Medicine and Health Sciences Commons^™

Self-Harm In Laboratory-Housed Primates: Where Is The Evidence That The Animal Welfare Act Amendment Has Worked?, Jonathan Balcombe, Hope Ferdowsian, Debra Durham

Animal Welfare Collection

The 1985 amendment to the United States Animal Welfare Act (AWA) to promote psychological well being of primates in the laboratory represents an acknowledgment of an important welfare problem concerning nonhuman animals. How effective has this amendment been? Perhaps the best-known contributor to psychological distress in primates in the laboratory is nonsocial housing; yet, available analyses suggest that little progress has been made in avoiding single-caging of these animals. Another way to assess psychological well being is to examine rates of self-abusive behavior in laboratory primates. If the AWA has been effective, then post-AWA self-harm rates might be lower than …

Chemical Composition And Product Quality Control Of Turmeric (Curcuma Longa L.), Shiyou Li, Wei Yuan, Guangrui Deng, Ping Wang, Peiying Yang, Bharat Aggarwal

Faculty Publications

Chemical constituents of various tissues of turmeric (Curcuma longa L.) have been extensively investigated. To date, at least 235 compounds, primarily phenolic compounds and terpenoids have been identified from the species, including 22 diarylheptanoids and diarylpentanoids, eight phenylpropene and other phenolic compounds, 68 monoterpenes, 109 sesquiterpenes, five diterpenes, three triterpenoids, four sterols, two alkaloids, and 14 other compounds. Curcuminoids (diarylheptanoids) and essential oils are major bioactive ingredients showing various bioactivities in in vitro and in vivo bioassays. Curcuminoids in turmeric are primarily accumulated in rhizomes. The essential oils from leaves and flowers are usually dominated by monoterpenes while those from …

Prehypertension And Endothelial Progenitor Cell Function., Oj Maceneaney, C A Desouza, B R Weil, E J Kushner, Gary Van Guilder, M L Mestek, J J Greiner, B L Stauffer

Health and Nutritional Sciences Faculty Publications

Prehypertension is associated with significant damage to the coronary vasculature and increased rates of adverse cardiovascular events. Circulating endothelial progenitor cells (EPCs) are critical to vascular repair and the formation of new blood vessels. We tested the hypothesis that prehypertension is associated with EPC dysfunction. Peripheral blood samples were collected from 83 middle-aged and older adults (51 M/32 F): 40 normotensive (age 53±2 yr; BP 111/74±1/1 mmHg) and 43 prehypertensive (54±2; 128/77±1/1 mmHg). EPCs were isolated from peripheral blood and EPC colony-forming capacity (colony-forming unit assay), migratory activity (Boyden chamber) and apoptotic susceptibility (active caspase-3 concentrations) were determined. There were …

The College Of Pharmacy, South Dakota State University

Jackrabbits Script and Scope (Formerly called College of Pharmacy and Allied Health Professions Magazine)

Dean’s message (Inside front cover)
[Page] 5 Research Rahman offers Research opportunities to undergraduates
[Page] 7 West River Health Camp Wicozani Academy spotlights native health-care providers
[Page] 9 Education Workshop uses mock patients to develop medical teamwork [Page] 11 Cover Story Avera Health and Science Center lives up to billing
[Page] 14 Administration Students, faculty benefit from new administrative approach
[Page] 15 Building Project Donors Independent pharmacies step forward with gifts
[Page] 17 Alumnus of the Year Alaskan independent pharmacist White honored by College
[Page] 18 Fall Convocation Presentation Diabetes project researches clinical stage
[Page] 19 Distinguished Alum Compounding catapults …

Financial Disagreements And Marital Conflict Tactics, Jeffery Dew, J Dakin

Human Development and Family Studies Faculty Publications

Recent studies have suggested that relative to other types of marital disagreement, financial disagreements are more problematic for couples. Using data from the National Survey of Families and Households (N = 3,861 couples), we tested whether different types of marital disagreements predicted self-reported marital conflict tactics. Considering the findings overall, financial disagreements were among the consistent top predictors of conflict tactics, including using heated arguments more frequently than calm discussion. Contrary to previous studies, however, disagreements over housework also predicted conflict tactics about as strongly as financial disagreements. Husbands’ reports of financial disagreements were more closely associated with conflict tactics …

Cultural Competancy In Nursing Education, Linda Eileen Wolf, Cheryl Delgado

Nursing Faculty Publications

No abstract provided.

