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2015

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Articles 11041 - 11070 of 11981

Full-Text Articles in Medicine and Health Sciences

Presence And Mobilization Of Staphylococcus Aureus Pathogenicity Islands (Sapis) Among Bovine Mastitis Isolates, Laura Kate Parker Jan 2015

Presence And Mobilization Of Staphylococcus Aureus Pathogenicity Islands (Sapis) Among Bovine Mastitis Isolates, Laura Kate Parker

All ETDs from UAB

Bovine mastitis is inflammation of the mammary gland that occurs in cattle, as a result of invading bacteria. Staphylococcus aureus, a causative agent of bovine mastitis, produces toxins such as the toxic shock syndrome toxin (TSST-1) and the staphylococcal enterotoxins (SEs). The genes for these toxins are coded on S. aureus pathogenicity islands (SaPIs), which are mobile genetic elements associated with virulence factors. SaPIs can be mobilized by bacteriophages, resulting in the production of transducing particles that can spread virulence factors throughout a bacterial population. This research assessed the role and prevalence of SaPIs among bovine mastitis samples. In this …


The Mspa Nanopore As A Sensor For Dna Sequencing, Mikhail Pavlenok Jan 2015

The Mspa Nanopore As A Sensor For Dna Sequencing, Mikhail Pavlenok

All ETDs from UAB

Nanopore sequencing is a novel and promising DNA sequencing method. This single molecule technique is capable of long reads, retains epigenetic information, and is inexpensive and fast. In this method ionic current is measured while single-stranded DNA is electrophoretically translocated through a nanometer-scale pore. Each passing nucleotide blocks current with characteristic amplitude and duration which are used to identify DNA sequence. MspA is the primary porin of M. smegmatis and mediates the diffusion of small, hydrophilic nutrients across the outer membrane. MspA is an octameric, channel-forming protein and represents the founding member of a new class of mycobacterial outer membrane …


Exploiting Novel Interactions With Parp1 In Dna Repair Proficient Human Breast Cancers, Jennifer Anne Stanley Jan 2015

Exploiting Novel Interactions With Parp1 In Dna Repair Proficient Human Breast Cancers, Jennifer Anne Stanley

All ETDs from UAB

Breast cancer remains the most frequently diagnosed cancer amongst women worldwide. Despite advances in treatment, patients with more aggressive basal-like and HER2-positive cancer experience high rates of recurrence and necessitate novel therapeutic approaches. A class of inhibitors targeted against poly (ADP-ribose) polymerases (PARP), important DNA repair proteins, are effective in cancers with a defective DNA repair response. As such, extensive preclinical and clinical research has examined their efficacy in these cancers. Although this data is promising, it is only applicable to a lim-ited patient population. The main goal of this dissertation is to expand the utility of these well-tolerated drugs …


Long-Term Stability Of Lefort I Maxillary Downdraft With Rigid Internal Fixation, Stephen Leonard Strickland Jan 2015

Long-Term Stability Of Lefort I Maxillary Downdraft With Rigid Internal Fixation, Stephen Leonard Strickland

All ETDs from UAB

ABSTRACT Objective: The objective of this study is to evaluate the skeletal and dental stability of a Le Fort I maxillary downgraft after a minimum 4year follow up period. Methods: This retrospective cohort study evaluated 18 patients' post-surgical stability after Le Fort I maxillary downgraft performed by a Z-osteotomy. Pre-surgical (T1), post-surgical (T2), post-orthodontic (T3), and long-term follow-up (T4) cephalometric radiographs were digitized and analyzed with Dolphin Imagining via a custom analysis to evaluate linear and angular skeletal and dental relapse. Results - The average Le Fort I maxillary down graft was 3.6mm. The average post-surgical orthodontic phase was 7.4 …


Three-Dimensional Age-Related Changes Of The Adult Face; African American Female Population, Christina Theresa Sutherland Jan 2015

