Medicine and Health Sciences Commons^™

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Alumni Named HELI Scholars

Epigenetic Regulation Of Bmp2 By 1,25-Dihydroxyvitamin D3 Through Dna Methylation And Histone Modification., Baisheng Fu, Hongwei Wang, Jinhua Wang, Ivana Barouhas, Wanqing Liu, Adam Shuboy, David A. Bushinsky, Dongsheng Zhou, Murray J. Favus

Borch Department of Medicinal Chemistry and Molecular Pharmacology Faculty Publications

Genetic hypercalciuric stone-forming (GHS) rats have increased intestinal Ca absorption, decreased renal tubule Ca reabsorption and low bone mass, all of which are mediated at least in part by elevated tissue levels of the vitamin D receptor (VDR). Both 1,25-dihydroxyvitamin D3(1,25(OH)2D3) and bone morphogenetic protein 2 (BMP2) are critical for normal maintenance of bone metabolism and bone formation, respectively. The complex nature of bone cell regulation suggests a potential interaction of these two important regulators in GHS rats. In the present study, BMP2 expression is suppressed by the VDR-1,25(OH)2D3 complex in Bone Marrow Stromal Cells (BMSCs) from GHS and SD …

The Effects Of Static Stretching On Muscular Hypertrophy During A Resistance Training Program, Zachary A. Martin

Senior Honors Theses

Abstract

Studies have shown that static stretching right before physical activity can negatively affect performance. In regards to weight lifting, it has been shown that static stretching immediately prior to lifting can decrease the maximum amount of weight that can be lifted. This study was created in order to determine if static stretching immediately prior to weight lifting over the course of nine weeks would result in smaller gains in muscle size compared to those who did not static stretch immediately prior to lifting over the course of nine weeks.

Travesty Of Trust: A Critical Look At Racial And Ethnic Discrimination In The Healthcare Setting, Thea A. Beaty

Senior Honors Theses

The purpose of this thesis is to review the overarching purpose of healthcare, examine race-related disparities in minority patient outcomes within specific fields of medical practice, and discuss whether these disparities are the result of racial discrimination within the clinical setting, or are due at least partially to genetic and environmental factors, followed by an examination of how cross-cultural education for healthcare professionals can be improved to equip medical personnel with the attitudes, knowledge, and skills necessary to provide effective care to a culturally diverse patient populace. The benefits of recruiting a culturally and linguistically diverse team of healthcare providers …

Community Health News, Georgia Southern University

Health Policy & Community Health: News & Publications (2011-2018)

• Alumni Named HELI Scholars

Interdisciplinary Health Fair And The Tendencies Of Young Adults To Receive Follow-Up Health Care, Kaelyn Monroe

Honors Theses

The following proposal outlines the planning, implementation, and follow-up regarding an organized health fair that aims to promote healthy lifestyle in a minority population. The health fair will be conducted on October 9' 2012 at Climax Scott's Alternative High School. The populations addressed through this project include: 60 students ranging from 16-19 years of age, 30 individuals 19 years or older and 10 teachers. The health fair will be organized by three senior-level Bronson School of Nursing students: Alexandra Scheidt, Abby Smith, and Kaelyn Momoe. The thesis project committee consists of: Dr. Sally Vliem, Professor Wendy Kershner, and Professor Alice …

Interdisciplinary Health Fair And The Tendencies Of Young Adults To Receive Follow-Up Health Care, Alexandra Scheidt

Honors Theses

The following proposal outlines the planning, implementation, and follow-up regarding an organized health fair that aims to promote healthy lifestyle in a minority population. The health fair will be conducted on October 9' 2012 at Climax Scott's Alternative High School. The populations addressed through this project include: 60 students ranging from 16-19 years of age, 30 individuals 19 years or older and 10 teachers. The health fair will be organized by three senior-level Bronson School of Nursing students: Alexandra Scheidt, Abby Smith, and Kaelyn Momoe. The thesis project committee consists of: Dr. Sally Vliem, Professor Wendy Kershner, and Professor Alice …

