Medicine and Health Sciences Commons^™

Adults With Type 1 Diabetes; Lifetime Perspectives, Laura Boone, Dr. Donna Freeborn

Journal of Undergraduate Research

The purpose of this qualitative study was to identify the stressors experienced throughout childhood and adolescence of adults with type 1 diabetes (T1D). Identification of stressors can be a helpful tool in improving the child and family’s quality of life and current treatment methodologies.

Nursing Education: The Role Of Debriefing For Nursing Students’ First Clinical Experience With Death, Laura Gilpin, Dr. Barabar Heise

Journal of Undergraduate Research

Death, particularly the unexpected death of a patient, is an emotionally charged, highstress situation for any nurse. Nursing students encounter scenarios involving death and dying in simulation laboratories, as well as in the clinical setting. It is essential a nurse learns how to process and cope with his or her emotions regarding the death of a patient since it may occur frequently during his or her career. If a nurse cannot cope with these emotions it could lead to burn out and damage to overall emotional health.

How Incarceration Affects Maternal Identify Of Female Inmates, Ashlee Manwaring, Dr. Janelle Macintosh

Journal of Undergraduate Research

I proposed an ORCA with Janelle Macintosh, RN, PhD, last fall, and was awarded the grant in February. Our original idea was to investigate how incarceration affects maternal identify of female inmates. This was closely related to Dr. Macintosh’s original dissertation proposal and completed dissertation. However, we were not able to successfully complete the required IRB for the Department of Corrections. We determined a change in population would probably be the best course of action. Our goal was to do the same research on a different population.

From The Frontier: Translating Research To Practice…Qi As The Hinge Point, Paul C. Erwin

Frontiers in Public Health Services and Systems Research

This article is number three in the series From the Frontier: Translating Research to Practice. The narrative describes the work of a practice-academic network in Minnesota which explored the degree to which having a culture of quality at the local health department level influenced the capacity to implement a new statewide initiative. The network conducted a mixed-methods study of grantees funded to develop and implement local policy, systems, and environmental change strategies to promote nutrition, increase activity, and reduce tobacco use and exposure. The results of their study indicated that grantees with higher performance levels in Quality Improvement (QI) …

Access To Primary Care: Comparing Driving Distance From Health Professional Shortage Area (Hpsa) Counties Versus Non-Hpsa Counties, Molly Cashion, Stephanie Jilcott-Pitts, Doyle Cummings, Christopher Duffrin, John Jones, Qiang Wu

Frontiers in Public Health Services and Systems Research

The criteria used to identify Health Professional Shortage Areas dates back to the 1970’s and very little has changed since then. This study examined driving distance from patient address to provider address as one component of a geographical HPSA. Primary care-related services located in adjacent areas to whole-county HPSAs are considered excessively distant when travel time exceeds 30 minutes or the equivalent of 20 miles in this study. We found similarities in travel distance to primary care-related services from patients living in HPSA counties compared to those living in non-HPSA counties. This could indicate the need to re-examine HPSA definitions …

Addressing Health Inequalities In The United States: Key Data Trends And Policy Action, Sara N. Bleich, Marian P. Jarlenski, Caryn N. Bell, Thomas A. Laveist

Frontiers in Public Health Services and Systems Research

Health inequalities, which have been well documented for decades, have recently become policy targets in the United States. This report summarizes current patterns and trends in health inequalities, commitments to reduce health inequalities, and progress made to eliminate health inequalities. Time trend data indicate improvements in health status and major risk factors but increases in morbidity, with black and lower-education individuals experiencing a disproportionate burden of disease. A common policy response has been priority setting in the form of national objectives or goals to address health inequalities. More research and better methods are needed to precisely measure relationships between stated …

Spontaneous Fluctuation Indices Of The Cardiovagal Baroreflex Accurately Measure The Baroreflex Sensitivity At The Operating Point During Upright Tilt, Christopher E. Schwartz, Marvin S. Medow, Zachary Messer, Julian M. Stewart

