Medicine and Health Sciences Commons^™

Huntington’S Disease, Loneliness, And Love, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Differences In Police, Ambulance, And Emergency Department Reporting Of Traffic Injuries On Karachi-Hala Road, Pakistan, Junaid Ali Bhatti, Junaid Razzak, Emmanuel Lagarde, Louis Rachid Salmi

Department of Emergency Medicine

Background

Research undertaken in developing countries has assessed discrepancies in police reporting of Road Traffic Injury (RTI) for urban settings only. The objective of this study was to assess differences in RTI reporting across police, ambulance, and hospital Emergency Department (ED) datasets on an interurban road section in Pakistan.

Methods

The study setting was the 196-km long Karachi-Hala road section. RTIs reported to the police, Edhi Ambulance Service (EAS), and five hospital EDs in Karachi during 2008 (Jan to Dec) were compared in terms of road user involved (pedestrians, motorcyclists, four-wheeled vehicle occupants) and outcome (died or injured). Further, records …

Ada News - 03/21/2011, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Caregiving Styles: A Typology Of Cognitive And Behavioral Processes Associated With Caring For A Family Member With Dementia, Mary A. Corcoran

Clinical Research and Leadership Faculty Posters and Presentations

This grounded theory study describes a typology of caregiving styles relevant to family members of an individual with ADRD, where caregiving style is defined as a culturally-based pattern in thinking and action. The goal of this study was to characterize the relationship between caregiver intentions and care strategies.

Engineered Nanomaterials: Exposures, Hazards, And Risk Prevention, Robert A. Yokel, Robert C. Macphail

Pharmaceutical Sciences Faculty Publications

Nanotechnology presents the possibility of revolutionizing many aspects of our lives. People in many settings (academic, small and large industrial, and the general public in industrialized nations) are either developing or using engineered nanomaterials (ENMs) or ENM-containing products. However, our understanding of the occupational, health and safety aspects of ENMs is still in its formative stage. A survey of the literature indicates the available information is incomplete, many of the early findings have not been independently verified, and some may have been over-interpreted. This review describes ENMs briefly, their application, the ENM workforce, the major routes of human exposure, some …

Medical School Watercooler Newsletter - March 20, 2011, Lindsey Lyle

Watercooler Newsletter

This is the March 20, 2011 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler

Contents Include

• USA SPF 90 Team to Give Free Skin Cancer Screenings

• USA College of Medicine to Host Gumbo Chili Showdown This Weekend

• Surgery Chair to Give Free Community Lecture

• Next Week's DSS - Dr. William Stanley

• "A Mathematical Habitat for Analyzing Biological Sequences"

Evaluation Of Preference For Exergames Among Elementary Students, Christie Ann Cacioppo

USF Tampa Graduate Theses and Dissertations

Obesity in children is a nationwide problem. Physical activity is one way to help children stay fit and prevent obesity. Unfortunately, access to technology involving sedentary behavior is easier than ever. Fortunately, for this generation of students there is a way to combine physical activity and technology through exergaming. In order to encourage students to participate in exergaming, the students should be able to play games they prefer. The purpose of this study was to apply a paired choice preference assessment, rank order card sort, and social validity surveys to determine the preference order of six exergames for six elementary …

Role Of The At2 Receptor In Modulating The Angiotensin Ii Contractile Response Of The Uterine Artery At Mid-Gestation, V. M. Pulgar, H. Yamashiro, J. C. Rose, L. G. Moore

Pharmaceutical Sciences

Introduction: During human pregnancy, circulating concentrations of components of the renin—angiotensin system increase, but pressor refractoriness to angiotensin II (Ang-II) is observed. Given the importance of the Ang-II pressor response in deciding susceptibility to preeclampsia and of the Ang-II system for controlling uterine vasoreactivity, we sought to address the effects of pregnancy on the reactivity of the isolated uterine artery (UA) in mice.

