Medicine and Health Sciences Commons^™

Community Health News, Georgia Southern University

Health Policy & Community Health: News & Publications (2011-2018)

• Analysis of Newspaper Coverage

Systematic Examination Of Infant Size And Growth Metrics As Risk Factors For Overweight In Young Adulthood, Andrew O. Odegaard, Audrey C. Choh, Ramzi W. Nahhas, Bradford Towne, Stefan A. Czerwinski, Ellen W. Demerath

Population and Public Health Sciences Faculty Publications

Objective:To systematically examine infant size and growth, according to the 2006 WHO infant growth standards, as risk factors for overweight status in young adulthood in a historical cohort. Specifically, to assess: Whether accounting for length (weight-for-length) provides a different picture of risk than weight-for-age, intervals of rapid growth in both weight-for-age and weight-for-length metrics, and what particular target ages for infant size and intervals of rapid growth associate most strongly with overweight as a young adult.Patients/Methods:Data analysis of 422 appropriate for gestational age white singleton infants enrolled in the Fels Longitudinal Study. Odds ratios (OR) for overweight and obesity in …

Eubacterial Spovg Homologs Constitute A New Family Of Site-Specific Dna-Binding Proteins, Brandon L. Jutras, Alicia M. Chenail, Christi L. Rowland, Dustin Carroll, M Clarke Miller, Tomasz Bykowski, Brian Stevenson

Microbiology, Immunology, and Molecular Genetics Faculty Publications

A site-specific DNA-binding protein was purified from Borrelia burgdorferi cytoplasmic extracts, and determined to be a member of the highly conserved SpoVG family. This is the first time a function has been attributed to any of these ubiquitous bacterial proteins. Further investigations into SpoVG orthologues indicated that the Staphylococcus aureus protein also binds DNA, but interacts preferentially with a distinct nucleic acid sequence. Site-directed mutagenesis and domain swapping between the S. aureus and B. burgdorferi proteins identified that a 6-residue stretch of the SpoVG α-helix contributes to DNA sequence specificity. Two additional, highly conserved amino acid residues on an adjacent …

Diaphragm Weakness In Mechanically Ventilated Critically Ill Patients, Gerald S. Supinski, Leigh Ann Callahan

Internal Medicine Faculty Publications

INTRODUCTION: Studies indicate that mechanically ventilated patients develop significant diaphragm muscle weakness, but the etiology of weakness and its clinical impact remain incompletely understood. We assessed diaphragm strength in mechanically ventilated medical ICU patients, correlated the development of diaphragm weakness with multiple clinical parameters, and examined the relationship between the level of diaphragm weakness and patient outcomes.

METHODS: Transdiaphragmatic twitch pressure (PdiTw) in response to bilateral magnetic stimulation of the phrenic nerves was measured. Diaphragm weakness was correlated with the presence of infection, blood urea nitrogen, albumin, and glucose levels. The relationship of diaphragm strength to patient outcomes, including mortality …

Early Detection Of Zoonotic Emerging Infectious Diseases, Thomas Cotter, Earl Stoddard Iii

Homeland Security Publications

No abstract provided.

Pparδ Binding To Heme Oxygenase 1 Promoter Prevents Angiotensin Ii-Induced Adipocyte Dysfunction In Goldblatt Hypertensive Rats, Komal Sodhi, Nitin Puri, Dong Hyun Kim, Terry D. Hinds Jr., Lance A. Stechschulte, Gaia Favero, Luigi Rodella, Joseph I. Shapiro M.D., David C. Jude, Nader X. Abraham

Biochemistry and Microbiology

Abstract:

OBJECTIVE: Renin–angiotensin system (RAS) regulates adipogenic response with adipocyte hypertrophy by increasing oxidative stress. Recent studies have shown the role of peroxisome proliferator-activated receptor-d (PPARδ) agonist in attenuation of angiotensin II-induced oxidative stress. The aim of this study was to explore a potential mechanistic link between PPARδ and the cytoprotective enzyme heme oxygenase-1 (HO-1) and to elucidate the contribution of HO-1 to the adipocyte regulatory effects of PPARδ agonism in an animal model of enhanced RAS, the Goldblatt 2 kidney 1 clip (2K1C) model.

