Medicine and Health Sciences Commons^™

Health-Related Quality Of Life And Life Satisfaction In Colorectal Cancer Survivors: Trajectories Of Adjustment, Jeff Dunn, Shu Kay Ng, William Breitbart, Joanne Aitken, Pip Youl, Peter D. Baade, Suzanne K. Chambers

Research outputs 2013

Background: This longitudinal study describes the five year trajectories of health-related quality of life (HR-QOL) and life satisfaction in long term colorectal cancer survivors.Patients and methods: A population-based sample of 1966 colorectal cancer survivors were surveyed at six time points from five months to five years post-diagnosis. Predictor variables were: socio-demographic variables, optimism; cancer threat appraisal; perceived social support. Quality of life was assessed with the Functional Assessment of Cancer Therapy-Colorectal (HR-QOL); and the Satisfaction with Life Scale. Growth mixture models were applied to identify trajectory classes and their predictors.Results: Distinct adjustment trajectories were identified for HR-QOL and life satisfaction. …

Assisted Vaginal Deliveries In Mothers Admitted As Public Or Private Patients In Western Australia, Kristjana Einarsdottir, Fatima Haggar, Sarah Stock, Anthony Gunnell, Fiona Stanley

Research outputs 2013

Background: Mothers delivering as private patients in Australia have a high rate of assisted deliveries, which could lead to adverse infant outcomes in this group of patients. We investigated whether the risk of adverse infant outcomes after assisted deliveries was different for mothers admitted as public or private patients for delivery, when compared with unassisted deliveries.

Methods and findings: We included 158,241 vaginal, singleton, term birth admissions in our study where the infant was live born and without birth defects. The study population was identified from statutory birth and hospital data collections held by the Western Australian (WA) Department of …

Development Of Neurology In Pakistan., Sardar M. Alam

Pakistan Journal of Neurological Sciences (PJNS)

On the eve of the 20th Annual Neurology Conference we can look back over the last two decades to assess the development of Neurology in Pakistan. Neurology first functioned under the banner of Pakistan Academy of Neurological Sciences (PANS) and then as Pakistan Society of Neurology (PSN).

Role Of Complementary And Alternative Medicine In Cardiovascular Diseases, Waris Qidwai, Peng Nam Yeoh, Victor Inem, Kashmira Nanji, Tabinda Ashfaq

Department of Family Medicine

No abstract provided.

Why I Am Worried About My Post Phd-Degree Life – A Commentary, Jung-Im Shin

Florida Public Health Review

Public health is an area where we will always need professionally-prepared people, but despite desperate needs in higher education, some soon-to-graduate PhD students are concerned that there might not be a place for them. Furthermore, some are concerned about balancing school, work, and family life. Perhaps now more than ever public health professional programs and schools need to devote resources toward career counseling and job placement.

The Sunland Training Centers: Florida’S Institutes For Children With Intellectual Disabilities, Kim Curry

Florida Public Health Review

Developmental disabilities affect about one out of every six children in the United States. These conditions create significant financial and social costs to families and society. Specifically, questions have long arisen as to how best to manage the needs of persons with intellectual disabilities. Historically, the nomenclature used to address intellectual disabilities has evolved as has the philosophy of venues to provide optimal care and the development of specific skills for conducting this care. Considerable dissension still exists about the type and nature of institutional care for even the most profoundly disabled individuals. This paper reviews relevant history, including laws, …

Potential Natural Product Phosphodiesterase Inhibitors, Michael John Cunningham

Electronic Theses and Dissertations

Three different studies set forth to investigate the role of phosphodiesterase (PDE) enzyme inhibitors in sexual dysfunction and mood regulation. First, naturalproducts were screened by computer modeling of PDE5A1. Second, compounds were isolated from a plant traditionally used as an aphrodisiac. Third, a new synthesis of psychoactive PDE4 inhibitor was attempted. An in silico screen was performed using chemical structures of isolated compounds thought to have some PDE inhibitory activity based on traditional use of the plants. A collection of compounds with structures similar to known natural product inhibitors was also included in the docking library. Glide docking software (Schrödinger) …

