Medicine and Health Sciences Commons^™

Electrostatic Charge Effects On Pharmaceutical Aerosol Deposition In Human Nasal-Laryngeal Airways, Jinxiang Xi, Xiuhua Si, Worth Longest

University Faculty Publications and Creative Works

Electrostatic charging occurs in most aerosol generation processes and can significantly influence subsequent particle deposition rates and patterns in the respiratory tract through the image and space forces. The behavior of inhaled aerosols with charge is expected to be most affected in the upper airways, where particles come in close proximity to the narrow turbinate surface, and before charge dissipation occurs as a result of high humidity. The objective of this study was to quantitatively evaluate the deposition of charged aerosols in an MRI-based nasal-laryngeal airway model. Particle sizes of 5 nm-30 μm and charge levels ranging from neutralized to …

Understanding Ligand Binding, Selectivity And Functions On The G Protein-Coupled Receptors: A Molecular Modeling Approach, Saheem Zaidi

Theses and Dissertations

The assessment of target protein molecular structure provides a distinct advantage in the rational drug design process. The increasing number of available G protein-coupled receptor crystal structures has enabled utilization of a varied number of computational approaches for understanding the ligand-receptor interactions, ligand selectivity and even receptor response upon ligand binding. The following dissertation examines the results from three different projects with varied objectives – i) structural modeling of human C-C chemokine receptor type 5 (CCR5) and assessment of the ligand binding pocket of the receptor, ii) assessment of the selectivity profile of naltrexone derivatives on the three opioid receptors …

Hospital Treatment Rates And Spill-Over Effects: Does Ownership Matter?, Badi H. Baltagi, Yin -Fang Yen

Center for Policy Research

This paper studies the effect of hospital ownership on treatment rates allowing for spatial correlation among hospitals. Competition among hospitals and knowledge spillovers generate significant externalities which we try to capture using the spatial Durbin model. Using a panel of 2342 hospitals in the 48 continental states observed over the period 2005 to 2008, we find significant spatial correlation of medical service treatment rates among hospitals. We also get mixed results on the effect of hospital ownership on treatment rates that depends upon the market structure where the hospital is located and which varies by treatment type.

The Role Of Gamma-Secretase Impairment And Amyloid Beta Degradation In Alzheimer's Disease Pathogenesis, Robert J. Baranello Jr.

MUSC Theses and Dissertations

Accumulation of the amyloid β (Aβ) protein in the brain as senile plaques is a signature lesion of Alzheimer's disease (AD). The mechanisms of Aβγ accumulation that foster its deposition is a subject of intense study and represent the primary targets for most drug development efforts in the field. As one of the most important neurodegenerative diseases in the world, it is imperative that we continue to move toward efficacious treatment strategies. A number of y-secretase inhibitors (GSIs), such as N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-butyl ester (DAPT), have been developed with the goal of reducing Aβ to treat AD. Although most studies show …

The Validity And Inter-Unit Reliability Of Custom-Made Surftrax Gps Units And Use During Surfing, Oliver Farley, M Andrews, Josh Secomb, Tai T. Tran, Lina Lundgren, Chris Abbiss, Jeremry Sheppard

ECU Posters

The purposes of the study were to: i) gain further understanding of the movement patterns during surfing using custom made GPS units which are designed for surfing (SurfTraX, Gold Coast, Australia), and ii) determine the validity and inter-unit reliability of these units.

Book Review: Understanding The Misunderstandings In Pilot-Controller Dialogue, Jason M. Newcomer

International Journal of Aviation, Aeronautics, and Aerospace

Misunderstandings in any environment can be detrimental, if not counterproductive, to the intentions, expectations, or objective(s) of any communication, but in complex airspace congested by heavy traffic, pilot-controller transmissions, and various meteorological phenomena, they can be catastrophic. Barshi and Farris combine 45 years of aviation experience, 20 years of related research, and advanced education with sound methodology to deliver a well-balanced combination of theoretical and practical work to the fields of aviation, human factors, and psychology. Though Misunderstandings in ATC Communications, the authors guide readers through a series of experiments, literature, and transcribed air traffic control recordings to explore …

Conformational Changes And Translocation Of Tissue-Transglutaminase To The Plasma Membranes: Role In Cancer Cell Migration, Ambrish Kumar, Jianjun Hu, Holly A. Lavoie, Kenneth B. Walsh, Donald J. Dipette, Ugra S. Singh

Faculty Publications

Background

Tissue-transglutaminase (TG2), a dual function G-protein, plays key roles in cell differentiation and migration. In our previous studies we reported the mechanism of TG2-induced cell differentiation. In present study, we explored the mechanism of how TG2 may be involved in cell migration.

