Medicine and Health Sciences Commons^™

Strategic Planning For Recruitment And Retention Of Older African Americans In Health Promotion Research Programs, Laura Dreer, Cynthia Owsley, June Weston

Journal of Health Disparities Research and Practice

The purpose of this study was to 1) describe a strategic plan for recruitment and retention used in conducting eye health education research with African-Americans living in urban and rural areas of Alabama and 2) characterize recruitment and retention patterns for this project.

We evaluated an eye health education program tailored specifically to older African Americans. InCHARGE was designed to promote eye disease prevention by conveying the personal benefits of annual dilated comprehensive eye care and teaching strategies to minimize barriers to eye care. The InCHARGEÓ program or a social contact control program was delivered at 20 senior centers in …

Developing An Action Learning Community Advocacy/Leadership Training Program For Community Health Workers And Their Agencies To Reduce Health Disparities In Arizona Border Communities, Kenneth A. Schachter Md, Mba, Maia Ingram Mph, Laurel Jacobs Drph, Mph, Hannah Hafter Mph, Jill Guernsey De Zapien Ba, Scott Carvajal Phd, Mph

Journal of Health Disparities Research and Practice

Community health workers (CHWs) make unique and important contributions to society. They serve as patient advocates, educators, and navigators in our health care system and a growing body of research indicates that they play an important role in the effective delivery of prevention and treatment services in underserved communities. CHWs also serve as informal community leaders and advocates for organizational and community change, providing valuable insiders' insights about health promotion and the interrelatedness of individuals, their community, its institutions, and the surrounding environment. Accion Para La Salud or Action for Health (Accion) is a CDC-funded community based participatory research (CBPR) …

Sharing Medicine: The Candidacy Of Medicines And Other Household Items For Sharing, Dominican Republic, Michael N. Dohn, Hugo Pilkington

Population and Public Health Sciences Faculty Publications

Background:

People share medicines and problems can result from this behavior. Successful interventions to change sharing behavior will require understanding people’s motives and purposes for sharing medicines. Better information about how medicines fit into the gifting and reciprocity system could be useful in designing interventions to modify medicine sharing behavior. However, it is uncertain how people situate medicines among other items that might be shared. This investigation is a descriptive study of how people sort medicines and other shareable items.

Methods and Findings:

This study in the Dominican Republic examined how a convenience sample (31 people) sorted medicines and rated …

Today - June 27, 2014, Loma Linda University Health

TODAY

Inside this issue:

-- Loma Linda University Sends Class of 2014 into the World to Spread the Message of Wholeness
-- Five School of Medicine Deans Gather at Graduation Event
-- President Barack Obama Recognizes Loma Linda University Health PossAbilitiies Program as 'Presidential Champion'
-- 23rd Annual Celebration of Life Honors Cancer Survivors
-- SAHP Welcomes Alumni Annual Homecoming
-- Center Restores Wholeness to Abused Children
-- LLU School of Medicine Celebrates 100th Anniversary
-- Candy or Medicine? Pharmacy Students Teach Children About Medicine Safety
-- High-altitude Reflections on a Most Improbably Dream
-- For the Kids: Reading and Literacy …

A Qualitative Examination Of Barriers And Motivators To Smoking Cessation Among Hiv Positive African American Msm Smokers, Alicia Kaye Matthews, Maria Vargas, Lisa Kuhns, Nitin Shappiva, Andrea C. King

Journal of Health Disparities Research and Practice

Purpose: To identify barriers and motivators to smoking cessation among HIV-positive African American men-who-have-sex with men (MSM) who smoke.

Procedures: A convenience sample of smokers was recruited for this study using a range of outreach approaches. Focus groups (N = 4) were conducted that examined: quit experiences, barriers to and motivators of cessation, cultural beliefs, and community norms. Established qualitative methods were used to conduct and analyze the focus groups.

Main Findings: Participants (N = 31) reporting being diagnosed with HIV+ for M = 12 years. More than 60% reported a quit attempt in the past year. Knowledge was about …

Trends And Disparities In Tb Among U.S.-Born Black And White Chicago Residents, 1998-2008, Susan A. Lippold, Lori Armstrong, Jennifer M. Carter, Xiomara Hardison

Journal of Health Disparities Research and Practice

ABSTRACT

OBJECTIVE: To describe the decline of tuberculosis (TB) cases among U.S.-born non-Hispanic (NH) black and white Chicago residents.