A Comparison Of Caregiver And Speech-Language Pathologist's Ratings Of Speech Outcome In Oral Cleft Clinic, Emily Swain

Honors Theses

Background: Cleft lip and/or palate is one of the most common congenital anomalies. The goal of treatment of cleft palate is normal speech, but a proportion of children with clefts exhibit speech disorders. Various outcome measures are used, but relatively few have focused on self-assessment or caregiver perception of outcome. The studies that have been done focus on comparing parents' and speech-language pathologists' ratings of speech outcome. These studies can be used to determine the degree to which caregivers are satisfied with speech outcome over time.

Purpose: The purpose of this study was to describe the relationship between speech ratings …

The Santa Clara, 2013-04-18, Santa Clara University

The Santa Clara

No abstract provided.

Pharmacology And Clinical Potential Of Guanylyl Cyclase C Agonists In The Treatment Of Ulcerative Colitis., Giovanni M Pitari

Department of Pharmacology and Experimental Therapeutics Faculty Papers

Agonists of the transmembrane intestinal receptor guanylyl cyclase C (GCC) have recently attracted interest as promising human therapeutics. Peptide ligands that can specifically induce GCC signaling in the intestine include endogenous hormones guanylin and uroguanylin, diarrheagenic bacterial enterotoxins (ST), and synthetic drugs linaclotide, plecanatide, and SP-333. These agonists bind to GCC at intestinal epithelial surfaces and activate the receptor's intracellular catalytic domain, an event initiating discrete biological responses upon conversion of guanosine-5'-triphosphate to cyclic guanosine monophosphate. A principal action of GCC agonists in the colon is the promotion of mucosal homeostasis and its dependent barrier function. Herein, GCC agonists are …

Today - April 18, 2013, Loma Linda University Health

TODAY

Inside this issue:

-- Center for Perinatal Biology anniversary draws internationally acclaimed scientists to LLU
-- LLUMC CEO recognized for leadership, vision, commitment
-- Chan Shun fund helps LLUSD graduates serve internationally
-- How Adventist health care saved Hai Le twice
-- Research coordinators retreat focuses on their contributions to research
-- My campus event brings minority high school students to Loma Linda University
-- Apprenticeship Bridge to College event draws future scientists to LLU
-- Information systems team bleeds to help others
-- New Women's Cancer and Surgical Oncology Center opens at LLUMC
-- New scholarship honors legacy of …

Testosterone, Cardiovascular, Men, Trial, Lin Xu, Guy Freeman, Benjamin J. Cowling, Mary Schooling

Publications and Research

Background
Testosterone therapy is increasingly promoted. No randomized placebo-controlled trial has been implemented to assess the effect of testosterone therapy on cardiovascular events, although very high levels of androgens are thought to promote cardiovascular disease.

Methods
A systematic review and meta-analysis was conducted of placebo-controlled randomized trials of testosterone therapy among men lasting 12+ weeks reporting cardiovascular-related events. We searched PubMed through the end of 2012 using “(“testosterone” or “androgen”) and trial and (“random*”)” with the selection limited to studies of men in English, supplemented by a bibliographic search of the World Health Organization trial registry. Two reviewers independently searched, …

Androgens Upregulate Cdc25c Protein By Inhibiting Its Proteasomal And Lysosomal Degradation Pathways., Yu-Wei Chou, Li Zhang, Sakthivel Muniyan, Humera Ahmad, Satyendra Kumar, Syed Mahfuzul Alam, Ming-Fong Lin