Three-Dimensional Age-Related Changes Of The Adult Face; African American Female Population, Christina Theresa Sutherland

All ETDs from UAB

Objectives: Treatment of older adults is one of the fastest growing areas in orthodontic practice. The objectives of this study are to: 1. Investigate the aging of the female African American face using three-dimensional surface imaging to understand how the soft tissue of the face matures in relation to the teeth and 2.) Compare the effects of aging on African American female faces to aging of Caucasian female faces. Methods: This is a cross-sectional study of 100 African American females with balanced faces. Five age groups (in years) were included: [20-30], [31-40], [41-50], [51-60], [61-70]. Three-dimensional (3D) surface images of …


Cost Effectiveness Of Hypertension Treatment: New Model, Methods, And Focus On African Americans, Gabriel Saidimu Tajeu Jan 2015

Cost Effectiveness Of Hypertension Treatment: New Model, Methods, And Focus On African Americans, Gabriel Saidimu Tajeu

All ETDs from UAB

This dissertation focuses on the potential benefits of hypertension (HTN) treatment for the general population and African Americans (AAs) specifically. We undertake three research projects that are interconnected. First, using a systematic review methodology we assess the current state of the cost-effectiveness of HTN treatment literature in order to identify potential gaps in the cost-effectiveness literature, methodological shortcomings, and provide policy makers and researchers with a summary of the current findings as well as methods used in the literature. Second, building off our findings in paper 1, we construct a cost-effectiveness model. We assess the cost-effectiveness of HTN treatment not …


Impact Of And Adoption Trends Of Hit In Cancer Care, Willi L. Tarver Jan 2015

Impact Of And Adoption Trends Of Hit In Cancer Care, Willi L. Tarver

All ETDs from UAB

The three discrete research projects which make up this dissertation provide empirical evidence on the impact of, and adoption trends of, health information technology (HIT) as it pertains to cancer care. The findings of these studies are important as they provide insight into the potential of HIT to improve the quality of cancer care in the US. The results of this dissertation suggest that based on the current literature, HIT interventions seem to be more successful when targeting physicians, care in the prevention phase of the cancer continuum, and/or decision making. Separately, when seeking to understand the adoption of electronic …


C-Reactive Protein, Autoimmunity, And Inflammation In The Central Nervous System, Tyler T. Wright Jan 2015

C-Reactive Protein, Autoimmunity, And Inflammation In The Central Nervous System, Tyler T. Wright

All ETDs from UAB

C-reactive protein (CRP) is an acute phase reactant whose blood concentration rises in response all types of inflammation. And while CRP is widely used as a clinical marker of inflammation, it has several biological functions, e.g. activation of the classical complement cascade and binding Fcγ receptors in order to mediate multiple immune processes. The full extent of CRP’s physiological activities has not yet been fully elucidated, but there is significant evidence to establish that CRP plays an important role in the onset and progression of autoimmune disease. Seminal work from our lab showed that human CRP, hepatically expressed in transgenic …


Intestinal Microbiota And Its Role In Mucosal And Systemic Immune Responses, Qing Zhao Jan 2015

Intestinal Microbiota And Its Role In Mucosal And Systemic Immune Responses, Qing Zhao

All ETDs from UAB

Host-microbiota mutualism is established with long-term co-evolution. The abundant and diverse microbes colonizing on the surface of the host’s body, especially those in the gastrointestinal (GI) tract, play an essential role in the development and maturation of the host’s immune system. Failure of intestinal microbial control may lead to the development of an array of autoimmune diseases, including inflammatory bowel disease (IBD). As a well-recognized inflammation mediator, Th17 cells are actually among the most abundant effector CD4+ T cells in the normal adult gut. What the role of intestinal Th17 cells is under steady state conditions and how the intestinal …