Structural Characterization And Bioactivity Of Cranberry Oligosaccharides, Kimberly M. Auker

Electronic Theses and Dissertations

Complex carbohydrates from plant sources, such as the fruits of cranberry (Vaccinium macrocarpon Aiton), promote human health in a variety of ways. However, complete studies of carbohydrate function often hinge on a detailed understanding and thorough elucidation of the chemical structure. Several methods have been used in the structure elucidation of cranberry oligosaccharides, such as derivatization folloby analysis using gas chromatography-mass spectrometry (GC-MS). In this manner, the identity and quantity of glycosyl units within two cranberry oligosaccharides were investigated through hydrolysis of the oligomers and subsequent synthesis of trimethylsilyl and alditol acetate derivatives. Further analysis using partially methylated alditol acetate …

Effects Of Sauna On Flexibility, Muscle Strength And Cortisol Level In People With Allergic Rhinitis, N Kunbootsri, P Arayawichanond, S Chainunsmith, J Kanpittaya, K Sawanyawisut, P Auvichayapat, T. Janyacharoen

Chulalongkorn Medical Journal

Backgrounds : Nowadays, the role of thermotherapy has been increase for therapeutic purposes. Sauna is known as a heat modality for relaxation, skin circulation, flexibility and pain reduction. It should be useful to alter muscle activity and reduce stress in people with allergic rhinitis. The advantage of sauna is muscle relaxation and increase of blood flow. It would be useful to know the effects of sauna in altering muscle and cortisol level in people with allergic rhinitis in order to determine suitable alternative treatment. However, none of studies has reported the effect of sauna on flexibility, muscle strength and cortisol …

Prevalence Of Ugt1a4 And Ugt2b7 Polymorphisms In Thai Patients, N Singkham, S Towanabut, S Lertkachatarn, B. Punyawudho

Chulalongkorn Medical Journal

Background : UGT1A4 and UGT2B7 play an important role in the metabolism of several endogenous substrates and xenobiotics including clozapine, morphine and lamotrigine. The polymorphisms of UGT1A4 and UGT2B7 may be associated with the variability of glucuronidation activity which leads to the interindividual variability of lamotrigine concentrations among patients. Even though, there is an evidence of the variation of UGT polymorphisms between races, the information of UGT polymorphisms in Thai population is limited. Objective : To investigate the frequencies of UGT1A4 and UGT2B7 polymorphisms in Thai patients. Setting : Prasat Neurological Institute, Bangkok. Research design : Prospective descriptive study. Patients …

Quality Of Life Of Registered Nurses In Private International Hospital., K Toojinda, S. Suppapitiporn

Chulalongkorn Medical Journal

Background : Nurse are a healthcare professionals who are responsible for medical clinics and public health. Therefore, the quality of life of registered nurses is vital to perceive on satisfaction towards their life and works. Objective : To study the quality of life and related factors of registered nurses in private international hospital. Design : A cross – sectional descriptive study. Setting : Private International Hospital. Materials and Methods : The research data collected from 281 samples of full-time registered nurses who worked from April 2010 – October 2010, not include the samples who’s under took leave exceed than 3 …

The Journey Of Addiction: Barriers To And Facilitators Of Drug Use Cessation Among Street Children And Youths In Western Kenya, Lonnie Embleton, Lukoye Atwoli, David Ayuku, Paula Braitstein

Internal Medicine, East Africa

This mixed-methods study examined barriers to and facilitators of street children’s drug use cessation in Eldoret, Kenya utilizing a cross-sectional survey and focus group discussions with a community-based sample of street-involved children and youth. The primary objective of this study was to describe factors that may assist or impede cessation of drug use that can be utilized in developing substance use interventions for this marginalized population. In 2011, 146 children and youth ages 10–19 years, classified as either children on the street or children of the street were recruited to participate in the cross-sectional survey. Of the 146 children that …

Should We Use Preoperative Epoetin-Α In The Mildly Anemic Patient Undergoing Simultaneous Total Knee Arthroplasty?, Lawrence A Delasotta, Fabio Orozco, S Mehdi Jafari, Jamie L Blair, Alvin Ong