Muscle Plasticity And Intramuscular Signaling In The Insulin-Resistant Obese Zucker Rat, Anjaiah Katta

Theses, Dissertations and Capstones

The ability to increase skeletal muscle mass may have important implications for the treatment of insulin resistance (IR) and diabetes [1-3]. Recent data suggest that IR muscle may adapt differently than normal muscle; however, molecular mechanism(s) responsible for this finding are not well understood [4]. Herein, we investigate the molecular mechanisms underlying the skeletal muscle remodeling in the IR Obese Zucker (OZ) rat.

The OZ rat is characterized by skeletal muscle insulin resistance, hyperglycemia, and hyperlipidemia. Compared to LZ rats, our data demonstrate that soleus muscle hypertrophy was significantly attenuated in the OZ rats after 3-weeks of muscle overload and …

Consensus-Based Reporting Standards For Diagnostic Test Accuracy Studies For Paratuberculosis In Ruminants, Ian A. Gardner, Søren S. Nielsen, Richard J. Whittington, Michael T. Collins, Douwe Bakker, Beth Harris, Srinand Sreevatsan, Jason E. Lombard, Raymond Sweeney, David L. Smith, Jerie Gavalchin, Shigetoshi Eda

Zoonotics and Wildlife Disease: Publications

The Standards for Reporting of Diagnostic Accuracy (STARD) statement was developed to encourage complete and transparent reporting of key elements of test accuracy studies in human medicine. The statement was motivated by widespread evidence of bias in test accuracy studies and the finding that incomplete or absent reporting of items in the STARD checklist was associated with overly optimistic estimates of test performance characteristics. Although STARD principles apply broadly, specific guidelines do not exist to account for unique considerations in livestock studies such as herd tests, potential use of experimental challenge studies, a more diverse group of testing purposes and …

Bovine Tuberculosis In A Nebraska Herd Of Farmed Elk And Fallow Deer: A Failure Of The Tuberculin Skin Test And Opportunities For Serodiagnosis, W. Ray Waters, Gary E. Stevens, Mark A. Schoenbaum, Kathy A. Orloski, Suelee Robbe-Austerman, N. Beth Harris, S. Mark Hall, Bruce V. Thomsen, Arach J. Wilson, Roger E. Brannian, Jeffrey T. Nelson, Shawn Schafer, Javan Esfandiari, Meghan Dutton, Rena Greenwald, Konstantin P. Lyashchenko

Zoonotics and Wildlife Disease: Publications

In 2009, Mycobacterium bovis infection was detected in a herd of 60 elk (Cervus elaphus) and 50 fallow deer (Dama dama) in Nebraska, USA. Upon depopulation of the herd, the prevalence of bovine tuberculosis (TB) was estimated at ∼71–75%, based upon histopathology and culture results. Particularly with elk, gross lesions were often severe and extensive. One year ago, the majority of the elk had been tested for TB by single cervical test (SCT), and all were negative. After initial detection of a tuberculous elk in this herd, 42 of the 59 elk were tested by SCT. …

Er Stress And Lipid Metabolism In Adipocytes, Beth S. Zha, Huiping Zhou

Microbiology and Immunology Publications

The role of endoplasmic reticulum (ER) stress is a rapidly emerging field of interest in the pathogenesis of metabolic diseases. Recent studies have shown that chronic activation of ER stress is closely linked to dysregulation of lipid metabolism in several metabolically important cells including hepatocytes, macrophages, β-cells, and adipocytes. Adipocytes are one of the major cell types involved in the pathogenesis of the metabolic syndrome. Recent advances in dissecting the cellular and molecular mechanisms involved in the regulation of adipogenesis and lipid metabolism indicate that activation of ER stress plays a central role in regulating adipocyte function. In this paper, …

Tumor Escape And Progression Of Her-2/Neu Negative Breast Cancer Under Immune Pressure, Maciej Kmieciak, Kyle K. Payne, Michael O. Idowu, Margaret M. Grimes, Laura Graham, Maria-Libera Ascierto, Ena Wang, Xiang-Yang Wang, Harry D. Bear, Masoud H. Manjili

Microbiology and Immunology Publications

Background Emerging data from pre-clinical and clinical studies suggest that HER-2/neu-specific T cell responses could induce HER-2/neu antigen loss in the tumor cells. These data suggest that patients with HER-2/neu negative breast cancer might have had HER-2/neu positive premalignant lesions in the past that progressed to HER-2/neu negative breast cancer under HER-2/neu-specific immune pressure.

