Medicine and Health Sciences Commons^™

Mechanisms Of The Contextual Interference Effect In Individuals Poststroke, Nicolas Schweughofer, Jeong-Yoon Lee, Hui-Ting Goh, Youggeun Choi, Sung Shin Kim, Jill Campbell Stewart Pt,Phd, Rebecca Lewthwaite, Carolee J. Winstein

Faculty Publications

Although intermixing different motor learning tasks via random schedules enhances long-term retention compared with “blocked” schedules, the mechanism underlying this contextual interference effect has been unclear. Furthermore, previous studies have reported inconclusive results in individuals poststroke. We instructed participants to learn to produce three grip force patterns in either random or blocked schedules and measured the contextual interference effect by long-term forgetting: the change in performance between immediate and 24-h posttests. Nondisabled participants exhibited the contextual interference effect: no forgetting in the random condition but forgetting in the blocked condition. Participants at least 3 mo poststroke exhibited no forgetting in …

The Raf/Mek/Extracellular Signal-Regulated Kinase 1/2 Pathway Can Mediate Growth Inhibitory And Differentiation Signaling Via Androgen Receptor Downregulation In Prostate Cancer Cells., Seung-Keun Hong, Jin-Hwan Kim, Ming-Fong Lin, Jong-In Park

Journal Articles: Biochemistry & Molecular Biology

Upregulated ERK1/2 activity is correlated with androgen receptor (AR) downregulation in certain prostate cancer (PCa) that exhibits androgen deprivation-induced neuroendocrine differentiation, but its functional relevance requires elucidation. We found that sustained ERK1/2 activation using active Raf or MEK1/2 mutants is sufficient to induce AR downregulation at mRNA and protein levels in LNCaP. Downregulation of AR protein, but not mRNA, was blocked by proteasome inhibitors, MG132 and bortezomib, indicating that the pathway regulation is mediated at multiple points. Ectopic expression of a constitutively active AR inhibited Raf/MEK/ERK-mediated regulation of the differentiation markers, neuron-specific enolase and neutral endopeptidase, and the cyclin-dependent kinase …

Sclerosing Adenosis And Radial Scar Of Breast :Imaging Findings And Breast Cancer Association, M Sakolnurak, D. Boonjunwetwat

Chulalongkorn Medical Journal

Background : Sclerosing adenosis and radial scar of the breast are benign conditions that may be mistaken for carcinoma on imaging and they are also considered independent risk for breast cancer. Objective : To demonstrate mammographic and ultrasonographic patterns of sclerosing adenosis and radial scar and to determinate the coexisting of both diseases to synchronous breast cancer. Material and Methods : Retrospective analysis of the pathology confirmed 80 sclerosing adenosis foci and 23 radial scar foci was performed. The mammographic and ultrasound features of each focus were analyzed. Coexisting of breast malignancy is also recorded. The result was reported descriptively. …

Prevalence Of Postpartum Depression And Associated Factors Among Nursing Mothers At King Chulalongkorn Memorial Hospital, S Withayavanitchai, C. Roomruangwong

Chulalongkorn Medical Journal

Background : There are evidences that postpartum depression (PPD) has major impacts on child-rearing capacities as well as disrupts mother-child bonding. Breastfeeding has been believed to have a role on increased positive mood, intensified bonding, and attenuated stress via the release of oxytocin, which has long been recognized as “love hormone”. However, the prevalence of PPD among breastfeeding women has not been studied. Objective : To examine the prevalence of postpartum depression as well as associated factors among nursing mothers at King Chulalongkorn Memorial Hospital. Design : A cross – sectional descriptive study. Setting : King Chulalongkorn Memorial Hospital. Materials …

What Are The Implications Of Accountable Care Organizations For Physical Medicine And Rehabilitation Practices?, John L. Melvin, Greg Worsowicz

Department of Rehabilitation Medicine Faculty Papers

The goal of delivering quality health care at a lower overall cost through accountable care organizations (ACO) as described as part of the Patient Protection and Affordable Care Act of 2010 (ACA) has gained momentum among payers, providers, and the public. The concept includes developing an organization that provides incentives for quality care while lowering the overall cost of the care. If the goals are met, then both providers and payers would be able to share in the financial savings produced by the lower health care costs achieved while improving the quality of care delivered. The Centers for Medicare and …