Methods

To study the mechanism of TG2-mediated cell migration, we used neuroblastoma cells (SH-SY5Y) which do not express TG2, neuroblastoma cells expressing exogenous TG2 (SHY_TG2), and pancreatic cancer cells which express high levels of endogenous TG2. Resveratrol, a natural compound previously shown to inhibit neuroblastoma and pancreatic cancer in the animal models, was utilized to …

A Wind Tunnel Study Of The Effect Of Adjacent Buildings On Near-Field Pollutant Dispersion From Rooftop Emissions, Ted Stathopoulos, Bodhisatta Hajra, Mauricio Chavez, Ali Bahloul

Rapports de recherche scientifique

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La dispersion des polluants des émissions de cheminées de toit dans la couche limite est fortement influencée par la présence de bâtiments avoisinants et la topographie locale. Il est donc très difficile d’évaluer précisément les concentrations dans le panache sur différentes surfaces de bâtiments. Les polluants émis par une cheminée de toit peuvent présenter des risques pour la santé des occupants des bâtiments s’ils se réintroduisent dans le bâtiment duquel ils émanent ou s’ils pénètrent dans un bâtiment voisin par des ouvertures se trouvant sur différentes surfaces de bâtiments. La plupart …

The Effect Of Upstream And Downstream Buildings On Dispersion Of Effluents: A Computational Fluid Dynamics (Cfd) Approach, Ali Bahloul, Ted Stathopoulos, Bodhisatta Hajra, Mauricio Chavez

Rapports de recherche scientifique

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La prédiction de la dispersion des émissions polluantes de cheminées de toit en milieu urbain est extrêmement complexe, tout particulièrement en présence de bâtiments voisins. Le comportement du panache dépend des caractéristiques du vent, mais il est aussi lourdement influencé par l’environnement. Il se peut ainsi que les effluents émis par une cheminée de toit se réintroduisent dans le bâtiment émetteur ou dans un bâtiment adjacent, exposant du coup les occupants à d’éventuels problèmes de santé. La conception et l’implantation optimales de cheminées d’évacuation pour limiter une telle réingestion au niveau …

Facteurs De Risque Associés Aux Glissades Chez Les Policiers Et Les Brigadiers Scolaires : Étude Exploratoire, Chantal Gauvin, David Pearsall, Mohsen Damavandi, Yannick Michaud-Paquette, Bruno Farbos, Daniel Imbeau

Rapports de recherche scientifique

Entre 2005 et 2007, les accidents de type glissades, trébuchements et chutes de même niveau ont représenté 12,6 % de l’ensemble des lésions indemnisées par la Commission de la santé et de la sécurité du travail du Québec (CSST) et ont entraîné des débours de 90 millions de dollars. Deux secteurs professionnels, soit les policiers et les brigadiers scolaires, ont sollicité l’appui de l’Institut de recherche Robert-Sauvé en santé et en sécurité du travail (IRSST) pour les aider à réduire et/ou prévenir les glissades qui, globalement, représentent près de la moitié de ces accidents. Afin de mieux cibler les interventions …

Troubles Psychiatriques Chez Les Patients Soumis À Une Évaluation Relative À L’Asthme Professionnel : Prévalence Et Impact Sur La Situation D’Emploi Et L’Utilisation Des Services De Santé, Kim L. Lavoie, Maryann Joseph, Hélène Favreau, Manon Labrecque, André Cartier, Catherine Lemière, Jean-Luc Malo, Denyse Gautrin, Blaine Ditto, Simon L. Bacon

