Medicine and Health Sciences Commons^™

Stem Cell Biology And Strategies For Therapeutic Development In Degenerative Diseases And Cancer, Angel A. Alvarez '98

Doctoral Dissertations

Stem cell biology is an exciting field that will lead to significant advancements in science and medicine. We hypothesize that inducing the expression of stem cell genes, using the embryonic stem cell gene nanog, will reprogram cells and dedifferentiate human mesenchymal stem cells into pluripotent stem cells capable of neural differentiation. The aims of initial studies are as follows:

Aim 1: Demonstrate that forced expression of the embryonic stem cell gene nanog induces changes in human mesenchymal stem cells to an embryonic stem cell-like phenotype.

Aim 2: Demonstrate that induced expression of nanog up-regulates the expression of multiple embryonic stem …

Oncolog, Volume 56, Number 04-05, April-May 2011, Zach Bohannan, Bryan Tutt

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Understanding and Managing Multiple Endocrine Neoplasia Syndromes: Endocrine tumors caused by multiple endocrine neoplasia syndromes (MEN) pose a dual threat-both from the tumors' potential for growth or metastasis and from their hormonal secretions
• Two-Stage Resection and Improved Chemotherapy Regimens Lengthen Survival for Patients with Lever Metastasis from Colorectal Cancer
• HOUSE CALL: Saving a Life by Donating Stem Cells: Fact about stem cell transplants
• IN BRIEF: Study Reveals How EZH2 Protein Promotes Breast Tumor-Initiating Cell Growth

Clergy Burnout, Compassion Fatigue, And Art Therapy, Joanna Harris Tarr

EVMS School of Health Professions Theses & Dissertations

The purpose of this study was to explore how art therapy can benefit clergy who are at a greater risk for experiencing burnout and compassion fatigue due to the unique personal stressors of their profession. As members of the helping professions who support people in the community through the local church during times of stress, death, birth, marriage and other important life junctures, they are often overworked (Strumpfer & Bands, 1996). Studies have determined that many clergy experience burnout and some may decide to leave the ministry, adding to the already declining numbers of those who decide to enter the …

Detection Of Folate Receptor From Fr+ Cancer Cells, Darpan Patel

All Capstone Projects

The aim was to detect cancer cells by using folate–PEG-Biotin probe with fluorescently labeled streptavidin for targeted drug delivery of anti-cancer drugs and diagnose cancer cells. Folate-PEG-Biotin (synthesized by Dr. Henne and Mr.Rohan Patel) was purified by HighPeformanceLiquidChromatography (HPLC) analysis and with the help of Liquid Chromatography/Mass Spectrometry (LC/MS) its identity was confirmed. Folate is a basic composition of cell metabolism in both synthesis of DNA and proteins. Growing cancer cells require high level of folic acid. Folate Receptor-α (FR-α) is a membrane bound protein having high affinity for folic acid and serves to transport of folate into cells. Poly …

A Method For Providing High-Volume Interprofessional Simulation Encounters In Physical And Occupational Therapy Education Programs, Michael J. Shoemaker Pt, Dpt, Jeanine Beasley Edd, Otr, Megan Cooper Bs, Ron Perkins Bsn, Rn, Jeanne Smith Bs, Ba, Chris Swank Ma

Publications

With an increasing emphasis on interprofessional education within the allied health professions, simulation has potential for being a useful teaching modality for providing collaborative learning experiences for occupational and physical therapist students. However, there are many challenges associated with conducting simulations with large numbers of students. We describe the design, planning, cost, and support staff time required for conducting an interprofessional simulation of the intensive care setting, including a methodology for maximizing resources and student opportunities for participation for 64 physical and occupational therapy students over a 4-hour time period. Qualitative analyses of student experiences are also presented.