Combined Fluorescence And Reflectance Spectroscopy For In Vivo Quantification Of Cancer Biomarkers In Low- And High-Grade Glioma Surgery, Pablo A. ValdéS, Anthony Kim, Keith D. Paulsen, Frederic Leblond, Olga M. Conde, Brent T. Harris, David W. Roberts

Dartmouth Scholarship

Biomarkers are indicators of biological processes and hold promise for the diagnosis and treatment of disease. Gliomas represent a heterogeneous group of brain tumors with marked intra- and inter-tumor variability. The extent of surgical resection is a significant factor influencing post-surgical recurrence and prognosis. Here, we used fluorescence and reflectance spectral signatures for in vivo quantification of multiple biomarkers during glioma surgery, with fluorescence contrast provided by exogenously-induced protoporphyrin IX (PpIX) following administration of 5-aminolevulinic acid. We performed light-transport modeling to quantify multiple biomarkers indicative of tumor biological processes, including the local concentration of PpIX and associated photoproducts, total hemoglobin …

The Characteristics Of Borrelia Hermsii Infection In Human Hematopoeitic Stem Cell-Engrafted Mice Mirror Those Of Human Relapsing Fever, Raja Vuyyuru, Hongqi Liu, Tim Manser, Kishore Alugupalli

Department of Microbiology and Immunology Faculty Papers

Rodents are natural reservoirs for a variety of species of Borrelia that cause relapsing fevers in humans. The murine model of this disease recapitulates many of the clinical manifestations of the human disease and has revealed that T cell-independent antibody responses are required to resolve the bacteremic episodes. However, it is not clear whether such protective humoral responses are mounted in humans.

The Role Of Mer In Apoptotic Cell Clearance In The Germinal Center, Tahsin N. Khan, Eric B. Wong, Ziaur S.M. Rahman, Phd

Department of Microbiology and Immunology Faculty Papers

Germinal centers (GCs) are specialized micro-environments that generate high affinity Ab-forming cells (AFCs) and memory B cells. Many B cells undergo apoptosis during clonal selection in GCs. The TAM (Tyro-3, Axl, and Mer) family receptor tyrosine kinases, including Mer, facilitate macrophage clearance of apoptotic cells. We previously showed that tingible body macrophages (TBMφs) in GCs express Mer. We observed that apoptotic cells (ACs) accumulated in GCs of mice deficient in Mer (Mer-/-), after immunization with T-dependent Ag. Accumulation of ACs in GCs of Mer-/- mice resulted in significantly increased AFCs, GCs, and Th1-skewed IgG2c Ab responses. We report here that …

The Role Of Colour Duplex Ultrasound In The Surveillance Of Patients Undergoing Endovascular Aneurysm Repair, Cleona Gray

Doctoral

No abstract provided.

Outcomes Of An Intensive Smoking Cessation Program For Individuals With Substance Use Disorders, Milan Khara, Lindsay Killam, Chizimuzo T.C. Okoli

Nursing Presentations

BACKGROUND: Individuals with substance use disorders (SUD) are disproportionately affected by tobacco use morbidity and mortality. Yet, with adequate intervention, such individuals can be successful in their smoking cessation efforts. The Tobacco Dependence Clinic (TDC) provides tobacco dependence treatment using combined behavioural counseling and pharmacotherapy for clients through the Mental Health and Addiction Services of the Vancouver Coastal Health Authority, British Columbia, Canada.

OBJECTIVES: To a) provide smoking cessation outcomes of participants accessing the TDC b) examine predictors of program completion and smoking cessation of participants of the TDC.