METHODS: Data from the National TB Surveillance System was used to analyze trends and characteristics of reported TB cases among U.S.-born NH black and U.S.-born NH white Chicago residents from 1998-2008.

RESULTS: Chicago reported a total of 3,821 TB cases over the 11-year time period. Of these, 1,916 were U.S.-born NH black and 235 were U.S.-born NH white. The proportion of cases attributable to U.S.-born NH blacks was 63% (294/469) in 1998 and 34% in 2008 (72/213). Analysis for trends from …

Gendered Violence, Hiv Acquisition, And Clinical/Behavioral Research, Liz Barr, Michele Peake Andrasik, Claire Rappoport, Jessica Mooney, Annet Davis Vogel, Lisa Rossi, Amina Alio

Journal of Health Disparities Research and Practice

HIV incidence and prevalence rates for US women continue to increase, especially among Black and Latina women. In addition, the link between violence and HIV acquisition has been well documented. However, the interaction between violence, HIV risk, and HIV acquisition remains an under-addressed issue in current clinical and behavioral HIV research designs. Because violence against women plays an important role in HIV acquisition and transmission, it is imperative for clinical research to address violence in trial design and implementation. In this article, we discuss the prevalence of violence in women’s lives; the role violence plays in HIV acquisition; and the …

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Alumni Accepted to Health Disparities Cyber-Mentoring Program

Variability In Eit Images Of Lung Ventilation As A Function Of Electrode Planes And Body Positions, Jie Zhang, Robert Patterson

Radiology Faculty Publications

This study is aimed at investigating the variability in resistivity changes in the lung region as a function of air volume, electrode plane and body position. Six normal subjects (33.8 ± 4.7 years, range from 26 to 37 years) were studied using the Sheffield Electrical Impedance Tomography (EIT) portable system. Three transverse planes at the level of second intercostal space, the level of the xiphisternal joint, and midway between upper and lower locations were chosen for measurements. For each plane, sixteen electrodes were uniformly positioned around the thorax. Data were collected with the breath held at end expiration and after …

New California Stem Cell Chief Stresses Speed And Efficiency In Search For Treatments, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Role Of Lysosomes In Silica-Induced Inflammasome Activation And Inflammation In Absence Of Macro, Rupa Biswas, Raymond F. Hamilton, Andrij Holian

Public and Community Health Sciences Faculty Publications

MARCO is the predominant scavenger receptor for recognition and binding of silica particles by alveolar macrophages (AM). Previously, it was shown that mice null for MARCO have a greater inflammatory response to silica, but the mechanism was not described. The aim of this study was to determine the relationship between MARCO and NLRP3 inflammasome activity. Silica increased NLRP3 inflammasome activation and release of the proinflammatory cytokine, IL-1b, to a greater extent in MARCO^-/- AM compared to wild type (WT) AM. Furthermore, in MARCO^-/- AM there was greater cathepsin B release from phagolysosomes, Caspase-1 activation, and acid sphingomyelinase activity …

Telehealth In The School Setting: An Integrative Review, Cori A. Reynolds, Erin Maughan

Student Works

Telehealth, the provision of healthcare through long-distance telecommunications technology, is a tool that can be used by school nurses to address and improve the health status of school children. The purpose of this literature review is to examine research related to implementation of telehealth in the school setting. A review of the literature was conducted using CINAHL, ERIC, Medline, and Pub Med databases, and the search terms telehealth, telecare, telemedicine, school, and schools. Fifteen research studies related to telehealth in the school setting were identified. Themes identified included: benefits, barriers, feasibility, and limitations of telehealth. Implications for practice are presented, …

Phosphoinositides: Minor Lipids Make A Major Impact On Photoreceptor Cell Functions, Raju V. S. Rajala, Ammaji Rajala, Andrew J. Morris, Robert E. Anderson

Internal Medicine Faculty Publications

Activation of the phosphoinositide (PI) cycle generates the second messengers that control various aspects of cellular signaling. We have previously shown that two PI cycle enzymes, type II phosphatidylinositol 5-phosphate 4-kinase (PIPK IIα) and phosphoinositide 3-kinase (PI3K), are activated through light stimulation. In our earlier studies, we measured enzyme activities, instead of directly measuring the products, due to lack of sensitive analytical techniques. Cells have very low levels of PIs, compared to other lipids, so special techniques and sensitive analytical instruments are necessary for their identification and quantification. There are also other considerations, such as different responses in different cell …

