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Articles 4201 - 4230 of 6784
Full-Text Articles in Medicine and Health Sciences
Lessons Learned Conducting Breastfeeding Intervention Research In Two Northern Plains Tribal Communities, Mary Beth Stepans, S Wilhelm, K Rodehorst-Weber, T Aguirre, M Hertzog, M Clarke, A Herboldsheimer
Lessons Learned Conducting Breastfeeding Intervention Research In Two Northern Plains Tribal Communities, Mary Beth Stepans, S Wilhelm, K Rodehorst-Weber, T Aguirre, M Hertzog, M Clarke, A Herboldsheimer
Walden Faculty and Staff Publications
AIM:
The overall purpose of this article was to describe the challenges and benefits of conducting breastfeeding intervention research with two Native American Tribal communities.
METHODS:
A focus group with an interpretive approach was used to collect data within this qualitative study as a means of incorporating a complex, holistic, subjective interpretation of the case managers' perceptions and experiences. In addition, researchers' field notes were used. Findings are discussed in relation to Rogers' Diffusion of Innovation Framework.
RESULTS:
Themes that emerged during the focus group discussions were related to innovation, relative advantage, complexity, compatibility, trialability, and observability.
CONCLUSIONS:
Conducting research …
Parental Perception Of Childhood Obesity And The School's Role On Prevention And Interventions In Childhood Obesity, Monique Jones
Parental Perception Of Childhood Obesity And The School's Role On Prevention And Interventions In Childhood Obesity, Monique Jones
Nursing Theses and Capstone Projects
Childhood obesity is a major health crisis that is becoming an epidemic among children and adolescents. Interventions must begin early and focus on prevention strategies to achieve the goal of increasing quality years of life for today's children and families. Parents with children in a local after school Boys & Girls club were surveyed regarding their perception of childhood obesity, the causes of childhood obesity, and the school's role in the prevention and treatment of childhood obesity. More than 90% of the participants identified inactivity, poor eating behavior, eating too much, and lack of money to buy nutritious foods as …
The Effect Of High-Fidelity Human Patient Simulation On Stress Levels Of Associate Degree Novice Nursing Students, Sallie Beth Todd
The Effect Of High-Fidelity Human Patient Simulation On Stress Levels Of Associate Degree Novice Nursing Students, Sallie Beth Todd
Nursing Theses and Capstone Projects
The clinical learning environment is an important component in the educational development of a student nurse. Nursing students have identified the clinical experience as one of the most stress producing components of their nursing education. Past research has shown high levels of stress can lead to decreased learning, affect clinical performance, increase clinical errors, and threaten physical or psychiatric wellbeing. Nurse educators' primary responsibilities are to help students effectively cope with their initial stress and facilitate student learning by applying the knowledge they gain in the classroom to the clinical environment. To allow students the opportunity to integrate theory into …
Diabetes Understanding Among Staff Nurses: Examining The Actual Versus Perceived Knowledge In The Acute Care Setting, Rebecca B. Ledbetter
Diabetes Understanding Among Staff Nurses: Examining The Actual Versus Perceived Knowledge In The Acute Care Setting, Rebecca B. Ledbetter
Nursing Theses and Capstone Projects
Diabetes is the fourth leading cause of death world-wide claiming a staggering 3.8 million lives globally each year to related complications (World Health Organization, 2011). Diabetes complications account for 20% of all acute care admissions or 1 in every 5 patients have a diabetes-related condition (American Diabetes Association, 2011). Patient education in the areas of lifestyle modification, healthy eating habits, and proper medication administration is research-supported to clinically decrease the likelihood of acute complications. Bedside, acute care nurses are at the front line of patient education delivery and have the opportunity to determine behavioral stages related to a patient's readiness …
A Comparison Of Patient And Nurse Perception Of Problem Areas Associated With Type 2 Diabetes, Kelley Oglesby
A Comparison Of Patient And Nurse Perception Of Problem Areas Associated With Type 2 Diabetes, Kelley Oglesby
Nursing Theses and Capstone Projects
The purpose of the study was to explore the difference in problem areas perceived and reported by patients with type 2 diabetes and registered nurses caring for patients with type 2 diabetes. Diabetes affects a large number of patients both physically and fiscally. Decreasing perception of problems by nurse case management intervention has the potential to adversely affect patients. A convenience sample of 20 patients and 10 nurses was obtained and completed the Problem Areas in Diabetes (PAID) questionnaire. Statistical analysis found a significant difference in perception of problems among patients and nurses.
