Medicine and Health Sciences Commons^™

Chromosome Missegregation In Human Cells Arises Through Specific Types Of Kinetochore–Microtubule Attachment Errors, Sarah L. Thompson, Duane A. Compton

Dartmouth Scholarship

Most solid tumors are aneuploid, and many missegregate chromosomes at high rates in a phenomenon called chromosomal instability (CIN). CIN reflects the erosion of mitotic fidelity, and it correlates with poor patient prognosis and drug resistance. The most common mechanism causing CIN is the persistence of improper kinetochore–microtubule attachments called merotely. Chromosomes with merotelic kinetochores often manifest as lagging chromosomes in anaphase, suggesting that lagging chromosomes fail to segregate properly. However, it remains unknown whether the lagging chromosomes observed in anaphase segregate to the correct or incorrect daughter cell. To address this question, we tracked the segregation of a single …

Advances In Information And Communication Technology (Ict): Issues, Challenges And Opportunities For Health Care Professionals, Waris Qidwai

Department of Family Medicine

No abstract provided.

Vocational Experiences Of Survivors Of Severe Tbi With Diverse Employment Patterns: An Explanatory Mixed Method Design, Erin J. Bush

College of Education and Human Sciences: Dissertations, Theses, and Student Research

Employment status is a salient outcome following traumatic brain injury (TBI). A return to productive activity relates in complex ways to quality of life, and loss of employment competence has potentially devastating effects on survivors. Currently, inadequate information exists about the distribution of occupations held by survivors, post-injury employment stability, and the frequency that survivors return to their pre-injury occupations. The research presented herein addressed these issues. This study consisted of two phases. Through Phase 1, the researcher gathered quantitative employment data regarding a pool of 283 survivors of severe TBI. She then conducted telephone interviews of family members of …

ความก้าวหน้าของภาควิชารังสีวิทยา, สุภัทรพร เทพมงคล

Chulalongkorn Medical Journal

No abstract provided.

พระราชกรณียกิจด้านการแพทย์และสาธารณสุขของ พระบาทสมเด็จพระจุลจอมเกล้าเจ้าอยู่หัว, สมรัตน์ จารุลักษณานันท์, อรนุช เกี่ยวข้อง

Chulalongkorn Medical Journal

No abstract provided.

Differentiating Renal Cell Carcinoma Clear Cell Subtype From Other Subtypes On Multiphasic Multidetector Computed Tomography, N Lertlarpwasin, K Sasiwimonphan, W. Kittikowit

Chulalongkorn Medical Journal

Background : Renal cell carcinomas (RCC) represent about 1 - 3% of all visceral cancers and 85% of renal cancers in adults. The tumors occur most often in old age, usually in sixth and seventh decades of life, and more predominantly in males. There are different prognosis between each subtype of RCC and different targeted therapy of choice for clear cell and non-clear cell subtypes of RCC. Subtype differentiation of RCC is quite important for guided treatments and predicted prognosis. (according to the NCCN's Clinical Practice Guideline for Renal Cancer 2009). Objective : This study aims to differentiate clear cell …

Ct Features Using In Differentiating Pleural Exudates From Transudates, N Piyavisetpat, K. Kittisatra

Chulalongkorn Medical Journal

Background : Pleural effusion is one of the most frequent findings of thoracic abnormality, detected by computed tomography (CT). Differentiation between exudative from transudative effusions is crucial for diagnosis of various pathologies. Objective : To determine the accuracy of computed tomography in enabling differentiation of pleural exudates from transudates. Setting : King Chulalongkorn Memorial Hospital. Research design : A retrospective study. Patients : Patients who had pleural effusions and underwent CT of thorax and thoracentesis within 14 days of each other from March 2005 to August 2007 were recruited. Methods : We analyzed 41 pleural effusions in 41 patients. Effusions …

An Experience With 53 Patients Of Transanal Endorectal Pull-Through For Hirschsprung's Disease, V Buranakitjaroen, V. Mahatharadol

Chulalongkorn Medical Journal

Background : Transanal endorectal pull-through (TEPT) has been widely used in the treatment of Hirschsprung's disease (HD). We have been using this technique as described by Mondrag n and Ortega - Salgado in our hospital since January 2004. Objective : To evaluate the results of TEPT in the management of HD. Design : Retrospective study. Setting : Queen Sirikit National Institute of Child Health. Method : Fifty - three patients underwent TEPT for HD from January 2004 to March 2011. Patients' hospital records were retrospectively analysed. The collected data included associated anomalies, age at diagnosis, enterocolitis before TEPT, weight at …

Cancer Risk From Pediatric Diagnostic Radiology; Should We Be Concerned ?, P Trinavarat, S Manaphol, N Yimpraphan, S. Assawakulkamnurd

