Medicine and Health Sciences Commons^™

Plasminogen Activator Inhibitor-1 Inhibitors And Methods Of Use Thereof To Modulate Lipid Metabolism, Daniel A. Lawrence, Dudley Strickland, Jacqueline Cale, Enming Joe Su, Cory Emal, Mark Warnock

Patents

The invention relates to plasminogen activator-I (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated PAI-1, cholesterol, or lipid levels.

Stroke Patient Rehabilitation: A Pilot Study Of An Android-Based Game, Ma. Mercedes T. Rodrigo

Department of Information Systems & Computer Science Faculty Publications

Background

Cerebral vascular accidents (strokes) are the primary cause of disability worldwide and the second leading cause of death both in the Philippines and internationally. In recent years, a number of computer-based applications have been developed to assist in the stroke recovery process.

Aim

This article discusses an Android-based tablet game, FINDEX, that aids in the rehabilitation process of stroke survivors with impaired fine motor skills.

Method

FINDEX was designed and developed in the Philippines. The game contains assessment and monitoring support for tracking the patient’s progress in terms of fine finger dexterity, for example, finger control, isolation and coordination, …

Can The Usa National Weather Service Heat Index Substitute For Wet Bulb Globe Temperature For Heat Stress Exposure Assessment?, Ivory Iheanacho

USF Tampa Graduate Theses and Dissertations

Heat stress occurs when the body cannot adequately cool itself due to the combined contributions of metabolic heat, environmental factors and clothing. Heat stress found in the workplace puts employees at risk of developing heat-related illnesses, disorders and could be fatal. The wet bulb globe temperature (WBGT) index is the current method used to assess environmental contributions to heat stress in an occupational setting. The purpose of this thesis was to explore whether the National Weather Service's Heat Index (HI) could substitute for the WBGT Index during occupational heat stress exposure assessment. The possibility of using the HI for heat …

What's Happening: June 23, 2014, Maine Medical Center

What's Happening

No abstract provided.

Metastatic Angiosarcoma And Kasabach-Merritt Syndrome, Suleiman Massarweh, Aun Munis, Rouzan Karabakhtsian, Edward Romond, Jessica Moss

Internal Medicine Faculty Publications

Angiosarcomas are exceedingly rare tumors that are often difficult to diagnose. Exceptionally unusual is the presentation of these tumors with Kasabach-Merritt Syndrome, a curious form of intratumoral coagulation that can be impossible to distinguish from intravascular coagulation, which is more common. Instant recognition of this clinical association can help making a prompt diagnosis and timely initiation of therapy.

A Novel Label-Free Colorimetric Assay For Dna Concentration In Solution, Molla R. Islam, Michael J. Serpe

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Optical devices were fabricated by sandwiching a “monolithic” poly(N-isopropylacrylamide-co-N-(3-aminopropyl) methacrylamide hydrochloride) (pNIPAm-co-APMAH) microgel layer between two semitransparent Au layers. These devices, referred to as etalons, exhibit characteristic multipeak reflectance spectra, and the position of the peaks in the spectra primarily depends on the distance between the Au surfaces mediated by the microgel layer thickness. Here, we show that the positively charged microgel layer can collapse in the presence of negatively charged single stranded DNA (ssDNA) due to ssDNA induced microgel crosslinking. The collapse results in a change in the etalon's optical properties, which can be used to detect target DNA …

Animal Arterivirus Infections, Denis Archambault, Udeni B. R. Balasuriya, Raymond R. R. Rowland, Hanchun Yang, Dongwan Yoo

Veterinary Science Faculty Publications

No abstract.

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Elsie Mae Cloud Peace Awards

White Nose Syndrome Of Bats: Lipid Profiling And Enzyme Identification In A Host/Pathogen System, Evan Lacy Pannkuk

Student Theses and Dissertations

Pseudogymnoascus destructans is a fungus isolated from cave-dwelling bats that is the pathogen responsible for white-nose syndrome (WNS) and the associated mass mortality of North American cave bats. This study addresses isolation and identification of biomolecules that may function in host/pathogen interactions in WNS. Fungal skin infections requires fungal adherence and growth on the host organism integumentary matrix, which consists of hard cornified insoluble structural proteins coated with lipid residues from epidermal cells or sebaceous secretions. There is a knowledge gap on how molecules present on the bat integument are utilized as carbon or nitrogen sources by P. destructans. I …