Rothman Institute Papers

Simultaneous knee arthroplasty is associated with significant blood loss. To prevent transfusion, three preoperative doses of epoetin-α were offered to mildly anemic simultaneous knee arthroplasty patients. A retrospective review, using ICD-9 codes, identified twenty patients from 2007-2009. Epoetin-α increased hemoglobin levels preoperatively (12.6 to 13.9, p

Physiotherapists Have Accurate Expectations Of Their Patients’ Future Health-Related Quality Of Life After First Assessment In A Subacute Rehabilitation Setting, Steven M. Mcphail, Emily Nalder, Anne-Marie Hill, Terry P. Haines

Physiotherapy Papers and Journal Articles

Background.

Expectations held by health professionals and their patients are likely to affect treatment choices in subacute inpatient rehabilitation settings for older adults. There is a scarcity of empirical evidence evaluating whether health professionals expectations of the quality of their patients’ future health states are accurate.

Methods.

A prospective longitudinal cohort investigation was implemented to examine agreement (kappa coefficients, exact agreement, limits-of-agreement, and intraclass-correlation coefficients) between physiotherapists’ (n=23) prediction of patients’ discharge health-related quality of life (reported on the EQ-5D-3L) and the actual health-related quality of life self-reported by patients (n=272) at their discharge assessment (using the EQ-5D-3L). The mini-mental …

Cost Effectiveness Of Patient Education For The Prevention Of Falls In Hospital: Economic Evaluation From A Randomized Controlled Trial, Terry P. Haines, Anne-Marie Hill, Keith D. Hill, Sandra G. Brauer, Tammy Hoffmann, Christopher Etherton-Beer, Steven M. Mcphail

Physiotherapy Papers and Journal Articles

Background

Falls are one of the most frequently occurring adverse events that impact upon the recovery of older hospital inpatients. Falls can threaten both immediate and longer-term health and independence. There is need to identify cost-effective means for preventing falls in hospitals. Hospital-based falls prevention interventions tested in randomized trials have not yet been subjected to economic evaluation.

Methods

Incremental cost-effectiveness analysis was undertaken from the health service provider perspective, over the period of hospitalization (time horizon) using the Australian Dollar (A$) at 2008 values. Analyses were based on data from a randomized trial among n = 1,206 acute and …

อัตมโนทัศน์ทางเพศ : ผู้ป่วยโรคกล้ามเนื้อหัวใจตาย (Sexual Self-Concept: Myocardial Infarction Patients), วินิตย์ หลงละเลิง, นรลักขณ์ เอื้อกิจ

Journal of Nursing Research, Innovation, and Health

อัตมโนทัศน์ทางเพศเป็นปัจจัยด้านจิต-สังคมที่มีอิทธิพลต่อพฤติกรรมทางเพศของบุคคล เนื่องจากเป็นความรู้สึกที่มีต่อพฤติกรรมทางเพศที่เกี่ยวกับตนเองและมีอิทธิพลต่อการสร้างความสัมพันธ์ กับผู้อื่นรวมทั้งการรับรู้เกี่ยวกับคุณลักษณะความสามารถของตนต่อพฤติกรรมทางเพศ การรับรู้อัตมโนทัศน์ ทางเพศ (Sexual self-concept) ประกอบด้วย 4 ด้าน คือ 1) ความพึงพอใจในการมีเพศสัมพันธ์ (Sexual satisfaction) 2) ความวิตกกังวลในการมีเพศสัมพันธ์ (Sexual anxiety) 3) การรับรู้สมรรถนะแห่ง ตนในการมีเพศสัมพันธ์ (Perceived sexual self-efficacy) และ 4) ภาวะซึมเศร้าในการมีเพศสัมพันธ์ (Sexual depression) แนวคิดดังกล่าวได้ประยุกต์ใช้กับผู้ป่วยโรคหัวใจวายและโรคกล้ามเนื้อหัวใจตายพบว่า อัตมโนทัศน์ทางเพศมีความสัมพันธ์ทางบวกกับพฤติกรรมทางเพศ เมื่อพิจารณารายด้าน พบว่าความพึงพอใจในการมีเพศสัมพันธ์และการรับรู้สมรรถนะแห่งตนในการมีเพศสัมพันธ์มีความสัมพันธ์ทางบวกกับ พฤติกรรมทางเพศของผู้ป่วยโรคหัวใจวายและโรคกล้ามเนื้อหัวใจตาย ขณะที่ความวิตกกังวลในการมีเพศสัมพันธ์และภาวะซึมเศร้าในการมีเพศสัมพันธ์มีความสัมพันธ์ทางลบกับพฤติกรรมทางเพศของผู้ป่วย โรคหัวใจวายและโรคกล้ามเนื้อหัวใจตาย