Caring For Women: A Profile Of The Midwifery Workforce In Massachusetts, Christa M. Kelleher, Dorothy Brewin

Publications from the Center for Women in Politics and Public Policy

This profile of the Commonwealth’s midwifery workforce provides state-level data on the demographic characteristics, employment context, and practice scope of midwives. It also offers a snapshot of populations served by mid-wives and public policy issues that affect midwives and midwifery care in Massachusetts. The report is based on a survey administered to midwives living and/or working in the state supplemented by in-depth interviews with five midwives, one obstetrician, and one state public health official. This report uniquely analyzes data collected from both certified nurse-midwives (CNMs) and directentry midwives (DEMs), including certified professional midwives (CPMs); this summary distinguishes between these two …

Uptake Of Nanoparticles Of Cerium Oxide And Yttrium Oxide By Acanthamoeba Castellanii (Protozoa) And Daphnia Magna (Crustacea), James R. Palmieri, Geneva Gehring, Catherine Minichino, Shaadi F. Elswaifi

Virginia Journal of Science

Currently, nanoparticles are synthesized and used at an unprecedented rate for industrial, medical, and research applications. The use of cerium oxide nanoparticles (CeONP) and yttrium oxide nanoparticles (YtONP) results in their spread as contaminants into the environment. Once in the environment, CeONP and YtONP can be taken up by organisms in the food chain where they may pose a public health risk. In this study we determine whether Acanthamoeba castellanii and Daphnia magna uptake CeONP or YtONP from their environment and thereby play a role in the transmission of the nanoparticles. Using electron microscopy, orgranisms exposed to the nanoparticles were …

Digest Of The Philadelphia College Of Osteopathic Medicine (Spring 2011), Philadelphia College Of Osteopathic Medicine

Digest

The Spring 2011 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Opening Remarks
• PCOM Updates
• Development News
• Moonlighting in the Big Leagues
• Closing the Gap in Primary Care
• In Love & War
• Driven by Adventure: Nilam Vaughan, DO ’11, recipient of the 2011 Mason W. Pressly Memorial Medal, GA–PCOM
• Stand by the Struggling: Jenna Stokes, DO ’11, recipient of the 2011 Simmy Ginsburg Humanitarian Award
• Class Notes
• In Memoriam
• My Turn Essay

Role Of The 3'Lghrr In Tcdd-Induced Suppression Of The Immunoglobulin Heavy Chain, Jayharsh L. Panchal, Eric J. Romer, David Ellis, Tharu Fernando, Courtney E. W. Sulentic

Celebration of Undergraduate & Graduate Research, Scholarship, and Creative Activities Materials

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) inhibits antibody secretion and immunoglobulin heavy chain (IgH) expression. Our previous work has shown that a possible mechanism for inhibition of IgH expression could be inhibition of the 3’IgH regulatory region (3’IgHRR). The 3’IgHRR has four enhancer regions (hs3a; hs1,2; hs3b; hs4) which are purported to control IgH gene expression. Previously we demonstrated a sensitive inhibition by TCDD of LPS-induced 3’IgHRR activity which is correlated with an inhibition of LPS-induced hs1,2 enhancer activity; however, the hs4 enhancer showed TCDD-induced activation following the co-treatment of TCDD and LPS. Therefore, the objective of the current study was to determine if …

State Methamphetamine Precursor Policies And Changes In Small Toxic Lab Methamphetamine Production, Duane C. Mcbride, Yvonne Terry-Mcelrath, Jamie Chriqui, Jean O'Connor, Curtis J. Vanderwaal, Karen Mattson

Faculty Publications

Domestic production of methamphetamine in small toxic labs (STLs) results in significant community safety and health consequences. This paper examines the effects of state-level policies implemented in the middle of the last decade in reaction to a rapid increase in STL labs. These policies focused on controlling access to the methamphetamine precursor chemicals ephedrine and pseudoephedrine and the relationship of such policies with actual STL seizure rates. Data include (a) primary legal research on state laws/regulations in all 50 states in effect as of October 1, 2005; and (b) STL seizure counts for 2004–2006. Results from random effects cross-sectional time-series …

Response To An Abnormal Ovarian Cancer-Screening Test Result: Test Of The Social Cognitive Processing And Cognitive Social Health Information Processing Models, Michael A. Andrykowski, Edward J. Pavlik

Behavioral Science Faculty Publications

All cancer screening tests produce a proportion of abnormal results requiring follow up. Consequently, the cancer-screening setting is a natural laboratory for examining psychological and behavioural response to a threatening health-related event. This study tested hypotheses derived from the social cognitive processing and cognitive-social health information processing models in trying to understand response to an abnormal ovarian cancer (OC) screening test result. Women (n = 278) receiving an abnormal screening test result a mean of 7 weeks earlier were assessed prior to a repeat screening test intended to clarify their previous abnormal result. Measures of disposition (optimism, informational coping style), …