METHOD: We first established a direct stimulatory effect of the PPARδ agonist (GW 501516) on …

Methods For Quantifying T Cell Receptor Binding Affinities And Thermodynamics, Kurt H. Piepenbrink, Brian E. Gloor, Kathryn M. Armstrong, Brian M. Baker

Food for Health: Publications

αβ T cell receptors (TCRs) recognize peptide antigens bound and presented by class I or class II major histocompatibility complex (MHC) proteins. Recognition of a peptide/MHC complex is required for initiation and propagation of a cellular immune response, as well as the development and maintenance of the T cell repertoire. Here we discuss methods to quantify the affinities and thermodynamics of interactions between soluble ectodomains of TCRs and their peptide/MHC ligands, focusing on titration calorimetry, surface plasmon resonance, and fluorescence anisotropy. As TCRs typically bind ligand with weak-to-moderate affinities, we focus the discussion on means to enhance the accuracy and …

Influence Of Cochlear Implantation On Sentence Intelligibility And Duration, Olga Peskova, Nirmal Kumar Srinivasan, Sujin Shin, Madhu Sundarrajan, Emily Tobey

All Faculty Scholarship

Cochlear implants (CI) allow children with hearing loss (HL) to achieve speech perception and production outcomes that make their spoken speech understandable to normal hearing adult listeners. This capability is characterize by wide variability of scores. In order to understand the factors that contribute to the overall variability, we investigated the effects of duration of cochlear implantation on speech intelligibility and sentence duration over time. Participants were 107 children implanted between the ages of 2 and 4 and tested at 2 time points there they were 8 and 16 years old. Participants repeated McGarr sentences, which vary in length from …

An Economic Analysis Of The Impact Of Refractive Error In Mozambique, Stephen Thompson

Conference Papers

Mozambique eyecare project carried out in June 2013 to estimate the socio-economic benefit of an Optometry Programme by calculating the benefits of addressing refractive error in terms of productivity gained as a result of the intervention.

An Automated Procedure For Detecting Human Frequency-Following Responses To Voice Pitch, Fuh Cherng Jeng, Jiong Hu

All Faculty Scholarship

The frequency-following response (FFR) to voice pitch has been widely examined in research laboratories and has demonstrated its potential to be transformed into a useful tool for patients with hearing, speech, and language disorders in the clinic. During the past decade, many aspects of the FFR have been reported. The presence of such a response, however, still relies on subjective interpretation of the observer. Aside from a recent study reporting two algorithms for detecting such a response, there has been limited number of studies reporting the development of an automated procedure for FFR. The purpose of this study is (1) …

Conference Learnings, Todd Burgert Rn

Patient Care Services / Nursing

No abstract provided.

The Obesity Epidemic, Lenka Kollar, Evienne Epifano, Molly Mckneight, Jeff Miskovich, Heather Moore

Student Papers in Public Policy

The incidence of chronic, noncommunicable diseases, such as heart disease, is increasing at an alarming rate on the global scale. The growing prevalence of overweight and obesity have led to an upsurge in cases of diabetes and other obesity-related diseases. About 18 million people die every year from heart disease, of which diabetes and obesity are major predisposing factors. Worldwide, more than 1.1 billion adults are overweight, 312 million of which are obese. The number of children that are overweight or obese is also growing (Hossain, Parvez et al.). Obesity, and the associated diseases, has become a worldwide epidemic and …

Maximizing The Delivery Performance Of Point-Of-Care Cd4+ T-Cell Counting Tests In Resource-Limited Settings - A Policy Brief, Nan Kong, J. Paul Robinson, Fenggang Yang

Purdue Policy Research Institute (PPRI) Policy Briefs

Managing HIV/AIDS presents challenges to public health policymakers, frontline workers, and researchers worldwide. A key strategy in the disease management is early diagnosis and rapid treatment initiation. While the technological field of point‐of‐care HIV/AIDS diagnostics has advanced significantly in the past two decades, several critical issues remain that hinder the deployment of point‐of‐care testing devices in resource‐deprived settings. In this policy brief, we discuss these issues, including technological specifics of point‐of‐care CD4⁺ T‐cell counting approaches and requirements of deploying them. We also discuss cultural and religious concerns on the deployment. At the end of the brief, we propose a …

2013 June 18 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

Biomarkers For Ovarian Cancer, Eric T. Fung, Frederick Ueland, J. R. Van Nagell, Paul D. Depriest, Andre T. Baron

Epidemiology and Environmental Health Faculty Patents

The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying ovarian cancer status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as ovarian cancer, ovarian cancer of low malignant potential, benign ovarian disease or other malignant condition. The biomarkers can be detected by SELDI mass spectrometry.

