Medicine and Health Sciences Commons^™

Entrepreneurial Factors For The Fitness Industry, Steven M. Herrmann

Master's Theses and Doctoral Dissertations

The following work examines the different aspects of opening an exercise-based business and identifies factors of the competitive environment that are conducive to opening a recreational and athletic strength training facility. Questions were answered regarding what type of exercise-based business could feasibly compete against the other exercise-based businesses and related non-profit organizations and what the existing exercise-based businesses and related non-profit organizations located within a 30-mile radius of southwest Dearborn, Michigan, were doing to survive in the current competitive economy. Information was gathered from100 fitness facility websites and 30 survey interviews from the managers and owners of the exercise-based businesses …

Analysis Of Gaba And Glutamate In The Mouse Dorsal Striatum, Stella Wisidagamage

Wayne State University Theses

ABSTRACT

ANALYSIS OF GABA AND GLUTAMATE IN MICE BRAIN

by

STELLA WISIDAGAMA

May 2011

Advisor: Dr. Tiffany Mathews

Major: Chemistry (Analytical)

Degree: Master of Science

GABA and glutamate are the predominant inhibitory and excitatory amino acid neurotransmitters in the central nervous system (CNS), respectively. However, their altered levels cause several neurological diseases including Parkinson's and Huntington's disease, schizophrenia, and epilepsy. It is important to measure their levels in the extra- and intracellular environments to better understand and develop improved therapeutics that will treat these neurological disorders. The principle aim of this study is to study the impacts of different endogenous …

Anticoagulation Clinic Led By Experiential Education Team, Asim Abu-Baker

Pharmacy Faculty/Staff Publications

No abstract provided.

Increased Hypoglycemia Associated With Renal Failure During Continuous Intravenous Insulin Infusion And Specialized Nutritional Support, Roland N. Dickerson, Leslie A. Hamilton, Kathryn A. Connor, George O. Maish, Martin A. Croce, Gayle Minard, Rex O. Brown

Pharmacy Faculty/Staff Publications

Objective: To evaluate glycemic control for critically ill, hyperglycemic trauma patients with renal failure who received concurrent intensive insulin therapy and continuous enteral (EN) or parenteral nutrition (PN).

Methods: Adult trauma patients with renal failure, who were given EN or PN concurrently with continuous graduated intravenous regular human insulin (RHI) infusion for at least 3 days were evaluated. Our conventional RHI algorithm was modified for those with renal failure by allowing greater changes in blood glucose concentrations (BG) before the infusion rate was escalated. BG was determined every 1-2 hours while receiving the insulin infusion. BG control was evaluated on …

Joseph Hersey Pratt, M.D.: The Man Who Would Be Osler, Charles T. Ambrose

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Joseph Hersey Pratt (1872-1956) was a member of the second class of the Johns Hopkins Medical School, where he became a devoted student of William Osler and life-long disciple. Pratt received his medical degree in 1898 and spent his professional career in Boston. He maintained a close association with Osler until the latter's death in 1919, when Osler's deification as a secular medical saint began. When Pratt died in 1956 at age 83, the Boston Globe eulogized him in an editorial which read, "Dr. Pratt earned a place in the group of Boston medical immortals who have done so much …

Osler And The Infected Letter: A History Of Disinfecting Mail With Special Reference To Smallpox, Charles T. Ambrose

Microbiology, Immunology, and Molecular Genetics Faculty Publications

In January 1876 William Osler, a young Canadian physician, was recovering from a mild case of smallpox contracted while attending patients at the Montreal General Hospital (Figure 1). In a letter written that same month to an old schoolmate (ArthurJarvis), Osier described his illness and noted in closing, "You need not be afraid of this letter. I will disinfect it before sending." Concern about disseminating smallpox via the letter was well founded. In his medical textbook of 1892, Osler would later write that smallpox can be conveyed by fomites: "the dried scales [of variola scabs] ... as a dust-like powder …

A New Hepato-Protective Flavone Glycoside From The Flowers Of Onopordum Alexandrinum Growing In Egypt, Maha Salama, Shahira Mohammed Ezzat

