Medicine and Health Sciences Commons^™

Alzheimer’S Disease, Carol Watwood

DLPS Faculty Publications

Alzheimer’s disease is a common health issue mostly found in elderly persons. An overview of the disease and a list of reliable Web-based information sources suitable for a general audience are presented.

Quality Of Service And Treatment Adherence In Individuals With End Stage Renal Disease, Kyle Joseph Fraga

Theses Digitization Project

The purpose of this study will focus on the patient's attitudes about their treatment. There is a certain stigma attached to dialysis that makes it an undesirable form of treatment. Individuals on dialysis may feel dependent and vulnerable. In addition, hospitals and dialysis clinics can be an unwelcoming and intimidating place. A person's belief about their treatment will influence how well they adhere to it.

High-Fidelity Simulation And Training To Improve Coordination Between Aerospace Specializations, Paul A. Craig, Richard G. Moffett, Glenn E. Littlepage, Michael B. Hein, Andrea M. Georgiou, Gerald L. Hill, Jennifer A. Henslee, Paul R. Carlson, Nora A. Cole, Joseph H. Cooper, Durant Bridges, Justice Amankwah, Donald J. Tipton, Alan Waid

International Symposium on Aviation Psychology - 2011

This Symposium contains the first reports of research being conducted at Middle Tennessee State University using a scenario-based teaching methodology with students across multiple disciplines of aviation training. The MTSU Center for Research on Aviation Training is a NASA funded project that had built a replica of an airline’s flight operations center. The basic research of the project involves the interactions between aviation professionals. These interactions can produce smooth and safe operations for passengers, profits for employers and economic benefits for the national and the world – or these interactions can yield chaos, frustration and loss of revenue. This research …

Is Thrombolytic Therapy Safe When Used To Treat Elderly Patients?, Daniel Yaeger

The Science Journal of the Lander College of Arts and Sciences

Recently, research has been conducted to determine if thrombolytic therapy works to dissolve clots and if it is a safe treatment option. The specific purpose of this study is to determine if thrombolytic therapy is safe for use in the elderly. This study was conducted by reviewing the relevant literature that has been published from the time that research began to test the usefulness of thrombolytic therapy. Numerous journals were examined to ensure impartiality and emerge with an unbiased conclusion. The journals were discovered using PubMed article finder, using Google as a search engine, and by scrutinizing relevant references found …

Refereed Articles Or Books Published During 2010-2011, College Of Health Professions

SHU Faculty Publications

This is a bibliography of faculty scholarship published during the academic year 2010-2011.

Decomposing The Intergenerational Disparity In Income And Obesity, Qi Zhang, Buhong Zheng, Ning Zhang, Youfa Wang

Community & Environmental Health Faculty Publications

Intergenerational disparity in income and health violates the norm of equal opportunity and deserves the attention of researchers and policy makers. To understand changes in intergenerational disparity, we created the intergenerational mobility index (IMI), which can simultaneously measure changes in income rankings and in health outcomes across two generations. We selected obesity as one health outcome to illustrate the application of IMI due to its severe health and financial consequences for society and the significant changes in the distribution of obesity across income groups. Although obesity has increased in all income groups in the last four decades, higher income groups …

Maximizing Treatment Fidelity In Public Health Clinical Trials, James Alan Neff

Community & Environmental Health Faculty Publications

(First paragraph) In relatively few pages (1), Professor Borelli provides a cogent overview of one of the vexing issues in assessing whether public health interventions “work.” The comprehensiveness of the presentation, covering issues ranging from treatment development through outcome evaluation, makes the article a valuable resource for practitioners and students in a variety of disciplines. Of particular value is the detailed template listing fidelity assessment strategies at the Treatment Design, Provider Training, Treatment Delivery, Treatment Receipt, and Treatment Enactment Stages.

Age-Associated Alterations In The F344xbn Rat Heart And The Efficacy Of Chronic Acetaminophen Ingestion As A Therapeutic Approach, Sunil K. Kakarla

Theses, Dissertations and Capstones

Despite advances in therapeutic and diagnostic strategies cardiovascular disease still remains the leading cause of death in older people. Recent studies suggest that age- related elevations in oxidative stress are associated with increases in cardiac apoptosis and compensatory hypertrophy of the remaining cardiomyocytes. Acetaminophen has been shown to exhibit cardioprotective effects following ischemia-reperfusion injury by acting as an antioxidant. Here, we investigate the molecular mechanisms underlying aging associated cardiac remodeling in male F344XBN rats and examine the efficacy of chronic acetaminophen ingestion as a therapeutic approach.