Journal Articles: Biochemistry & Molecular Biology

Cdc25C is a cell cycle protein of the dual specificity phosphatase family essential for activating the cdk1/Cyclin B1 complex in cells entering into mitosis. Since altered cell cycle is a hallmark of human cancers, we investigated androgen regulation of Cdc25C protein in human prostate cancer (PCa) cells, including androgen-sensitive (AS) LNCaP C-33 cells and androgen-independent (AI) LNCaP C-81 as well as PC-3 cells. In the regular culture condition containing fetal bovine serum (FBS), Cdc25C protein levels were similar in these PCa cells. In a steroid-reduced condition, Cdc25C protein was greatly decreased in AS C-33 cells but not AI C-81 or …

Kannaday: Healthcare Industry Needs To Drive Changes, Kim Hill

News and Events (Discontinued Series)

No abstract provided.

Ethanol Regulation Of Glucocorticoid Responsive Genes, Blair Costin

Theses and Dissertations

Glucocorticoid hormones modulate acute and chronic behavioral and molecular responses to drugs of abuse including psychostimulants and opioids. Acute ethanol activates the hypothalamic pituitary adrenal (HPA) axis causing the release of adrenal glucocorticoid hormones, but following chronic ethanol the HPA axis is dysregulated in both humans and rodents. Thus, there is growing evidence that glucocorticoids might also modulate behavioral and molecular responses to ethanol. Previous microarray studies in the Miles’ laboratory have shown that the well-known glucocorticoid responsive gene, Serum and Glucocorticoid-regulated Kinase 1, Sgk1, is prominently up regulated by acute ethanol (2 g/kg) in the prefrontal cortex (PFC) of …

Residential Treatment Of Adult Women With Eating Disorders, Chelsea Cook

Honors Theses

A qualitative-type study was done in which residents of a residential eating disorder facility were interviewed about their eating disorder and daily life in the treatment center. The Academy of Nutrition and Dietetics uses the Nutrition Care Process which includes Intervention amongst its four steps. This study will look at the intervention of nutrition education and counseling on these residents and relate it back to Social Learning theory.

Eight residents agreed to the study. All participants were female, and ages ranged from 18-38 with an average age of 24.75. The registered dietitian serving the residents was also interviewed. Interviews were …

The Effects Of Selected Drugs On The Memory Recall Of Sleep Deprived Mice, Jenn Pauldurai

Capstone Research Projects

Humans often make use of the neurotransmission altering effects of drugs such as caffeine, ephedrine, and ethanol. These drugs induce changes in memory and learning ability, specifically when used for sleep deprivation. English white mice (Mus musculus) have been shown to exhibit similar cognitive changes when administered drugs while sleep deprived. A sample of 20 mice was divided into three experimental groups (each group receiving a different drug) and one control group. Maze-testing demonstrated that mice performance decreased with sleep deprivation (Treatment-1) but all groups returned to baseline performance when injected (IP) with selected drugs (Treatment-2), regardless of …

Prevalence Of Secondary Traumatic Stress Among Disaster Relief Volunteers, Erica Ballard

Theses and Dissertations

Secondary Traumatic Stress is a stress response brought about by working with or having a close relationship with a person or population affected by a traumatic event. It has been found in doctors, nurses, social workers, psychologists, and aid workers. The purpose of this study was to further understand the prevalence of STS in disaster relief volunteers. Thirty-five former and current volunteers for various disaster relief organizations filled out a survey about their experience, the Secondary Traumatic Stress Scale and the Compassion Fatigue Scale-Revised. Out of 35 participants, 91% were found to have at least one symptom of STS or …

A Study Of Small Rnas From Cerebral Neocortex Of Pathology-Verified Alzheimer's Disease, Dementia With Lewy Bodies, Hippocampal Sclerosis, Frontotemporal Lobar Dementia, And Non-Demented Human Controls, Sébastien S. Hébert, Wang-Xia Wang, Qi Zhu, Peter T. Nelson