Materials and methods : Blood pressure was measured throughout pregnancy in awake C57BL/6J mice. UA segments were isolated from three groups of animals (non-pregnant, mid [day 12—13] and late [day 18—19] gestation) and studied by wire …

Role Of The At2 Receptor In Modulating The Angiotensin Ii Contractile Response Of The Uterine Artery At Mid-Gestation, V. M. Pulgar, H. Yamashiro, J. C. Rose, L. G. Moore

Pharmaceutical Sciences

No abstract provided.

Threshold Regression Models Adapted To Case-Control Studies, And The Risk Of Lung Cancer Due To Occupational Exposure To Asbestos In France, Antoine Chambaz, Dominique Choudat, Catherine Huber, Jean-Claude Pairon, Mark J. Van Der Laan

U.C. Berkeley Division of Biostatistics Working Paper Series

Asbestos has been known for many years as a powerful carcinogen. Our purpose is quantify the relationship between an occupational exposure to asbestos and an increase of the risk of lung cancer. Furthermore, we wish to tackle the very delicate question of the evaluation, in subjects suffering from a lung cancer, of how much the amount of exposure to asbestos explains the occurrence of the cancer. For this purpose, we rely on a recent French case-control study. We build a large collection of threshold regression models, data-adaptively select a better model in it by multi-fold likelihood-based cross-validation, then fit the …

The P53 Inhibitor Mdm2 Facilitates Sonic Hedgehog- Mediated Tumorigenesis And Influences Cerebellar Foliation, Reem Malek, Jennifer Matta, Natalie Taylor, Mary Ellen Perry, Susan Mendrysa

Department of Basic Medical Sciences Faculty Publications

Disruption of cerebellar granular neuronal precursor (GNP) maturation can result in defects in motor coordination and learning, or in medulloblastoma, the most common childhood brain tumor. The Sonic Hedgehog (Shh) pathway is important for GNP proliferation; however, the factors regulating the extent and timing of GNP proliferation, as well as GNP differentiation and migration are poorly understood. The p53 tumor suppressor has been shown to negatively regulate the activity of the Shh effector, Gli1, in neural stem cells; however, the contribution of p53 to the regulation of Shh signaling in GNPs during cerebellar development has not been determined. Here, we …

Asymptomatic And Unrecognized Cement Pulmonary Embolism Commonly Occurs With Vertebroplasty, Marianne T. Luetmer, B J. Bartholmai, A E. Rad, D F. Kallmes

Pre-medicine Student Work

BACKGROUND AND PURPOSE: Cement PE represents a potentially serious complication following vertebroplasty. To determine the frequency and extent of cement PE during percutaneous vertebroplasty, we performed a retrospective review of chest CT scans obtained in patients who had previously undergone ≥1 vertebroplasty procedure. MATERIALS AND METHODS: After approval by our local institutional review board, we retrospectively evaluated 244 patients who had undergone vertebroplasty at 465 levels and subsequently underwent chest CT. A thoracic radiologist evaluated the presence, number, size, and location of discrete cement PEs. We catalogued the following data: age, sex, number of treated vertebrae, cement volume per vertebra, …

The Role Of Community Health Centers In Addressing The Needs Of Uninsured Low-Income Workers: Implications Of Proposed Federal Funding Reductions, Peter Shin, Sara J. Rosenbaum

Geiger Gibson/RCHN Community Health Foundation Research Collaborative

The severe economic downturn over the past few years has demonstrated the heightened importance of strengthening the health care safety net, particularly for working Americans who may have lost their health insurance coverage or do not have access to employer-sponsored benefits. Both historically and most recently during the current recession, health centers have played a critical role in providing services to the working poor, assuring that they continue to receive timely preventive care that obviates the need for, and minimizes use of, more costly services. We estimate that 1 in 4 low income, uninsured working adults depend on health centers …