NYMC Faculty Publications

Spontaneous fluctuation indices of cardiovagal baroreflex have been suggested to be inaccurate measures of baroreflex function during orthostatic stress compared with alternate open-loop methods (e.g. neck pressure/suction, modified Oxford method). We therefore tested the hypothesis that spontaneous fluctuation measurements accurately reflect local baroreflex gain (slope) at the operating point measured by the modified Oxford method, and that apparent differences between these two techniques during orthostasis can be explained by a resetting of the baroreflex function curve. We computed the sigmoidal baroreflex function curves supine and during 70° tilt in 12 young, healthy individuals. With the use of the modified Oxford …

Caloric Restriction Augments Radiation Efficacy In Breast Cancer., Anthony D Saleh, Brittany A Simone, Juan Palazzo, Jason E Savage, Yuri Sano, Tu Dan, Lianjin Jin, Colin E Champ, Shuping Zhao, Meng Lim, Frederica Sotgia, Kevin Camphausen, Richard G Pestell, James B Mitchell, Michael P Lisanti, Nicole L Simone

Kimmel Cancer Center Faculty Papers

Dietary modification such as caloric restriction (CR) has been shown to decrease tumor initiation and progression. We sought to determine if nutrient restriction could be used as a novel therapeutic intervention to enhance cytotoxic therapies such as radiation (IR) and alter the molecular profile of triple-negative breast cancer (TNBC), which displays a poor prognosis. In two murine models of TNBC, significant tumor regression is noted with IR or diet modification, and a greater regression is observed combining diet modification with IR. Two methods of diet modification were compared, and it was found that a daily 30% reduction in total calories …

Conference Learnings, Jennifer King Rnc, Bsn, Jenna Herb Rn, Bsn, Connie Erasmo Bsn, Rn

Patient Care Services / Nursing

No abstract provided.

When To Start Antiretroviral Therapy: The Need For An Evidence Base During Early Hiv Infection, James D. Lundgren, Abdel G. Babiker, Fred M. Gordin, Alvaro H. Borges, James D. Neaton

Epidemiology Faculty Publications

Background

Strategies for use of antiretroviral therapy (ART) have traditionally focused on providing treatment to persons who stand to benefit immediately from initiating the therapy. There is global consensus that any HIV+ person with CD4 counts less than 350 cells/μl should initiate ART. However, it remains controversial whether ART is indicated in asymptomatic HIV-infected persons with CD4 counts above 350 cells/μl, or whether it is more advisable to defer initiation until the CD4 count has dropped to 350 cells/μl. The question of when the best time is to initiate ART during early HIV infection has always been vigorously debated. The …

A Preliminary Report Of Percutaneous Craniofacial Osteoplasty In A Rat Calvarium, William J. Parkes, Md, Jewel Greywoode, Md, Brian J. O'Hara, Md, Ryan N. Heffelfinger, Md, Howard Krein, Md, Phd

Department of Otolaryngology - Head and Neck Surgery Presentations and Grand Rounds

Objective: To evaluate the potential for injectable, permanent bone augmentation by assessing the biocompatibility and bioactivity of subperiosteal hydroxylapatite (Radiesse) deposition in a rat model.

Methods: Fourteen adult Sprague Dawley rats were injected in the parietal skull with hydroxylapatite (n=10) or a carrier gel control (n=4), using a subperiosteal injection technique on the right and a subcutaneous injection technique on the left. At 1, 3, and 6 months, 3 rats (1 negative control, 2 variables) were sacrificed. At 12 months, the remaining 5 rats were sacrificed. After each harvest, the calvaria were examined under both light and polarized microscopy.

Results: …

Protection Of Dietary Polyphenols Against Oral Cancer, Yijian Ding, Hua Yao, Yanan Yao, Leonard Yenwong Fai, Zhuo Zhang

Toxicology and Cancer Biology Faculty Publications

Oral cancer represents a health burden worldwide with approximate 275,000 new cases diagnosed annually. Its poor prognosis is due to local tumor invasion and frequent lymph node metastasis. Better understanding and development of novel treatments and chemo-preventive approaches for the preventive and therapeutic intervention of this type of cancer are necessary. Recent development of dietary polyphenols as cancer preventives and therapeutic agents is of great interest due to their antioxidant and anti-carcinogenic activities. Polyphenols may inhibit carcinogenesis in the stage of initiation, promotion, or progression. In particular, dietary polyphenols decrease incidence of carcinomas and exert protection against oral cancer by …