Sanders-Brown Center on Aging Faculty Publications

MicroRNAs (miRNAs) are small (20-22 nucleotides) regulatory non-coding RNAs that strongly influence gene expression. Most prior studies addressing the role of miRNAs in neurodegenerative diseases (NDs) have focused on individual diseases such as Alzheimer's disease (AD), making disease-to-disease comparisons impossible. Using RNA deep sequencing, we sought to analyze in detail the small RNAs (including miRNAs) in the temporal neocortex gray matter from non-demented controls (n = 2), AD (n = 5), dementia with Lewy bodies (n = 4), hippocampal sclerosis of aging (n = 4), and frontotemporal lobar dementia (FTLD) (n = 5) cases, together accounting for the most prevalent …

Feeling The Hope, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Functional And Quality-Of-Life Outcomes In Geriatric Patients With Type-Ii Dens Fracture., Alexander R Vaccaro, Christopher K Kepler, Branko Kopjar, Jens Chapman, Christopher Shaffrey, Paul Arnold, Ziya Gokaslan, Darrel Brodke, John France, Mark Dekutoski, Rick Sasso, S Tim Yoon, Christopher Bono, James Harrop, Michael G Fehlings

Rothman Institute Papers

BACKGROUND: Dens fractures are relatively common in the elderly. The treatment of Type-II dens fractures remains controversial. The aim of this multicenter prospective cohort study was to compare outcomes (assessed with use of validated clinical measures) and complications of nonsurgical and surgical treatment of Type-II dens fractures in patients sixty-five years of age or older.

METHODS: One hundred and fifty-nine patients with a Type-II dens fracture were enrolled in a multicenter prospective study. Subjects were treated either surgically (n = 101) or nonsurgically (n = 58) as determined by the treatment preferences of the treating physicians and the patients. The …

Test–Retest Reliability For Voluntary And Evoked Measures Of Peak Torque, Electromechanical Delay, And Rate Of Torque Development In Older Men., Nathaniel D. M. Jenkins

Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research

The purpose of this study was to examine the test-retest reliability for peak torque (PT), rates of torque development (RTD), and electromechanical delay (EMD) calculated during voluntary and evoked muscle actions in men ages 65 and older. Fifteen older men (mean ± standard deviation (SD) age = 72.3 ± 7.3 years) completed 3 evoked and 3 voluntary isometric muscle actions of the leg extensors during two visits separated by 48 to 72 h. PT and EMD were calculated during voluntary and evoked muscle actions. RTD was quantified as the peak RTD, overall RTD, RTD in time intervals of 0-30 (RTD30), …

When Evil Met Science: Nazi Medicine And Eugenics, Ashley Corey

Honors Theses

During World War II, millions of innocent people were murdered in Nazi Germany. For Hitler and his followers, having a pure race meant having a strong, unified country, and Germany took this idea to extreme and disturbing lengths. Corruption filled the government at all levels. As physicians were the only people authorized to run the gas chambers, traditional healers became death symbols. The Nazis and their physicians used their power to manipulate and murder for the collective goals of the country, as well as the personal gains that came with the high-end job titles. As I reveal the history and …

Estradiol Reduces Susceptibility Of Cd4+ T Cells And Macrophages To Hiv-Infection, Marta Rodriguez-Garcia, Nabanita Biswas, Mickey V. Patel, Fiona D. Barr, Sarah G. Christ, Chrsitina Ochsenbauer, John V. Fahey, Charles R. Wira

Dartmouth Scholarship

The magnitude of the HIV epidemic in women requires urgent efforts to find effective preventive methods. Even though sex hormones have been described to influence HIV infection in epidemiological studies and regulate different immune responses that may affect HIV infection, the direct role that female sex hormones play in altering the susceptibility of target cells to HIV-infection is largely unknown. Here we evaluated the direct effect of 17-b-estradiol (E₂) and ethinyl estradiol (EE) in HIV-infection of CD4⁺ T-cells and macrophages. Purified CD4⁺ T-cells and monocyte-derived macrophages were generated in vitro from peripheral blood and infected with …

Prevalence Of Pregnancy Folkloric Beliefs Among Nurse-Midwifery Client Populations, Iris Aleece Campbell

Honors Theses

OBJECTIVE: To explore prevalence of pregnancy related folklore beliefs by conducting a survey of CM/CNMs in the United States. Research questions included: What folklore beliefs are most commonly encountered by nurse-midwives? Does the prevalence of folklore beliefs differ by geography? Does the type of folklore beliefs differ by the ethnicity and culture of the nurse-midwifery clientele?