Methods We conducted a pilot study in patients with HER-2/neu positive and HER-2/neu negative breast cancers as well as a patient with ductal carcinoma in situ (DCIS). HER-2/neu expression was determined by FISH. HER-2/neu-specific T cell responses were determined by using IFN-γ ELISA. Expression of IFN-γ …

Accountable Care Organization Musical Chairs: Will There Be A Seat Remaining For The Small Group Or Solo Practice?, Amy Vaughan, Alberto Coustasse

Management Faculty Research

When it was introduced in the Affordable Care Act of 2010 as the new 2012 payment model for Medicare, an accountable care organization (ACO) was a new and untested concept in healthcare delivery and payment. The authors estimated the likelihood of engagement in ACOs by small group and solo healthcare practitioners. An evaluation of five case studies showed that significant organizational, financial, and technological challenges had to be met in order to launch an ACO. Sufficient resources to meet those challenges were best supplied by large organizations. Small or solo practices participated only through varying levels of integration as salaried …

Efficacy And Safety Of Dabigatran: A Comparison Of Food And Drug Administration Approved Dosing Regimens, Kenneth Lupi Pharmd, Joseph Ottinger Rph, Ms, Mba, Bcps

Department of Pharmacy

No abstract provided.

Using Script Concordance Testing (Sct) As A New Modality Of Assessment For Graduate Entry Medical Students – A Pilot Study., Michael Wan, Rosa Canalese, Lawrence T. Lam, Gavin Frost, Paul Duggan

Medical Conference Papers

Background: SCT is a new modality of assessment in medical education. By presenting a clinical scenario, additional pieces of information are given and the students are asked to assess whether this information increases or decreases the probability of the diagnosis. This reflects the clinician’s everyday real-world script determination. It tests the clinical reasoning and problem solving ability and how they apply their learned knowledge in the context of uncertainty. Their decision is compared to a panel of clinicians. Studies have shown that the scores correlate with the level of training and predict future performance on clinical reasoning

Methods: The School …

All-Terrain Vehicle-Related Injuries And Hospitalization: An Examination Of The Influence Of Age And Alcohol Or Drugs, Shelby Bohl, Manoj Sharma, Chester Jones

Walden Faculty and Staff Publications

All-terrain vehicle (ATV) related injuries are a significant source of morbidity, mortality, disability, and hospitalization, and serious injuries among the elderly are increasing. In addition, alcohol and drug use are prevalent among those injured in ATV-related incidents. However, studies indicate varying alcohol and drug use patterns among age groups and less attention has been paid to the experience of older adults and to the influence of substance abuse (alcohol or drug involvement). Therefore, the purpose of this study was to examine the relationship between age, substance abuse and hospitalization resulting from ATV incidents among injured adults over the age of …

Relationship Between Graduate Students' Statistics Self-Efficacy, Statistics Anxiety, Attitude Toward Statistics, And Social Support, Michelle Perepiczka, Nichelle Chandler, Michael Becerra

Walden Faculty and Staff Publications

Statistics plays an integral role in graduate programs. However, numerous intra- and interpersonal factors may lead to successful completion of needed coursework in this area. The authors examined the extent of the relationship between self-efficacy to learn statistics and statistics anxiety, attitude towards statistics, and social support of 166 graduate students enrolled in master’s and doctoral programs within colleges of education. Results indicated that statistics anxiety and attitude towards statistics were statistically significant predictors of self-efficacy to learn statistics, yet social support was not a statistically significant predictor of self-efficacy. Insight into how this population responds to statistics courses and …

Pten Protein Loss By Immunostaining: Analytic Validation And Prognostic Indicator For A High Risk Surgical Cohort Of Prostate Cancer Patients, Tamara L. Lotan, Bora Gurel, Siobhan Sutcliffe, David Esopi, Wennuan Liu, Jianfeng Xu, Jessica L. Hicks, Ben H. Park, Elizabeth Humphreys, Alan W. Partin, Misop Han, George J. Netto, William B. Isaacs, Angelo M. De Marzo

Biostatistics Faculty Publications

No abstract provided.