METHODS: Participants of the TDC receive a structured 8 week group …

Oncolog, Volume 56, Number 11-12, November - December 2011, Sarah Bronson, Zach-Bryan Bogannan-Tutt

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Transoral Laser Microsurgery for Laryngeal and Oropharyngeal Tumors: A minimally invasive surgery for treating cancers of the larynx and oropharynx has cute rates similar to those of open surgery and radiation therapy in selected patients.
• Exploring Causes of and Treatments for Neuropathy in Cancer Patients: Among the most troubling side effects of cancer treatment in some patient is chronic chemotherapy neuropathy syndrome, in which tingling, numbness, and pain in the hands and feet persist long after the completion of treatment
• Prostate Cancer Screening: Patient should understand the purpose and limitations of the prostate-specific antigen test
• HOUSE CALL: Smoking Cessation: Medications …

Patient-Provider Communication Data: Linking Process And Outcomes In Oncology Care, Lisa Kennedy Sheldon, Fangxin Hong, Donna L. Berry

Nursing Faculty Publication Series

Overview: Patient–provider communication is vital to quality patient care in oncology settings and impacts health outcomes. Newer communication datasets contain patient symptom reports, real-time audiofiles of visits, coded communication data, and visit outcomes. The purpose of this paper is to: (1) review the complex communication processes during patient–provider interaction during oncology care; (2) describe methods of gathering and coding communication data; (3) suggest logical approaches to analyses; and (4) describe one new dataset that allows linking of patient symptoms and communication processes with visit outcomes. Challenges: Patient–provider communication research is complex due to numerous issues, including human subjects’ concerns, methods …

Interferons As Therapeutic Agents In Infectious Diseases, Mckenzie C. Ferguson, Scott Bergman, Cathy Santanello

Pharmacy Faculty Research, Scholarship, and Creative Activity

This article explains the rationale for development of interferons as therapeutic agents, and describes commercial products available today. It also provides a summary of studies that have been performed with interferons for use as exogenous biological response modifiers in viral infections. Overall, the best data exist for treatment of viral hepatitis B and C, for which interferons are a cornerstone of therapy. Although infections with human papillomavirus and common cold viruses sometimes respond favorably to interferons, their outcomes are far from ideal. Finally, the role of interferons as vaccine adjuvants is still being explored but could be promising.

Factors Related To Psychiatric Readmissions In A Large Community Academic Hospital, William Stern, Edward R. Norris Md, Fapa, Fapm, Karen Burke Rn, Julia R. Correll Ba, Michael Kaufmann Md

Department of Psychiatry

No abstract provided.

Voluntary Career Transition Of Managers In China: A Grounded Theory Study, Judy Yi Sun

Nursing Theses and Dissertations

The purpose of this study is to investigate Chinese managers' voluntary career transitions (VCTs) in the contemporary Chinese organizational and socioeconomic context to offer an understanding and an explanation of the mass VCT phenomenon coupled with the Chinese organizational transformation. The study followed a qualitative research design with the traditional grounded theory approach. Following a theoretical sampling process, twenty-two Chinese managers were selected and interviewed for the study. The findings were reported in relation to three guiding research questions. A contextualized typology of VCTs emerged from data that revealed different patterns of VCTs from behavioral, cognitive and affective aspects. Career …

Factors Influencing The Implementation Of A Point-Of-Care Screening Tool For Delirium, Beth Ann Swan, Phd, Crnp, Faan, Julie Becker, Phd, Mph, Rickie Brawer, Mph, Phd, Christopher N. Sciamanna, Md, Mph

College of Nursing Faculty Papers & Presentations

Given the ample evidence delirium in hospitalized older adults is under diagnosed and not recognized by nurses up to 85% of the time, interventions are needed at the point of care to assist nurses in recognizing delirium. In this qualitative study, factors that might influence the implementation of a point-of-care screening tool for delirium were examined.

Program...Validate...Infuse: Developing An Iv Infusion Validation Tool, Nancy Humes Bsn, Rn, Nicole Zimmerman Bsn, Rn

Patient Care Services / Nursing

No abstract provided.

The Utilization Of A Sub-Glottic Endotracheal Tube To Reduce Ventilator Associated Pneumonia Rate, Kenneth Miller Med, Rrt-Nps, Robert Leshko Bs,Rrt, Angela Lutz Bs, Rrt-Nps, Linda Cornman Bs, Rrt-Nps

Patient Care Services / Nursing

No abstract provided.