อิทธิพลของความรู้สึกไม่แน่นอนในความเจ็บป่วย ความแตกฉานด้านสุขภาพ การสนับสนุนทางสังคมต่อคุณภาพชีวิตของผู้ป่วยภาวะหัวใจล้มเหลว (The Influence Of Uncertainty In Illness, Health Literacy, And Social Support On Quality Of Life Of Patients With Heart Failure), วนิดา หาจักร, ดวงรัตน์ วัฒนกิจไกรเลิศ

Journal of Nursing Research, Innovation, and Health

วัตถุประสงค์: เพื่อศึกษาคุณภาพชีวิตของผู้ป่วยภาวะหัวใจล้มเหลว และทำนายความรู้สึกไม่แน่นอนใน ความเจ็บป่วย ความแตกฉานด้านสุขภาพ และการสนับสนุนทางสังคมที่มีต่อคุณภาพชีวิตของผู้ป่วย ภาวะหัวใจล้มเหลว \nรูปแบบการวิจัย: การวิจัยเชิงความสัมพันธ์พยากรณ์ \nวิธีดำเนินการวิจัย: กลุ่มตัวอย่าง คือ ผู้ป่วยภาวะหัวใจล้มเหลวอายุมากกว่าหรือเท่ากับ 18 ปี ที่มา ติดตามรับการรักษา ณ คลินิกโรคหัวใจ โรงพยาบาลสรรพสิทธิประสงค์ จังหวัดอุบลราชธานี จำนวน 85 ราย เครื่องมือที่ใช้ในการเก็บรวบรวมข้อมูล คือ แบบสอบถามข้อมูลส่วนบุคคล แบบสอบถามความ รู้สึกไม่แน่นอนในความเจ็บป่วยฉบับชุมชน แบบประเมินความแตกฉานด้านสุขภาพขั้นพื้นฐานสำหรับ ผู้ป่วยภาวะหัวใจล้มเหลว แบบวัดการช่วยเหลือทางสังคมแบบพหุมิติ และแบบสอบถามวิถีชีวิตของ ผู้ป่วยภาวะหัวใจล้มเหลว ผ่านการตรวจสอบความตรงตามเนื้อหาและวิเคราะห์ความเที่ยงแล้ว มีค่า ความเที่ยงมากกว่า 0.80 วิเคราะห์ข้อมูลโดยใช้สถิติเชิงพรรณนา สัมประสิทธิ์สหสัมพันธ์ของเพียร์สัน \nและการวิเคราะห์ถดถอยแบบเข้าพร้อมกัน \nผลการวิจัย: \n1. ผู้ป่วยภาวะหัวใจล้มเหลวมีคุณภาพชีวิตอยู่ในระดับปานกลางร้อยละ 54.1 \n2. ผู้ป่วยภาวะหัวใจล้มเหลวมีความแตกฉานด้านสุขภาพอยู่ในระดับไม่เพียงพอร้อยละ 47.1\n3. ความรู้สึกไม่แน่นอนในความเจ็บป่วยเพียงตัวแปรเดียวที่สามารถทํานายคุณภาพชีวิตของ ผู้ป่วยภาวะหัวใจล้มเหลวได้อย่างมีนัยสำคัญทางสถิติ (B = 651, p < .001) \n4. ความรู้สึกไม่แน่นอนในความเจ็บป่วย ความแตกฉานด้านสุขภาพ การสนับสนุนทางสังคม สามารถร่วมกันทำนายคุณภาพชีวิตของผู้ป่วยภาวะหัวใจล้มเหลวได้ร้อยละ 46.8 อย่างมีนัยสําคัญทางสถิติ AWANG (R2 = .468, p < .001) \nสรุปและข้อเสนอแนะ: \nการศึกษาครั้งนี้พบว่าความรู้สึกไม่แน่นอนในความเจ็บป่วยสามารถทำนายคุณภาพ ชีวิตได้สูง จึงควรนำผลการวิจัยที่ได้มาพัฒนาโปรแกรมการดูแลผู้ป่วย และมีการทดสอบประสิทธิผลของ โปรแกรม เพื่อลดความรู้สึกไม่แน่นอนในความเจ็บป่วยที่จะส่งผลให้ผู้ป่วยภาวะหัวใจล้มเหลวมีคุณภาพชีวิต ที่ดีต่อไป