Brain Electrical Source Localization Of The Masking Level Difference In College Age Students, Amanda Fujiki, Dr. David Mcpherson

Journal of Undergraduate Research

The term auditory processing disorder (APD) refers to a diverse collection of problems in the processing of auditory information. An individual with an APD may have hearing acuity within normal limits; that is, the middle ear (conductive) and inner ear (sensory) systems may function typically. The individual may demonstrate a breakdown occurring within the central nervous system, however, and this breakdown may limit the individual’s ability to understand, interpret, and use auditory information. Auditory processing disorders are thought to interfere with language development and literacy learning (Geffner, 2007, MacFarland & Cacace, 2009). The effects of APD may be highly variable …

Gender Differences In The Acoustic Parameters Of Contrastive Stress Production, Bryce Bristow, Dr. Shawn Nissen

Journal of Undergraduate Research

I was able to present the following research at the American Speech-Language and Hearing Association 2012 National Conference. I made a poster and talked to professionals and researchers from across the nation.

Brain Electrophysiological Source Localization Of Mmn & P300 Response In Auditory Processing, Amy Ragsdale, Dr. David Mcpherson

Journal of Undergraduate Research

Source localization is a tool used to identify a precise visual location within the brain which allows for interpretation of the source of the brain activity. In this research, source localization is used to provide a more accurate identification and evaluation of the neurophysiological sources that contribute to the brain’s responses to speech-like and non-speech stimuli.

Post-Prandial Upright Exercise Echocardiography In Hypertrophic Cardiomyopathy, Ellina C. Feiner Md, Milla Arabadjian Fnp, Glenda Winson Rn, Bette Kim Md, Farooq Chaudhry Md, Mark V. Sherrid Md

Department of Medicine

No abstract provided.

The Effect Of Age On Speech Motor Performance During Divided Attention, Dallin J. Bailey

Theses and Dissertations

The present study examined the divided attention effects of three non-speech tasks on concurrent speech motor performance. These tasks targeted linguistic, cognitive, and manual motor activity. Participants included 60 healthy adults separated into three different age groups of twenty participants each: college-age (20s), middle-aged (40s), and older adults (60s). Each participant completed a speech task once in isolation and once concurrently with each of the three non-speech tasks: a semantic decision task, a quantitative comparison task, and a manual motor task. The non-speech tasks were also performed in isolation. The speech task involved repeating a target phrase each time a …

Intermedin Protects Against Myocardial Ischemia-Reperfusion Injury In Diabetic Rats., Hong Li, Yunfei Bian, Nana Zhang, Jia Guo, Cheng Wang, Wayne Bond Lau, Chuanshi Xiao

Department of Emergency Medicine Faculty Papers

BACKGROUND: Diabetic patients, through incompletely understood mechanisms, endure exacerbated ischemic heart injury compared to non-diabetic patients. Intermedin (IMD) is a novel calcitonin gene-related peptide (CGRP) superfamily member with established cardiovascular protective effects. However, whether IMD protects against diabetic myocardial ischemia/reperfusion (MI/R) injury is unknown. METHODS: Diabetes was induced by streptozotocin in Sprague--Dawley rats. Animals were subjected to MI via left circumflex artery ligation for 30 minutes followed by 2 hours R. IMD was administered formally 10 minutes before R. Outcome measures included left ventricular function, oxidative stress, cellular death, infarct size, and inflammation. RESULTS: IMD levels were significantly decreased in …

The Effect Of Using Low Dose Exposure To A Humanoid Robot To Elicit Social Engagement Behaviors In Children With Autism Interacting With A Familiar Adult, Cambrie Nicole Roueche

Theses and Dissertations

This study examined the effects of low dose exposure to a humanoid robot on the social engagement skills of four children with autism during select activities with a familiar adult. Participants included two males and two females who ranged in age from four to nine at the commencement of the study. The current study was part of a larger investigation focused on the effect of exposure to a robot on social engagement with a variety of social partners and situations. Children participated in variable multiple baseline sessions followed by a varied number of sessions of traditional treatment. After traditional treatment, …

Can Emotion Understanding Be Taught?: Evaluating An Intervention Protocol To Increase Emotion Understanding In Children With Language Impairment, Lucy Brimhall, Dr. Martin Fujiki

Journal of Undergraduate Research

Specific language impairment is traditionally defined as a diagnosis referring to “children who have difficulty learning language in the absence of intellectual disability, sensory and physical deficits, severe emotional disturbances, environmental factors, and brain damage” (Kamhi, AG 1998). Recent study of the behavior of children with SLI has revealed that there is a discrepancy between the social communication skills of typically developing children and those with SLI (Brinton & Fujiki, 2004).

