regarding these factors is limited. We examined the association between commonly cited risk factors and the prevalence of hemorrhoids. Methods: We performed a cross sectional study of participants who underwent a colonoscopy in a colorectal adenoma prevention trial and who had a detailed assessment of bowel habits, diet and activity. The presence of hemorrhoids was extracted from the subjects’ colonoscopy reports. We used logistic regression to estimate odds ratios and 95% confidence intervals while adjusting for age and sex. …

A Pilot Study Of Demographic And Dopaminergic Genetic Contributions To Weight Change In Kidney Transplant Recipients, Ansley Stanfill, Donna Hathaway, Ann Cashion, Ramin Homayouni, Patricia Cowan, Carol Thompson, Behrouz Madahian, Yvette Conley

Nursing Faculty Publications

Kidney transplant recipients often experience a significant amount of weight gain in the first year post-transplantation. While demographic factors such as age, race, and sex have been associated with weight gain in this population, these factors do not explain all of the variability seen. A number of studies have suggested that genetics also plays a critical role in weight changes. Recently, alterations in the activity of the neurotransmitter dopamine have been associated with weight change, and gene expression studies in kidney transplant recipients have supported this association. The purpose of this pilot study is to first examine the feasibility and …

Expert And Crowd-Sourced Validation Of An Individualized Sleep Spindle Detection Method Employing Complex Demodulation And Individualized Normalization, Laura B. Ray, Stephane Sockeel, Melissa Soon, Arnaud Bore, Ayako Myhr, Bobby Stojanoski, Rhodri Cusack, Adrian M. Owen, Julien Doyon, Stuart M. Fogel

Anatomy and Cell Biology Publications

A spindle detection method was developed that: (1) extracts the signal of interest (i.e., spindle-related phasic changes in sigma) relative to ongoing "background" sigma activity using complex demodulation, (2) accounts for variations of spindle characteristics across the night, scalp derivations and between individuals, and (3) employs a minimum number of sometimes arbitrary, user-defined parameters. Complex demodulation was used to extract instantaneous power in the spindle band. To account for intra- and inter individual differences, the signal was z-score transformed using a 60 s sliding window, per channel, over the course of the recording. Spindle events were detected with a z-score …

Effect Of Dexamethasone Prodrug On Inflamed Temporomandibular Joints In Juvenile Rats., Mitchell Knudsen, Matthew Bury, Callie Holwegner, Adam L. Reinhardt, Fang Yuan, Yijia Zhang, Peter J. Giannini, David B. Marx, Dong Wang, Richard A. Reinhardt

Journal Articles: College of Dentistry

INTRODUCTION: Juvenile idiopathic arthritis (JIA) often causes inflammation of the temporomandibular joint (TMJ) and has been treated with both systemic and intra-articular steroids, with concerns about effects on growing bones. In this study, we evaluated the impact of a macromolecular prodrug of dexamethasone (P-DEX) with inflammation-targeting potential applied systemically or directly to the TMJ.

METHODS: Joint inflammation was initiated by injecting two doses of complete Freund's adjuvant (CFA) at 1-month intervals into the right TMJs of 24 growing Sprague-Dawley male rats (controls on left side). Four additional rats were not manipulated. With the second CFA injection, animals received (1) 5 …

Relationship Between Acoustic Measures And Speech Naturalness Ratings In Parkinson’S Disease: A Within-Speaker Approach, Marie I. Klopfenstein

SIUE Faculty Research, Scholarship, and Creative Activity

This study investigated the acoustic basis of across-utterance, within-speaker variation in speech naturalness for four speakers with dysarthria secondary to Parkinson’s disease (PD). Speakers read sentences and produced spontaneous speech. Acoustic measures of fundamental frequency, phrase-final syllable lengthening, intensity and speech rate were obtained. A group of listeners judged speech naturalness using a nine-point Likert scale. Relationships between judgements of speech naturalness and acoustic measures were determined for individual speakers with PD. Relationships among acoustic measures also were quantified. Despite variability between speakers, measures of mean F0, intensity range, articulation rate, average syllable duration, duration of final syllables, vocalic nucleus …