Rapports de recherche scientifique

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Contexte : L’asthme professionnel (AP) est un important problème de santé au travail qui a un impact tant sur le secteur de l’emploi que sur les ressources en santé et l’individu lui-même. Entre 10 % et 30 % des asthmatiques qui le sont devenus à l’âge adulte mentionnent que leur asthme s’aggrave au travail et qu’il est souvent difficile à diagnostiquer et à traiter. La majorité (environ 70 %) des patients référés pour une évaluation relative à l’AP ne reçoivent pas un diagnostic d’AP, et jusqu’à 30 % d’entre eux ne …

Psychiatric Disorders Among Patients Under Investigation For Occupational Asthma: Prevalence And Impact On Employment Status And Health Service Use, Kim L. Lavoie, Maryann Joseph, Hélène Favreau, Manon Labrecque, André Cartier, Catherine Lemière, Jean-Luc Malo, Denyse Gautrin, Blaine Ditto, Simon L. Bacon

Rapports de recherche scientifique

Cliquez ici pour la version française de ce rapport

Contexte : L’asthme professionnel (AP) est un important problème de santé au travail qui a un impact tant sur le secteur de l’emploi que sur les ressources en santé et l’individu lui-même. Entre 10 % et 30 % des asthmatiques qui le sont devenus à l’âge adulte mentionnent que leur asthme s’aggrave au travail et qu’il est souvent difficile à diagnostiquer et à traiter. La majorité (environ 70 %) des patients référés pour une évaluation relative à l’AP ne reçoivent pas un diagnostic d’AP, et jusqu’à 30 % d’entre eux ne …

Nanomatériaux : Guide De Bonnes Pratiques Favorisant La Gestion Des Risques En Milieu De Travail, Claude Ostiguy, Maximilien Debia, Brigitte Roberge, André Dufresne

Rapports de recherche scientifique

Les nanotechnologies présentent aujourd’hui des enjeux majeurs en termes technologique, économique, éthique, social et environnemental, car elles offrent le potentiel d’améliorer de façon substantielle les propriétés de multiples produits dans tous les secteurs d’activité tant en matière de production de matériaux aux performances inédites que de diagnostic et de traitement médical. Les nanomatériaux favorisent ainsi l’émergence de nouveaux marchés, la création d’emplois, l’amélioration de la qualité de vie et peuvent contribuer à la protection de l’environnement. Du reste, l’impact se fait déjà sentir dans des secteurs aussi diversifiés que l’agroalimentaire, l’aérospatiale, la cosmétique, la construction et la santé. Au Québec, …

Chute Par-Dessus Bord De L’Équipage Des Homardiers Du Québec : Analyse Des Risques Et Pistes De Prévention, Sylvie Montreuil, Francis Coulombe, Jean-Guy Richard, Michel Tremblay

Rapports de recherche scientifique

L’activité de pêche commerciale est l’une des plus dangereuses du domaine industriel. Des chutes par-dessus bord se produisent chaque saison de pêche et leurs conséquences sont généralement graves, parfois mortelles. Au cours des dernières années, deux décès sont survenus dans ces circonstances au Québec lors d’activités de pêche au homard. De façon générale les causes documentées des chutes par-dessus bord sont la perte d’équilibre et l’entraînement par le gréement de pêche. Les objectifs de cette recherche sont : 1) d’analyser les risques de chute par-dessus bord et leurs déterminants lors de la pêche au homard, 2) de documenter les moyens …

Childhood Obesity In Asia: The Value Of Accurate Body Composition Methodology, Andrew P. Hills, Najat Mokhtar, Sharon Brownie, Nuala M. Byrne

School of Nursing & Midwifery, East Africa

Childhood obesity, a significant global public health problem, affects an increasing number of low- and middle-income countries, including in Asia. The obesity epidemic has been fuelled by the rapid nutrition and physical activity transition with the availability of more energy-dense nutrient-poor foods and lifestyles of many children dominated by physical inactivity. During the growing years the pace and quality of grow this best quantified by a combination of anthropometric and body composition measures. However, where normative data are available, this has typically been collected on Caucasian children. To better define and characterise overweight and obesity in Asian children, and to …

A Single Competency-Based Education And Training And Competency-Based Career Framework For The Australian Health Workforce: Discussing The Potential Value Add, Sharon Brownie, Janelle Thomas