Sustained Safety And Effectiveness Of Paclitaxel-Eluting Stents For Femoropopliteal Lesions: 2-Year Follow-Up From The Zilver Ptx Randomized And Single-Arm Clinical Studies., Michael D Dake, Gary M Ansel, Michael R Jaff, Takao Ohki, Richard R Saxon, H Bob Smouse, Scott A Snyder, Erin E O'Leary, Gunnar Tepe, Dierk Scheinert, Thomas Zeller, Zilver Ptx Investigators

Heart and Vascular Articles

Objectives: A prospective, multinational randomized controlled trial (RCT) and a complementary single-arm study evaluated the 2-year safety and effectiveness of a paclitaxel-coated drug-eluting stent (DES) in patients with superficial femoral artery lesions. The RCT compared the DES with percutaneous transluminal angioplasty (PTA) and provisional bare-metal stent (BMS) placement.

Background: Local drug delivery for superficial femoral artery lesions has been investigated with the intent of limiting restenosis similarly to DES for the coronary arteries. One-year outcomes of DES in the superficial femoral artery are promising, but longer-term benefits have not been established.

Methods: In the RCT, patients were randomly assigned to …

What's Happening: June 17, 2013, Maine Medical Center

What's Happening

No abstract provided.

Rural Children Experience Different Rates Of Mental Health Diagnosis And Treatment, David Hartley Phd, Mph, Jennifer D. Lenardson Mhs, Nathaniel J. Anderson Ms, Mph, Samantha J. Neuwirth Md

Mental Health / Substance Use Disorders

Research indicates that privately insured, rural adults have lower use of office-based mental health services, but higher use of prescription medicines than their urban counterparts. Patterns for rural children may be different from urban children because of the limited supply of pediatric mental health providers in rural areas, which may lead to reduced access and lower use of mental health services in rural areas versus urban. Using data on children ages 5-17 from the 2002-2008 of the Medical Expenditure Panel Survey, researchers from the Maine Rural Health Research Center find that rural children are significantly less likely to be diagnosed …

Ada News - 06/17/2013, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Student Perception Of How Simulation Applies To Clinical Experience, Brooke Alleger, Dr. Debra Wing

Journal of Undergraduate Research

For students in the nursing program at Brigham Young University, lab time in the Nursing Learning Center in the basement of the Spencer W. Kimball Tower is a regular part of the classroom experience. In this lab, nursing skills such as assessments, starting IVs, inserting catheters and cleaning wounds are taught and practiced. Once basic skill sets are taught, students are challenged with real-life scenarios requiring them to think critically and practice a subset of learned skills on a mannequin during simulation labs.

Developing An Instrument To Assess Immunization Requirements Among Utah Health Care Workers In The Outpatient Setting, Nathan Wiley, Dr. Beth Luthy

Journal of Undergraduate Research

The health care environment is ideal for the spread of immunization-preventable and communicable diseases (Goldstein, Kincade, Gamble, & Bearman, 2004). Communicable diseases, such as pertussis, are highly contagious and easily transmitted by health care workers (HCWs) to at-risk patients (CDC, 1997; Sandora, Gidengil, & Lee, 2008). Pediatric patients, especially those under 5 years of age, are especially vulnerable to immunization-preventable diseases since they have not yet completed all immunizations in a given series. Since 2006, the CDC has recommended the cocoon immunization strategy, a program that aims to protect newborns from pertussis by immunizing caregivers of the infant (TCH, 2010). …

Healing All Around The World: French Nurses’ Perspective Of The French Healthcare System, Cami Schiel, Dr. Leslie Miles

Journal of Undergraduate Research

The purpose of this project was to examine how foreign nurses (specifically French nurses) perceived their healthcare system, and those in other countries. This ultimately led to additional insight into where they get their perceptions, positive and negative aspects of different types of healthcare systems, and some differences between the French and American systems. It was fascinating.