Monitoring Congestive Heart Failure Across The Healthcare Continuum, Katrina E. Walker
Monitoring Congestive Heart Failure Across The Healthcare Continuum, Katrina E. Walker
Nursing Theses and Capstone Projects
Congestive heart failure is a chronic condition where the heart no longer pumps adequate blood and oxygen to bodily organs. CHF is a chronic condition that affects millions of people on a yearly basis. Common diseases that cause CHF are coronary artery disease, high blood pressure, and diabetes. CHF patients face many compilations that affect their daily activities. Along with morbidity CHF has major financial implications because much of the cost associated with CHF healthcare is avoidable. The purpose of this study is to evaluate the effects of monitoring congestive heart failure across the healthcare continuum with application to the …
Nursing Students' Perception Of Comfort, Norma Mott
Nursing Students' Perception Of Comfort, Norma Mott
Nursing Theses and Capstone Projects
One of the most important goals of nursing care is to provide comfort to patients and their families. In order to provide comfort, nurses must be able to recognize and respond to patients in distress. Inconsistencies in the delivery of comfort care are based largely on the nurse's educational preparation. The degree to which comfort and comforting is evidenced in nursing performance depends in great measure on the way upcoming nurses perceive the concept during their education.
In this descriptive study guided by Kolcaba's Comfort Theory, the researcher surveyed a convenience sample of Associate Degree Nursing students to assess their …
Effects Of Early Initiation Of Induced Therapeutic Hypothermia, Frank Castelblanco
Effects Of Early Initiation Of Induced Therapeutic Hypothermia, Frank Castelblanco
Nursing Theses and Capstone Projects
Cardiac arrests are responsible for about 325,000 deaths annually in the United States (Heart Rhythm Foundation, 2010). The majority of these cardiac arrests occur outside the hospital setting, with a dismal national survival rate of 8% (American Heart Association, 2010). The Bernard (2002) and HACA (2002) studies demonstrated that by initiating therapeutic hypothermia as a treatment modality for cardiac arrests the survival rate could be as high as 49% and 55% respectively. Therapeutic hypothermia can be initiated in many different settings. The question remains, does the setting of the initiation of therapeutic hypothermia effect patient outcomes? The purpose of this …
The Incidence Of Individual Sexually Based Counseling By School Nurses In An Urban School System, Tiffany Dunlap
The Incidence Of Individual Sexually Based Counseling By School Nurses In An Urban School System, Tiffany Dunlap
Nursing Theses and Capstone Projects
The purpose of this study is to evaluate the incidence of individual counseling on sexual issues by school nurses in a large, urban, public school system in the Southeastern United States (U.S). Utilizing a descriptive, non-experimental method for the study, a secondary data analysis was conducted by the researcher using information self-reported by 117 school nurses regarding individual counseling of students in grades kindergarten through twelve on sexual topics. The topics included in the study were pregnancy, puberty/reproductive health and sexual abuse. There was a relationship established between grade level and rate of individual counseling. School nurses in the school …
The Effects Of Education And Training On Nurses' Perception Of Lateral Violence In The Healthcare Field, Tamara Cook
The Effects Of Education And Training On Nurses' Perception Of Lateral Violence In The Healthcare Field, Tamara Cook
Nursing Theses and Capstone Projects
The effects of lateral violence are costly for all aspects of the healthcare profession. Lateral violence is an act of aggression directed towards another nurse. Educating nurses of lateral violence and its appearance may prove to increase nurse's perception of lateral violence therefore decreasing its occurrence. This study will explore the effects of education and training on nurses' perception of lateral violence in the healthcare field. Lateral violence threatens the integrity of each nurse, the nursing profession, and the organization. Increasing the awareness of lateral violence attempts to make a culture change among nurses in the healthcare profession. Minimizing lateral …
Preparing The New Graduate Nurse Entering Critical Or Progressive Care Practice Areas: What Is The Effect Of Blended Orientation Approaches On Their Level Of Self-Confidence And Satisfaction With Current Orientation Methods?, Jennifer L. Forbes
Nursing Theses and Capstone Projects
The transition from student nurse to professional nurse is often difficult for the new graduate especially if transitioning into critical or progressive care areas of practice. It is imperative for new graduates to receive a clinical orientation that meets their educational and transitional needs. The orientation process should provide them with a strong foundation in critical or progressive care practices. Educators are challenged to provide educational opportunities while accommodating diverse learning needs and continuing to maintain competency that ensures the highest quality of patient care and improved patient care outcomes.
