Medicine and Health Sciences Commons^™

Phenethyl Isothiocyanate Exhibits Antileukemic Activity In Vitro And In Vivo By Inactivation Of Akt And Activation Of Jnk Pathways, N. Gao, Amit Budhraja, S. Cheng, E.-H. Liu, J. Chen, Z. Yang, D. Chen, Zhuo Zhang, Xianglin Shi

Toxicology and Cancer Biology Faculty Publications

Effects of phenethyl isothiocyanate (PEITC) have been investigated in human leukemia cells (U937, Jurkat, and HL-60) as well as in primary human acute myeloid leukemia (AML) cells in relation to apoptosis and cell signaling events. Exposure of cells to PEITC resulted in pronounced increase in the activation of caspase-3, -8, -9, cleavage/degradation of PARP, and apoptosis in dose- and time-dependent manners. These events were accompanied by the caspase-independent downregulation of Mcl-1, inactivation of Akt, as well as activation of Jun N-terminal kinase (JNK). Inhibition of PI3K/Akt by LY294002 significantly enhanced PEITC-induced apoptosis. Conversely, enforced activation of Akt by a constitutively …

A Comparative Study Of Rotary Instrumentation Of The Maxillary First Premolar Buccal Root Utilizing Cone Beam Computed Tomography, Stephan Zigo

Theses and Dissertations

The study objective was to determine cementum-dentin wall thickness along the furcation groove in maxillary bifurcated first premolars after preparation with three successively larger, 0.04 tapered, nickel titanium rotary files. Pre-instrumentation and post-instrumentation imaging was accomplished utilizing Cone Beam Computed Tomography. All data was analyzed using an ANOVA. Instrumentation resulted in a significant reduction in dentin-cementum wall thickness (p < .001). At mid-groove, predicted dentin-cementum wall thickness (95% CI) was equal to or less than the proposed standard (0.50 mm) for apical file sizes 30, 35, and 40 respectively. Instrumentation of the mid-groove in maxillary first premolars reduces dentin-cementum wall thickness to levels that may be insufficient to ensure tooth integrity.

An In Vitro Comparison Of Cyclic Fatigue Of Profile® Vortex™ And Endosequence™ Rotary Nickel-Titanium Files, Fawaz Al-Foraih

Theses and Dissertations

The purpose of this study was to determine the number of rotations to fracture (cyclic fatigue) of the Profile® Vortex™ files (Dentsply Tulsa Dental Specialties, Tulsa, OK) compared to the EndoSequence™ files (Brasseler USA, Savannah, GA) using an in-vitro apparatus simulating a curved canal. Two hundred Profile® Vortex™ files of 25mm length were divided equally into ten groups, one for each of the Profile® Vortex™ files 20/0.04, 20/0.06, 25/0.04, 25/0.06, 30/0.04, 30/0.06, 35/0.04, 35/0.06, 40/0.04, and 40/0.06. Two hundred EndoSequence™ files of 25mm length were divided equally into ten groups of the same tip and taper sizes analogous to the …

Tyrie, Betsy (Fa 22), Manuscripts & Folklife Archives

Folklife Archives Finding Aids

Finding aid only for Folklife Archives Project 22.  "The Life of Dr. C. C. Howard," an oral history project conducted by Betsy Tyrie about Dr. Carl Clifford Howard, the outstanding Glasgow, Kentucky, physician who was instrumental in the fight against tuberculosis and in founding hospitals in Glasgow.  Project contains interviews with Dr. Howard's family, friends, and colleagues as well as archived autobiographical information about Howard.

Antidepressants And Breast And Ovarian Cancer Risk: A Review Of The Literature And Researchers' Financial Associations With Industry, Lisa Cosgrove, Ling Shi, David E. Creasey, Maria Anaya-Mckivergan, Jessica A. Myers, Krista F. Huybrechts

Counseling, School Psychology & Sport Faculty Publication Series

Background

Antidepressant (AD) use has been purported to increase the risk of breast and ovarian cancer, although both epidemiological and pre-clinical studies have reported mixed results [1]–[6]. Previous studies in a variety of biomedical fields have found that financial ties to drug companies are associated with favorable study conclusions [7].

