Medicine and Health Sciences Commons^™

Effect Of Case Management On Neonatal Mortality Due To Sepsis And Pneumonia, Anita K. M. Zaidi, Hammad A. Ganatra, Sana Syed, Simon Cousens, Anne C. C. Lee, Robert Black, Zulfiqar A. Bhutta, Joy E. Lawn

Department of Paediatrics and Child Health

Background: Each year almost one million newborns die from infections, mostly in low-income countries. Timely case management would save many lives but the relative mortality effect of varying strategies is unknown. We have estimated the effect of providing oral, or injectable antibiotics at home or in first-level facilities, and of in-Patient hospital care on neonatal mortality from pneumonia and sepsis for use in the Lives Saved Tool (LiST). Methods: We conducted systematic searches of multiple databases to identify relevant studies with mortality data. Standardized abstraction tables were used and study quality assessed by adapted GRADE criteria. Meta-analyses were undertaken where …

Quantal Amplitude At The Cone Ribbon Synapse Can Be Adjusted By Changes In Cytosolic Glutamate., Theodore M. Bartoletti, Wallace B. Thoreson

Journal Articles: Ophthalmology

PURPOSE: Vision is encoded at photoreceptor synapses by the number of released vesicles and size of the post-synaptic response. We hypothesized that elevating cytosolic glutamate could enhance quantal size by increasing glutamate in vesicles.

METHODS: We introduced glutamate (10-40 mM) into cone terminals through a patch pipette and recorded excitatory post-synaptic currents (EPSCs) from horizontal or OFF bipolar cells in the Ambystoma tigrinum retinal slice preparation.

RESULTS: Elevating cytosolic glutamate in cone terminals enhanced EPSCs as well as quantal miniature EPSCs (mEPSCs). Enhancement was prevented by inhibiting vesicular glutamate transport with 1S,3R-1-aminocyclopentane-1,3-dicarboxylate in the patch pipette. A low affinity glutamate …

Dual Testing Algorithm Of Bed-Ceia And Axsym Avidity Index Assays Performs Best In Identifying Recent Hiv Infection In A Sample Of Rwandan Sex Workers, Sarah L. Braunstein, Denis Nash, Andrea A. Kim, Ken Ford, Lambert Mwambarangwe, Chantal M. Ingabire, Joseph Vyankandondera, Janneke H. H. M. Van De Wijgert

Publications and Research

Background

To assess the performance of BED-CEIA (BED) and AxSYM Avidity Index (Ax-AI) assays in estimating HIV incidence among female sex workers (FSW) in Kigali, Rwanda.

Methodology and Findings

Eight hundred FSW of unknown HIV status were HIV tested; HIV-positive women had BED and Ax-AI testing at baseline and ≥12 months later to estimate assay false-recent rates (FRR). STARHS-based HIV incidence was estimated using the McWalter/Welte formula, and adjusted with locally derived FRR and CD4 results. HIV incidence and local assay window periods were estimated from a prospective cohort of FSW. At baseline, 190 HIV-positive women were BED and Ax-AI …

Does Comorbidity Explain The Ethnic Inequalities In Cervical Cancer Survival In New Zealand? A Retrospective Cohort Study, Naomi Brewer, Barry Borman, Diana Sarfati, Mona Jeffreys, Steven T. Fleming, Soo Cheng, Neil Pearce

Epidemiology and Environmental Health Faculty Publications

BACKGROUND: There are large ethnic differences in cervical cancer survival in New Zealand that are only partly explained by stage at diagnosis. We investigated the association of comorbidity with cervical cancer survival, and whether comorbidity accounted for the previously observed ethnic differences in survival.

METHODS: The study involved 1,594 cervical cancer cases registered during 1994-2005. Comorbidity was measured using hospital events data and was classified using the Elixhauser instrument; effects on survival of individual comorbid conditions from the Elixhauser instrument were also assessed. Cox regression was used to estimate adjusted cervical cancer mortality hazard ratios (HRs).

RESULTS: Comorbidity during the …

Hypertension As A Chief Complaint In The Emergency Department, Steven P. Frei Md, David B. Burmeister Do, Facep, Jesse F. Coil Do

Department of Emergency Medicine

No abstract provided.

Expression Stability Of Putative Reference Genes In Equine Endometrial, Testicular, And Conceptus Tissues, Claudia Klein, Josep Rutllant, Mats H. T. Troedsson

Veterinary Science Faculty Publications

BACKGROUND: Quantitative RT-PCR data are commonly normalized using a reference gene. A reference gene is a transcript which expression does not differ in the tissue of interest independent of the experimental condition. The objective of this study was to evaluate the stability of mRNA expression levels of putative reference genes in three different types of equine tissue, endometrial, testicular, and conceptus tissue.

FINDINGS: The expression stability of four (uterine tissue) and six (testicular and conceptus tissue) was assessed using descriptive data analysis and the software programs Normfinder and geNorm. In uterine samples, 18S showed the largest degree of variation in …

Activation Of Multiple Apoptotic Pathways In Human Nasopharyngeal Carcinoma Cells By The Prenylated Isoflavone, Osajin, Tsung-Teng Huang, Fu-Guo Liu, Chia-Fong Wei, Chia-Chen Lu, Chang-Chieh Chen, Hung-Chi Lin, David M. Ojcius, Hsin-Chih Lai

All Dugoni School of Dentistry Faculty Articles

Osajin is a prenylated isoflavone showing antitumor activity in different tumor cell lines. The underlying mechanism of osajin-induced cancer cell death is not clearly understood. In the present study, the mechanisms of osajin-induced cell death of human nasopharyngeal carcinoma (NPC) cells were explored. Osajin was found to significantly induce apoptosis of NPC cells in a dose- and time-dependent manner. Multiple molecular effects were observed during osajin treatment including a significant loss of mitochondrial transmembrane potential, release of cytochrome c into the cytosol, enhanced expression of Fas ligand (FasL), suppression of glucose-regulated protein 78 kDa (GRP78), and activation of caspases-9, -8, …