Neural Activations During Visual Sequence Learning Leave A Trace In Post-Training Spontaneous Eeg, Clara Moisello, Hadj Boumediene Meziane, Simon Kelly, Bernardo Perfetti, Svetlana Kvint, Nicholas Voutsinas, Daniella Blanco, Angelo Quartarone, Giulio Tononi, Maria Felice Ghilardi

Publications and Research

Recent EEG studies have shown that implicit learning involving specific cortical circuits results in an enduring local trace manifested as local changes in spectral power. Here we used a well characterized visual sequence learning task and high density-(hd-)EEG recording to determine whether also declarative learning leaves a post-task, local change in the resting state oscillatory activity in the areas involved in the learning process. Thus, we recorded hd-EEG in normal subjects before, during and after the acquisition of the order of a fixed spatial target sequence (VSEQ) and during the presentation of targets in random order (VRAN). We first determined …

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Health Risk Behaviors

Epidemiology News, Georgia Southern University

Biostatistics, Epidemiology & Environmental Health Sciences: News & Publications (2011-2018)

• Health Risk Behaviors

The Effects Of Green Smoothie Consumption On Blood Pressure And Health-Related Quality Of Life: A Randomized Controlled Trial, Emiko Maeda

Dissertations and Theses

Chronic diseases are among the leading causes of death globally, and as much as 80% of these deaths are reported to be preventable with proper diet and lifestyle. Although extensive research has demonstrated that the increased consumption of fruits and vegetables offers protective health effects from many chronic illnesses, populations in both developed and developing nations consistently fall short of the recommended intake of 5 or more servings a day. This study investigated the effects of daily consumption of Green Smoothies for 4 consecutive weeks on blood pressure and health-related quality of life. Green Smoothies are a blended drink consisting …

The Effects Of Emotion On Acoustic Characteristics Of Vocal Vibrato In Trained Singers, Sharee Oakes Holmes

Theses and Dissertations

The purpose of this study was to investigate the effects of emotion on several key acoustic features of vibrato including vibrato rate, extent, and steadiness (measured by FM rate COV and FM extent COV). We hypothesized that intensity of emotion would have a significant effect on vibrato rate, extent, and periodicity, although the direction of these changes was undetermined. There were 10 participants, including eight females and two males, who were graduate student singers with high competency ratings. Each participant completed a series of tasks including sustained vowels at several pitch and loudness levels, an assigned song that was determined …

Automated Channel Assessment For Single Chip Medradio Transceivers, Mark Alexander Hillig

Dissertations and Theses

Modern implantable and body worn medical devices leverage wireless telemetry to improve patient experience and expand therapeutic options. Wireless medical devices are subject to a unique set of regulations in which monitoring of the available frequency spectrum is a requirement. To this end, implants use software protocols to assess the in-band activity to determine which channel should be used. These software protocols take valuable processing time and possibly degrade the operational lifetime of the battery. Implantable medical devices often take advantage of a single chip transceiver as the physical layer for wireless communications. Embedding the channel assessment task in the …

Automated Identification Of Relative Clauses In Child Language Samples, Erika E. Ehlert

Theses and Dissertations

Relative clauses are grammatical constructions that are of relevance in both typical and impaired language development. Thus, the accurate identification of these structures in child language samples is clinically important. In recent years, computer software has been used to assist in the automated analysis of clinical language samples. However, this software has had only limited success when attempting to identify relative clauses. The present study explores the development and clinical importance of relative clauses and investigates the accuracy of the software used for automated identification of these structures. Two separate collections of language samples were used. The first collection included …

Introduction To Ipe: A School-Wide Orientation Initiative, Audrey Zapletal, Ms, Otr/L, Susan Toth-Cohen, Phd, Otr/L, Susan Wainwright, Phd, Pt, Frances Gilman, Dhsc, Rt, R, Ct, Cv, Mr

Department of Occupational Therapy Posters and Presentations

Session Objectives:

Present an innovative approach to orienting new students from various healthcare disciplines on Interprofessional Educa(on (IPE).

Discuss strategies to shape incoming students’ attitudes toward working in teams.

Discuss challenges and opportunities in coordinating a large-­‐scale IPE event.