Understanding Mesosystemic Influences On Reported Health Among Rural Low-Income Women: A Structural Equation Analysis, Tiffany Wigington

College of Education and Human Sciences: Dissertations, Theses, and Student Research

While ensuring access to health insurance and health care services is important, emerging research indicates that individual health and well-being result from a complex array of environmental, social, and psychological factors. The delineation of how factors of health and well-being unfold and impact rural low-income women is particularly salient for social workers who provide services to rural residents and who work within a rural context. Utilizing components from the ecological systems perspective, this study explored how the factors associated with health risk influenced reported health and mesosystemic processes among rural low-income women. This sample (n=304) for this study was drawn …

Preschool Children’S Willingness To Try And Preference For Docosahexaenoic Acid Omega-3 Foods, Bethany Joann Bettenhausen

Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research

During the preschool years, obesigenic eating habits are formed which are strongly associated with risk of developing chronic diseases later in life particularly cardiovascular disease. Docosahexaenoic acid (DHA) omega-3 fatty acid is a polyunsaturated fat with known benefits for heart health, brain cell structure, and retinal development. Current intakes of DHA are below recommended levels. United States (US) Midwestern children may be particularly at risk for suboptimal intakes of DHA. However, foods fortified with life’sDHA^TM, a product of Martek Biosciences and omega-3 eggs may provide culturally acceptable sources of DHA to Midwestern children.

Very little is known about …

Omega-3 Dietary Intakes, Knowledge, And Attitudes In Patients Screened For Colon Cancer, Cindy Kaminski

Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research

Objective: The purpose of this study was to estimate Omega-3 (n-3) fatty acid intakes in colonoscopy patients and to examine knowledge and attitudes held about dietary fats.

Subjects/Methods: Men (n=32) and women (n=47) patients were recruited from a Midwestern gastroenterology clinic. A dietitian obtained informed consent, a food recall and response from a 152-item n-3 food frequency questionnaire (n-3 FFQ) at the clinic using visuals and food models. Two additional 24-h recalls, including a weekend recall, were returned by mail. A questionnaire measuring diet fatty acids knowledge, diet attitudes and beliefs was also obtained.

Results: Daily intake of n-3 fatty …

Falls Injuries: Causes, Consequences, And Prevention, Ray Marks

Publications and Research

Falls have been and continue to be a leading cause of death among older persons in the United States, affecting at least one in three persons, or as many as one in two persons over 65 years of age each year. This present Special Edition thus sought to examine current research concerning the causes, consequences, and intervention approaches in the context of falls injuries among the elderly.

Transylvania Medical Alumni Served Both Sides During The Civil War, Charles T. Ambrose

Microbiology, Immunology, and Molecular Genetics Faculty Publications

No abstract provided.

A Comparison Of Muscular Activation During The Back Squat And Deadlift To The Countermovement Jump, David Robbins Cscs, Nasm-Cpt

SHU Theses and Dissertations

The purpose of this study was to determine whether the back squat (BS) or deadlift (DL) is most similar to the countermovement jump (CMJ) in terms of peak muscular activation. The muscles assessed in this study were the erector spinae (ES), gluteus maximus (GM), biceps femoris (BF), vastus medialis (VM), and gastrocnemius (GN). These five muscles were chosen do to their involvement in all of these exercises. Ten college-aged males (24±1.18yrs) with a minimum of 1 year strength training experience volunteered for this study. Participants must have been strength trained and could BS and DL 1.5 x bodyweight. Results showed …

The Acute Effect Of Self-Myofascial Release On Lower Extremity Plyometric Performance, Brian J. Fama, David R. Bueti

SHU Theses and Dissertations

The purpose of this study was to evaluate the acute effect of a Foam Roller (FR) warm up routine and a dynamic warm-up routine on strength, power, and reactive power using a squat jump (SJ) countermovement jump (CMJ) and depth jump (DJ). Nine college aged recreational males with a minimum of 1-year experience in plyometric training completed the study. Following baseline testing, subjectswere randomly assigned to a warm up protocol on the second session of the study and then completed the otherprotocol on the third day of the study. The best of three jumps were recorded. RMANOVA revealed a significant …