Cultural Authenticity And Recovery Maintenance In A Rural First Nation Community, Aimee Nygaard

Aboriginal Policy Research Consortium International (APRCi)

This study explored a rural, First Nation understanding of factors, particularly the role of culture, supporting recovery maintenance from problem substance use. A cross- sectional, qualitative research design and community-based methodology were used. Participants included 20 members of a rural Canadian community self-identifying as recovering, or recovered, problem substance users, and those with professional experience with First Nations recovery. Semi-structured, open-ended interviews gathered in-depth accounts of the recovery experience examined through a thematic analysis. Culture emerged as a contested concept, and was viewed along a spectrum from detrimental, to somewhat helpful to very beneficial in the recovery process. Community change …

An Exercise In Molecular Epidemiology: Human Rhinovirus Prevalence And Genitics, Catherine J. Albright, David J. Hall

Chemistry Department Faculty Publications

Human rhinovirus (HRV) is one of the most common human respiratory pathogens and is responsible for the majority of upper respiratory illnesses. Recently, a phylogeny was constructed from all known Ameri- can Type Culture Collection (ATCC) HRV sequences. From this study, three HRV classifications (HRVA, HRVB, and HRVC) were determined and techniques for classifying new isolates of HRV were reported. The genetic change of this virus in specific populations over time is of great interest to understand the evolution and epidemiology of viruses. To facilitate the collections of HRV sequences over a number of years, a virology experiment was designed …

Intimate Partner Violence In Urban Pakistan: Prevalence, Frequency, And Risk Factors, Tazeen S. Ali, Nargis Asad, Ingrid Mogren, Gunilla Krantz

School of Nursing & Midwifery

Background: Intimate partner violence (IPV) is an important public health issue with severe adverse consequences. Population-based data on IPV from Muslim societies are scarce, and Pakistan is no exception. This study was conducted among women residing in urban Karachi, to estimate the prevalence and frequency of different forms of IPV and their associations with sociodemographic factors.
Methods: This cross-sectional community-based study was conducted using a structured questionnaire developed by the World Health Organisation for research on violence. Community midwives conducted face-to-face interviews with 759 married women aged 25-60 years.
Results: Self-reported past-year and lifetime prevalence of physical violence was 56.3 …

Healing At The End Of Life: A Journey Of Hope Of The Christian Community, Bro. Ignatius Perkins, O.P.

Faculty Conference Presentations

Presented at the Catholic and Dominican Institute, Mount Saint Mary College, Newburg, New York, March 16, 2011.

Developing Countries, Vaccine Access And Influenza Outbreaks: Ethics And Global Health Governance When Facing A Pandemic, Shawn Smallman

International & Global Studies Faculty Publications and Presentations

The threat posed by influenza pandemics raises serious ethical issues, as well as questions of global health governance. In order to create pre-pandemic vaccines, global health authorities need access to virus from regional outbreaks. But because the countries where these outbreaks occur are unlikely to benefit from the vaccine, they are sometimes reluctant to share this seed stock, and may try to make proprietary arrangements with pharmaceutical companies, as briefly occurred in Indonesia. Although these arrangements may increase developing countries' access to vaccine, they hamper the global cooperation necessary to prepare for influenza outbreaks. Developing countries, in contrast, point to …

Today - March 16, 2011, Loma Linda University

TODAY

Inside this issue:

-- Loma Linda University Medical Center-Murrieta opens
-- Loma Linda City Council moves toward approval of pedestrian walkway project
-- Physical therapy graduate inducted into Rose Bowl Hall of Frame
-- Social work graduate students brave the night to survey the unsheltered
-- AACR awards 50 Minority Scholar in Cancer Research Awards
-- Loma Linda University School of Medicine dedicates the class of 2014
-- School of Nursing hosts delegation from South Korea
-- Volunteer opportunities for Goal 4 Health youth soccer league
-- Shona sculpture at Highland Springs Medical Plaza depicts family embrace
-- Physical therapy …

Seeing The Unseen:Targeting Neonatal Mortality In Rural Vietnam., Zulfiqar Ahmed Bhutta

Department of Paediatrics and Child Health

No abstract provided.