Cinématique Et Modélisation Biomécanique De L’Épaule Lors De Tâches De Manutention, Landry Desmoulins, Benjamin Michaud, Paul Allard, André Plamondon, Mickaël Begon

Rapports de recherche scientifique

De récentes revues de la littérature épidémiologique montrent que travailler avec les bras en position levée augmente la probabilité de développer des troubles musculosquelettiques (TMS) aux épaules. Bien que l’origine et les mécanismes de TMS à l’épaule manquent d’évidence dans la littérature scientifique, réaliser une tâche avec les bras en position levée cause un chargement de la musculature de l’épaule plus important. Cependant, peu d’éléments permettent d’expliquer les raisons pour lesquelles cette posture avec les bras élevés est gênante, et comment celle-ci affecte le membre supérieur en mouvement. La modélisation musculosquelettique du corps humain est aujourd’hui un moyen efficace et …

Manipulating The Tumor Microenvironment For Therapeutic Benefit, Kate M. Bailey

USF Tampa Graduate Theses and Dissertations

The physical tumor microenvironment contributes significantly to carcinogenesis, cancer progression and metastatic dissemination. Two main components of the tumor microenvironment, hypoxia and acidosis, are present in nearly every solid tumor and act as powerful selection forces against the tumor. Hypoxia and acidosis promote tumor heterogeneity and contribute to chemotherapy and radiotherapy resistance. This dissertation interrogates methods to target the tumor microenvironment including two novel studies describing mechanisms of buffer therapy resistance and targeting tumor hypoxia with vasodilators to enhance the efficacy of a hypoxia activated prodrug, TH-302.

In the first study, mechanisms of buffer therapy resistance were identified and detailed. …

Cancer And Infection, Kathleen Hope Plummer

USF Tampa Graduate Theses and Dissertations

E. coli is the most frequently isolated Gram negative pathogen from bacteremia in cancer patients and is repeatedly recovered from many other extraintestinal illnesses. These infections are commonly endogenous in nature and interfere with the treatment of cancer resulting in increased healthcare costs, morbidity, and mortality rates. Cancer and the treatments related to cancer cause alterations in the microbiome of the gut and other organs. Despite this point, there is a serious lack of knowledge about the genetic types of E. coli infecting cancer patients. This gap results in vague prevention strategies and limited treatment options for cancer patients. Multi …

Family-Specific, Novel, Deleterious Germline Variants Provide A Rich Resource To Identify Genetic Predispositions For Brcax Familial Breast Cancer., Hongxiu Wen, Yeong C. Kim, Carrie Snyder, Fengxia Xiao, Elizabeth A. Fleissner, Dina Becirovic, Jiangtao Luo, Bradley Downs, Simon Sherman, Kenneth Cowan, Henry T. Lynch, San Ming Wang

Journal Articles: Eppley Institute

BACKGROUND: Genetic predisposition is the primary risk factor for familial breast cancer. For the majority of familial breast cancer, however, the genetic predispositions remain unknown. All newly identified predispositions occur rarely in disease population, and the unknown genetic predispositions are estimated to reach up to total thousands. Family unit is the basic structure of genetics. Because it is an autosomal dominant disease, individuals with a history of familial breast cancer must carry the same genetic predisposition across generations. Therefore, focusing on the cases in lineages of familial breast cancer, rather than pooled cases in disease population, is expected to provide …

Crohn’S Disease Linked Polymorphisms Associated With Autophagy Contribute To Th17 Cell Induction Through Increasing The Expression Of Il-1Β And Tnf-Α, Daniel Clayton Morse

Pursuit - The Journal of Undergraduate Research at The University of Tennessee

Genome wide association studies (GWAS) have linked polymorphisms in autophagy genes to Crohn’s Disease (CD). Interestingly, recent studies have shown that defective autophagy leads to increased levels of the cytokines IL-1b and TNF-a, which play a critical role in Th17 cell differentiation. This is significant because CD is marked by a Th17 cell mediated inflammatory response. This article examines the manners in which defective expression of autophagy linked proteins, can indirectly amplify and sustain Th17 cell induction through increasing the production of Th17 positively differentiating cytokines (IL-1b and TNF-a) and decreasing the production of a Th17 down regulating cytokine, IL-10.