Establishing Reliability And Validity Of The Chinese Version Of The Jefferson Scale Of Empathy, Hanoch Livneh, Jung-Feng Cheng, Yu-Min Lai

Counselor Education Faculty Publications and Presentations

[Article in Chinese]

Background: Empathy is an important concept and necessary skill for health care providers. Many studies have adopted the Jefferson Scale of Empathy - Health care Providers Version (JSE-HP) to collect data used to measure healthcare provider empathy. However, this scale has not been used to assess healthcare providers in Taiwan. Purpose: Study purposes were to: (a) translate the JSE-HP into Chinese, (b) examine validity and reliability of the translated scale, and (c) use the scale to measure empathyin a sample of Taiwan healthcare providers.

Methods: Researchers used a backward translation approach to translate the JSE-HP …

Dual Chamber Pacemaker Implants--A New Opportunity In Pakistan For Children With Congenital And Acquired Complete Heart Block, Awais Ashfaq, Mansoor Ahmed Khan, Mehnaz Atiq, Muhammad Muneer Amanullah

Section of Cardiothoracic Surgery

Implantation of cardiac pacemakers has been practiced for at least five decades with continuous developments of the hardware. The invention of dual chamber pacemakers has initiated a debate concerning its superiority over single chamber ventricular pacemakers. Throughout the world, surgeons have been using dual chambered permanent pacemakers with successful follow ups. However, Pakistan has not yet taken the advantage of such pacemaker devices till now. We report three cases that underwent a dual chamber permanent pacemaker implantation for the first time in children less than 8 kg with successful follow ups.

Discrimination, Perceived Social Inequity, And Mental Health Among Rural-To-Urban Migrants In China, Danhua Li, Xiaoming Li, Bo Wang, Yan Hong, Xiaoyi Fang, Xiong Qin, Bonita Stanton

Faculty Publications

Status-based discrimination and inequity have been associated with the process of migration, especially with economics-driven internal migration. However, their association with mental health among economy-driven internal migrants in developing countries is rarely assessed. This study examines discriminatory experiences and perceived social inequity in relation to mental health status among rural-to-urban migrants in China. Cross-sectional data were collected from 1,006 rural-to-urban migrants in 2004-2005 in Beijing, China. Participants reported their perceptions and experiences of being discriminated in daily life in urban destination and perceived social inequity. Mental health was measured using the symptom checklist-90 (SCL-90). Multivariate analyses using general linear model …

A Sodium Salt Of The Dimer Of Boronoterephthalic Acid Anhydride, Scott Simmons, Albert Fratini, Vladimir Benin

Chemistry Faculty Publications

The title compound, sodium bis­(6-carb­oxy-1-hy­droxy-3-oxo-1,3-dihydro-2,1-benzoxaborol-1-yl)oxidanium, Na+·C16H15B2O13-, was prepared in two steps from 2-bromo-p-xylene. Its crystal structure was determined at 140 K and has triclinic (P) symmetry. The compound presents a unique structural motif, including two units of the cyclic anhydride of boronoterephthalic acid, joined by a protonated, and thereby trivalent, oxonium center. Association in the crystal is realized by complementary hydrogen bonding of the carboxyl groups, as well as by coordination of the sodium cations to the oxygen centers on the five-membered rings.

Theoretical Investigation Of A Reported Antibiotic From The 'Miracle Tree' Moringa Oleifera, Michael Horwath, Vladimir Benin

Chemistry Faculty Publications

Moringa oleifera, sometimes called the “Miracle Tree,” has received international attention for its potential to improve health in impoverished tropical areas. In addition to high vitamin content in the leaves and pods, the tree contains compounds with antioxidant and antibacterial properties. This study focused on the theoretical investigation of the suggested structure of one antibacterial compound, “pterygospermin,” whose existence was proposed after some studies of the roots of M. oleifera. The structure of pterygospermin was first proposed by a research group working in the 1950s, but later studies have not found evidence of this compound and have instead …

The Neurochemistry Of Spontaneous Recurrent Seizures In Patients With Medication-Refractory Epilepsy, Eyiyemisi Cynthia Damisah

