Medicine and Health Sciences Commons^™

From Good Intentions To Proven Interventions: Effectiveness Of Actions To Reduce The Health Impacts Of Air Pollution, Luisa V. Giles, Prabjit Barn, Nino Kuenzli, Isabelle Romieu, Murray A. Mittleman, Stephan Van Eeden, Ryan Allen, Chris Carlsten, Dave Stieb, Curtis W. Noonan, Audrey Smargiassi, Joel D. Kaufman, Shakoor Hajat, Tom Kosatsky, Michael Brauer

Biomedical and Pharmaceutical Sciences Faculty Publications

BACKGROUND: Associations between air pollution and a multitude of health effects are now well established. Given ubiquitous exposure to some level of air pollution, the attributable health burden can be high, particularly for susceptible populations. OBJECTIVES: An international multidisciplinary workshop was convened to discuss evidence of the effectiveness of actions to reduce health impacts of air pollution at both the community and individual level. The overall aim was to summarize current knowledge regarding air pollution exposure and health impacts leading to public health recommendations. DISCUSSION: During the workshop, experts reviewed the biological mechanisms of action of air pollution in the …

Using A Measure Of Occupational Stereotype To Assess Ingroup-Outgroup Bias Among Aerospace Specializations, Richard G. Moffett Iii, Michael B. Hein, Glenn L. Littlepage

International Symposium on Aviation Psychology - 2011

Safe and efficient flight operations require the effective intergroup coordination across multiple aerospace specializations. Various factors can impact this coordination including attitudes such as occupational stereotypes. This study reports on the development of a measure to assess ingroupoutgroup bias among aerospace specializations. Students from six aerospace specializations (Administration, Aircraft Maintenance, Air Traffic Control, Flight Dispatch and Scheduling, Professional Pilot, and Technology) at a southern university completed a questionnaire designed to assess stereotypes using adjectives to describe the members of ingroups and outgroups. Results indicate that students who had identified themselves as pilots or dispatchers exhibited ingroupoutgroup bias but in different …

Situation Awareness, Workload, And Performance In Midterm Nextgen: Effect Of Variations In Aircraft Equipage Levels Between Scenarios, L. Paige Bacon, Thomas Z. Strybel, Kim-Phuong L. Vu, Joshua M. Kraut, Jimmy H. Nguyen, Vernol Battiste, Walter Johnson

International Symposium on Aviation Psychology - 2011

We investigated the impact of mixed equipage traffic on air traffic controller (ATC) performance, workload and situation awareness in an airspace simulation of an en route sector. Nine retired ATCs and seven student ATCs managed traffic and responded to probe questions designed to measure workload and situation awareness. ATC performance was measured with the AT-SAT OTS Performance Rating Form. Although workload decreased with increasing mixtures of equipped aircraft, the number of LOS appeared to be related more to the percentage of alerted conflicts in the scenario. The probe measure of workload and situation awareness was related to AT-SAT ratings.

Use Of Digital Performance Data In The Flight Training Environment, Lauren M. Vala, Michael S. Nolan, Brian G. Dillman, John P. Young

International Symposium on Aviation Psychology - 2011

The ability to record and monitor flight data in primary training aircraft has dramatically changed in the last decade. By taking advantage of digital data recording equipment on single engine aircraft, the implementation of Flight Operations Quality Assurance (FOQA) programs is now feasible for non-airline operations. The integration of FOQA data into training and evaluation will provide multiple opportunities for utilization of this data in a variety of applications. Differences between the operational environments of airlines and collegiate training programs must be addressed if FOQA is to be properly integrated into a collegiate training environment. Through interviews of key university, …

Decision Support Tools And Layouts For Momu (Multiple Operator Multiple Uav) Environments, Tal Oron-Gilad, Talya Porat, Jacob Silbiger, Michal Rottem-Hovev

International Symposium on Aviation Psychology - 2011

The objective of this research is to design and develop tools, layouts, techniques and procedures to aid operators in handling Multiple Operator Multiple UAV (unmanned aerial vehicle) environments. In this paper we describe a study conducted on proficient operators, examining a new tool - 'Maintain Video Quality'. This tool aims to facilitate handoffs and UAV switching among operators. Experimental methodology and preliminary findings are discussed.