Chulalongkorn Medical Journal

Diagnostic radiology has an important role in pediatrics. Some imaging modalities give high radiation doses and there is a rising concern on the safety of radiation. This article aims to provide information on the increased risk of cancer from radiation used in diagnostic radiology. The information may help in the process of decision making in referring pediatric patients to CT and in communicating with their parents. Radiation doses in diagnostic radiology in pediatrics are mostly low, but some may reach the moderate level. From the recent knowledge, many believe that even a low-dose radiation has a certain risk of cancer …

Anxiety Over Living In Society In Juvenile Delinquents Being Prepared For Discharge From Observation And Protection Centers, D Somboonpong, P. Chandarasiri

Chulalongkorn Medical Journal

Background : Anxiety or nervousness originated from anticipations is formed in thoughts of each person that they would be in danger. This causes him/her to feel inefficient, it is unnecessarily wasting of mental health. In addition, anxiety is one of most the serious obstacles to success in life or occupation achievement. Thus, the studying of anxiety level and other factors causing anxiety to a juvenile delinquents preparing to discharge are necessary in order to be a guideline in deducing and preventing the anxiety is necessary. This helps the juvenile who are about to be discharged can take normal steps in …

แนะนำหนังสือ, บัณฑิต เจ้าปฐมกุล

Chulalongkorn Medical Journal

No abstract provided.

ดรรชนีผู้แต่งจุฬาลงกรณ์เวชสาร 2011, N/A

Chulalongkorn Medical Journal

No abstract provided.

Parent-Led Activity And Nutrition (Plan) For Healthy Living: Design And Methods, William T. Dalton, Karen E. Schetzina, Nicole Holt, Hazel Fulton-Robinson, Ai-Leng Ho, Fred Tudiver, Mathew T. Mcbee, Tiejian Wu

ETSU Faculty Works

Child obesity has become an important public health concern, especially in rural areas. Primary care providers are well positioned to intervene with children and their parents, but encounter many barriers to addressing child overweight and obesity. This paper describes the design and methods of a cluster-randomized controlled trial to evaluate a parent-mediated approach utilizing physician's brief motivational interviewing and parent group sessions to treat child (ages 5–11 years) overweight and obesity in the primary care setting in Southern Appalachia. Specific aims of this pilot project will be 1) to establish a primary care based and parent-mediated childhood overweight intervention program …

Racing Start Safety: Head Depth And Head Speed During Competitive Backstroke Starts, Brian V. Wright, Andrew C. Cornett, Josh C. White, Alexander P. Willmott, Joel M. Stanger

Kinesiology Faculty Publications

Research on competitive swim start safety has focused on starts involving a dive from above the water surface. The purpose of this study was to determine the depths, speeds, and distances attained when executing backstroke starts, which begin in the water, and to investigate whether or not these variables are a function of age. Backstroke starts (n = 122) performed in 1.22 m of water during competition were stratified according to age group (8&U, 9-10, 11-12, 13-14, and 15&O). Dependent measures were maximum depth of the center of the head (MHD), head speed at maximum head depth (SPD), and distance …

Health Care Access And Use Among The Rural Uninsured [Policy Brief], Erika C. Ziller Phd, Jennifer D. Lenardson Mhs, Andrew F. Coburn Phd

Access / Insurance

In a landmark series of reports, the Institute of Medicine’s Committee on the Consequences of Uninsurance noted the policy significance of the “cascading” effects of uninsurance on patients, families, and communities.¹ Multiple studies confirm that rural residents are more likely to be uninsured than their urban counterparts.^2-4 Additionally, there is ample evidence that the uninsured have poorer access to care, delay care, and obtain care at levels of greater acuity than those with health insurance.⁵ However, the impact of being uninsured versus insured in rural areas, particularly compared to urban areas, is largely unknown.

Using data from …

A Model For Enhancing Diversity, Equity, Inclusion, And Belonging In A Speech Pathology And Audiology Program, Elizabeth R Oommen R. Oommen, Peggy Goetz, Brian M. Kreisman, Megan Nickelson, Morgan Bykerk

University Faculty Publications and Creative Works

Purpose: The SPAUD department at Calvin University recognized the need for initiatives that focused on intentionally enfolding and supporting Black, Indigenous, and people of color (BIPOC), international, and third culture students in a competitive major like communication sciences and disorders (CSD). These initiatives focused on diversity, equity, inclusion, and belonging (DEIB) practices, specifically: (1) to support retention and empowerment of students through peer mentoring and small group meetings; and (2) to equip the department to empower faculty and students to thrive together in the program and in their vocation through capacitybuilding.