Identification Of Cd24 As A Cancer Stem Cell Marker In Human Nasopharyngeal Carcinoma, Chun-Hung Yang, Hui-Ling Wang, Yi-Sheng Lin, K. P. Shravan Kumar, Hung-Chi Lin, Chih-Jung Chang, Chia-Chen Lu, Tsung-Teng Huang, Jan Martel, David M. Ojcius, Yu-Sun Chang, John Ding-E. Young, Hsin-Chih Lai

All Dugoni School of Dentistry Faculty Articles

Cancer stem cells (CSCs) represent a unique sub-population of tumor cells with the ability to initiate tumor growth and sustain self-renewal. Although CSC biomarkers have been described for various tumors, only a few markers have been identified for nasopharyngeal carcinoma (NPC). In this study, we show that CD24⁺ cells isolated from human NPC cell lines express stem cell genes (Sox2, Oct4, Nanog, Bmi-1, and Rex-1), and show activation of the Wnt/β-catenin signaling pathway. CD24⁺ cells possess typical CSC characteristics that include enhanced cell proliferation, increased colony and sphere formation, maintenance of cell differentiation potential in prolonged …

Reducing Colorectal Cancer Incidence And Disparities: Performance And Outcomes Of A Screening Colonoscopy Program In South Carolina, Sudha Xirasagar, Yi-Jhen Li, James B. Burch, Virginie G. Daguisé, Thomas G. Hurley, James R. Hébert

Faculty Publications

This study evaluated the efficiency, effectiveness, and racial disparities reduction potential of Screening Colonoscopies for People Everywhere in South Carolina (SCOPE SC), a state-funded program for indigent persons aged 50–64 years (45–64 years for African American (AA)) with a medical home in community health centers. Patients were referred to existing referral network providers, and the centers were compensated for patient navigation. Data on procedures and patient demographics were analyzed. Of 782 individuals recruited (71.2% AA), 85% (665) completed the procedure (71.1% AA). The adenoma detection rate was 27.8% (males 34.6% and females 25.1%), advanced neoplasm rate 7.7% (including 3 cancers), …

Medical School Watercooler Newsletter - June 22, 2014, Lindsey Lyle

Watercooler Newsletter

This is the June 22, 2014 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• Medical Students Volunteer at Camp Rap-A-Hope
• Dr. Jon Simmons Awarded Two Research Grants
• Dr. Wilson Receives Distinguished Service Award
• Class of 2016 Medical Students Receive White Coats

Accurate Murmur Recognition By Cardiologists – Premature Requiem Or Phoenix Rising?, Yassir Nawaz Md, Matthew W. Martinez Md, Michael J. Barrett Md

Department of Medicine

No abstract provided.

A Retrospective Chart Review To Determine Proper Stress Test Utilization In Low Risk Chest Pain Patients, Yassir Nawaz Md, Bilal Ayub Md

Department of Medicine

No abstract provided.

Spatial Mapping Of Macular Pigment Optical Density And Its Relationship To Contrast Sensitivity And Glare Disability, Christopher Michael Putnam

Dissertations

This dissertation explored the relationship of the macular pigment optical density (MPOD) spatial profile with measures of contrast sensitivity (CS), glare disability (GD), relative glare disability (RGD) and intraocular light scatter. A novel device capable of measuring MPOD across the central 16 degrees of retina along 8 principle meridians using customized heterochromatic flicker photometry (cHFP) at eccentricities of 0, 2, 4, 6 and 8 degrees was built. MPOD was calculated as both discrete and integrated values at all measured retinal loci. CS was measured using vertical grating stimuli of 3, 6 and 9 cycles per degree (cpd) also presented at …

Attention Deficit Hyperactivity Disorder: Comparison Of Medication Efficacy And Cost, Robert M. David, Karlen E. Luthy, Janelle L. B. Macintosh, Lacey M. Eden

Student Works

Although a common psychological disorder, pharmacological treatment of Attention Deficit Hyperactivity Disorder can be a costly endeavor. Among 4-5 year olds, methylphenidate is a safe, efficacious, and cost-effective option for short-, intermediate-, and long-acting medication options. Short-acting methylphenidate, intermediate-acting methylphenidate ER and SR, and long-acting methylphenidate LA are the most efficacious and cost-effective medications. Selection of non-stimulant medications should be based upon recommended guidelines rather than primarily on cost. For children incapable of swallowing pills, the most efficacious and cost-effective treatments are short-acting dextroamphetamine liquid and long-acting methylphenidate LA capsules that can be opened and sprinkled over food.