Fty720 (Fingolimod) Provides Insight Into The Molecular Mechanisms Of Multiple Sclerosis, Madelyn Elizabeth Crawford

Pursuit - The Journal of Undergraduate Research at The University of Tennessee

Multiple sclerosis (MS) is a neurodegenerative disorder caused by a prolonged immune- mediated inflammatory response that targets myelin. Nearly all of the drugs approved for the treatment of MS are general immunosuppressants or only function in symptom management. The oral medication fingolimod, however, is reported to have direct therapeutic effects on cells of the central nervous system in addition to immunomodulatory functions. Fingolimod is known to interact with sphingosine-1-phosphate (S1P) receptors, and the most widely- accepted theory for its mechanism of action is functional antagonism of the receptor. This review examines significant neuromodulatory effects achieved by functional antagonism of the …

Alpha, Beta, Launch: A Newbie's Guide To Educational Video Game Development, Colleen Krahulik, Lori Goszczynski

Journal of Interactive Humanities

This paper details the process we went through to develop an educational video game, which includes: research on implementing video games into the classroom, vendor selection, video game design, and curriculum development. Throughout the video game development process, we faced challenges such as budget, time constraint, and varying areas of expertise. This paper serves as a guideline for similar organizations interested in educational video game development.

Play game on desktop or tablet: www.avma.org/videogame

Play within browser: https://www.avma.org/KB/K12/videogame/index.html

Human Mesenchymal Stem Cells Modulate Inflammatory Cytokines After Spinal Cord Injury In Rat, Lucia Machová Urdzíková, Jiří Růžička, Michael Labagnara, Kristýna Kárová, Šárka Kubinová, Klára Jiráková, Raj Murali, Eva Syková, Meena Jhanwar-Uniyal, Pavla Jendelová

NYMC Faculty Publications

Transplantation of mesenchymal stem cells (MSC) improves functional recovery in experimental models of spinal cord injury (SCI); however, the mechanisms underlying this effect are not completely understood. We investigated the effect of intrathecal implantation of human MSC on functional recovery, astrogliosis and levels of inflammatory cytokines in rats using balloon-induced spinal cord compression lesions. Transplanted cells did not survive at the lesion site of the spinal cord; however, functional recovery was enhanced in the MSC-treated group as was confirmed by the Basso, Beattie, and Bresnahan (BBB) and the flat beam test. Morphometric analysis showed a significantly higher amount of remaining …

Cama Newsletter - June, 2014, Civil Aviation Medical Association

Browse all Civil Aviation Medical Association Newsletters

A twelve page newsletter of the Civil Aviation Medical Association. The newsletter provided news about civil aviation medicine and information related to the organization.

Should Expectations About The Rate Of New Antiretroviral Drug Development Impact The Timing Of Hiv Treatment Initiation And Expectations About Treatment Benefits?, Amin Khademi, R. Scott Braithwaite, Denis Saure, Andrew J. Schaefer, Kimberly Nucifora, Mark S. Roberts

Publications

Background: Many analyses of HIV treatment decisions assume a fixed formulary of HIV drugs. However, new drugs are approved nearly twice a year, and the rate of availability of new drugs may affect treatment decisions, particularly when to initiate antiretroviral therapy (ART).

Objectives: To determine the impact of considering the availability of new drugs on the optimal initiation criteria for ART and outcomes in patients with HIV/AIDS.

Methods: We enhanced a previously described simulation model of the optimal time to initiate ART to incorporate the rate of availability of new antiviral drugs. We assumed that the future rate of availability …

Medical Student Led Grief & Loss Support Group, Amy Waldner

E-Learning Modules

The George Washington University School of Medicine and Health Sciences initiated a medical student peer to peer support group organized and led entirely by students. It is unique from traditional groups in that it is devoid of faculty/administrative presence and exists purely to support students who are suffering from acute or prolonged grief. The group meets once per month and discusses topics that are particularly difficult for medical students who have recently lost a close friend or family member. All students are invited and announcements are provided monthly via email. Faculty and students have made a concerted effort to encourage …