Methods and Findings

We searched English-language articles in MEDLINE, PsychINFO, the Science Citations Index and the Cochrane Central Register of Controlled Clinical Trials (through November 2010). A total of 61 articles that assessed the relationship between breast and ovarian cancer and AD use and articles that examined the effect of …

Estimation Of The Number Of Days Required To Determine Usual Antioxidant Intakes And Assessment Of The Prevalence Of Nutrient Inadequacy Among College Students, Catherine G. Davis

Master's Theses

High intake of antioxidant rich foods has been shown to decrease risk factors of chronic disease.  Young adulthood may be crucial in establishing healthy lifestyles including adequate nutrient consumption.

The present study was designed 1) to estimate usual nutrient intakes, 2) to calculate the number of days required to estimate usual antioxidant intake, and 3) to assess intake adequacy from diet and diet + supplement sources by using the Estimated Average Requirement (EAR).  The USDA Flavonoid and Proanthocyanidin databases, food consumption data, and dietary supplement use data from 60 students aged 18-25 years at the University of Connecticut were utilized. …

Bayesian Effect Estimation Accounting For Adjustment Uncertainty, Chi Wang, Giovanni Parmigiani, Francesca Dominici

Harvard University Biostatistics Working Paper Series

No abstract provided.

Nanotubes As Mitochondrial Uncouplers, Patrick G. Sullivan

Neuroscience Faculty Patents

A method of uncoupling mitochondria in a subject including administering nanotubes to the subject in a therapeutically effective amount, wherein the nanotubes are self-rectifying is provided. A method of decreasing reactive oxygen species and decreasing detrimental loading of Ca²⁺ into mitochondria is provided, including administering a pharmaceutically effective amount of nanotubes into the subject. A method of reducing weight, treating cancer, reducing the effects of traumatic brain injury, or reducing the effects of ageing, in a subject including administering a pharmaceutically effective amount of nanotubes into the subject is also provided.

2011 April 5 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

Role Of Multidetector Computed Tomography (Mdct) In Patients With Ovarian Masses., Fatima Mubarak, Muhammad Shahbaz Alam, Waseem Akhtar, Saima Hafeez, Noureen Nizamuddin

Department of Radiology

Objective:To evaluate the diagnostic accuracy of multidetector 64-slice computed tomography (MDCT) in the diagnosis and differentiation of benign and malignant ovarian masses using histopathology and surgical findings as the gold standard. Material And

Methods:

This study was conducted in Aga Khan University Hospital, Karachi, Pakistan. Data was reviewed retrospectively from 1 November 2008 to 12 December 2009. One hundred Patients found to have ovarian masses on CT scan were included in the study. CT scan was performed in all these Patients after administration of oral and IV contrast. Ovarian masses were classified as benign and malignant on scan findings. …

High-Activity Mutants Of Butyrylcholinesterase For Cocaine Hydrolysis And Method Of Generating The Same, Chang-Guo Zhan, Hoon Cho, Hsin-Hsiung Tai

Pharmaceutical Sciences Faculty Patents

A novel computational method and generation of mutant butyrylcholinesterase for cocaine hydrolysis is provided. The method includes molecular modeling a possible BChE mutant and conducting molecular dynamics simulations and hybrid quantum mechanical/molecular mechanical calculations thereby providing a screening method of possible BChE mutants by predicting which mutant will lead to a more stable transition state for a rate determining step. Site-directed mutagenesis, protein expression, and protein activity is conducted for mutants determined computationally as being good candidates for possible BChE mutants, i.e., ones predicted to have higher catalytic efficiency as compared with wild-type BChE. In addition, mutants A199S/A328W/Y332G, A199S/F227A/A328W/Y332G, A199S/S287G/A328W/Y332G, …

An Insight Into The Suspected Hba2' Cases Detected By High Performance Liquid Chromatography In Pakistan., Maliha Nusrat, Bushra Moiz, Amna Nasir, Mashhooda Rasool Hashmi