College Of Osteopathic Medicine Program Overview, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

The Central Cavity In Trimeric Glutamate Transporters Restricts Ligand Diffusion, Gregory Patrick Leary, David Charles Holley, Emily F. Stone, Brent Russell Lyda, Leonid Kalachev, Michael Kavanaugh

Biomedical and Pharmaceutical Sciences Faculty Publications

A prominent aqueous cavity is formed by the junction of three identical subunits in the excitatory amino acid transporter (EAAT) family. To investigate the effect of this structure on the interaction of ligands with the transporter, we recorded currents in voltage-clamped Xenopus oocytes expressing EAATs and used concentration jumps to measure binding and unbinding rates of a high-affinity aspartate analog that competitively blocks transport (β-2-fluorenyl-aspartylamide; 2-FAA). The binding rates of the blocker were approximately one order of magnitude slower than l-Glu and were not significantly different for EAAT1, EAAT2, or EAAT3, but 2-FAA exhibited higher affinity for the neuronal transporter …

Correlations Of Physiological Activities In Nocturnal Cheyne–Stokes Respiration, Alexander Umantsev, Alexander Golbin

Chemistry and Physics Faculty Working Papers

We have conducted a power–spectrum–density (PSD) analysis of the distinct sleep stages of a previously diagnosed nocturnal Cheyne–Stokes patient (NCSR) and studied the correlations of different physiological activities. This is the first study where the correlations were analyzed separately for different sleep stages and the influence of arousals was completely eliminated. Mathematical analysis of the polysomnographical records revealed clear indicators of the disorder in the form of large peaks in a very-low frequency range of ƒ ˜ 0.02 Hz. We have shown existence of the significant entrainment of the cerebral and cardiac activities with respiration during different stages of sleep …

Human Chondrosarcoma Cells Acquire An Epithelial-Like Gene Expression Pattern Via An Epigenetic Switch: Evidence For Mesenchymal-Epithelial Transition During Sarcomagenesis., Matthew P. Fitzgerald, Francoise Gourronc, Melissa L.T. Teoh, Matthew J. Provenzano, Adam J. Case, James A. Martin, Frederick E. Domann

Journal Articles: Cellular & Integrative Physiology

Chondrocytes are mesenchymally derived cells that reportedly acquire some epithelial characteristics; however, whether this is a progression through a mesenchymal to epithelial transition (MET) during chondrosarcoma development is still a matter of investigation. We observed that chondrosarcoma cells acquired the expression of four epithelial markers, E-cadherin,desmocollin 3, maspin, and 14-3-3σ, all of which are governed epigenetically through cytosine methylation. Indeed, loss of cytosine methylation was tightly associated with acquired expression of both maspin and 14-3-3σ in chondrosarcomas. In contrast, chondrocyte cells were negative for maspin and 14-3-3σ and displayed nearly complete DNA methylation. Robust activation of these genes was also …

Articulation Rate And Its Relationship To Disfluency Type, Duration, And Temperament In Preschool Children Who Stutter, Victoria Tumanova, Patricia M. Zebrowski, Rebecca Throneburg, Mavis E. Kulak Kayikci

Faculty Research and Creative Activity

The purpose of this study was to examine the relationship between articulation rate, frequency and duration of disfluencies of different types, and temperament in preschool children who stutter (CWS). In spontaneous speech samples from 19 children CWS (mean age = 3:9; years: months), we measured articulation rate, the frequency and duration of (a) sound prolongations; (b) soundsyllable repetitions; (c) single syllable whole word repetitions; and (d) clusters. Temperament was assessed with the Children’s Behavior Questionnaire (Rothbart et al., 2001). There was a significant negative correlation between articulation rate and average duration of sound prolongations (p<0.01), and between articulation rate and frequency of stuttering-like disfluencies (SLDs) (p<0.05). No other relationships proved statistically significant. Results do not support models of stuttering development that implicate particular characteristics of temperament as proximal contributors to stuttering; however, this is likely due to the fact that current methods, including the ones used in the present study, do not allow for the identification of a functional relationship between temperament and speech production. Findings do indicate that for some CWS, relatively longer sound prolongations co-occur with relatively slower speech rate, which suggests that sound prolongations, across a range of durations, may represent a distinct type of SLD, not just in their obvious perceptual characteristics, but in their potential influence on overall speech production at multiple levels.

Maternal Effects On Ethanol Teratogenesis In A Cross Between A/J And C57bl/6j Mice, David Gilliam, Nate Valdez, Scott Branson, Ashley Dixon, Chris Downing

SPS Faculty Publications

Genetic factors influence adverse pregnancy outcome in both humans and animal models. Animal research reveals both the maternal and fetal genetic profiles are important for determining the risk of physical birth defects and prenatal mortality. Using a reciprocal-cross breeding design, we investigated whether the mother’s genes may be more important than fetal genes in determining risk for ethanol teratogenesis. Examination of possible synergistic genetic effects on ethanol teratogenesis was made possible by using two mouse strains known to be susceptible to specific malformations. Inbred A/J (A) and C57BL/6J (B6) mice were mated to produce four fetal genotype groups: the true-bred …

Institute Of Clinical And Translational Sciences News, Vol. 3, Issue 4

ICTS Newsletters

No abstract provided.