Intensivists And Organizational Performance, Glenn Barthwick Liddle Jan 2015

Intensivists And Organizational Performance, Glenn Barthwick Liddle

All ETDs from UAB

Because of the high intensity of care and the extremely complex medical conditions being treated, intensive care units (ICUs) represent one of the most significant units within a hospital. Despite the significance of the ICU, the majority of the care provided in the ICU has historically been managed and coordinated by referring or attending physicians, who often do not have the specialized training needed to effectively care for the exceedingly acute patients in the ICU. More recently, however, a growing number of hospitals have begun staffing the ICU with intensivists. Intensivists are uniquely trained physicians that specialize in providing care …


Spiritual Pathways To Healing And Recovery: An Intensive Single-N Study Of An Eating Disorder Patient, Kawika Allen, Troy Lea, P. Scott Richards, Peter W. Sanders, Jason A. Mcbride Jan 2015

Spiritual Pathways To Healing And Recovery: An Intensive Single-N Study Of An Eating Disorder Patient, Kawika Allen, Troy Lea, P. Scott Richards, Peter W. Sanders, Jason A. Mcbride

Faculty Publications

This article presents an in-depth single case study of 8 sessions of spiritually integrated psychotherapy with a 20-year-old woman recovering from an Eating Disorder. The inclusion and utility of session-to-session outcome data as well as systematic follow up data in conjunction with in-depth qualitative interviews are shown. Dr. H and client’s perspectives are highlighted over the course of treatment. Clinical areas of focus were extracted from the the qualitative interviews and the therapeutic process is described. Single-case study statistical analyses were conducted to highlight clinical gains and maintenance.


Bringing Spiritually Oriented Psychotherapies Into The Health Care Mainstream: A Call For Worldwide Collaboration, Kawika Allen, P. Scott Richards, Peter W. Sanders, Troy Lea, Jason A. Mcbride Jan 2015

Bringing Spiritually Oriented Psychotherapies Into The Health Care Mainstream: A Call For Worldwide Collaboration, Kawika Allen, P. Scott Richards, Peter W. Sanders, Troy Lea, Jason A. Mcbride

Faculty Publications

The purpose of this article is to describe an overall strategy and specific plans for bringing spiritually oriented treatment approaches into the health care mainstream. We describe Bridges, a practice-research network created in 2012 that is devoted to helping practitioners, researchers, educators, and pastoral professionals collaboratively pursue this goal. We describe the achievements of Bridges thus far, which include a website for networking, an online psychotherapy research system, several completed studies, and grant funding for future collaborative research studies. We conclude with an invitation to health care professionals around the world to join with us in efforts to mainstream spirituality …


Ebola Preparedness - An Ed Perspective, Bettina Laier Jan 2015

Ebola Preparedness - An Ed Perspective, Bettina Laier

All Publications

No abstract provided.


Pain Management Of Medical-Surgical Patients At Homestead Hospital: The Role Of Nurse-Patient Communication, Dianne Crabtree, Kathy Gruny, Kimberly Figueroa, Veronica Zamoyski, Carrie Bilek, Rachael Rodriguez, Luchie Anne Dwyer Jan 2015

Pain Management Of Medical-Surgical Patients At Homestead Hospital: The Role Of Nurse-Patient Communication, Dianne Crabtree, Kathy Gruny, Kimberly Figueroa, Veronica Zamoyski, Carrie Bilek, Rachael Rodriguez, Luchie Anne Dwyer

All Publications

No abstract provided.


Addressing Moral Distress In Critical Care Nurses, Rose Allen, Eve Butler Jan 2015

Addressing Moral Distress In Critical Care Nurses, Rose Allen, Eve Butler

All Publications

No abstract provided.


Promoting Comfort During Ct-Coronary Angiogram, Margo Archer, Dawn Arevalo, Kelly Vazquez Jan 2015

Promoting Comfort During Ct-Coronary Angiogram, Margo Archer, Dawn Arevalo, Kelly Vazquez

All Publications

No abstract provided.