Expression And Purification Of Recombinant Ledgf/P75, Ivonne R. Reyes^, Daniel Reyes, Manuel Llano*

COURI Symposium Abstracts, Spring 2011

HIV infection requires the integration of a DNA copy of the viral genome into the host chromosome. The cellular protein LEDGF/p75 has an essential role in this process. Different cellular proteins interact with LEDGF/p75, but the significance of these interactions for HIV infection is unknown. To further characterize these protein interactions, we will use recombinant LEDGF/p75 wild type (WT) and mutants. LEDGF/p75 WT was PCR amplified and cloned N- terminally fused to glutathione S-transferase (GST). This expression plasmid was later used to generate deletion mutants targeting different LEDGF/p75 functional domains. These constructs were transformed into E. coli Rosetta. Optimal conditions …

Screening Of Metal-Based Azole Derivatives Antiparasitic Activity On Trypanosoma Cruzi And Leishmania Major, Teresia A. Carreon^, Linda Herrera, Miguel Vasquez, Roberto A. Sanchez-Delgado, Rosa A. Maldonado*

COURI Symposium Abstracts, Spring 2011

The trypanosomatids Leishmania major and Trypanosoma cruzi are parasites that affect millions of people worldwide. Leishmaniasis is naturally transmitted via sandflies while T. cruzi is transmitted by kissing bugs. Due to immigration and deployment to endemic regions, lack of screening in blood banks and climatic changes these neglected diseases have become a growing health concern in the United States. The lack of vaccines to prevent/treat the diseases and the toxicity of current treatments supports the need for new drug treatments. Azole compounds inhibit the sterol synthesis pathway of these parasites, which has been validated as a drug target. T.cruzi epimastigote …

Neuromagnetic Measures Of Word Processing In Bilinguals And Monolinguals, Yingying Wang, Jing Xiang, Jennifer Vannest, Tom Holroyd, Daria Narmoneva, Paul Horn, Yinhong Liu, Douglas Rose, Ton Degrauw, Scott Holland

Center for Brain, Biology, and Behavior: Faculty Publications

Objective: This study aimed to use magnetoencephalography (MEG) to examine the question of whether Mandarin-English bilingual speakers recruit the same cortical areas or develop distinct language-specific networks without overlaps for word processing.

Methods: Eight healthy Mandarin-English bilingual adults and eight healthy English monolingual adults were scanned while single-word paradigms were audio-visually presented.

Results: Our results showed significantly stronger beta-band power suppression in the right inferior parietal lobe (IPL) covering the supramarginal gyrus (BA 40) and angular gyrus (BA 39) for bilinguals when processing Mandarin versus English. Moreover, there were no significant differences between bilinguals and monolinguals in the left inferior …

Myxoid Chondrosarcoma Of The Phalanx With An Ews Translocation: A Case Report And Review Of The Literature, David B. Bumpass, Michael Kyriakos, David A. Rubin, Paul R. Manske, Charles A. Goldfarb

Open Access Publications

No abstract provided.

Animal Health Matters, David H. Zeman, Russ Daly

Animal Health MATTERS Newsletter

[Page] 1-Terrorism on the Prairie? [Page] 2-Director's Message: Essential State Infrastructure for Animal Health [Page] 3-Reflections on the Veterinary Medical Loan Repayment [Page] 4-Program (VMLRP), 2010 [Page] 6-The Clinical Pathology Section at SDSU’s ADRDL [Page] 6-Calf Scours Submissions at SDSU ADRDL [Page] 6-Calf Scours / Enteritis Submission Guidelines [Page] 7-Veterinary and Biomedical Sciences Department Welcomes New Full-Time Staff Members Pieces and Parts [Page] 7-Veterinary and Biomedical Sciences Department Faculty Members Honored [Page] 7-Continuing Education Events