Institute Of Clinical And Translational Sciences News, Vol. 4, Issue 2

ICTS Newsletters

No abstract provided.

Institute Of Clinical And Translational Sciences News, Vol. 4, Issue 3

ICTS Newsletters

No abstract provided.

Continuing Dental Education Catalog Jan-June 2011, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Snapshot 2011: Maine Workers With Disabilities, Maine’S Commission On Disability And Employment, Choices Ceo Project

Disability & Aging

No abstract provided.

The Paternal Component Of The ‘‘Healthy Migrant’’ Effect: Fathers’ Natality And Infants’ Low Birth Weight, Ambika Krishnakumar, Sandra D. Lane, Meghan Hall, Evaline Tso, Natasha Pinto, William Suk

Falk College Research Center

This study examines the predictors of birth outcomes among women of European and African ancestry and considers the birthplace of the babies’ fathers (foreign born vs. native born) as a protective factor. This is a secondary data analysis of 146,431 singleton births among women of European and African ancestry, both native-born and foreign-born, in a 21 birth hospital region of Central New York State from 1996 to 2003. Foreign born fathers were found to have 15% fewer low birth weight infants than US-born fathers, after controlling for the race and birthplace of the mother, tobacco use and Medicaid. Although this …

Applying An Empirical Hydropathic Forcefield In Refinement May Improve Low-Resolution Protein X-Ray Crystal Structures, Vishal N. Koparde, J. Neel Scarsdale, Glen E. Kellogg

Medicinal Chemistry Publications

Background

The quality of X-ray crystallographic models for biomacromolecules refined from data obtained at high-resolution is assured by the data itself. However, at low-resolution, >3.0 Å, additional information is supplied by a forcefield coupled with an associated refinement protocol. These resulting structures are often of lower quality and thus unsuitable for downstream activities like structure-based drug discovery.

Methodology

An X-ray crystallography refinement protocol that enhances standard methodology by incorporating energy terms from the HINT (Hydropathic INTeractions) empirical forcefield is described. This protocol was tested by refining synthetic low-resolution structural data derived from 25 diverse high-resolution structures, and referencing the resulting …

A Regional Model Of Interprofessional Education, M. Olenick, E. Foote, P. Vanston, J. Szarek, Z. Vaskalis, M. J. Dimattio, R. A. Smego

Osteopathic Medicine, Jerry M. Wallace School of

No abstract provided.

Prerequisites In Behavioral Science And Business: Opportunities For Dental Education., David G. Dunning, Brian M. Lange, Robert D. Madden, Koko K. Tacha

Journal Articles: College of Dentistry

There is increasing pressure on recent dental school graduates to understand and successfully utilize patient management and business management strategies to run a productive dental office. Dental schools are faced with the dilemma to either add more credit hours in their already crowded curriculum or adjust predental school requirements. All fifty-nine U.S. dental schools were assessed online to determine admission requirements in the areas of behavioral science and business education. Results show that only 11.9 percent of the schools require prerequisite course work in behavioral science and no school requires prerequisite course work in business. However, 64.4 percent and 30.5 …

Web-Based Interventions For Weight Loss And Weight Maintenance Among Rural Midlife And Older Women: Protocol For A Randomized Controlled Trial., Patricia A. Hageman, Carol H. Pullen, Melody Hertzog, Linda S, Boeckner, Susan Noble Walker

Journal Articles: Physical Therapy

BACKGROUND: Weight loss is challenging and maintenance of weight loss is problematic among midlife and older rural women. Finding effective interventions using innovative delivery methods that can reach underserved and vulnerable populations of overweight and obese rural women is a public health challenge.

METHODS/DESIGN: This Women Weigh-In for Wellness (The WWW study) randomized-controlled trial is designed to compare the effectiveness of theory-based behavior-change interventions using (1) website only, (2) website with peer-led support, or (3) website with professional email-counseling to facilitate initial weight loss (baseline to 6 months), guided continuing weight loss and maintenance (7-18 months) and self-directed weight maintenance …

Applying Principles Of Music Scene Analysis To Synchronous Auditory Warning Signals, Matthew J. Davis

International Symposium on Aviation Psychology - 2011

In emergency situations pilots are often presented with the difficult task of distinguishing between simultaneous auditory warning signals, each with varying levels of importance. This inability to effectively discriminate between synchronous warnings can lead the pilot to ignore certain signals, to misinterpret them, or to be simply unaware of their presence. The creation of signals that could be easily construed and distinguished from other simultaneous signals would not only be desirable but would also contribute to increased situational awareness and better decision-making during emergencies.