Study design/methodology/approach: This is a case study paper outlining …

Postenucleation Adjuvant Chemotherapy With Vincristine, Etoposide, And Carboplatin For The Treatment Of High-Risk Retinoblastoma., Swathi Kaliki, Carol L Shields, Sanket U Shah, Ralph C Eagle, Jerry A Shields, Ann Leahey

Wills Eye Hospital Papers

BACKGROUND: Analysis of 52 eyes with high-risk retinoblastoma managed with postenucleation adjuvant chemotherapy using vincristine sulfate, etoposide phosphate, and carboplatin showed no evidence of systemic metastasis in any case during a mean (range) follow-up of 66 (12-202) months.

PURPOSE: To determine the efficacy of postenucleation adjuvant chemotherapy with vincristine, etoposide, and carboplatin in the prevention of metastasis for patients with high-risk retinoblastoma.

METHODS: Retrospective, nonrandomized, interventional case series of 52 eyes in 51 patients with high-risk retinoblastoma consisting of tumor invasion into the anterior segment, posterior uvea 3 mm or greater, postlaminar optic nerve, or any combination of posterior uvea …

Molecular Methods And Platforms For Infectious Diseases Testing: A Review Of Fda-Approved And Cleared Assays, Rajyasree Emmadi, Jerry B. Boonyaratanakornkit, Rangaraj Selvarangan, Venkatakrishna Shyamala, Barbara L. Zimmer, Laurina Williams, Bonita Bryant, Ted Schutzbank, Michele M. Schoonmaker, Jean A. Amos Wilson, Leslie Hall, Preeti Pancholi, Kathryn Bernard

Manuscripts, Articles, Book Chapters and Other Papers

The superior sensitivity and specificity associated with the use of molecular assays has greatly improved the field of infectious disease diagnostics by providing clinicians with results that are both accurate and rapidly obtained. Herein, we review molecularly based infectious disease diagnostic tests that are Food and Drug Administration approved or cleared and commercially available in the United States as of December 31, 2010. We describe specific assays and their performance, as stated in the Food and Drug Administration's Summary of Safety and Effectiveness Data or the Office of In Vitro Diagnostic Device Evaluation and Safety's decision summaries, product inserts, or …

A Bayesian Model For Gene Family Evolution, Liang Liu, Lili Yu, Venugopal Kalavacharla, Zhanji Liu

Biostatistics: Faculty Publications

Background

A birth and death process is frequently used for modeling the size of a gene family that may vary along the branches of a phylogenetic tree. Under the birth and death model, maximum likelihood methods have been developed to estimate the birth and death rate and the sizes of ancient gene families (numbers of gene copies at the internodes of the phylogenetic tree). This paper aims to provide a Bayesian approach for estimating parameters in the birth and death model.

Results

We develop a Bayesian approach for estimating the birth and death rate and other parameters in the birth …

On The Incidence Of Pulmonary Embolism In Spinal Arthrodesis And The Need For Better Evidence And Prevention Guidelines, Zachary J. Senders, Bs, Benjamin Zussman, Bs, James S. Harrop, Md

JHN Journal

Pulmonary Embolism (PE) is a rare but serious event that may occur after spinal surgery. Vascular endothelial damage during surgery and immobilization of the patient after surgery contribute to a higher risk of thrombosis and subsequent PE. Prophylaxis including intermittent pneumatic compression stockings, heparin, and other interventions is often employed by the treatment team to lower the risk of thromboembolic complications. In orthopedic, trauma, burn and other high-risk surgical patients, the incidence of PE has been thoroughly studied, and this knowledge has been used to establish prophylaxis guidelines specifically for these patients. The incidence of PE in spinal fusion patients, …

Surgical Management Of Fungal Vertebral Osteomyelitis, Benjamin M. Zussman, Bs, David L. Penn, Ms, James S. Harrop, Md

JHN Journal

Fungal vertebral osteomyelitis (FVO) is an uncommon but aggressive disease that may cause spinal instability, neurological insult, and possible death. Little data about treatment strategies and patient outcomes exist. A retrospective review of medical and surgical management with follow-up of this disease was performed.

Bevacizumab: A Controversial Agent Against High-Grade Gliomas, Sussan Salas, Md, Miguel Guzman, Md, Kevin Judy, Md

JHN Journal

Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor in adults. Despite the current regimen of surgical resection with subsequent external beam radiotherapy and temozolomide, mean survival is 14.6 months and 2-year survival is 26%. GBM is a highly vascular tumor, a result of its increased expression of vascular endothelial growth factor (VEGF) compared to other brain tumors. VEGF promotes endothelial cell proliferation, and is thought to have a pivotal role during tumor progression. Multiple treatment modalities have targeted VEGF and VEGF receptors (VEGFTs) due to their essential roles in the regulation of angiogenic processes. Bevacizumab is a …

Case Report On Intracranial Hemorrhage Related To Type I Cryoglobulinemia, Richard Dalyai, Md, L. Fernando Gonzalez, Md

JHN Journal

A traumatic intracranial hemorrhage (ICH) is a common neurosurgical pathology that affects about 20 of 100,000 people every year with a mortality of at least 40%. However, a specific etiology, cannot be identified in about 30% of spontaneous ICH. Here, we present a rare case of ICH related to a patient's previously undiagnosed cryoglobinemia.