School of Nursing & Midwifery, East Africa

This brief discusses the policy implications of a research study commissioned by Health Workforce Australia (HWA) within its health workforce innovation and reform work program. The project explored conceptually complex and operationally problematic concepts related to developing a whole-of-workforce competency-based education and training and competency-based career framework for the Australian health workforce and culminated with the production of three reports published by HWA. The project raised important queries as to whether such a concept is desirable, feasible or implementable – in short what is the potential value add and is it achievable? In setting the scene for discussion, the foundation …

Integrating Phage Therapy Into Western Medicine, Jacob B. Jaminet

Undergraduate Research Posters

The World Health Organization has described the rise of antibiotic use as a “global heath security emergency” (who.int). With the growing concern about antibiotic resistant bacteria, there has been an increased interest in bacteriophages. Bacteriophages are high-specific viruses that only infect bacteria. The use of bacteriophages medicinally to treat bacteria is called phage therapy. Research in phage therapy gained momentum until the introduction of antibiotics. While the USA and other Western countries accepted antibiotics, the Soviet Union and their satellite nations still continued to research phages. Since the funding for research was supplied by the Soviet military, the results of …

Distillers Grains Supplementation In A Forage System With Spayed Heifers, Kari L. Gillespie, Terry J. Klopfenstein, James C. Macdonald Donald, Brandon L. Nuttelman, Cody J. Schneider, Jerry D. Volesky, Galen Erickson

Nebraska Beef Cattle Reports

Spayed heifers were developed into yearlings by grazing corn residue and bromegrass, followed by native range, and were finished on a common diet. Treatments were 2 lb or 5 lb of wet distillers grains with solubles (WDGS; DM basis) supplement on corn residue daily, and modified distillers grains with solubles (MDGS) fed at 0.6% BW daily or no MDGS during summer grazing. Feeding 5 lb increased winter ADG by 0.68 lb (year 1) or 0.40 lb (year 2) compared to 2 lb, and increased HCW after finishing. Summer supplementation increased summer ADG by 0.50 lb (year 1) or 0. 44 …

Feeding Elevated Levels Of Corn Silage And Mdgs In Finishing Diets, Dirk B. Burken, Brandon L. Nuttelman, Terry J. Klopfenstein Klopfenstein, Galen E. Erickson

Nebraska Beef Cattle Reports

A finishing experiment evaluatedsubstitution of corn silage and modified distillers grains with solubles (MDGS) in place of corn. The treatment arrangementwas a 2 X 2 + 1 factorial with 15 or 45% corn silage and 20 or 40% MDGS plus a control containing 5% cornstalks and 40% MDGS. There were interactions between corn silage and MDGS for carcass adjusted performance. As corn silage inclusion was increased in the diet, F:G increased when fed with 20% MDGS, however there was no difference when fed with 40% MDGS.

Transitioning Cattle From Ramp® To A Finishing Diet On Feedlot Performance And Feed Intake Variance, Cody J. Schneider, Brandon L. Nuttelman, Dirk B. Burken Burken, Terry J. Klopfenstein, Galen E. Erickson

Nebraska Beef Cattle Reports

Individually fed cattle were adapted to high grain diets with a traditional grain adaptation program or one of two RAMP^® adaptation programs. RAMP programs adapted cattle to a finishing diet gradually over 28 days in four steps or directly without an adaptation. Feed intake variance among d was greater for traditionally adapted cattle compared to either RAMP program, but DMI was not different during the adaptation period. Over the 138-day period, feedlot performance and carcass traits were not affected by adaptation treatment. Cattle fed RAMP for 10 days can be transitioned to a finishing ration containing 47.5% Sweet Bran …

Use Of A Pelleted Corn Residue Complete Feed In Receiving Diets, Sarah J. Peterson, Brandon L. Nuttelman, Dirk B. Burken Burken, James C. Macdonald, Matt K. Luebbe, Galen E. Erickson

Nebraska Beef Cattle Reports

The effects of feeding a complete pelleted feed to newly received steer calves (585 ± 4 lb; n = 1318 ) was compared to a control ration consisting of 32% (DM basis) wet or modified distillers grains, 32% alfalfa hay, 32% dry-rolled corn, and 4% supplement. The pelleted complete feed consisted of 35% corn residue and a blend of grain byproducts and minerals. Feeding the complete pelleted feed increased DMI but decreased ADG, thereby reducing feed efficiency. The pelleted feed numerically reduced morbidity. Feeding a complete pellet consisting of corn residue appears to be a viable option for receiving calves …