The Role Of Streptococcus Mutans In The Formation Of Dental Caries: An Ecological Perspective, Jason Yeshaya Friedman

The Science Journal of the Lander College of Arts and Sciences

The teeth are among the most distinctive and productive features of the human species. It is the longest lasting surface of the body and can be used in research studies many years after death. Yet, in the living individual, the integrity of the teeth is constantly assaulted by a microbial challenge so great that dental caries, or decay, ranks as one of the most widespread medical afflictions. According to studies, dental caries rank third in medical costs, behind only heart disease and cancer (Loesche 1996). This review will attempt to describe what is responsible for dental caries, namely a bacterium …

Graduate-Level Nursing-College Of Allied Health And Nursing 2011, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Articulation Rate And Its Relationship To Disfluency Type, Duration, And Temperament In Preschool Children Who Stutter, Victoria Tumanova, Patricia Zebrowski, Rebecca Throneburg, Mavis Kulak Kayikci

Faculty Research and Creative Activity

The purpose of this study was to examine the relationship between articulation rate, frequency and duration of disfluencies of different types, and temperament in preschool children who stutter (CWS). In spontaneous speech samples from 19 children CWS (mean age = 3:9; years: months), we measured articulation rate, the frequency and duration of (a) sound prolongations; (b) soundsyllable repetitions; (c) single syllable whole word repetitions; and (d) clusters. Temperament was assessed with the Children’s Behavior Questionnaire (Rothbart et al., 2001). There was a significant negative correlation between articulation rate and average duration of sound prolongations (p<0.01), and between articulation rate and frequency of stuttering-like disfluencies (SLDs) (p<0.05). No other relationships proved statistically significant. Results do not support models of stuttering development that implicate particular characteristics of temperament as proximal contributors to stuttering; however, this is likely due to the fact that current methods, including the ones used in the present study, do not allow for the identification of a functional relationship between temperament and speech production. Findings do indicate that for some CWS, relatively longer sound prolongations co-occur with relatively slower speech rate, which suggests that sound prolongations, across a range of durations, may represent a distinct type of SLD, not just in their obvious perceptual characteristics, but in their potential influence on overall speech production at multiple levels.

Intravenous Erythropoietin In Patients With St-Segment Elevation Myocardial Infarction - Reveal: A Randomized Controlled Trial, S. S. Najjar, S. V. Rao, C. Melloni, S. V. Raman, T. J. Povsic, L. Melton, G. W. Barsness, K. Prather, L. Gruberg, R. A. Harrington, +10 Additional Authors

Journal Articles

Context: Acute ST-segment elevation myocardial infarction (STEMI) is a leading cause of morbidity and mortality. In experimental models of MI, erythropoietin reduces infarct size and improves left ventricular (LV) function. Objective: To evaluate the safety and efficacy of a single intravenous bolus of epoetin alfa in patients with STEMI. Design, Setting, and Patients: A prospective, randomized, double-blind, placebo-controlled trial with a dose-escalation safety phase and a single dose (60 000 U of epoetin alfa) efficacy phase; the Reduction of Infarct Expansion and Ventricular Remodeling With Erythropoietin After Large Myocardial Infarction (REVEAL) trial was conducted at 28 US sites between October …

Management Of Hypertension Among Patients With Coronary Heart Disease, O. Olafiranye, F. Zizi, P. Brimah, G. Jean-Louis, A. N. Makaryus, S. Mcfarlane, G. Ogedegbe

Journal Articles

Evidence suggests that coronary heart disease (CHD) is the most common outcome of hypertension. Hypertension accelerates the development of atherosclerosis, and sustained elevation of blood pressure (BP) can destabilize vascular lesions and precipitate acute coronary events. Hypertension can cause myocardial ischemia in the absence of CHD. These cardiovascular risks attributed to hypertension can be reduced by optimal BP control. Although several antihypertensive agents exist, the choice of agent and the appropriate target BP for patients with CHD remain controversial. In this succinct paper, we examine the evidence and the mechanisms for the linkage between hypertension and CHD and we discuss …

Ada News Convention Daily - 2011 Day 2, American Dental Association, Publishing Division

ADA News

The ADA News Daily (also called the ADA News Convention Daily) is a special edition of the ADA News published each day during American Dental Association Annual Sessions.

Ada News Convention Daily - 2011 Day 1, American Dental Association, Publishing Division

ADA News

The ADA News Daily (also called the ADA News Convention Daily) is a special edition of the ADA News published each day during American Dental Association Annual Sessions.

Complexity Of Using Multiple Data Sources For Population Management In Colorectal Cancer Screening: The Experience Of Satis-Phi/Crc, Brian Stello Md, Amanda E. Borsky Mpp, Can, Daniel M. Harris Phd, Melanie B. Johnson Mpa, Staci Morrissey Bs, Mona Sarfaty Md, Ronald E. Myers Phd

Department of Family Medicine

No abstract provided.