Yale Medicine Thesis Digital Library

Approximately 1% of the general population suffers from epilepsy. 30% of these patients cannot control their seizures with currently available antiepileptic drugs. One of the devastating features of epilepsy is the uncertainty of when a seizure will occur. The discovery of new approaches aimed at predicting and treating impending epileptic seizures is therefore particularly important. Using state-of-the-art chemical profiling by mass spectrometry, we explored seizure-specific changes in the metabolome (profile of all small molecule chemicals) of the brain extracellular fluid (ECF) in patients with drug­resistant mesial temporal lobe epilepsy (MTLE). We hypothesized that several unique brain chemistry alterations precede and …

The Effects Of A Community-Based Hospice Experience On Attitudes And Self Perceived Competencies Of Senior Nursing Students, Irene Gilliland

Nursing Theses and Dissertations

Death is a universal phenomenon. Of all health professionals, the nurse is the most likely one to be present at the time of death. Although nursing curricula provide mandatory clinical experiences in labor and delivery, pediatrics, psychiatry and adult medical surgical areas, there is no mandatory requirement for a clinical experience with death. In fact, before 1999, there was not even a requirement to teach about death and dying in undergraduate nursing curricula. As a result, students (who later become nurses), feel unprepared to take care of dying patients. Because death has meanings beyond just the cessation of vital signs, …

An Analysis Of How Self-Efficacy Relates To The Driver’S Of The Active Sport Tourist, Debey Grimes

UNLV Theses, Dissertations, Professional Papers, and Capstones

The active sport tourist is a subset within the tourism industry that can be further analyzed to understand this type of traveler. The driver’s of such a tourist include Risk Theory, Individual’s view, Geographical Approach, Role Theory, Consumer Behavior and Group Based Nostalgia. These drivers are compared and analyzed to self-efficacy and how a sport decision or destination relates to self-efficacy. The sources of self-efficacy are defined and an analysis of the active sport tourist’s relationship through the cognitive, motivational, affective and selection processes are explored.

The Analyses Of State And Federal Medical Marijuana Laws And How They Apply To Employment, Lizaveta Sergeev

UNLV Theses, Dissertations, Professional Papers, and Capstones

The purpose of this study is to analyze and discuss the current discrepancies in the legal system as it applies to medical marijuana in the employment sector. The laws regarding the legalization of medical marijuana are relatively new and have many constraints when applied to employment. On the federal level, medical marijuana remains illegal. Many states have passed some form of legislation legalizing medical marijuana. Unfortunately, only two states have laws that protect users from being discriminated in employment. This leaves employers and employees uncertain about what actions to take when dealing with medical marijuana in the employment sector.

A Novel Approach For A New Era: Successful Integration Of Multidisciplinary, Hepatitis C Care Within An Established Hiv Primary Care Practice, Joseph L. Yozviak Do, Facp, Orlando J. Penaloza Md, Facp, Timothy J. Friel Md

Department of Medicine

No abstract provided.

Numerical Prediction Of The Haemodynamic Impact Of Coronary Stent Implantation, Jonathan Murphy

Doctoral

Arterial restenosis limits the effectiveness of coronary stenting. Restenosis is caused by excessive tissue growth which is stimulated by arterial injury and alterations to the arterial WSS. The altered WSS results from stent-induced disturbances to the natural haelnodynamics of the artery. Recent numerical studies have predcted only minor digerences in altered WSS between different stent designs using a commonly employed threshold assessment technique. While it is possible that there are only minor differences, it is more likely that the assessment technique is incapable of fully elucidating the altered WSS created by stent implantation. This thesis proposes a methodology that involves …

Can Water Professionals Transform Pharmaceutical Disposal Practices Of Hospice Nurses?, Jennifer L. Mccoy, Kimberly P. Holland

Dissertations, Theses and Capstone Projects (Full IR Collection)

This project is an explanatory case study that illustrates the problems associated with pharmaceutical disposal in regard to water quality. The purpose of the study is to investigate the current pharmaceutical disposal practices of hospice nurses, the attitudes of hospice nurses regarding current pharmaceutical disposal practices, and explore ways to educate the hospice community about the concerns associated with flushing pharmaceuticals. The study consisted of reviewing secondary research, completing a survey, forming a focus group, implementing a pilot study, and developing an education plan and outreach materials.

The researchers partnered with two local nonprofit organizations, Georgia Association of Water Professionals …