Aging in male F344XBN rats is characterized by a significant increase in heart size, …

Identification Of Genes Involved In Hematopoietic Stem Cell Differentiation And Leukemia Differentiation And Leukemia, Jasjeet Bhullar

Theses, Dissertations and Capstones

Hematopoiesis is maintained by a proper balance between self renewal and multipotent differentiation of the hematopoietic stem cells (HSC). Acute myelogenous leukemia (AML) is characterized by the blockage in the differentiation of HSC, while self renewal and proliferation is preserved. It is important to understand the mechanisms involved in the inhibition of hematopoietic differentiation and maintenance of the HSC state in order to develop better therapies for AML. In these studies I have explored the role of Hsp90, omega-3 fatty acids and YB-1 in hematopoietic differentiation. EML, a hematopoietic precursor cell line, was used as a model for the hematopoietic …

Photosensitizer Drug Delivery Via An Optical Fiber, Matibur Zamadar, Goutam Ghosh, Adaic Kapillai Mahendran, Mihaela Minnis, Bonnie I. Kruft, Ashwini Ghogare, David Aebisher, Alexander Greer

Faculty Publications

: An optical fiber has been developed with a maneuverable miniprobe tip that sparges O2 gas and photodetaches pheophorbide (sensitizer) molecules. Singlet oxygen is produced at the probe tip surface which reacts with an alkene spacer group releasing sensitizer upon fragmentation of a dioxetane intermediate. Optimal sensitizer photorelease occurred when the probe tip was loaded with 60 nmol sensitizer, where crowding of the pheophorbide molecules and self-quenching were kept to a minimum. The fiber optic tip delivered pheophorbide molecules and singlet oxygen to discrete locations. The 60 nmol sensitizer was delivered into petrolatum; however, sensitizer release was less efficient in …

Ua61/1 Wku Nursing Class 2011, Wku Nursing

WKU Administration Documents

Members of the 2011 nursing class: Tamra Atwood, Shelly Davis, Connie Dickson, Traci Gentry, Marita Hockstedler, Josie Kroeger, Wendy Lai, Levita Larson, Nicole Loy, Allison McCutchen, Jackie Pardue, Jennifer Parrott, Kellye Rone, Annette Ploeg, Thomas Vogler, Louise Webb, Brandi White, Annie Wilson and Katrina Wood.

Efficacy And Safety Of Once-Daily Aclidinium In Chronic Obstructive Pulmonary Disease, Paul W. Jones, Stephen I. Rennard, Alvar Agusti, Pascal Chanez, Helgo Magnussen, Leonardo Fabbri, James F. Donohue, Eric D. Bateman, Nicholas J. Gross, Rosa Lamarca, Cynthia Caracta, Esther Garcia Gil

Journal Articles: Pulmonary & Critical Care Med

BACKGROUND: The long-term efficacy and safety of aclidinium bromide, a novel, long-acting muscarinic antagonist, were investigated in patients with moderate to severe chronic obstructive pulmonary disease (COPD).

METHODS: In two double-blind, 52-week studies, ACCLAIM/COPD I (n=843) and II (n=804), patients were randomised to inhaled aclidinium 200 μg or placebo once-daily. Patients were required to have a post-bronchodilator forced expiratory volume in 1 second (FEV1)/forced vital capacity ratio of ≤70% and FEV1< 80% of the predicted value. The primary endpoint was trough FEV1 at 12 and 28 weeks. Secondary endpoints were health status measured by St George's Respiratory Questionnaire (SGRQ) and time to first moderate or severe COPD exacerbation.