New graduate nurses hired into the critical or progressive care …
Effect Of Remote Fetal Monitoring In An Inpatient Obstetrical Unit: A Retrospective Review, Lauren Reavis
Effect Of Remote Fetal Monitoring In An Inpatient Obstetrical Unit: A Retrospective Review, Lauren Reavis
Nursing Theses and Capstone Projects
Electronic Fetal Monitoring (EFM) has been used as a tool for inpatient obstetrical care in the United States since the 1980's. The litigious nature of our society has caused much emphasis to be placed upon EFM use and interpretation; however, little evolution has occurred in monitoring techniques. The review of relevant literature found a significant gap in knowledge in regards to research of the current monitoring practice. Therefore, this study was aimed to look at the effect of remote monitoring, like the practice currently used in telemetry, on inpatient obstetrical care. The study used a retrospective review to look at …
The Nurse's Knowledge Of Blood Conservation As A Part Of Blood Management, Lindsey Putnam Austin
The Nurse's Knowledge Of Blood Conservation As A Part Of Blood Management, Lindsey Putnam Austin
Nursing Theses and Capstone Projects
Medicine has historically regarded blood transfusion as an integral component of major surgery or illness. However, clinical studies have shown that allogeneic blood transfusions are associated with increased morbidity and decreased survival. Knowledge of this research and the concepts of blood conservation so as to avoid unnecessary blood transfusions is needed in order to deliver holistic care and serve as patient advocate. This knowledge reaches every specialty of nursing care.
This study of the nurse's knowledge of blood conservation as a part of blood management utilizes The Conservation Model developed by Myra E. Levine in 1973. Levine's work is a …
A Study Of The Presence Of Relational Aggression In The Adult Population, Kathy C. Williams
A Study Of The Presence Of Relational Aggression In The Adult Population, Kathy C. Williams
Nursing Theses and Capstone Projects
Aggression can result in a challenge of the basic human need for safety and security (Plotnik, 1999). Historically there has been extensive research regarding physical aggression. However, only in the past two decades has relational aggression received attention. Most research studies regarding relational aggression have focused upon children, adolescents and young adults. The purpose of this study was to explore the presence of relational aggression in the adult population. The Self-Report of Aggression and Social Behavior Measure tool was used to survey a convenience sample of 67 nursing students. The participants were students enrolled in the school of nursing (associate, …
The Effect Of Emergency Department Length Of Stay On Clinical Outcomes For Critically Ill Or Injured Patients, Sheila Radcliff
The Effect Of Emergency Department Length Of Stay On Clinical Outcomes For Critically Ill Or Injured Patients, Sheila Radcliff
Nursing Theses and Capstone Projects
The purpose of the study was to identify the effects of the emergency department length of stay on clinical outcomes for critically ill or injured patients in the regional referral community hospital. Delays in transfer have been associated with increased mortality rates, prolonged length of stays, and poor outcomes. Emergency departments are designed to respond to immediate life or limb threatening emergencies.