The Health Care Access And Cost Consequences Of Reducing Health Center Funding, Peter Shin, Sara J. Rosenbaum

Geiger Gibson/RCHN Community Health Foundation Research Collaborative

For over four decades, community health centers have served a critical role in providing affordable access to quality care to some of the nation's most vulnerable populations. Health centers have historically enjoyed broad bipartisan support, based on the evidence documenting their high quality care, crucial role in both urban and rural communities, and ability to "bend the cost curve."

On February 20, 2011, the U.S. House of Representatives voted to reduce discretionary health center funding by $1.3 billion in FY 2011 alone. Although the spending bill was rejected by the U.S. Senate on March 10, 2011, final spending measures for …

Advances And Future Challenges In Adenoviral Vector Pharmacology And Targeting, Reeti Khare, Christopher Y. Chen, Eric A. Weaver, Michael A. Barry

Nebraska Center for Virology: Faculty Publications

Adenovirus is a robust vector for therapeutic applications, but its use is limited by our understanding of its complex in vivo pharmacology. In this review we describe the necessity of identifying its natural, widespread, and multifaceted interactions with the host since this information will be crucial for efficiently redirecting virus into target cells. In the rational design of vectors, the notion of overcoming a sequence of viral “sinks” must be combined with re-targeting to target populations with capsid as well as shielding the vectors from pre-existing or toxic immune responses. It must also be noted that most known adenoviral pharmacology …

Activated Krasg¹²D Is Associated With Invasion And Metastasis Of Pancreatic Cancer Cells Through Inhibition Of E-Cadherin., Satyanarayana Rachagani, S Senapati, S Chakraborty, Moorthy P. Ponnusamy, Sushil Kumar, Lynette Smith, Maneesh Jain, Surinder K. Batra

Journal Articles: Biochemistry & Molecular Biology

BACKGROUND: Pancreatic cancer (PC) harbours an activated point mutation (Kras(G12D)) in the Kras proto-oncogene that has been demonstrated to promote the development of PC.

METHODS: This study was designed to investigate the effect of the oncogenic Kras(G12D) allele on aggressiveness and metastatic potential of PC cells. We silenced the oncogenic Kras(G12D) allele expression in CD18/HPAF and ASPC1 cell lines by stable expression of shRNA specific to the Kras(G12D)allele.

RESULTS: The Kras(G12D) knockdown cells exhibited a significant decrease in motility (P

CONCLUSIONS: The results of this study suggest that the Kras(G12D) allele promotes metastasis in PC cells partly through the downregulation …

Nih Public Access Policy Overview, Kate Krause, Laurissa B. Gann

Library Staff Publications

A PowerPoint presentation from a webinar about the National Institute of Health's Public Access Policy.

• Overview of the Policy
• Who Has to Comply?
• When do you Have to Comply?
• How to Secure the Required Copyright
• How to Submit your Article
• How to Cite your Article
• How to Cite with EndNote
• More Information Sources
• Questions and Answers

Educational Needs And Causes Of False Diagnosis Of Atypical Squamous Cells Of Unknown Significance At A University Hospital, Neeta Kumar, Shahin Sayed, Zahir Moloo

Pathology, East Africa

The entity of atypical squamous cells of undetermined significance (ASCUS) in The Bethesda System 2001 for reporting cervical cytology is characterized by equivocal diagnosis, poor reproducibility and debatable management. This retrospective study was done to analyse the causes of false ASCUS if any and identify the educational needs as part of quality assurance programme. Cervical smears of all ASCUS cases reported over the one-year period were reviewed by the Cytopathologist. Relevant clinical data was retrieved. ASCUS was the most common type of abnormality representing 43.0 % cases among 294 abnormal smears reported during study period. 16.0% cases were found to …