Comparison Of Long-Term Progestin-Based Synchronization Protocols On Fixed-Time Ai Pregnancy Rate In Beef Heifers, Rebecca A. Vraspir, Adam F. Summers, Doug O'Hare Hare, Larry D. Rowden, Rick N. Funston

Nebraska Beef Cattle Reports

Yearling Angus heifers at a commercial ranch in the Nebraska Sandhills were randomly assigned to one of two progestin-based fixed-time AI protocols (MGA or 14-day CIDR) to compare pregnancy rates. Heifers had similar fixed-time AI pregnancy rates between MGA and 14-day CIDR. A similar proportion of MGA and 14-day CIDR heifers displayed a second estrus; however, heifers previously synchronized with MGA tended to have a greater second AI pregnancy rate. Overall pregnancy rate was similar between MGA and 14-day CIDR treatments. The MGA system was the more cost effective synchronization protocol in this study.

Effect Of Feeding De-Oiled Wet Distillers Grains Plus Solubles On Beef Oxidation And Tenderness, Katherine I. Domenech, Kim A. Varnold, Michelle E. Semler, Michael D. Chao, Tommi F. Jones, Galen E. Erickson, Chris R. Calkins

Nebraska Beef Cattle Reports

Cattle fed a de-oiled wet distiller’s grains plus solubles (WDGS) diet were compared to cattle fed corn or traditional (full-fat) WDGS diets to determine effects on discoloration, oxidation, and tenderness of beef aged for seven and 21 days. At seven days of aging, dietary treatment had no effect on discoloration. At 21 days of aging, beef from cattle fed de-oiled WDGS had less oxidation than the corn control and several of the full-fat WDGS treatments. Although tenderness increased with aging and retail display, dietary treatment had no effect on tenderness. These findings suggest that these dietary treatments, followed by a …

Effect Of Feeding Different Types Of Byproducts And Concentrations Throughout A Beef Growing System On Ground Beef Color And Lipid Oxidation, Joe O. Buntyn, Brandy D. Cleveland, Amy L. Redfield Redfield, James C. Macdonald, Galen E. Erickson, Tommi F. Jones, Ty B. Schmidt, Gary A. Sullivan

Nebraska Beef Cattle Reports

The objective of this trial was to evaluate the effect of feeding different concentrations of wet distillers grains during winter backgrounding and either modified wet distillers grains or Sweet Bran^® during the finishing phase on ground beef color and lipid oxidation. After a 14 day aging period, ground beef patties were made and placed in a simulated retail display for seven days. There were no overall differences in lipid oxidation between treatments but was a treatment by day interaction for discoloration. Ground beef from heifers finished with modified wet distillers grains discolored at a greater extent when compared to …

Shelf Life Of Cooked Ground Beef Patties From Cattle Fed Wet Distillers Grains With Solubles, Nathan T. Dierks, Tommi F. Jones, Kimberly A. Varnold Varnold, Derek J. Schroeder, Amy L. Redfield, Gary A. Sullivan

Nebraska Beef Cattle Reports

Cattle were grazed without or with energy supplementation of wet distillers grains with solubles (WDGS) during backgrounding, and were finished on a corn-based diet with or without 35% WDGS. Ground beef patties were made from shoulder clods, cooked, and stored in a refrigerated or frozen state. Cattle supplemented with WDGS had greater lipid oxidation in cooked ground beef patties regardless of finishing diet or storage type.