A quantitative, descriptive, retrospective design was used in this study. Data was collected from APACHE II, trauma databases, and ED logs. The study was conducted in a 752 bed hospital in the western North Carolina. Data was analyzed …
Long-Term Effects Of Self-Control On Alcohol Use And Sexual Behavior Among Urban Minority Young Women, Kenneth W. Griffin, Lawrence M. Scheier, Bianca Acevedo, Jerry L. Grenard, Gilbert J. Botvin
Long-Term Effects Of Self-Control On Alcohol Use And Sexual Behavior Among Urban Minority Young Women, Kenneth W. Griffin, Lawrence M. Scheier, Bianca Acevedo, Jerry L. Grenard, Gilbert J. Botvin
CGU Faculty Publications and Research
High risk alcohol use and sexual behaviors peak in young adulthood and often occur in the same individuals. Alcohol use has been found to impair decision-making and contribute to high risk sexual activity. However, the association between alcohol use and risky sexual behavior may also reflect enduring individual differences in risk taking, sociability, self-control, and related variables. Both behaviors can serve similar functions related to recreation, interpersonal connection, and the pursuit of excitement or pleasure. The present study examined the extent to which high risk drinking and sexual behavior clustered together in a sample of urban minority young adult women, …
No Complaining..., James R. Krebs, Gayle A. Brazeau
No Complaining..., James R. Krebs, Gayle A. Brazeau
Pharmacy Practice Faculty Publications
It is said that hunger is a great motivator. If only the hunger for knowledge were as great as the hunger for physical sustenance. This statement could be lodged as a complaint, but that would defeat the purpose of this essay. How is it possible to turn the toil of our learning into the enlightenment for self-improvement?
An Epichromatin Epitope: Persistence In The Cell Cycle And Conservation In Evolution, Ada L. Olins, Markus Langhans, Marc Monestier, Andreas Schlotterer, David G. Robinson, Corrado Viotti, Hanswalter Zentgraf, Monika Zwerger, Donald E. Olins
An Epichromatin Epitope: Persistence In The Cell Cycle And Conservation In Evolution, Ada L. Olins, Markus Langhans, Marc Monestier, Andreas Schlotterer, David G. Robinson, Corrado Viotti, Hanswalter Zentgraf, Monika Zwerger, Donald E. Olins
Pharmaceutical Sciences Faculty Publications
Interphase nuclear architecture is disrupted and rapidly reformed with each cell division cycle. Successive cell generations exhibit a “memory” of this nuclear architecture, as well as for gene expression. Furthermore, many features of nuclear and mitotic chromosome structure are recognizably species and tissue specific. We wish to know what properties of the underlying chromatin structure may determine these conserved features of nuclear architecture. Employing a particular mouse autoimmune anti-nucleosome monoclonal antibody (PL2-6), combined with deconvolution immunofluorescence microscopy, we present evidence for a unique epitope (involving a ternary complex of histones H2A and H2B and DNA) which is localized only at …
Evaluation Of Syracuse Healthy Start’S Program For Abnormal Flora Management To Reduce Preterm Birth Among Pregnant Women, Emilia H. Koumans, Sandra D. Lane, Richard Aubry, Kathleen Demott, Noah Webster, Brooke A. Levandowski
Evaluation Of Syracuse Healthy Start’S Program For Abnormal Flora Management To Reduce Preterm Birth Among Pregnant Women, Emilia H. Koumans, Sandra D. Lane, Richard Aubry, Kathleen Demott, Noah Webster, Brooke A. Levandowski
Falk College Research Center
Randomized trials of bacterial vaginosis (BV) treatment among pregnant women to reduce preterm birth have had mixed results. Among non-pregnant women, BV recurs frequently after treatment. Randomized trials of early BV treatment for pregnant women in which recurrence was retreated have shown promise in reducing preterm birth. Syracuse’s Healthy Start (SHS) program began in 1997; in 1998 prenatal care providers for pregnant women living in high infant mortality zip codes were encouraged to screen for abnormal vaginal flora at the first prenatal visit. Vaginal swabs were sent to a referral hospital laboratory for Gram staining and interpretation. SHS encouraged providers …
It Takes At Least Two: Male Partner Factors, Racial/Ethnic Disparity, And Chlamydia Trachomatis Among Pregnant Women, Jessica Weisz, Sara Lozyniak, Sandra D. Lane, Robert Silverman, Kathy Demott, Martha A. Wojtowycz