Il-4 Signaling Drives A Unique Arginase+/Il-1Β+ Microglia Phenotype And Recruits Macrophages To The Inflammatory Cns: Consequences Of Age-Related Deficits In Il-4rα After Traumatic Spinal Cord Injury, Ashley M. Fenn, Jodie C.E. Hall, John C. Gensel, Phillip G. Popovich, Jonathan P. Godbout

Spinal Cord and Brain Injury Research Center Faculty Publications

Alternative activation of microglia/macrophages (M2a) by interleukin (IL)-4 is purported to support intrinsic growth and repair processes after CNS injury. Nonetheless, alternative activation of microglia is poorly understood in vivo, particularly in the context of inflammation, injury, and aging. Here, we show that aged mice (18-19 months) had reduced functional recovery after spinal cord injury (SCI) associated with impaired induction of IL-4 receptor α (IL-4Rα) on microglia. The failure to successfully promote an IL-4/IL-4Rα response in aged mice resulted in attenuated arginase (M2a associated), IL-1β, and chemokine ligand 2 (CCL2) expression, and diminished recruitment of IL-4Rα⁺ macrophages to …

Mcivor, Wilfred J., B. 1897? (Mss 506), Manuscripts & Folklife Archives

Manuscript Collection Finding Aids

Finding aid only for Manuscripts Collection 506. Personal patient ledger (1931-1932) of Dr. W.J. McIvor, a physician practicing at Moseley Hospital in Henderson, Kentucky. Includes an unidentified photograph of a woman and the cover of an 1897 book on writing and engrossing.

Money Management For The Severe And Persistently Mentally Ill, Simone Kurtz-Dougherty

Theses and Dissertations

Five men diagnosed with Severe and Persistent Mental Illness (SPMI) were recruited from a partial care program to participate in a study on the efficacy of teaching money management skills. The participants were also assessed on perceived stress, financial strain, and symptomology. The men were randomly assigned to either an experimental group or a waitlist control group; both groups received an intervention for money management consisting of a workshop on budgeting and weekly coaching based on expenses. Participants in the experimental group received the money management class immediately after a pretest baseline was established and the wait-list control group received …

Erectile Dysfunction As A Motivational Tool For Health Behavior Change In Men With Diabetes, Camille W. Allred, Donna Freeborn

Student Works

The purpose of this literature review is to outline a health promotion plan for healthcare providers and diabetes educators, using erectile dysfunction (ED) as a motivational tool to change health behaviors for men with diabetes. Because the most severe complications might not manifest themselves until later in life, patients with either type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM) are less likely to make the dramatic behavioral changes necessary to control their diabetes at the time of diagnosis. Twenty-eight articles obtained from CINAHL and Medline databases were examined. Eleven of those articles were selected for analysis based …

Applying Modeled Hemi-Ellipsoids To The Study Of Pressure Distribution In Normal And Paraplegic Seated Subjects, Alicia Billington

USF Tampa Graduate Theses and Dissertations

The three goals of this research were to investigate how normal subjects move while seated, how paraplegic patients move while seated, and whether seated movements can be modeled using a hemi-ellipsoid shape. Pressure readings were recorded at 11 Hz using a 36 by 36 sensor pressure map by XSENSOR. Subjects were instructed to move or perform pressure relief as they normally would while seated. Analysis was performed using Microsoft Excel with Solver and Matrix.xla add-ins and automated with VBA code. Major movements and time intervals between movements were calculated by locating the area of maximum pressure on each hemi-buttock for …

Application Of Nuclear Magnetic Resonance Based Metabolomics To Study The Central Metabolism Of Staphylococci, Bo Zhang

Department of Chemistry: Dissertations, Theses, and Student Research

Metabolomics studies the collection of small molecules (metabolites) involved in enzymatically catalyzed reactions, cell signaling and cellular structure. Perturbations in metabolite concentrations have been used to reflect the activity of corresponding enzymes or proteins. Nuclear magnetic resonance (NMR) spectroscopy is a well-known approach for the structure determination of biological macromolecules. Alternatively, NMR has recently been established as a valuable tool of metabolomics, in which NMR spectral signals correlate small molecules with cellular activities. This has been accomplished through the chemometric analysis of high-throughput one dimensional ¹H spectra (metabolic fingerprinting) and quantitative metabolite identification based on two dimensional ¹H, …