Synopsis

Interprofessional experiences are a vital part of healthcare education, and early introduction can positively impact students’ attitudes and knowledge about their team members’ roles. While students at academic health centers (AHC’s) have opportunites to engage in IPE, such opportunites can be overwhelming given significant challenges to coordination and implementation. Addressing these challenges, an interprofessional team at Jefferson School of Health …

Nfat5 Represses Canonical Wnt Signaling Via Inhibition Of Β-Catenin Acetylation And Participates In Regulating Intestinal Cell Differentiation, Qingding Wang, Yuning Zhou, Piotr G. Rychahou, Chunming Liu, Heidi L. Weiss, B. Mark Evers

Surgery Faculty Publications

The intestinal mucosa undergoes a continual process of proliferation, differentiation, and apoptosis, which is regulated by multiple signaling pathways. The Wnt/β-catenin pathway has a critical role in this process. Previously, we have shown that the calcineurin-dependent nuclear factor of activated T cell (NFAT) is involved in the regulation of intestinal cell differentiation, as noted by the alteration of brush-border enzyme intestinal alkaline phosphatase (IAP) activity. Here, we show that calcineurin-independent NFAT5 interacts with β-catenin to repress Wnt signaling. We found that overexpression of NFAT5 inhibits, whereas knockdown of NFAT5 increases, TOPflash reporter activity and the expression of …

Management Of Intracranial Bleeding Associated With Dabigatran Use In A Neuroscience Hospital, Alejandro Perez, Md, Lynda Thomson, Geno J. Merli, Md

Department of Pharmacology and Experimental Therapeutics Faculty Papers

Dabigatran, an alternative to warfarin for prevention of stroke with non-valvular atrial fibrillation (AF), offers advantages of a fixed dosage, minimal laboratory monitoring and limited medication interactions. Dabigatran requires dosage adjustment in renal dysfunction and is contraindicated if severe dysfunction. No identified dabigatran reversal agent exists.

Methods: As part of an ongoing quality initiative, novel anticoagulant associated adverse events (AE) are monitored at a dedicated neuroscience hospital.

Results: 5 cases of intracranial bleeding associated with dabigatran occurred from 12/2011-4/2012. All patients were on anticoagulation for AF, the most common dose of dabigatran was 150 mg BID. Mean admission values were …

Influence Of Media Composition On The Growth Rate Of Chlorella Vulgaris And Scenedesmus Acutus Utilized For Co2 Mitigation, Czarena L. Crofcheck, Xinyi E, Aubrey Shea, Michael D. Montross, Mark Crocker, Rodney Andrews

Biosystems and Agricultural Engineering Faculty Publications

Atmospheric carbon dioxide levels have increased since the industrial revolution due to increasing combustion of fossil fuels. One possible CO₂ mitigation strategy is the use of microalgae for mitigation of CO₂. This paper focuses on the influence of media composition on the growth rate of two microalgae strains, Chlorella vulgaris and Scenedesmus actus. A KNO₃ based medium was found to work better for Chlorella, while a urea based equivalent worked better for Scenedesmus. The urea based media investigated here resulted in growth similar to that found with previously reported KNO₃ based media. …

Envelope Determinants Of Equine Lentiviral Vaccine Protection, Jodi K. Craigo, Corin Ezzelarab, Sheila J. Cook, Chong Liu, David W. Horohov, Charles J. Issel, Ronald C. Montelaro

Veterinary Science Faculty Publications

Lentiviral envelope (Env) antigenic variation and associated immune evasion present major obstacles to vaccine development. The concept that Env is a critical determinant for vaccine efficacy is well accepted, however defined correlates of protection associated with Env variation have yet to be determined. We reported an attenuated equine infectious anemia virus (EIAV) vaccine study that directly examined the effect of lentiviral Env sequence variation on vaccine efficacy. The study identified a significant, inverse, linear correlation between vaccine efficacy and increasing divergence of the challenge virus Env gp90 protein compared to the vaccine virus gp90. The report demonstrated approximately 100% protection …

Brain Imaging Of Event Related Potentials In Children With Language Impairment, Hillary Ann Benton

Theses and Dissertations

Event related potentials (ERPs) may provide specific information about how particular aspects of language are processed by the brain over time. This study investigated the electrophysiology of language processing in two children with language impairment (LI) when compared to five typically developing children. The N400, P600, and the early left anterior negativity (ELAN) were analyzed after participants listened to linguistically correct, syntactically incorrect, and semantically incorrect sentences. Participants were instructed to indicate whether the sentences were correct or incorrect. Latency and amplitude of the ERP components were compared between the two groups of participants and sentence types. Results from the …