Decreasing Blood Culture Contamination In The Ed, Bettina Laier Jan 2015

Decreasing Blood Culture Contamination In The Ed, Bettina Laier

All Publications

No abstract provided.


Facing Falls By Staying In The Zone, Beatriz Taboada, Charles Juste, Rocio Ramirez Jan 2015

Facing Falls By Staying In The Zone, Beatriz Taboada, Charles Juste, Rocio Ramirez

All Publications

No abstract provided.


Pediatric Emergency Department Rapid Care Model, Netonua Reyes, Rene Bascoy, Rosa Rousseau, Francisco A. Medina Mejia, Julian Diavanti, Pedro Marin, Tanisha R. Jones, Sandra Young, Andrea Gibson Jan 2015

Pediatric Emergency Department Rapid Care Model, Netonua Reyes, Rene Bascoy, Rosa Rousseau, Francisco A. Medina Mejia, Julian Diavanti, Pedro Marin, Tanisha R. Jones, Sandra Young, Andrea Gibson

All Publications

No abstract provided.


Baker Act Project, Lucy Arcila, Evelyn Quinones Lassalle, Carla Green, Melinda Patton, Melinda Collins Jan 2015

Baker Act Project, Lucy Arcila, Evelyn Quinones Lassalle, Carla Green, Melinda Patton, Melinda Collins

All Publications

No abstract provided.


Outcomes Of Sepsis Patients Using Noninvasive Cardiac Output Monitoring To Guide Fluid Resuscitation, Rosemary Lee, Rosie Sanchez, Laura Berni, Joyce Nealey, Maria Ojeda Jan 2015

Outcomes Of Sepsis Patients Using Noninvasive Cardiac Output Monitoring To Guide Fluid Resuscitation, Rosemary Lee, Rosie Sanchez, Laura Berni, Joyce Nealey, Maria Ojeda

All Publications

No abstract provided.


Unit Retention Strategies, Steven Trush, Rosa Filomeno, Joyce Jones, Martha Gaitan Jan 2015

Unit Retention Strategies, Steven Trush, Rosa Filomeno, Joyce Jones, Martha Gaitan

All Publications

No abstract provided.


Faculty Publications 2014, Lsu Health Sciences Center New Orleans Jan 2015

Faculty Publications 2014, Lsu Health Sciences Center New Orleans

Historical Faculty Publications

This Faculty bibliography contains 898 publications.


Written Discourse Performance After Blast Injury, Brittany M. Loomis Jan 2015

Written Discourse Performance After Blast Injury, Brittany M. Loomis

Masters Theses

A blast injury (BI) is caused by a wave from a bomb which damages organs, specifically the brain. Once soldiers/veterans have sustained a BI, they will most likely present with a cognitive-communication deficit resulting from the traumatic brain injury. Language related symptoms are most apparent in written language skills due to the high level of cognitive function required for writing. This study investigated written discourse skills following a BI. Written discourse samples were collected from four participants and four controls. A description of the Butcher Picture from the Aphasia Diagnostic Profile was analyzed for productivity, efficiency, and local and global …


The Impact Of Nutrition Education On Fruit And Vegetable Consumption Of Elementary School Students, Constance Evans Herriott Jan 2015

The Impact Of Nutrition Education On Fruit And Vegetable Consumption Of Elementary School Students, Constance Evans Herriott

Masters Theses

The purpose of this study was to determine the effect of nutrition education on the fruit and vegetable consumption of third grade students. This was in an effort to determine whether nutrition education played a role in the consumption of fruits and vegetables because current intakes are very low. This quasi-experimental study consisted of a relatively small convenience sample at a rural elementary school. For this study, thirty-minute nutrition education lessons were delivered for four consecutive weeks to the experimental group. In order to assess the impact of the lessons, fruit and vegetable plate waste were gauged prior to and …


Cyber-Victimization, Depression, And Social Anxiety Among College Students, Kenna L. Mager Jan 2015