Pharmacy

A bioactivity-guided fractionation of the ethyl acetate fraction of the flowers of Onopordum alexandrinum L. (Asteraceae) yielded a new flavonoidal glycoside designated as acacetin-7-O-galacturonide (9), alongside with nine known flavonoids; 6-methoxy-apigenin (hispidulin) (1), acacetin (2), apigenin (3), luteolin (4), kaempferol (5), eriodictyol (6), apigenin-7-O-glucoside (7), luteolin-7-O-glucoside (8), and kaempferol-3-O-rutinoside (10). The compounds were assayed for their hepatoprotective activity against CCl4-induced hepatic cell damage in rats and free radical scavenging activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH). Compounds 4, 6, 9, and 10 have not been previously reported from flowers of O. alexandrinum L., and this is the first report of acacetin-7-O-galacturonide (9) in …

A Perfusion Mri Study Of Emotional Valence And Arousal In Parkinson's Disease, Sunsern Limsoontarakul, Meghan C. Campbell, Kevin J. Black

Open Access Publications

No abstract provided.

More Than 200 Genes Required For Methane Formation From H₂ And Co₂ And Energy Conservation Are Present In Methanothermobacter Marburgensis And Methanothermobacter Thermautotrophicus, Anne-Kristin Kaster, Meike Goenrich, Henning Seedorf, Heiko Liesegang, Antje Wollherr, Gerhard Gottschalk, Rudolf K. Thauer

Open Access Publications

No abstract provided.

Cxcr7 Antagonism Prevents Axonal Injury During Experimental Autoimmune Encephalomyelitis As Revealed By In Vivo Axial Diffusivity, Lillian Cruz-Orengo, Ying-Jr Chen, Joong Hee Kim, Denise Dorsey, Sheng-Kwei Song, Robyn S. Klein

Open Access Publications

No abstract provided.

Engraftment Of Insulin-Producing Cells From Porcine Islets In Non-Immune-Suppressed Rats Or Nonhuman Primates Transplanted Previously With Embryonic Pig Pancreas, Marc R. Hammerman

Open Access Publications

No abstract provided.

Diagnosis And Management Of Fetal Growth Restriction, Jacqueline E. A. K. Bamfo, Anthony O. Odibo

Open Access Publications

No abstract provided.

An Evolutionary Genomic Approach To Identify Genes Involved In Human Birth Timing, Jevon Plunkett, Scott Doniger, Guilherme Orabona, Thomas Morgan, Ritva Haataja, Mikko Hallman, Hilkka Puttonen, Ramkumar Menon, Edward Kuczynski, Errol Norwitz, Victoria Snegovskikh, Aarno Palotie, Leena Peltonen, Vineta Fellman, Emily A. Defranco, Bimal P. Chaudhari, Tracy L. Mcgregor, Jude J. Mcelroy, Matthew T. Oetjens, Kari Teramo, Ingrid Borecki, Justin Fay, Louis Muglia

Open Access Publications

No abstract provided.

Dynamic Analysis Of Amyloid Β-Protein In Behaving Mice Reveals Opposing Changes In Isf Versus Parenchymal Aβ During Age-Related Plaque Formation, Soyon Hong, Omar Quintero-Monzon, Beth L. Ostaszewski, Daniel R. Podlisny, William T. Cavanaugh, Ting Yang, David M. Holtzman, John R. Cirrito, Dennis J. Selkoe

Open Access Publications

No abstract provided.

Micrornas Modulate Schwann Cell Response To Nerve Injury By Reinforcing Transcriptional Silencing Of Dedifferentiation-Related Genes, Andreu Viader, Li-Wei Chang, Timothy Fahrner, Rakesh Nagarajan, Jeffrey Milbrandt

Open Access Publications

No abstract provided.

Resorufin Analogs Preferentially Bind Cerebrovascular Amyloid: Potential Use As Imaging Ligands For Cerebral Amyloid Angiopathy, Byung Hee Han, Meng-Liang Zhou, Ananth K. Vellimana, Eric Milner, David H. Kim, Jacob K. Greenberg, Wenhua Chu, Robert H. Mach, Gregory J. Zipfel

Open Access Publications

No abstract provided.

Pregnancy In Multiple System Atrophy: A Case Report, Lirong Zhu, Nigel J. Cairns, Samer D. Tabbal, Brad A. Racette

Open Access Publications

No abstract provided.