Teachers' Awareness And Skills In Addressing Students With Anxiety Symptoms, Looyee Figueroa

PCOM Psychology Dissertations

This study explored teachers' awareness toward students who may have mental-health needs, specifically with anxiety issues. This study also examined whether the teachers' training backgrounds, acquired degrees, stress levels, and years of teaching influenced their awareness and use of strategies in addressing students with attitudinal and behavioral issues and anxiety issues. In addition, this study examined teachers' perceptions on the importance of building relationships with students who have behavioral and attitudinal issues and anxiety issues. Results from the study found that teachers' awareness levels were inconsistent when teaching students who may have anxiety issues, and they were more consistent in …

Are Women Aware? : Factors Related To Women's Knowledge Of Risk And Preventive Factors In Breast Cancer, Sandra M. Walther

Dissertations

Problem. Women have a one-in-eight chance of being diagnosed with breast cancer in their lifetime. In the past decade, there has only been a decrease of less than 1% in breast cancer morbidity and mortality rates. Breast cancer continues to be a feared disease that ravages even its survivors, and grips many with fear. Furthermore, breast cancer remains the highest cost of care among cancers. In 1990 the overall cost of care for breast cancer was $4.2 billion. In 2010, the total cost of breast cancer care rose to almost $17 billion, and by 2020 the cost trends show …

Electroporation-Mediated Gene Transfer Directly To The Swine Heart, Barbara Hargrave, Harre Downey, Cathryn Lundberg, Annelise Israel, Yeong-Jer Chen, Richard Heller

Bioelectrics Publications

In vivo gene transfer to the ischemic heart via electroporation holds promise as a potential therapeutic approach for the treatment of heart disease. In the current study, we investigated the use of in vivo electroporation for gene transfer using three different penetrating electrodes and one non-penetrating electrode. The hearts of adult male swine were exposed through a sternotomy. Eight electric pulses synchronized to the rising phase of the R wave of the electrocardiogram were administered at varying pulse widths and field strengths following an injection of either a plasmid encoding luciferase or one encoding green fluorescent protein. Four sites on …

Teams Of Community Health Workers And Nursing Students Effect Health Promotion Of Underserved Urban Neighborhoods, Gail Landheer Zandee, Debra Bossenbroek, Dianne Slager, Beth Gordon

University Faculty Publications and Creative Works

Objective(s): The purpose of this study was to explore the effectiveness of CHW/ nursing student teams in promoting secondary protection and improving access to care for residents of three urban underserved neighborhoods. The study also sought to measure CHW and resident satisfaction of such a program. Design and Sample: Quasi-experimental and nonexperimental designs were used for the study. Convenience samples consisted of residents who participated in the CHW program during 2005–2006, CHWs and residents who participated in the CHW program during 2005–2007 and a systematic random sample of residents across the three neighborhoods. Measures: Three quantitative measures …

Use Of Evidence-Based Practice Among Athletic Training Educators, Clinicians, And Students, Part 2: Attitudes, Beliefs, Accessibility, And Barriers, Cailee W. Mccarthy, Dorice A. Hankemeier, Jessica M. Walter, Eric J. Newton, Bonnie L. Van Lunen

Rehabilitation Sciences Faculty Publications

Context: Successful implementation of evidence-based practice (EBP) within athletic training is contingent upon understanding the attitudes and beliefs and perceived barriers toward EBP as well as the accessibility to EBP resources of athletic training educators, clinicians, and students.