Cyber-Victimization, Depression, And Social Anxiety Among College Students, Kenna L. Mager

Masters Theses

Cyber-victimization, a new form of bullying, emerged with the development and evolution of technology. Recent research shows discrepancies in cyber-victimization definitions and there are inconsistencies of methods used to measure cyber-victimization. This paper reviewed the literature on cyber-victimization and developed a new scale to measure cyber-victimization with the intention of making cyber-victimization research more consistent. The current study examined known correlates of cyber-victimization (e.g., depression and social anxiety) in a sample of college students using the newly developed measure. The current study also explored the moderating role of social support in the relationship between cyber-victimization and depression, as well as …


Moral Judgments Of Differing Transgressions & The Influence Of Willingness To Seek Counseling & Religiosity, Marni Naleway Jan 2015

Moral Judgments Of Differing Transgressions & The Influence Of Willingness To Seek Counseling & Religiosity, Marni Naleway

Masters Theses

The purpose of this study was to examine how moral judgments differ towards substance abusers and unfaithful spouses. Furthermore, the study compared judgments regarding the gender of the transgressor, the transgressor's willingness to go to counseling, and the participant's level of religiosity. Participants in the study were provided with a scenario describing a substance abuse transgression or an infidelity transgression followed by a survey of questions inquiring about their judgments towards the transgressor. Results indicated individuals judge a transgressor more harshly in an infidelity transgression compared to a substance abuse transgression. Results also indicated a gender bias between transgressions as …


The Effects Of Cued Speech On Phonemic Awareness Skills, Jessica M. Phillips Jan 2015

The Effects Of Cued Speech On Phonemic Awareness Skills, Jessica M. Phillips

Masters Theses

Research suggests phonemic awareness is enhanced through multimodality training. Cued Speech is a multimodality system that combines hand signs with mouth movements to represent phonemes of the spoken language. This system has been utilized successfully in developing phonological awareness with children with hearing loss. However, no research is available on its effectiveness with children who are not deaf or hard-of-hearing. The efficacy of the use of Cued Speech for the enhancement of phonological skills in typically developing 1st grade students was evaluated in this study. Twenty-six 1st graders identified as low-achieving readers by their classroom teachers were administered the …


Rapid Response Teams Versus Critical Care Outreach Teams: Unplanned Escalations In Care And Associated Outcomes, Valerie Danesh Jan 2015

Rapid Response Teams Versus Critical Care Outreach Teams: Unplanned Escalations In Care And Associated Outcomes, Valerie Danesh

Electronic Theses and Dissertations

The incidence of unplanned escalations during hospitalization is undocumented, but estimates may be as high as 1.2 million occurrences per year in the United States. Rapid Response Teams (RRT) were developed for the early recognition and treatment of deteriorating patients to deliver time-sensitive interventions, but evidence related to optimal activation criteria and structure is limited. The purpose of this study is to determine if an Early Warning Score-based Critical Care Outreach (CCO) model is related to the frequency of unplanned intra-hospital escalations in care compared to a RRT system based on staff nurse identification of vital sign derangements and physical …


Development Of Cytotoxic Natural Killer Cells For Ovarian Cancer Treatment, Veethika Pandey Jan 2015

Development Of Cytotoxic Natural Killer Cells For Ovarian Cancer Treatment, Veethika Pandey

Electronic Theses and Dissertations

Ovarian cancer is a leading cause of gynecological malignancy. Cytoreductive surgery and frontline platinum/taxane-based chemotherapy provides good initial efficacy in the treatment, but poor long-term patient survival. This is mainly caused by tumor relapse due to intraperitoneal spreading and ineffective alternate therapies to treat these resistant tumors. The challenge in the field is to develop strategies that would prove effective in these patients and extend overall survival. Over the years, various treatments have been developed for the treatment of cancer amongst which, adoptive cell immunotherapy has shown promising results. But despite the efficacy seen in the clinic, there are concerns …