Genotype And Cardiovascular Phenotype Correlations With Tbx1 In 1,022 Velo-Cardio-Facial/Digeorge/22q11.2 Deletion Syndrome Patients, Tingwei Guo, Donna Mcdonald-Mcginn, Anna Blonska, Alan L. Shanske, Anne S. Bassett, Eva Chow, Mark Bowser, Molly Sheridan, Frits Beemer, Koen Devriendt, Ann Swillen, Jeroen Breckpot, Maria C. Digilio, Bruno Marino, Bruno Dallapiccola, Courtney Carpenter, Xin Zheng, Jacob Johnson, Jonathan Chung, Anne Marie Higgins, Nicole Philip, Tony J. Simon, Karlene Coleman, Damian Heine-Suner, Jordi Rosell, Wendy R. Kates, Marcella Devoto, Elizabeth Goldmuntz, Elaine Zackai, Tao Wang, Robert J. Shprintzen, Beverly Emanuel, Bernice Morrow, The International Chromosome 22q11.2 Consortium

Communication Disorders Faculty Publications

Haploinsufficiency of TBX1, encoding a T-box transcription factor, is largely responsible for the physical malformations in velo-cardio-facial /DiGeorge/22q11.2 deletion syndrome (22q11DS) patients. Cardiovascular malformations in these patients are highly variable, raising the question as to whether DNA variations in the TBX1 locus on the remaining allele of 22q11.2 could be responsible. To test this, a large sample size is needed. The TBX1 gene was sequenced in 360 consecutive 22q11DS patients. Rare and common variations were identified. We did not detect enrichment in rare SNP (single nucleotide polymorphism) number in those with or without a congenital heart defect. One exception …

Characterization Of The Drosophila Slowpoke Binding Protein (Slob) Promoter, Amanda L. Sheldon, Lauren Manderfield, Irwin B. Levitan

Farber Institute for Neuroscience Faculty Papers

Drosophila SLOWPOKE (SLO) is a voltage and calcium dependent, large conductance potassium channel important for action potential repolarization, neuronal excitability, neurotransmitter release, and hormone secretion. SLO binding protein (SLOB) binds to and modulates SLO activity. We have shown previously that modulation of SLO by SLOB has profound effects on SLO channel currents, synaptic transmisison, and metabolism. Multiple isoforms of SLOB exist and are encoded by multiple transcripts; the isoforms are named based on their predicted protein molecular weights, in kilodaltons. In the Drosophila brain, SLOB57/51 proteins are expressed especially prominently in insulin producing neurons of the pars intercerebralis, while SLOB71/65 …

The Association Between Parity, Infant Gender, Higher Level Of Paternal Education And Preterm Birth In Pakistan: A Cohort Study, Kiran Shaikh, Shahirose Sadrudin Premji, Marianne S. Rose, Ambreen Kazi, Shaneela Khowaja, Suzanne Tough

School of Nursing & Midwifery

Background:

High rates of antenatal depression and preterm birth have been reported in Pakistan. Self reported maternal stress and depression have been associated with preterm birth, however findings are inconsistent. Cortisol is a biological marker of stress and depression, and its measurement may assist in understanding the influence of self reported maternal stress and depression on preterm birth.

Methods:

In a prospective cohort study pregnant women between 28 to 30 weeks of gestation from the Aga Khan Hospital for Women and Children completed the A-Z Stress Scale and the Centre for Epidemiology Studies Depression Scale to assess stress and depression …

Brca1 Status In Pakistani Breast Cancer Patients With Moderate Family History, Tariq Moatter, Muniba Aban, Shaista Khan, Iqbal Azam, Shahid Pervez

Department of Pathology and Laboratory Medicine

OBJECTIVE: To determine BRCA1 status in breast carcinoma patients of Pakistani origin.

STUDY DESIGN: Observational study.

PLACE AND DURATION OF STUDY: The Oncology Clinics of the Aga Khan University Hospital, Karachi, between May 2005 and December 2009.