Obesity Hypoventilation Syndrome: Understanding, Diagnosing, And Treating, Chad W. Padovich

Student Works

The effects of obesity are multifaceted and lead to poor quality of life, increased risk of cardiovascular disease, stroke, and death. Obesity hypoventilation syndrome (OHS) is a widely misunderstood and under diagnosed disease process, which carries specific diagnostic criteria. The purpose of this work is to: (1) provide practitioners with a better understanding of OHS and how it differs from other obesity related breathing disorders (such as Obstructive Sleep Apnea, OSA), (2) provide diagnostic criteria of OHS, (3) provide work up recommendations, and (4) provide current recommended treatment. Data Sources: An electronic search of the literature was conducted to identify …

Negative Reinforcement In Infant Care Simulation: Alternative Caregiver Responses To Prevent Child Abuse, Miriam Tye

USF Tampa Graduate Theses and Dissertations

This study was conducted to replicate and extend previous research on infant caregiver behavior by demonstrating negative reinforcement of infant caregiver behavior in response to crying and teaching appropriate care responses under conditions of inconsolable crying. A computerized infant simulator was used to create a laboratory simulation of infant caregiving. In Study 1, participants were exposed to negative reinforcement conditions and an extinction condition. In the negative reinforcement condition, participants engaged in caregiving responses to escape from the cry. In the extinction condition, the cry was inescapable and two of three participants stopped engaging in the previously reinforced caregiving response. …

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Mrs. Eisenhart to Serve on Executive Board

The Efficacy Of Social Communication Intervention On Teacher Report Of Sociability For Children With Language Impairment, Julianne Grover Smith Guerra

Theses and Dissertations

Recent research indicates that many children with Language Impairment (LI) have difficulty with social communication skills. This study assessed the impact of a social communication intervention on teacher perceptions of social withdrawal in children who received the treatment. The intervention targeted emotion understanding using the presentation of children's stories, facial picture cards, and journaling. Teacher perception was measured using the three withdrawal subscales of the Teacher Behavior Rating Scale (TBRS): Solitary-Active withdrawal, Solitary-Passive withdrawal, and Reticence. Following treatment all five participants received lower ratings of withdrawn behavior on some of the subscales. Only one participant received a rating indicting increased …

Community Health News, Georgia Southern University

Health Policy & Community Health: News & Publications (2011-2018)

• Mrs. Eisenhart to Serve on Executive Board

Characterization Of Waste Anesthetic Gas Exposures To Veterinary Workers In The Tampa Bay Area, Kyle Vogel

USF Tampa Graduate Theses and Dissertations

Veterinarians routinely conduct surgical operations on animals while veterinary technicians administer anesthetic gas to sedate the animal prior to an operation. One commonly used anesthetic agent in veterinary clinics is isoflurane. Veterinary workers have the potential to be exposed to this gas during surgical operations. The Occupational Safety and Health Administration (OSHA) does not have a specific Permissible Exposure Limit (PEL) for isoflurane, however The National Institutes for Health (NIH) does advise that workers should not be exposed to isoflurane in concentrations exceeding 2 parts per million (ppm) for an 8 hour Time Weighted Average (TWA).

Animal clinics vary in …

Correlating Periodontal Disease And Cardiovascular Disease: A Comparative Study Of Research Methodology, Alexandra Hensen

Honors Theses

This meta-analysis compares and contrasts three types of population-based research methodology currently used to analyze correlations between Periodontal disease and Cardiovascular disease, the most wide spread diseases in the Western industrialized world. The three studies that were analyzed in this thesis include: "Gender Differences in the Relationship Between Periodontal Disease, Tooth Loss, and Atherosclerosis," published in the Journal of Stroke and Cerebrovascular Diseases (2013), this was a cross-sectional population-based study; "Periodontal Disease and Mortality in Type 2 Diabetes" published in Diabetes Care (2005), this was a longitudinal population-based study; and "Identification of a Shared Genetic Susceptibility Locus for Coronary Heart …

Enhancing The Quality Of Healthcare Delivery In Refugee Communities With Photo Voice, Timothy M. Daly Do, Nicole Defenbaugh Phd, Brenda Depaula

Department of Family Medicine

No abstract provided.

How Medicaid Expansions And Future Community Health Center Funding Will Shape Capacity To Meet The Nation’S Primary Care Needs: A 2014 Update, Leighton Ku, Julia Zur, Emily Jones, Peter Shin, Sara J. Rosenbaum

Geiger Gibson/RCHN Community Health Foundation Research Collaborative

No abstract provided.