Type I Interferon Negatively Controls Plasmacytoid Dendritic Cell Numbers In Vivo, Melissa Swiecki, Yaming Wang, William Vermi, Susan Gilfillan, Robert D. Schreiber, Marco Colonna

Open Access Publications

No abstract provided.

The Parkinsonian Mimetic, Mpp+, Specifically Impairs Mitochondrial Transport In Dopamine Axons, Jeong S. Kim-Han, Jo Ann Antenor-Dorsey, Karen L. O'Malley

Open Access Publications

No abstract provided.

The Mammalian Cone Visual Cycle Promotes Rapid M/L-Cone Pigment Regeneration Independently Of The Interphotoreceptor Retinoid-Binding Protein, Alexander V. Kolesnikov, Peter H. Tang, Ryan O. Parker, Rosalie K. Crouch, Vladimir J. Kefalov

Open Access Publications

No abstract provided.

Critical Role Of Astroglial Apolipoprotein E And Liver X Receptor-Α Expression For Microglial Aβ Phagocytosis, Dick Terwel, Knut R. Steffensen, Philip B. Verghese, Markus P. Kummer, Jan-Åke Gustafsson, David M. Holtzman, Michael T. Heneka

Open Access Publications

No abstract provided.

Specification Of A Foxj1-Dependent Lineage In The Forebrain Is Required For Embryonic-To-Postnatal Transition Of Neurogenesis In The Olfactory Bulb, Benoit V. Jacquet, Nagendran Muthusamy, Laura J. Sommerville, Guanxi Xiao, Huixuan Liang, Yong Zhang, Michael J. Holtzman, H. T. Ghashghaei

Open Access Publications

No abstract provided.

A Sensitive High-Throughput Assay For Evaluating Host-Pathogen Interactions In Cryptococcus Neoformans Infection, Deepa Srikanta, Meng Yang, Matthew Williams, Tamara L. Doering

Open Access Publications

No abstract provided.

Toward An Interactive Article: Integrating Journals And Biological Databases, Arun Rangarajan, Tim Schedl, Karen Yook, Juancarlos Chan, Stephen Haenel, Lolly Otis, Sharon Faelten, Tracey Depellegrin-Connelly, Ruth Isaacson, Marek S. Skrzypek, Steven J. Marygold, Raymund Raymund, J Michael Cherry, Paul W. Sternberg, Hans-Michael Müller

Open Access Publications

No abstract provided.

Lung Transplantation For Pulmonary Fibrosis In Dyskeratosis Congenita: Case Report And Systematic Literature Review, Neelam Giri, Rees Lee, Albert Faro, Charles B. Huddleston, Frances V. White, Blanche P. Alter, Sharon A. Savage

Open Access Publications

No abstract provided.

Identification Of Transcriptional Regulatory Networks Specific To Pilocytic Astrocytoma, Hrishikesh Deshmukh, Jinsheng Yu, Jahangheer Shaik, Tobey J. Macdonald, Arie Perry, Jacqueline E. Payton, David H. Gutmann, Mark A. Watson, Rakesh Nagarajan

Open Access Publications

No abstract provided.

Opposing Synaptic Regulation Of Amyloid-Β Metabolism By Nmda Receptors In Vivo, Deborah K. Verges, Jessica L. Restivo, Whitney D. Goebel, David M. Holtzman, John R. Cirrito

Open Access Publications

No abstract provided.

Hiv Protease Inhibitors Act As Competitive Inhibitors Of The Cytoplasmic Glucose Binding Site Of Gluts With Differing Affinities For Glut1 And Glut4, Richard C. Hresko, Paul W. Hruz

Open Access Publications

No abstract provided.

Exenatide Improves Glucose Homeostasis And Prolongs Survival In A Murine Model Of Dilated Cardiomyopathy, Arpita Kalla Vyas, Kai-Chen Yang, Dennis Woo, Anatoly Tzekov, Attila Kovacs, Patrick Y. Jay, Paul W. Hruz

Open Access Publications

No abstract provided.

Actin Depolymerizing Factor Controls Actin Turnover And Gliding Motility In Toxoplasma Gondii, Simren Mehta, L. David Sibley

Open Access Publications

No abstract provided.