Department of Pathology and Laboratory Medicine

Background:Hemoglobin A2' (delta 16 Gly Arg) is globally the commonest delta chain variant of HbA2. It is clinically and hematologically silent but its sole importance lies in the underestimation of HbA2 quantity during the workup of beta-thalassaemia trait. High performance liquid chromatography (HPLC) identifies it as a small S-window peak with a mean retention time of 4.59 0.03 minutes. This study aims at describing the frequency of detection of HbA2' by HPLC in Pakistan and its confirmation at a molecular level. Potential HbA2' cases were identified by a retrospective review of 10186 HPLC chromatograms in year 2006. Prospective samples …

Ada News - 04/04/2011, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Examining Physiological, Physical, And Cognitive Changes Over A Thirteen Week Training Program, Vanessa L. Roof

Department of Psychology: Dissertations, Theses, and Student Research

Ten members of Lincoln Fire and Rescue in Lincoln,  Nebraska agreed to participate in a thirteen week tactical strength and conditioning fitness program conducted by Athology Inc. that included a Physiological, Physical, and Cognitive Component.  Participants completed three workouts per week lasting approximately 90 minutes each, conducted by fitness trainers from Athology Inc.  Participants completed lab draws at the beginning and end of the program as well as an EKG at the onset of the program, conducted off-site at a local hospital.  Participants completed performance and agility testing at the onset and end of the program.  Lastly, participants completed cognitive …

Medical School Watercooler Newsletter - April 3, 2011, Lindsey Lyle

Watercooler Newsletter

This is the April 3, 2011 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler

Contents Include

• Noted Author, Orthopaedic Surgeon To Visit USA College of Medicine

• Next Week's DSS - Dr. Lawrence Mandarino

• Cardiology, Pulmonary/Critical Care Fellowship Programs Receive Accreditation Renewal from ACGME

• USA Biomedical Library's Community Day Event To Feature Meteorologist Alan Sealls

• Dr. John E. Oakes Retirement Reception

The Faceless Faces Of Huntington's Disease, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Barriers & Incentives To Obtaining A Bachelor Of Science Degree In Nursing, Tiffany Boring, Brianna Burnette

Graduate Research Projects

No abstract provided.

Uconn School Of Medicine Dean's Newsletter, Spring 2011, Cato T. Laurencin

Annual Reports - Education

No abstract provided.

Mold And Alternaria Skin Test Reactivity And Asthma In Children In Connecticut, Todd W. Lyons, Dorothy B. Wakefield, Michelle M. Cloutier

UCHC Articles - Research

Background

Sensitivity to mold has been associated with asthma incidence, persistence, and severity.

Objective

To examine the relationship between skin test reactivity (STR) to molds and specifically to Alternaria and asthma severity in a group of ethnically diverse children in Connecticut.

Methods

Demographics and STR to 14 local allergens, including Alternaria, Penicillium, and mold mix, were obtained for 914 Puerto Rican, African American, and non-Hispanic white children.

Results

A total of 126 children (14%) had a positive skin test result to mold, and 58 (6%) demonstrated STR to Alternaria. Compared with non-Hispanic white children, there was no difference in the …

Inhibitory Activities Of Omega-3 Fatty Acids And Traditional African Remedies On Keloid Fibroblasts, I-Ping Chen, Richard S. Feinn, Ernst J. Reichenberger

UCHC Articles - Research

Keloids develop when scar tissue responds to skin trauma with proliferative fibrous growths that extend beyond the boundaries of the original wound and progress for several months or years. Keloids most frequently occur in individuals of indigenous sub-Saharan African origin. The etiology for keloids is still unknown and treatment can be problematic as patients respond differently to various treatment modalities. Keloids have a high rate of recurrence following surgical excision. Some West African patients claim to have had successful outcomes with traditional African remedies—boa constrictor oil (BCO) and shea butter—leading the authors to investigate their effects on cultured fibroblasts. The …

Calcium Intake In The United States From Dietary And Supplemental Sources Across Adult Age Groups: New Estimates From The National Health And Nutrition Examination Survey 2003–2006, Kelsey M. Mangano, Stephen J. Walsh, Anne M. Kenny, Jane E. Kerstetter

UCHC Articles - Research

Background

Adequate lifelong calcium intake is essential in optimizing bone health. Recent National Health and Nutrition Examination Survey data were used to quantify variation in calcium intake across adult age groups and to relate age-associated changes in calcium intake with energy intake. Additional goals were to assess differences in dietary calcium intake between supplemental calcium users and nonusers and to evaluate associations between age and calcium density in the diet.