Communicating Uncertainty Can Lead To Less Decision Satisfaction: A Necessary Cost Of Involving Patients In Shared Decision Making?, Mary Politi, Melissa A. Clark, Hernando Ombao, Don Dizon, Glyn Elwyn

Health Literacy and Communication Faculty Publications

No abstract provided.

Interprofessional Education About Patient Decision Support In Specialty Care, Mary Politi, Arwen H. Pieterse, Tracy Truant, Cornelia Borkhoff, Vikram Jha, Laura Kuhl, Jennifer Nicolai, Claudia Goss

Health Literacy and Communication Faculty Publications

No abstract provided.

Prostate Involvement During Sexually Transmitted Infections As Measured By Prostate-Specific Antigen Concentration, Siobhan Sutcliffe, Remington L. Nevin, Ratna Pakpahan, Debra J. Elliott, Stephen R. Cole, Angelo M. De Marzo, Charlotte A. Gaydos, William B. Isaacs, William G. Nelson, Lori J. Sokoll, Johnathan M. Zenilman, Steven B. Cersovsky, Elizabeth A. Platz

Cancer Prevention Faculty Publications

No abstract provided.

Lessons Learned From Experiences In Academic Leadership, Kenneth Lee Mccall, Gayle A. Brazeau

Pharmacy Practice Faculty Publications

We believe there is nothing better than life and its experiences to mold one’s individual leadership abilities, skills, and talents. We have, like many before us, realized some of these lessons can and will only be achieved with service and leadership activities and responsibilities to our college and to numerous professional educational, practice, and scientific organizations. Three specific lessons learned through personal experiences are offered below which we believe may benefit those who have an interest in academic leadership positions.

Enhancement Of Medical Interns' Levels Of Clinical Skills Competence And Self-Confidence Levels Via Video Ipods: Pilot Randomized Controlled Trial, Margaret M. Hansen Edd, Msn, Rn, George Oosthuizen, John Windsor, Iain Doherty, Samuel Greig, Katrina Mchardy, Lloyd Mccann

Nursing and Health Professions Faculty Research and Publications

Background: Designing and delivering evidence-based medical practice for students requires careful consideration from medical science educators. Social Web (Web 2.0) applications are a part of today’s educational technology milieu; however, empirical research is lacking to support the impact of interactive Web 2.0 mobile applications on medical educational outcomes.
Objectives: The aim of our study was to determine whether instructional videos provided by iPod regarding female and male urinary catheter insertion would increase students’ confidence levels and enhance skill competencies.
Methods: We conducted a prospective study with medical trainee intern (TI) participants: 10 control participants (no technological intervention) and 11 intervention …

Experience In The Use Of Social Media In Medical And Health Education, Chris Paton, Panagiotis Bamidis, Gunther Eysenbach, Margaret M. Hansen Edd, Msn, Rn, Miguel Cabrer

Nursing and Health Professions Faculty Research and Publications

Objectives: Social media are online tools that allow collaboration and community building. Succinctly, they can be described as applications where “users add value”. This paper aims to show how five educators have used social media tools in medical and health education to attempt to add value to the education they provide.

Methods: We conducted a review of the literature about the use of social media tools in medical and health education. Each of the authors reported on their use of social media in their educational projects and collaborated on a discussion of the advantages and disadvantages of this approach to …

Eeg Complexity As A Biomarker For Autism Spectrum Disorder Risk, William Bosl, Adrienne Tierney, Helen Tager-Flusberg, Charles Nelson

Nursing and Health Professions Faculty Research and Publications

Background: Complex neurodevelopmental disorders may be characterized by subtle brain function signatures early in life before behavioral symptoms are apparent. Such endophenotypes may be measurable biomarkers for later cognitive impairments. The nonlinear complexity of electroencephalography (EEG) signals is believed to contain information about the architecture of the neural networks in the brain on many scales. Early detection of abnormalities in EEG signals may be an early biomarker for developmental cognitive disorders. The goal of this paper is to demonstrate that the modified multiscale entropy (mMSE) computed on the basis of resting state EEG data can be used as a biomarker …