Macrophages And Neutrophils From Humans And Mice Kill Larval Strongyloides Stercoralis During Innate Immunity, Sandra Bonne-Annee, Laura A. Kerepesi, Jessica A. Hess Ligas, David Abraham, Phd

Department of Microbiology and Immunology Faculty Papers

The parasitic nematode Strongyloides stercoralis (Ss) infects 30-100 million people worldwide, yet little is known about the immune response in humans. Previous studies on innate immunity to Ss in mice have demonstrated a role for eosinophils, neutrophils (PMN) and complement activation in the protective immune response.

Innate And Adaptive Immunity To The Nematode Strongyloides Stercoralis In A Mouse Model., Sandra Bonne-Annee, Jessica A. Hess, David Abraham

Department of Microbiology and Immunology Faculty Papers

Mice have been used to the study the mechanisms of protective innate and adaptive immunity to larval Strongyloides stercoralis. During primary infection, neutrophils and eosinophils are attracted by parasite components and kill the larvae by release of granule products. Eosinophils also function as antigen-presenting cells for the induction of a Th2 response. B cells produce both IgM and IgG that collaborate with neutrophils to kill worms in the adaptive immune response. Vaccine studies have identified a recombinant diagnostic antigen that induced high levels of immunity to infection with S. stercoralis in mice. These studies demonstrate that there are redundancies in …

Salud Y Saludos: The E-News Of The College Of Health Sciences, College Of Health Sciences

College of Health Sciences

Monthly e-newsletter of the College of Health Sciences.

Childhood Obesity And Blood Pressure: Back To The Future?, Bonita Falkner, Samuel Gidding

Department of Pediatrics Faculty Papers

The prevalence of childhood hypertension is increasing.^{1, 2} Studies that apply the 95^th percentile definition and repeat measurements on three separate visits, report a pediatric hypertension prevalence of approximately 3.5%^{3, 4}, and among obese children and adolescents the prevalence of both hypertension and prehypertension is even greater. The recently documented increase in hypertension among the young is due largely to the childhood obesity epidemic and possibly other secular changes in lifestyles. These publications and others confirm that hypertension is a prevalent child health condition, especially among overweight and obese children. A consistent positive association between body …

Social And Clinical Predictors Of Prostate Cancer Treatment Decisions Among Men In South Carolina, Sara E. Wagner, Bettina F. Drake, Keith Elder, James R. Hébert

Faculty Publications

OBJECTIVE:

To assess social and clinical influences of prostate cancer treatment decisions among white and black men in the Midlands of South Carolina.

METHODS:

We linked data collected on treatment decision making in men diagnosed with prostate cancer from 1996 through 2002 with clinical and sociodemographic factors collected routinely by the South Carolina Central Cancer Registry (SCCCR). Unconditional logistic regression was used to assess social and clinical influences on treatment decision.

RESULTS:

A total of 435 men were evaluated. Men of both races who chose surgery (versus radiation) were more likely to be influenced by their physician and by family/friends. …

The Prevalence Of Cervico-Arterial Dissection In Sub-Arachnoid Hemorrhage In The United States, Ali Seifi, Md, Fred Rincon, Md, Msc, Mitchell Maltenfort, Phd, Pascal Jabbour, Md, Rodney Bell, Md, Michael Moussouttas, Md

Department of Neurology Faculty Papers

Objectives: In this study, we sought to determine the prevalence of cervico-arterial dissection in aubarachnoid hemorrhage (SAH) using a large administrative database.

The Prevalence And Risk Factors Of Acute Myocardial Infarction (Ami) After Acute Ischemic Stroke (Ais) In The United States, Ali Seifi, Md, Fred Rincon, Md, Msc, Michael Moussouttas, Md, Mitchell Maltenfort, Phd, Matthew Vibbert, Md, Rodney Bell, Md, Maria Carissa Pineda, Md, Diana Tzeng, Md, Jacqueline Urtecho, Md, Anish Koka, Md, William Mcbride, Md

Department of Neurology Faculty Papers

Objectives: To determine the prevalence and risk factors for, and the association with in-hospital mortality of, AMI after AIS, and to study the effect of intravenous recombinant tissue plasminogen activator (r-tPA) in this setting. We hypothesized that AMI would be associated with lower survival rate at hospital discharge but that intravenous r-tPA would be associated with lower risk of AMI.