RESULTS: At 12 and 28 weeks, aclidinium improved trough FEV1 versus placebo in ACCLAIM/COPD I (by 61 and 67 mL; both p< 0.001) and ACCLAIM/COPD II (by 63 and 59 mL; both p< 0.001). More patients had a SGRQ improvement≥4 units at 52 weeks with aclidinium versus placebo in ACCLAIM/COPD I (48.1% versus 39.5%; p=0.025) and ACCLAIM/COPD II (39.0% versus 32.8%; p=0.074). The time to first exacerbation was significantly delayed by aclidinium in ACCLAIM/COPD II (hazard ratio [HR] 0.7; 95% confidence interval [CI] 0.55 to 0.92; p=0.01), but not ACCLAIM/COPD I (HR 1.0; 95% CI 0.72 to 1.33; p=0.9). Adverse events were minor in both studies.

CONCLUSION: Aclidinium is effective and well tolerated …

Colorectal Cancer In Montgomery County, Ohio: A Descriptive Analysis, Ursula Turner

Master of Public Health Program Student Publications

In the United States colorectal cancer (CRC) is one of the most common malignancies, and is the third leading cause of cancer deaths (Sharma & O’Keefe, 2007). Approximately 270,000 cases of colorectal cancer were diagnosed in 2008 with 81,900 cases resulting in death. There were 16,520 cases diagnosed in African Americans and 7,120 resulted in death or significant illness (American Cancer Society, 2008). Mortality as the result of CRC is greater among the African American population with 27% and 38% higher death rates for African American males and females when compared with Caucasian males and females (Agarwal, 2005). CRC is …

A Geospatial Analysis Of The Role Of Urban Forestry In Outdoor Ambient Air Pollution Reduction In Dayton, Ohio, Nicholas P. Clemens

Master of Public Health Program Student Publications

Objective: Air pollution is associated with negative respiratory and cardiovascular health outcomes. According to the American Lung Association listing for 2011, the Dayton-Springfield-Greenville, OH area ranks 22 out of 277 US cities for year round particulate pollution. The tree canopy cover plays a significant role to reduce air pollution. The purpose of this analysis was to quantify the role of urban forestry in the Dayton, Ohio metropolitan area in reducing air pollution.

Methods: Using a peer-reviewed model designed by the US Forest Service, the imagery data was analyzed to create a descriptive analysis of the canopy cover in the Dayton, …

Nation's Future: Preparedness For Burn Victims, Jacqueline Tippett

Master of Public Health Program Student Publications

Natural and manmade disasters have occurred throughout the decades, within the United States and around the globe. Increased incidence and awareness of terrorist attacks have caused the US to re-evaluate its safety and preparedness efforts to prevent such events from happening and to develop an adequate response plan if such unfortunate events do occur. Therefore, the purpose of this research is to (1) review and discuss the American Burn Association’s (ABA) paradigm for emergency planning in burn disasters, (2) give recommendation about the National Response Framework (NRF) guidelines on “all hazards” response as they pertains to burns, and (3) give …

An Examination Of Ohio’S Physical Education Academic Content Standard 4, Benchmark A For Grades 9-12, Gabriel Jones

Master of Public Health Program Student Publications

Objective: The purpose of this study was to describe select physical education teachers’ perceptions of the effectiveness and accuracy of the assessments for Ohio's Physical Education Academic Content Standard 4 Benchmark A in determining the fitness and physical activity levels of high school students. A secondary purpose was to describe the fitness levels of high school physical education students, based on assessment data.

Methods: Participants were forty-one physical education teachers and ninety high school students from southwest Ohio. Data were collected from the teachers through an online questionnaire and from students with FITNESSGRAM testing. FITNESSGRAM data from one local school …

Acl Injuries In Montgomery County, Oh: Moving Toward The Development Of A Prediction Model, Kelly Estes

Master of Public Health Program Student Publications

Anterior cruciate ligament (ACL) tears are one of the most frequent soft tissue injuries of the knee. A torn ACL leaves the knee joint unstable and at risk for further damage to other soft tissues manifested as pain, dislocation, and osteoarthritis. A better understanding of the dimensional details of knee joints suffering ACL tears and a prediction model for individuals susceptible to tears is needed. Using a cross-sectional study design, magnetic resonance images (MRIs) of 72 patients with knee injuries were evaluated from an orthopedic surgery group practice. The status of the ACL was the main variable of interest, creating …