The Composite First Person Narrative: Texture, Structure, And Meaning In Writing Phenomenological Descriptions, Marcia Stanley Wertz, Marcianna Nosek, Susan Mcniesh, Elizabeth Marlow

Nursing and Health Professions Faculty Research and Publications

This paper illustrates the use of composite first person narrative interpretive methods, as described by Todres, across a range of phenomena. This methodology introduces texture into the presently understood structures of phenomena and thereby creates new understandings of the phenomenon, bringing about a form of understanding that is relationally alive that contributes to improved caring practices. The method is influenced by the work of Gendlin, Heidegger, van Manen, Gadamer, and Merleau-Ponty. The method’s applicability to different research topics is demonstrated through the composite narratives of nursing students learning nursing practice in an accelerated and condensed program, obese female adolescents attempting …

Transmen: The Hiv Risk Of Gay Identity, Stefan Rowniak, C Chesla, C D. Rose, W L. Holzemer

Nursing and Health Professions Faculty Research and Publications

Many female-to-male transgender individuals, or transmen, are situated within the gay community, one of the highest risk communities for HIV, yet there has been little research regarding the experience of risk for these transmen. Seventeen transmen were interviewed regarding their sexuality and HIV risk behavior. Fourteen of the 17 reported having non-trans gay men as sexual partners. Risk behaviors included not using condoms with multiple partners who were HIV-positive, or of unknown HIV status. Aspects of risk included the unfamiliarity of the gay community and the lack of safe sex negotiating skills. The dynamics of acceptance and rejection between transmen …

Impact Of Congestive Heart Failure Discharge Planning On Congestive Heart Failure Re-Admission Rates, Sula E. Mazimba

Master of Public Health Program Student Publications

Background: Congestive Heart Failure (CHF) is the most common diagnosis accounting for more healthcare costs than any diagnosis. CHF readmissions contribute significantly to this expenditure. Quality of care in heart failure is linked to process based performance measures. This study evaluated the relationship between adherence to performance metrics and 30 day readmission rates.

Methods: This was a single center case-control study that evaluated 6063 consecutive patients admitted with CHF from December 2001 through December 2008. Data was collected for readmission to the hospital within 30 days and compliance to the heart failure performance measures at discharge.

Results: The rate of …

State Preparedness: A Study Of State Plans, Zachary Fehrman

Master of Public Health Program Student Publications

Non-pharmaceutical interventions (NPIs) have been used since the early years of public health. The Centers for Disease Control and Prevention (CDC) provides a standard definition for NPI and what NPI strategies are contained within the definition. This paper seeks to discover if state pandemic influenza plans use the term NPI and its strategies, and if states’ use of NPI strategies in their state pandemic plans is consistent with the CDC definition. To determine how states were defining and using the term NPI and NPI strategies a survey of forty-eight (48) state plans was conducted using each respective states’ pandemic plan. …

The Continuing Challenge Of Aviation Safety In Africa., Dr. Maxine Lubner, Dr. Stephen Braccio, Michael Bartron, Al Logie

International Symposium on Aviation Psychology - 2011

This study follows an epidemiological approach to examine possible predictors of and current interventions for safety in aviation transportation in two regions with widely different safety records: New York (NY) representing several regions in the US, and Tanzania (Tz), representing several regions in Africa. For most transportation modes, NY has one of the best and Tz has among the worst safety records. This paper identifies some of the similarities and differences between the two regions in order to find ways to improve the safety record in Tz and to ensure that safety continues to improve in NY. Several US, African, …

Multiteam Coordination In Simulated Airline Operations: Assessment Of Interpositional Knowledge And Task Mental Models, Glenn E. Littlepage, Jennifer A. Henslee

International Symposium on Aviation Psychology - 2011

Effective airline operations require coordination among various specializations such as pilot, flight dispatch, and maintenance. Interpositional knowledge (IPK) and task mental models are emergent cognitive states that can facilitate effective coordination. This study examined the extent of IPK and similarity and accuracy of task mental models among aerospace students. Results indicated relatively low levels of IPK and mental model similarity and moderate levels of mental model accuracy. Training activities that enhance IPK and task mental models have the potential to improve coordination and performance of airline personnel.