Design

This cross-sectional analysis determined calcium and energy intake for National Health and Nutrition Examination Survey respondents during 2003–2006. Diet was assessed with 24-hour recall and supplement use via questionnaire. …

Flight Physician - April, 2011, Civil Aviation Medical Association

Browse all Civil Aviation Medical Association Newsletters

A sixteen page newsletter of the Civil Aviation Medical Association. The newsletter provided news about civil aviation medicine and information related to the organization.

Youth Dating Culture In Urban Vietnam: Attitudes, Behaviors, And Influences, Alexa Difiore

Independent Study Project (ISP) Collection

This paper attempts to research urban youth’s attitudes and behaviors concerning everything having to do with dating (the process, PDA, typical dating spots and behavior) and opinions towards “hot issues” in contemporary, Vietnam such as pre-marital sex and co-habitation. My research question focuses on what the term “dating” means among youth in urban Vietnam, and the various influences that affect youth’s dating and sexual lives. Through an extensive literature review, I learned that there is an overall lack of information and discussion about sex in Vietnam. There is also a general idea that from parents, the government, and school that …

Mid-Atlantic Ethics Committee Newsletter, Spring-Summer 2011

Mid-Atlantic Ethics Committee Newsletter

No abstract provided.

Com Outlook Spring 2011, College Of Osteopathic Medicine

COM Outlook

No abstract provided.

Influenza Vaccination Of The Health Care Workforce: A Literature Review, Alexandra M. Stewart, Marisa A. Cox, Mallory O'Connor

Health Policy and Management Faculty Publications

Since 1981, the Centers for Disease Control and Prevention (CDC) has recommended that all health care workers (HCWs) receive an annual influenza vaccination. The Healthy People objectives aimed for 60% coverage of HCW influenza vaccination by 2010 and 90% coverage by 2020. Although influenza vaccine uptake among HCWs has trended upward over the past several years, the percentage of immunized HCWs has remained approximately 40% between 2004 and 2008.

In order to complete the literature review, researchers identified and analyzed peer reviewed literature, news articles, professional organization position statements, and institutional policies published between 1991 and 2011. In the absence …

Evolution Of The Air Toxics Under The Big Sky Program, Nancy Marra, Diana Vanek, Carolyn Hester, Andrij Holian, Tony Ward, Earle Adams, Randy Knuth

Public and Community Health Sciences Faculty Publications

As a yearlong exploration of air quality and its relation to respiratory health, the “Air Toxics Under the Big Sky” program offers opportunities for students to learn and apply science process skills through self-designed inquiry-based research projects conducted within their communities. The program follows a systematic scope and sequence designed to first lay a strong foundation, followed by activities intended to expand understanding, and ending with a final step aimed at achieving retention of content and principles learned. The foundation consists of content regarding environmental health sciences and human health. The next level guides students during their independent study projects …

Chhs April 2011 E-Newsletter, Dr. John Bonaguro, Dean, Vashon S. Wells, Editor, Wku College Of Health & Human Services

College of Health & Human Services Publications

No abstract provided.

The College Of Health & Human Services [Annual Report], Wku College Of Health & Human Services, Dr. John Bonaguro, Dean

College of Health & Human Services Publications

No abstract provided.

Exercise Technique: Reverse Lunge Into A Step-Up, Kim Fischer

Health and Sport Sciences Faculty Scholarship

THE TECHNIQUE OF A REVERSE LUNGE INTO A STEP-UP IS DESCRIBED AND DEMONSTRATED THROUGH THE USE OF PHOTOGRAPHS IN THIS COLUMN. AN EXERCISE PRESCRIPTION IS GIVEN.