It Takes At Least Two: Male Partner Factors, Racial/Ethnic Disparity, And Chlamydia Trachomatis Among Pregnant Women, Jessica Weisz, Sara Lozyniak, Sandra D. Lane, Robert Silverman, Kathy Demott, Martha A. Wojtowycz
Falk College Research Center
Chlamydia trachomatis (CT), the most prevalent sexually transmitted infection in the United States, disproportionately infects women and people of color. This study aimed to identify risk factors for racial and ethnic disparities for CT infection, re-infection, and persistent infection among pregnant women. We present a secondary analysis of births from a retrospective cohort study in Syracuse, NY from January 2000 through March 2002. African American women [OR 3.35 CI (2.29, 4.92)], Latin American women [OR 4.35 CI (2.52, 7.48)], unmarried women [OR 7.57 CI (4.38, 13.10)], and teen mothers [OR 3.87 CI (2.91, 5.16)] demonstrated statistically significant increased risk for …
The Influence Of Macrophage Depletion On Ligament Healing, Connie S. Chamberlain, Ellen M. Leiferman, Kayt E. Frisch, Sijian Wang, Xipei Yang, Nico Van Rooijen, Geoff S. Baer, Stacey L. Brickson, Ray Vanderby
The Influence Of Macrophage Depletion On Ligament Healing, Connie S. Chamberlain, Ellen M. Leiferman, Kayt E. Frisch, Sijian Wang, Xipei Yang, Nico Van Rooijen, Geoff S. Baer, Stacey L. Brickson, Ray Vanderby
Faculty Publications - Biomedical, Mechanical, and Civil Engineering
Despite a complex cascade of cellular events to reconstruct damaged extracellular matrix (ECM), ligament healing results in a mechanically inferior, scar-like tissue. During normal healing, the number of macrophages significantly increases within the wound site. Then, granulation tissue expands into any residual, normal ligamentous tissue (creeping substitution), resulting in a larger region of healing, greater mechanical compromise, and an inefficient repair process. To study the effects of macrophages on the repair process, bilateral, surgical rupture of their medial collateral ligaments (MCLs) was done on rats. Treatment animals received liposome-encapsulated clodronate, 2 days before rupture to ablate phagocytosing macrophages. Ligaments were …
Pledge Your Body For Your Bread: Welfare, Drug Testing, And The Inferior Fourth Amendment, Jordan C. Budd
Pledge Your Body For Your Bread: Welfare, Drug Testing, And The Inferior Fourth Amendment, Jordan C. Budd
Law Faculty Scholarship
Proposals to subject welfare recipients to periodic drug testing have emerged over the last three years as a significant legislative trend across the United States. Since 2007, over half of the states have considered bills requiring aid recipients to submit to invasive extraction procedures as an ongoing condition of public assistance. The vast majority of the legislation imposes testing without regard to suspected drug use, reflecting the implicit assumption that the poor are inherently predisposed to culpable conduct and thus may be subject to class-based intrusions that would be inarguably impermissible if inflicted on the less destitute. These proposals are …
Preliminary Report On Patent Literature, Search Methodology And Patent Status Of Medicines On The Who Eml 2009, Jon R. Cavicchi, Stanley P. Kowalski
Preliminary Report On Patent Literature, Search Methodology And Patent Status Of Medicines On The Who Eml 2009, Jon R. Cavicchi, Stanley P. Kowalski
Law Faculty Scholarship
Over the past several decades the World Health Organization (WHO) has produced the Essential Medicines List (EML) to assist countries in deciding what medicines should be essential and available in National Essential Medicine Lists.1 WHO, through the work of regional offices, supports nations using the EML to ensure the quality, availability, and affordability of pharmaceuticals required to promote and advance public health in nations across the globe. However in some cases, access to EML pharmaceuticals might be complicated by existing patents, i.e., where issued, patent rights might pose obstacles to access and inclusion in national EMLs. Indeed, in developed and …
2011 Cancer Care Annual Report, Children's Mercy Hospital
2011 Cancer Care Annual Report, Children's Mercy Hospital
Cancer Center Annual Reports
Annual report of cancer care and oncology services at the Children's Mercy Hospital, Kansas City MO, a pediatric medical center.