Objective: To assess the attitudes, beliefs, and perceived barriers toward EBP and accessibility to EBP resources among athletic training educators, clinicians, and students.

Design: Cross-sectional study.

Setting: Online survey instrument.

Patients or Other Participants: A total of 1209 athletic trainers participated: professional athletic training education program directors (n = 132), clinical preceptors (n = 266), clinicians (n = 716), postprofessional athletic training …

Use Of Evidence-Based Practice Among Athletic Training Educators, Clinicians, And Students, Part 1: Perceived Importance, Knowledge, And Confidence, Dorice A. Hankemeier, Jessica M. Walter, Cailee W. Mccarty, Eric J. Newton, Stacy E. Walker, Shana L. Pribesh, Beth E. Jamali, Sarah A. Manspeaker, Bonnie L. Van Lunen

Rehabilitation Sciences Faculty Publications

Context:

Although evidence-based practice (EBP) has become more prevalent, athletic trainers' perceptions of importance and knowledge of these concepts and their confidence in EBP are largely unknown.

Objective:

To assess perceived importance and knowledge of and confidence in EBP concepts in athletic trainers in various roles and with different degree levels.

Design:

Cross-sectional study.

Setting:

Online survey instrument.

Patients or Other Participants:

The survey was sent to 6702 athletic training educators, clinicians, and postprofessional students. A total of 1209 completed the survey, for a response rate of 18.04%.

Main Outcome Measure(s):

Demographic information and perceived importance and knowledge of and …

Instruction And Jump-Landing Kinematics In College-Aged Female Athletes Over Time, Jena Etnoyer, Nelson Cortes, Stacie I. Ringleb, Bonnie L. Van Lunen, James A. Onate

Rehabilitation Sciences Faculty Publications

Context: Instruction can be used to alter the biomechanical movement patterns associated with anterior cruciate ligament (ACL) injuries.

Objective: To determine the effects of instruction through combination (self and expert) feedback or self-feedback on lower extremity kinematics during the box–drop-jump task, running–stop-jump task, and sidestep-cutting maneuver over time in college-aged female athletes.

Design: Randomized controlled clinical trial.

Setting: Laboratory.

Patients or Other Participants: Forty-three physically active women (age = 21.47 ± 1.55 years, height = 1.65 ± 0.08 m, mass = 63.78 ± 12.00 kg) with no history of ACL or lower extremity injuries or surgery in the 2 months …

Perceptions Of Approved Clinical Instructors: Barriers In The Implementation Of Evidence-Based Practice, Dorice A. Hankemeier, Bonnie L. Van Lunen

Rehabilitation Sciences Faculty Publications

Context: As evidence-based practice (EBP) becomes prevalent in athletic training education, the barriers that Approved Clinical Instructors (ACIs) experience in implementing it with students need to be understood.

Objective: To investigate barriers ACIs face when implementing EBP concepts in clinical practice and in teaching EBP to professional athletic training students and to investigate the educational emphases to improve the barriers.

Design: Qualitative study.

Setting: Telephone interviews.

Patients or Other Participants: Sixteen ACIs (11 men, 5 women; experience as an athletic trainer = 10 ± 4.7 years, experience as an ACI = 6.81 ± 3.9 years) were interviewed.

Data Collection and …

Test-Retest Reliability And Construct Validity Of The Tinetti Performance-Oriented Mobility Assessment In People With Stroke, Jennifer Canbek, George Fulk, John Echternach

Rehabilitation Sciences Faculty Publications

Background and Purpose: The Tinetti Performance-Oriented Mobility Assessment (POMA) is commonly used to measure balance ability in older adults. The purpose of this study was to determine the test-retest reliability and minimal detectable change (MDC) of the POMA and explore its cross-sectional and longitudinal construct validity for use in people early after stroke.