Antihypertensive Treatment Differentially Affects Vascular Sphingolipid Biology In Spontaneously Hypertensive Rats, Léon J. A. Spijkers, Ben J. A. Janssen, Jelly Nelissen, Merlijn J. P. M. T. Meens, Dayanjan Wijesinghe, Charles E. Chalfant, Jo G. R. De Mey, Astrid E. Alewijnse, Stephan L. M. Peters

Biochemistry and Molecular Biology Publications

We have previously shown that essential hypertension in humans and spontaneously hypertensive rats (SHR), is associated with increased levels of ceramide and marked alterations in sphingolipid biology. Pharmacological elevation of ceramide in isolated carotid arteries of SHR leads to vasoconstriction via a calcium-independent phospholipase A2, cyclooxygenase-1 and thromboxane synthase-dependent release of thromboxane A2. This phenomenon is almost absent in vessels from normotensive Wistar Kyoto (WKY) rats. Here we investigated whether lowering of blood pressure can reverse elevated ceramide levels and reduce ceramide-mediated contractions in SHR.

Methods and Findings

For this purpose SHR were treated for 4 weeks with the angiotensin …

Crystal Structure Of Thrombin In Complex With S-Variegin: Insights Of A Novel Mechanism Of Inhibition And Design Of Tunable Thrombin Inhibitors, Cho Yeow Koh, Sundramurthy Kumar, Maria Kazimirova, Patricia A. Nuttall, Uvaraj P. Radhakrishnan, Seongcheol Kim, Pudur Jagadeeswaran, Takayuki Imamura, Jun Mizuguchi, Sadaaki Iwanaga, Kunchithapadam Swaminathan, R. Manjunathan Kini

Biochemistry and Molecular Biology Publications

The inhibition of thrombin is one of the important treatments of pathological blood clot formation. Variegin, isolated from the tropical bont tick, is a novel molecule exhibiting a unique ‘two-modes’ inhibitory property on thrombin active site (competitive before cleavage, noncompetitive after cleavage). For the better understanding of its function, we have determined the crystal structure of the human α-thrombin:synthetic-variegin complex at 2.4 Å resolution. The structure reveals a new mechanism of thrombin inhibition by disrupting the charge relay system. Based on the structure, we have designed 17 variegin variants, differing in potency, kinetics and mechanism of inhibition. The most active …

Hypertension Is Associated With Marked Alterations In Sphingolipid Biology: A Potential Role For Ceramide, Leon J. A. Spijkers, Rob F. P. Van Den Akker, Ben J. A. Janssen, Jacques J. Debets, Jo G. R. De Mey, Erik S. G. Stroes, Bart-Jan H. Van Den Bom, Dayanjan Wijesinghe, Charles E. Chalfant, Luke Macaleese, Gert B. Eijkel, Ron M. A. Heeren, Astrid E. Alewijnse, Stephan L. M. Peters

Biochemistry and Molecular Biology Publications

Background

Hypertension is, amongst others, characterized by endothelial dysfunction and vascular remodeling. As sphingolipids have been implicated in both the regulation of vascular contractility and growth, we investigated whether sphingolipid biology is altered in hypertension and whether this is reflected in altered vascular function.

Methods and Findings

In isolated carotid arteries from spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats, shifting the ceramide/S1P ratio towards ceramide dominance by administration of a sphingosine kinase inhibitor (dimethylsphingosine) or exogenous application of sphingomyelinase, induced marked endothelium-dependent contractions in SHR vessels (DMS: 1.4±0.4 and SMase: 2.1±0.1 mN/mm; n = 10), that were virtually …

Strength And Hypertrophy Responses To Constant And Decreasing Rest Intervals In Trained Men Using Creatine Supplementation, Tacito P. Souza-Junior, Jeffrey M. Willardson, Richard Bloomer, Richard D. Leite, Steven J. Fleck, Paulo R. Oliveira, Robert Simao

Faculty Research and Creative Activity

The purpose of the current study was to compare strength and hypertrophy responses to resistance training programs that instituted constant rest intervals (CI) and decreasing rest intervals (DI) between sets over the course of eight weeks by trained men who supplemented with creatine monohydrate (CR).