Custom-Molded Foot-Orthosis Intervention And Multisegment Medial Foot Kinematics During Walking, Mark Geil
Custom-Molded Foot-Orthosis Intervention And Multisegment Medial Foot Kinematics During Walking, Mark Geil
Faculty Articles
No abstract provided.
Genome-Wide Gene-Environment Study Identifies Glutamate Receptor Gene Grin2a As A Parkinson's Disease Modifier Gene Via Interaction With Coffee, Taye H. Hamza, Honglei Chen, Erin M. Hill-Burns, Shannon L. Rhodes, Jennifer Montimurro, Denise M. Kay, Albert Tenesa, Victoria I. Kusel, Patricia Sheehan, Muthukrishnan Eaaswarkhanth, Dora Yearout, Ali Samii, John W. Roberts, Pinky Agarwal, Yvette Bordelon, Yikyung Park, Liyong Wang, Jianjun Gao, Jeffery M. Vance, Kenneth S. Kendler, Silviu-Alin Bacanu, William K. Scott, Beate Ritz, John Nutt, Stweart A. Factor, Cyrus P. Zabetian, Haydeh Payami
Genome-Wide Gene-Environment Study Identifies Glutamate Receptor Gene Grin2a As A Parkinson's Disease Modifier Gene Via Interaction With Coffee, Taye H. Hamza, Honglei Chen, Erin M. Hill-Burns, Shannon L. Rhodes, Jennifer Montimurro, Denise M. Kay, Albert Tenesa, Victoria I. Kusel, Patricia Sheehan, Muthukrishnan Eaaswarkhanth, Dora Yearout, Ali Samii, John W. Roberts, Pinky Agarwal, Yvette Bordelon, Yikyung Park, Liyong Wang, Jianjun Gao, Jeffery M. Vance, Kenneth S. Kendler, Silviu-Alin Bacanu, William K. Scott, Beate Ritz, John Nutt, Stweart A. Factor, Cyrus P. Zabetian, Haydeh Payami
Psychiatry Publications
Our aim was to identify genes that influence the inverse association of coffee with the risk of developing Parkinson's disease (PD). We used genome-wide genotype data and lifetime caffeinated-coffee-consumption data on 1,458 persons with PD and 931 without PD from the NeuroGenetics Research Consortium (NGRC), and we performed a genome-wide association and interaction study (GWAIS), testing each SNP's main-effect plus its interaction with coffee, adjusting for sex, age, and two principal components. We then stratified subjects as heavy or light coffee-drinkers and performed genome-wide association study (GWAS) in each group. We replicated the most significant SNP. Finally, we imputed the …
Spag16, An Axonemal Central Apparatus Gene, Encodes A Male Germ Cell Nuclear Speckle Protein That Regulates Spag16 Mrna Expression, David R. Nagarkatti-Gude, Ruth Jaimez, Scott C. Henderson, Maria E. Teves, Zhibing Zhang, Jerome F. Strauss Iii
Spag16, An Axonemal Central Apparatus Gene, Encodes A Male Germ Cell Nuclear Speckle Protein That Regulates Spag16 Mrna Expression, David R. Nagarkatti-Gude, Ruth Jaimez, Scott C. Henderson, Maria E. Teves, Zhibing Zhang, Jerome F. Strauss Iii
Biochemistry and Molecular Biology Publications
Spag16 is the murine orthologue of Chlamydomonas reinhardtii PF20, a protein known to be essential to the structure and function of the “9+2” axoneme. In Chlamydomonas, the PF20gene encodes a single protein present in the central pair of the axoneme. Loss of PF20 prevents central pair assembly/integrity and results in flagellar paralysis. Here we demonstrate that the murine Spag16 gene encodes two proteins: 71 kDa SPAG16L, which is found in all murine cells with motile cilia or flagella, and 35 kDa SPAG16S, representing the C terminus of SPAG16L, which is expressed only in male germ cells, and is …