Rationale, Design, And Baseline Characteristics Of A Randomized, Placebo-Controlled Cardiovascular Outcome Trial Of Empagliflozin (Empa-Reg Outcometm), Bernard Zinman, Silvio E. Inzucchi, John M. Lachin, Christoph Wanner, Roberto Ferrari, David Fitchett, Erich Bluhmki, Stefan Hantel, Joan Kempthorne-Rawson, Jennifer Newman, Odd Erik Johansen, Hans Juergen Woerle, Uli C. Broedl

Epidemiology Faculty Publications

Background

Evidence concerning the importance of glucose lowering in the prevention of cardiovascular (CV) outcomes remains controversial. Given the multi-faceted pathogenesis of atherosclerosis in diabetes, it is likely that any intervention to mitigate this risk must address CV risk factors beyond glycemia alone. The SGLT-2 inhibitor empagliflozin improves glucose control, body weight and blood pressure when used as monotherapy or add-on to other antihyperglycemic agents in patients with type 2 diabetes. The aim of the ongoing EMPA-REG OUTCOMETM trial is to determine the long-term CV safety of empagliflozin, as well as investigating potential benefits on microvascular outcomes.

Methods

Patients who …

Safety Hazards Education For Mothers Who Are Homeless: Target Teaching To Improve Knowledge Of Safety Hazards For Children Under Five Years Of Age, Susan Halpern Fliesher

Dissertations

The leading cause of morbidity and mortality in children in the U. S. is unintentional injury (Center for Disease Control Child Injury Report, 2000 to 2006), but there is little information about homeless mothers with children and child unintentional injury. Frencher et al. (2010) compared lower socioeconomic families with children with housing to homeless families with children, and found that unintentional injury was 13% higher among homeless children. Mothers who are homeless often need to navigate a variety of temporary housing and may lack understanding of child safety hazards in strange environments, limiting their ability to ensure their children’s safety …

A Central Role For Carbon-Overflow Pathways In The Modulation Of Bacterial Cell Death., Vinai Chittezham Thomas, Marat Sadykov, Sujata S. Chaudhari, Joselyn Jones, Jennifer L. Endres, Todd J. Widhelm, Jong-Sam Ahn, Randeep S. Jawa, Matthew C. Zimmerman, Kenneth W. Bayles

Journal Articles: Pathology and Microbiology

Similar to developmental programs in eukaryotes, the death of a subpopulation of cells is thought to benefit bacterial biofilm development. However mechanisms that mediate a tight control over cell death are not clearly understood at the population level. Here we reveal that CidR dependent pyruvate oxidase (CidC) and α-acetolactate synthase/decarboxylase (AlsSD) overflow metabolic pathways, which are active during staphylococcal biofilm development, modulate cell death to achieve optimal biofilm biomass. Whereas acetate derived from CidC activity potentiates cell death in cells by a mechanism dependent on intracellular acidification and respiratory inhibition, AlsSD activity effectively counters CidC action by diverting carbon flux …

Unique Interdisciplinary Public Health Model Doubles Latent Tuberculosis Infection Treatment Completion Of Refugee Patients In A Large Metropolitan Area, Christine O'Leary, Pharmd, Kevin Scott, Md, Marc Altshuler, Md, Karen Kitagawa-James, Rn, Bsn, Maria Hervada-Paige, Mss

Department of Family & Community Medicine Presentations and Grand Rounds

Background and Purpose:

The Jefferson Center for Refugee Health (JCRH), a component of Jefferson Family Medicine Associates (JFMA), is the first and largest single provider of refugee health in Philadelphia; over 1,000 refugee primary care visits are provided annually. Refugee patients are disproportionately affected by latent tuberculosis infection (LTBI) compared to the general population of the United States; and though treatment of LTBI is highly effective at reducing conversion to active tuberculosis (TB), completion rates among the foreign-born are reported to be less than 50%. To establish baseline LTBI incidence and treatment completion rates for our refugee population, the JCRH …

Immunomodulatory Activity Of Interferon-Beta, Lloyd H. Kasper, Anthony T. Reder

Dartmouth Scholarship

Multiple sclerosis (MS) is a complex disorder of the central nervous system that appears to be driven by a shift in immune functioning toward excess inflammation that results in demyelination and axonal loss. Beta interferons were the first class of disease-modifying therapies to be approved for patients with MS after treatment with this type I interferon improved the course of MS on both clinical and radiological measures in clinical trials. The mechanism of action of interferon-beta appears to be driven by influencing the immune system at many levels, including antigen-presenting cells, T cells, and B cells. One effect of these …