Methods: Participants were recruited if they had a first documented stroke and were receiving physical therapy during inpatient rehabilitation. The POMA, gait speed, and motor Functional Independence Measure (FIM) scores were collected at admission and at discharge from inpatient rehabilitation. A second trial of the POMA was …

Using The Theory Of Planned Behavior As A Predictor Of Radiologic Technologists' Use Of Patient Radiation Protection Best Practices: A Regional Study, Brenda L. Boyd

Dissertations

Problem. A growing concern exists that patients are receiving an increase in radiation exposure while undergoing medical imaging exams. According to a March 2009 report by the National Council on Radiation Protection and Measurements (NCRP), the U.S. population's total exposure to ionizing radiation has nearly doubled over the past two decades. With the introduction of new digital radiology equipment, patient dose is on the rise. Possible reasons for a radiologic technologist's behavior include: influence by availability or lack of equipment, policies, social pressure, attitudes, and a safety culture. Little research has been done in this area, specifically with applying a …

Effectiveness Of Low-Level Laser Therapy Combined With An Exercise Program To Reduce Pain And Increase Function In Adults With Shoulder Pain: A Critically Appraised Topic, Aimee L. Thornton, Cailee W. Mccarty, Mollie-Jean Burgess

Rehabilitation Sciences Faculty Publications

Clinical Scenario: Shoulder pain is a common musculoskeletal condition that affects up to 25% of the general population. Shoulder pain can be caused by any number of underlying conditions including subacromial impingement syndrome, rotator-cuff tendinitis, and biceps tendinitis. Regardless of the specific pathology, pain is generally the number 1 symptom associated with shoulder injuries and can severely affect daily activities and quality of life of patients with these conditions. Two of the primary goals in the treatment of these conditions are reducing pain and increasing shoulder range of motion (ROM).(3) Conservative treatment has traditionally included a therapeutic exercise program targeted …

Aortic Dissection Presenting As Gait Disturbance: A Case Report., Michael Estreicher, Joseph Portale, Bernard Lopez

Department of Emergency Medicine Faculty Papers

Emergency medicine dogma traditionally teaches that aortic dissection presents as tearing chest pain, radiating to the back. This case report describes a 55 year old woman presenting with a left homonymous hemianopsia and resultant gait disturbance. Initial head CT demonstrated a right parietal infarct, and chest radiograph demonstrated a markedly widened mediastinum. Acute Stanford Type A aortic dissection was subsequently confirmed. This report provides further evidence for atypical, painless presentations of aortic dissection. Given recent literature on the increasing prevalence of painless dissection, the disease entity should be included in the differential diagnosis for stroke, and a simple portable chest …

Tumor Necrosis Factor-Α And Lymphotoxin-Α Mediate Myocardial Ischemic Injury Via Tnf Receptor 1, But Are Cardioprotective When Activating Tnf Receptor 2., Yanqing Zhang, Jianli Zhao, Wayne Bond Lau, Li-Yuan Jiao, Baojiang Liu, Yuexing Yuan, Xiaoliang Wang, Erhe Gao, Walter J Koch, Xin-Liang Ma, Yajing Wang

Department of Emergency Medicine Faculty Papers

OBJECTIVE: This study determines the roles of tumor necrosis factor-α (TNFα) and lymphotoxin-α (LTα) in post-myocardial infarction (post-MI) cardiac injury, and identifies the TNF receptor type responsible for TNFα- and LTα-mediated cardiac injury.

METHODS AND RESULTS: Adult male wild type (WT), TNFα(-/-), LTα(-/-), TNFR1(-/-), and TNFR2(-/-) mice were subjected to MI via coronary artery occlusion. Functional, histological, and biochemical analyses were performed 1 to 7 days post-MI. In WT mice, MI significantly increased both TNFα and LTα levels in plasma, but in distinct temporal manner. Plasma TNFα peaked 1 day after MI, and decreased toward baseline 3 days after MI. …