Development Of Melanopsin-Based Irradiance Detecting Circuitry, David S. Mcneill, Catherine J. Sheely, Jennifer L. Ecker, Tudor C. Badea, Duncan Morhardt, William Guido, Samer Hattar
Development Of Melanopsin-Based Irradiance Detecting Circuitry, David S. Mcneill, Catherine J. Sheely, Jennifer L. Ecker, Tudor C. Badea, Duncan Morhardt, William Guido, Samer Hattar
Anatomy and Neurobiology Publications
Background
Most retinal ganglion cells (RGCs) convey contrast and motion information to visual brain centers. Approximately 2% of RGCs are intrinsically photosensitive (ipRGCs), express melanopsin and are necessary for light to modulate specific physiological processes in mice. The ipRGCs directly target the suprachiasmatic nucleus (SCN) to photoentrain circadian rhythms, and the olivary pretectal nucleus (OPN) to mediate the pupillary light response. How and when this ipRGC circuitry develops is unknown.
Results
Here, we show that some ipRGCs follow a delayed developmental time course relative to other image-forming RGCs. Specifically, ipRGC neurogenesis extends beyond that of other RGCs, and ipRGCs begin …
Influence Of Continuous Venovenous Hemofiltration And Continuous Venovenous Hemodiafiltration On The Disposition Of Doripenem, Iolanda Cirillo, Nicole Vaccaro, Dainius Balis, Rebecca Redman, Gary R. Matzke
Influence Of Continuous Venovenous Hemofiltration And Continuous Venovenous Hemodiafiltration On The Disposition Of Doripenem, Iolanda Cirillo, Nicole Vaccaro, Dainius Balis, Rebecca Redman, Gary R. Matzke
Pharmacotherapy and Outcomes Science Publications
The pharmacokinetics, safety, and tolerability of a single 1-hour, 500-mg intravenous infusion of doripenem were assessed in dialysis-dependent subjects with stage 5 chronic kidney disease undergoing continuous renal replacement therapy (CRRT) via 12-hour continuous venovenous hemofiltration (CVVH) (n = 6) or continuous venovenous hemodiafiltration (CVVHDF) (n = 5). Healthy volunteers were also assessed (n = 12). Concentrations of doripenem and the primary metabolite doripenem-M-1 were measured in plasma and ultrafiltrate or ultrafiltrate/dialysate by a validated liquid chromatography-tandem mass spectrometry method. In dialysis-dependent subjects, levels of systemic exposure to doripenem and doripenem-M-1 were approximately 3- and 5-fold greater, respectively, than those …
Nursing Homes' Compliance With State Nurse Staffing Standards And Its Relation To Quality-Of-Care Deficiencies, Seung Chun Paek
Nursing Homes' Compliance With State Nurse Staffing Standards And Its Relation To Quality-Of-Care Deficiencies, Seung Chun Paek
Electronic Theses and Dissertations
The purpose of this dissertation is to examine nursing homes‟ compliance with state minimum nurse staffing standards and its relation to quality-of-care deficiencies. Specifically, this study, reviewing staffing standards from 50 states and the District of Columbia for the year 2007, proposes a unique algorithm to calculate the states‟ expected nurse staffing levels for individual nursing homes in order to investigate their compliance with the state nurse staffing standards. By using hierarchical linear modeling method, this study attempts to capture the impact of the staffing standards on actual nurse staffing levels under resource dependence perspectives. Path analysis using structural equation …