The Effects Of Smoking On Pregnant Women, Meir Cohen

The Science Journal of the Lander College of Arts and Sciences

Smoking during pregnancy is accepted as the most significant avoidable risk factor for an unsuccessful pregnancy result. Smoking is linked with fetal growth restriction, and increasing evidence also suggests that smoking can cause stillbirth, preterm birth, placental abruption, and possibly sudden infant death syndrome. Smoking during pregnancy is also associated with enhanced risks of spontaneous abortions, ectopic pregnancies, and placenta previa, and it might increase risks of behavioral disorders in childhood. Studies have shown with randomized controlled trials, that smoking intervention during pregnancy has had limited success. Smoking during pregnancy continues to be an important risk factor for maternal and …

Comparação Das Habilidades Motoras Em Crianças Com Síndrome De Down E Crianças Sem Distúrbios De Desenvolvimento [Comparison Of Motor Skills In Children With Down Syndrome And Children Without Developmental Disorders], Laura De Moura Rodrigues, Edla Da Silva, Juliana Saccol Martins, Patricia Pereira

Other Topics

The aim of this study was to assess gross motor abilities, classifying them in stages, of children with Down syndrome and children without developmental disorders, and to compare them with each other. Twelve children with Down syndrome, from two special schools and twelve children without development disorders, from a regular school of Caxias do Sul city, in Brazil, were evaluated.

Six gross motor abilities were assessed: balance in one foot, walking on straight line, running, jumping on one foot, throwing and catching, through the tables of Gallahue and Ozmun (2001).

The children with Down syndrome could not keep up with …

Preparation Of Tissues And Cells For Infrared And Raman Spectroscopy And Imaging, Fiona Lyng, Ehsan Gazi, Peter Gardner

Books/Book Chapters

No abstract provided.

Raman Microscopy: Complement Or Competitor, Hugh Byrne, Ganesh Sockalingum, Nick Stone

Books/Book Chapters

No abstract provided.

Libro De Actividades Por El Mes Nacional De La Salud Dental Infantil [Spanish Language Version: National Children's Dental Health Month Activity Book] (2011), American Dental Association Foundation

National Children's Dental Health Month

No abstract provided.

Gastric Antral Web In A 103-Year-Old Patient, Waheed Gul, Khurram Abbass, Ronald J. Markert, Christopher J. Barde

Internal Medicine Faculty Publications

No abstract provided.

The Harmful, Nontherapeutic Use Of Animals In Research Is Morally Wrong, Nathan Nobis

Experimentation Collection

It is argued that using animals in research is morally wrong when the research is nontherapeutic and harmful to the animals. This article discusses methods of moral reasoning and discusses how arguments on this and other bioethical issues might be defended and critiqued. A basic method of moral argument analysis is presented and used to show that common objections to the view that “animal research is morally wrong” fail: ie, common arguments for the view that “animal research is morally permissible” are demonstrably unsound or in need of defense. It is argued that the best explanations why harmful, nontherapeutic research …

Systematic Review Of Chimpanzee Use In Monoclonal Antibody Research And Drug Development: 1981-2010, Raija Bettauer

Experimentation Collection

This survey examines the extent to which live chimpanzees have been used in monoclonal antibody (mAb) research and the drug approval process. The survey covers 193 scientific articles published during the years 1981-2010, as well as preclinical studies leading to the approval of mAb drugs by the Food and Drug Administration of the United States. The frequency of the articles has decreased by more than two-thirds from their highs in the late 1980’s, and the aggregate number of chimpanzees used in these studies has decreased by more than 90%.

The experimental protocols ranged from single or multiple blood draws to …

A Kenyan Perspective On The Use Of Animals In Science Education And Scientific Research In Africa And Prospects For Improvement, Charles Kimwele, Duncan Matheka, Hope Ferdowsian

Experimentation Collection

Introduction: Animal experimentation is common in Africa, a region that accords little priority on animal protection in comparison to economic and social development. The current study aimed at investigating the prevalence of animal experimentation in Kenya, and to review shortfalls in policy, legislation, implementation and enforcement that result in inadequate animal care in Kenya and other African nations. Methods: Data was collected using questionnaires, administered at 39 highly ranked academic and research institutions aiming to identify those that used animals, their sources of animals, and application of the three Rs. Perceived challenges to the use of non-animal alternatives and common …