Differences In Fecal Bacterial Community Composition Between Beef Steers Which Are High-Shedders And Low-Shedders Of Shiga Toxin-Producing Escherichia Coli (Stec), Nirosh D. Aluthge, Yoshitha A. Wanniarachchi, Brandon L. Nuttelman Nuttelman, Cody J. Schneider, Terry J. Klopfenstein, Galen E. Erickson, Samodha C. Fernando

Nebraska Beef Cattle Reports

The community composition of the fecal microbiota was compared between beef steers which were high-shedders and low-shedders of Shiga toxin-producing Escherichia coli. Based on Shannon and Chao 1 diversity indices, the high-shedders had a more diverse fecal bacterial community than the low-shedding steers. Members of the genus Prevotella were observed as being more abundant in the low-shedders compared to the high-shedders, while Succinivibrio were more abundant in the high-shedders. Isolation of specific bacteria which are significantly more abundant in low-shedders may pave the way to developing direct-fed microbials which are effective in reducing STEC shedding among high-shedding beef steers.

Optimal Marketing Date Of Steers Depends On Marketing Strategy, James C. Macdonald, Cody J. Schneider, Kelsey M. Rolfe Rolfe, Stephen D. Kachman, Terry J. Klopfenstein, Galen E. Erickson

Nebraska Beef Cattle Reports

Seven research trials conducted over five years at the University of Nebraska–Lincoln were summarized to determine how animal performance changes through the finishing period on a live and carcass weight basis. Live weight, carcass weight, carcass ADG, and carcass feed efficiency all changed quadratically throughout the feeding period; live ADG and live feed efficiency declined linearly. During times of negative profit margins, optimal profitability for steers marketed on a live-basis occurred by selling early, whereas optimal profitability was achieved by feeding steers marketed on a carcass-basis longer.

The Effects Of Diet And Cooler Aging On Specific Flavor Notes In Beef, Kimberly A. Varnold, Chris R. Calkins, Rhonda K. Miller Miller, Galen E. Erickson

Nebraska Beef Cattle Reports

Crossbred steers (n = 64) were grazed on warm- or cool-season grass-dominated pastures, without or with energy supplementation of wet distillers grains with solubles (WDGS), and were finished on a corn-based diet with or without 35% WDGS. Finishing on corn increased desirable flavor notes and decreasedundesirable flavor notes in both L. dorsi and B. femoris steaks. In addition, grazing on warm-season grasses increased the prevalence of undesirable flavors but was often dissipated by the addition WDGS supplementation. Longer aging periods tended to increase the prevalence of undesirable flavors, especially in B. femoris steaks. It is recommended producers provide WDGS supplementation, …

Clinical Features, Proximate Causes, And Consequences Of Active Convulsive Epilepsy In Africa, Symon M. Kariuki, William Matuja, Albert Akpalu, Angelina Kakooza-Mwesige, Martin Chabi, Ryan G. Wagner, Myles Connor, Eddie Chengo, Anthony K. Ngugi, Rachael Odhiambo, Christian Bottomley, Steven White, Josemir W. Sander, Brian G. R. Neville, Charles R. J. C. Newton

Internal Medicine, East Africa

Purpose: Epilepsy is common in sub-Saharan Africa (SSA), but the clinical features and consequences are poorly characterized. Most studies are hospital-based, and few studies have compared different ecological sites in SSA. We described active convulsive epilepsy (ACE) identified in cross-sectional community-based surveys in SSA, to understand the proximate causes, features, and consequences.

Methods: We performed a detailed clinical and neurophysiologic description of ACE cases identified from a community survey of 584,586 people using medical history, neurologic examination, and electroencephalography (EEG) data from five sites in Africa: South Africa; Tanzania; Uganda; Kenya; and Ghana. The cases were examined by clinicians to …

Mycoplasma Genitalium Promotes Epithelial Crossing And Peripheral Blood Mononuclear Cell Infection By Hiv-1, Kishore Das, Georgina De La Garza, Edward B. Siwak, Virginia L. Scofield, Subramanian Dhandayuthapani

School of Medicine Publications

Background

Mycoplasma genitalium co-infection in HIV-infected individuals has been reported to increase the shedding of HIV in the urogenital region of females. To better understand this relationship, we investigated the influence of M. genitalium on the transmission and replication of HIV using an in vitro model.

Methods

The Transwell co-culture system was employed to assess the crossing of an endocervical cell barrier by HIV-1. Immunocytochemistry and confocal microscopy were used to assess the distribution of the nectin-1 molecule on M. genitalium -infected epithelial cells of the End1/E6E7 endocervical cell line, grown as monolayers in the insert wells. Peripheral blood mononuclear …