Les Effets Additifs Potentiels Associés À Des Expositions Aiguës Par Inhalation De Mélanges De Substances Chimiques : Outil D’Aide À La Gestion Des Situations D’Urgence, Jonathan Côté, François Lemay, Adolf Vyskocil, Marc Baril, Daniel Drolet, Naima El Majidi, France Gagnon, Claude Viau

Rapports de recherche scientifique

Lors de déversements accidentels de substances chimiques dans l’environnement, que ce soit dans le cas d’incidents routiers ou ferroviaires (transport de matières dangereuses), ou encore d’accidents industriels, des travailleurs, des secouristes, des pompiers et même la population générale peuvent être exposés simultanément, sur de courtes périodes, à d’importantes concentrations de plusieurs substances chimiques. Dans de telles situations, une exposition simultanée à plusieurs substances peut induire des risques plus importants pour un travailleur que s’il est exposé successivement à chacun de ces polluants considérés individuellement. Il est donc important, comme le stipulent l’ American Conference of Governmental Industrial Hygienists (ACGIH) et …

Effects Of Patient-Directed Music Intervention On Anxiety And Sedative Exposure In Critically Ill Patients Receiving Mechanical Ventilatory Support A Randomized Clinical Trial, Annie Heiderscheit, Linda L. Chlan, Craig R. Weinert, Mary Fran Tracy, Debra J. Skaar, Jill L. Guttormson, Kay Savik

Faculty Authored Articles

Importance:

Alternatives to sedative medications, such as music, may alleviate the anxiety associated with ventilatory support.

Objective:

To test whether listening to self-initiated patient-directed music (PDM) can reduce anxiety and sedative exposure during ventilatory support in critically ill patients.

Design, Setting, and Patients:

Randomized clinical trial that enrolled 373 patients from 12 intensive care units (ICUs) at 5 hospitals in the Minneapolis-St Paul, Minnesota, area receiving acute mechanical ventilatory support for respiratory failure between September 2006 and March 2011. Of the patients included in the study, 86% were white, 52% were female, and the mean (SD) age …

Alternative Hospital Gift Bags And Breastfeeding Exclusivity, Yeon Bai, Shahla M. Wunderlich, Rickie Kashdan

Department of Nutrition and Food Studies Scholarship and Creative Works

The type of gift bags given to new mothers at the time of discharge from the hospital can influence their confidence in breastfeeding. Most hospitals in the US continue to distribute commercial gift bags containing formula samples despite the reported negative influence of commercial bags on the duration of breastfeeding. This study compared breastfeeding outcomes in women receiving three different kinds of gift bags at discharge. A prospective intervention study was conducted during the 2009-2010 in New Jersey. Three breastfeeding cohorts were recruited and assigned to three groups: COMMERCIAL received discharge bags containing formula samples, BF-INFO received breastfeeding information and …

Dynamic And Opposing Adjustment Of Movement Cancellation And Generation In An Oculomotor Countermanding Task., Brian D Corneil, Joshua C Cheng, Samanthi C Goonetilleke

Brain and Mind Institute Researchers' Publications

Adaptive adjustments of strategies help optimize behavior in a dynamic and uncertain world. Previous studies in the countermanding (or stop-signal) paradigm have detailed how reaction times (RTs) change with trial sequence, demonstrating adaptive control of movement generation. Comparatively little is known about the adaptive control of movement cancellation in the countermanding task, mainly because movement cancellation implies the absence of an outcome and estimates of movement cancellation require hundreds of trials. Here, we exploit a within-trial proxy of movement cancellation based on recordings of neck muscle activity while human subjects attempted to cancel large eye-head gaze shifts. On a subset …

Analyzing Return On Investment In Public Health: Implications And Future Directions, Glen P. Mays

Health Management and Policy Presentations

Return on investment (ROI) analyses of public health programs, policies, and services are being undertaken with increasing frequency to provide assessments of the value of these activities. This presentation reviews current initiatives and future directions for improving the quality of ROI studies and their application to real-world public health policy and administrative decisions.