METHODS: After IRB and ACNM approval, a geographically diverse sample of 1,000 active CM/CNM members was sent an invitation email. The survey was developed following a literature review to include 12 pregnancy beliefs. Responders were asked to rate how frequently they heard each (never-I, …

Quantifying Head Injury Severity Following Pediatric Patient Falls, Janet Dufek, N.A. Ryan-Wenger, K.C Mefferd

Interdisciplinary Research Scholarship Day

The purpose of this study was to retrospectively calculate the head injury criteria (HIC) values for pediatric patient falls and correlate these values to documented injury severity (MERP) scores. A second purpose was to examine the relationship between child ages and associated HIC15 values in an attempt to scale the values obtained from pediatrics to adult values.

Gender Differences In Frontal Plane Lower Extremity Kinetic Variability During Landing, Andrew Nordin

Interdisciplinary Research Scholarship Day

Investigations of human movement variability have been used as a
means of exploring neuromotor functioning, where performance variability is
thought to provide the system with flexibility and a mechanism for adaptation to
movement repetition [1,2,4,6]. Operationally, variability has been considered to
fall within optimal limits (Figure 1), while excessively high or low variability has
been implicated in injury susceptibility [1,2,4,6]. Landing has been explored
due to a high incidence of injury in athletic performance, as well as the ability
to easily control task demands through increases in landing height [3,4].
The purpose of this investigation was to evaluate changes in …

Pre- And Post-Interrvention Perceptions Of Illness, Health, And The Home Environment Among Nevada Healthy Homes Participants, Michelle Ching, Shawn Gerstenberger

Interdisciplinary Research Scholarship Day

The Nevada Healthy Homes Partnership (NVHHP) is a collaborative program between the University of Nevada, Las Vegas (UNLV), Southern Nevada Health District (SNHD), Rebuilding Together (RBT), HELP of Southern Nevada, and other public/private housing authorities and health agencies in Southern Nevada.

Interactive Video Gaming: Do We Feel Like We Are Exercising?, Antonio Santo, Shaelee Allen, Janet Dufek, Paul Hafen, Michael Jarrett, Krystina Moschella, Robert Rietjens, James Navalta, Richard Tandy, Jacob E. Barkley

Interdisciplinary Research Scholarship Day

The primary purpose of this study was to determine if the rating of perceived exertion (RPE) and hedonics (liking or enjoyment) changed during 30 contiguous minutes of playing select, interactive video games on the Nintendo Wii system. A secondary purpose was to determine if RPE and liking differed among games.These data suggest that individuals do perceive difference in the amount of work they are performing during extended play of the same game or among sedentary and physically interactive games. Additionally, liking was similar during extended game play and among games suggesting that the physical interaction with the game may be …

Cardiovascular Risk Factors Prevalent Among Filipino-Americans: A Cross-Sectional Study, Alona Angosta

Interdisciplinary Research Scholarship Day

Filipino Americans are the 2nd largest Asian subgroup in the United States and their leading cause of death is cardiovascular disease (CVD). Despite this, little is known about their prevalence of CVD risk factors. This study revealed that many Filipino Americans living in Clark County, Nevada are at risk of heart disease because of the presence of CVD risk factors. Intensive lifestyle modification and treatment are recommended to help decrease the prevalence of heart disease in this group and improve their overall health outcomes. Nurses and nurse practitioners are in excellent position to educate their Filipino American clients regarding heart …