METHODOLOGY: Fifty three breast cancer patients based on clinical and laboratory diagnosis were recruited for this study. Moderate family history was defined as having a close relative (mother, daughter, sister) diagnosed with breast cancer under 45 years. Peripheral blood samples were collected from each patient in a 5 ml tube containing EDTA as anticoagulant. Subsequent to DNA extraction, mutational analysis of BRCA1 exons …

Vesicular Stomatitis Virus In The Treatment Of Hepatocellular Carcinoma, Celene Joza

Animal Science

No abstract provided.

Ct Appearances Of Responsive Gastrointestinal Stromal Tumors (Gists) After Imatinib Mesylate Treatment, S Sriariyametta, V Sriuranpong, K Arjhansiri, B. Chaopathomkul

Chulalongkorn Medical Journal

Background : Gastrointestinal stromal tumors (GISTs) have their specific receptor that allows the use of specific target drug. CT scan is the imaging technique of choice to evaluate the response of the tumor. There are some conflicts about CT parameter such as size and density that confuse radiologists in the evaluation of the tumor response. Objective : Our objective is to evaluate CT appearances in patients with GISTs who have response after imatinib treatment by combination of RECIST criteria and density, vascularity, solid nodule and cystic change of the tumor. Design : Retrospective study Setting : King Chulalongkorn Memorial Hospital, …

The Patient Dose From Digital Mammography Systems Using Molybdenum And Tungsten Targets, K Theerakul, A. Krisanachinda

Chulalongkorn Medical Journal

Background : Two digital mammographic systems of different targets and filters offer different radiation doses to patients. Objective : To determine the average glandular dose (AGD), the entrance surface air kerma (ESAK) from cranio-caudal (CC) and medio-lateral oblique (MLO) projections and the dose reference level (DRL) from CC projection at both breasts when two digital mammogram systems of molybdenum (Mo) target and molybdenum or rhodium (Rh) filters of one system and tungsten (W) target and rhodium filter of the other system were clinically used. Methods : Patients' data from two digital mammography systems were analyzed in terms of the compressed …

Creativity Thinking Of Chulalongkorn Medical Students, J Nakniyom, C. Nimnuan

Chulalongkorn Medical Journal

Background : Creativity is an important attribute of physicians. Creativity helps improve and enhance medical students' ability to think and provide qualified and effective services. Objective : To study the level of creative thinking and factors affecting the creative thinking of Chulalongkorn Medical students. Design : A cross – sectional descriptive study. Setting : Faculty of Medicine, Chulalongkorn University. Materials and Methods : The data were collected by questionnaires from 434 medical students of Chulalongkorn University who were in the first to the fifth year in 2010. Questionnaire consisted of demographic data, creative thinking and achievement motivation measures. The data …

คำขอบคุณ, N/A

Chulalongkorn Medical Journal

No abstract provided.

ดรรชนีบทความจุฬาลงกรณ์เวชสาร 2011, N/A

Chulalongkorn Medical Journal

No abstract provided.

A Primer For Consumer Involvement In Medicaid Nursing Facility Reimbursement: Lessons From New York And Minnesota, Edward Alan Miller, Cynthia Rudder

Gerontology Institute Publications

Medicaid is the major purchaser of nursing home care in the United States. To ensure that providers behave appropriately, the federal and state governments have established an extensive set of regulations that nursing homes must comply with if they are to be reimbursed for patients insured by Medicaid. Consumers exert considerable influence here by focusing on regulations and enforcement of non-compliance.

States also seek to align providers’ interests with those of other interested parties through controls and incentives built into state reimbursement systems, including with respect to facility cost and quality, access to care, payment equity, service capacity, and budgetary …

Consumer Involvement In Medicaid Nursing Facility Reimbursement: Lessons From New York And Minnesota For State Policymakers, Edward Alan Miller, Cynthia Rudder

Gerontology Institute Publications

Medicaid is the major purchaser of nursing home care in the United States. State governments design their methods of reimbursing nursing homes to achieve desired policy objectives related to facility cost and quality, access to care, payment equity, service capacity, and budgetary control.

Often, participation in the process of developing Medicaid payment policy is limited to state agency officials and providers of care and, occasionally, union representatives and state legislative staff. Invited less frequently to reimbursement policy discussions are consumer representatives. Lack of consumer involvement in the development of state rate setting systems has the potential to result in the …