Local Health Departments’ Governance: A Visual Display Using Lhd Shape Files, Gulzar H. Shah Dr., Carolyn J. Leep, Reba Novich

Health Policy & Management: Faculty Presentations (2008-2022)

Analyses conducted for public health systems and services research (PHSSR) frequently include a variable that represents the relationship between state and local health departments (i.e., a governance category) in their analyses, either as an explanatory variable or a control variable. A number of organizations and researchers has categorized states according to governance, but the categorizations have been inconsistent across studies. This lack of agreement regarding governance category has been problematic for PHSSR.

The Association of State and Territorial Health Officials (ASTHO) in conjunction with NORC at the University of Chicago and with input from the National Association of County and …

Pain Quality Descriptors In Persons With Limb Loss, Angelica I. Garcia, Cecile B. Evans

College of Health Sciences Poster Presentations

Background: Phantom limb pain is very common, and its pain quality descriptors give insight to the lived experience of phantom limb pain.

Significance: This study reports unique phantom limb pain quality descriptor categories.

Richardson, Lewis George, 1829-1906 (Sc 207), Manuscripts & Folklife Archives

Manuscript Collection Finding Aids

Finding aid only and scan (Click on "additional files" below) Manuscripts Small Collection 207. Copy of 1 February 1852 letter from Lewis George Richardson, a medical student at the University of Louisville, to his father, Reverend George Richardson, Russellville, Logan County, Kentucky. He writes of his schooling, the Louisville winter, and his prospects for the future. Also includes a biographical sketch of Dr. Richardson written by a grandchild.

An Evaluation Of Presence And Source Of Fecal Contamination At Golden Gardens Park, Jamie Minick, Nicola K. Beck, J. Scott Meschke

College of Health Sciences Poster Presentations

Golden Gardens is an 87.8 acre Park in Seattle, WA that has come under recent scrutiny over concerns about water quality in the streams and at the beach. Located just north of Shillshole marina in Seattle it has a swimming beach which is 1439 m in length, as well as a forested region directly east of the beach on a relatively steep hill with several drainages flowing into the sound. The purpose of this study was to assess the levels of indicator bacteria in beach water and in the fresh water drainages and to determine if the bacterial contamination is …

Dhhs' And Epa's Proposal To Lower Fluoride Levels In Drinking Water, Shannon Wirz

College of Health Sciences Poster Presentations

On January 7th, 2011 the U.S. DHHS recommended setting the level of fluoride in drinking water to the lowest end of the current optimal range (0.7 to 1.2 ppm). EPA is initiating a review of the maximum amount of fluoride allowed in drinking water based on scientific assessments of health effects from too much fluoride. MCL (Maximum Contaminant Level) is the legal threshold limit on the amount of a substance allowed in public water systems. EPA sets the MCL to address adverse health effects. Current MCL for fluoride is 4 mg/L. The EPA is unsure if they will revise the …

Student Behaviors In A Virtual Reality-Based Clinical Setting: Lessons Learned, Jane Elizabeth Classen, Kelley Connor, Maximillian Veltman

College of Health Sciences Poster Presentations

Nursing simulations in Virtual Reality (VR) are increasingly becoming a valuable tool utilized in nursing education world-wide to enhance learning and provide additional contextual learning experiences. Although technology is becoming more user-friendly, there is still a need for technological support being provided to nursing students. This project identified student support needs that were necessary for VR nursing simulations.

Autoimmune Melanocyte Destruction Is Required For Robust Cd8+ Memory T Cell Responses To Mouse Melanoma, Katelyn T. Byrne, Anik L. Côté, Peisheng Zhang, Shannon M. Steinberg, Yanxia Guo, Rameeza Allie, Weijun Zhang, Marc S. Ernstoff, Edward J. Usherwood, Mary Jo Turk

Dartmouth Scholarship

A link between autoimmunity and improved antitumor immunity has long been recognized, although the exact mechanistic relationship between these two phenomena remains unclear. In the present study we have found that vitiligo, the autoimmune destruction of melanocytes, generates self antigen required for mounting persistent and protective memory CD8⁺ T cell responses to melanoma. Vitiligo developed in approximately 60% of mice that were depleted of regulatory CD4⁺ T cells and then subjected to surgical excision of large established B16 melanomas. Mice with vitiligo generated 10-fold larger populations of CD8⁺ memory T cells specific for shared melanoma/melanocyte antigens. CD8 …

Congenital Bone Marrow Failure In Dna-Pkcs Mutant Mice Associated With Deficiencies In Dna Repair, Shichuan Zhang, Hirohiko Yajima, Hoangdinh Huynh, Junke Zheng, Elsa Callen, Hua-Tang Chen, Nancy Wong, Samuel Bunting, Yu-Fen Lin, Mengxia Li, Kyung-Jone Lee, Michael Story, Eric Gapud, Barry P. Sleckman, André Nussenzweig, Cheng Cheng Zhang, David J. Chen, Benjamin P.C. Chen

Open Access Publications

No abstract provided.

Medical School Watercooler Newsletter - April 10, 2011, Lindsey Lyle

Watercooler Newsletter

This is the April 10, 2011 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler

Contents Include

• April Med School Café - Potential Cures for Type I Diabetes

• USA Welcomes Pediatrics Practice Director

• Lectures Slated Honoring Legacy of Two of Mobile's Surgeons

• Preliminary Recommendations Released for New Version of MCAT

• USA College of Medicine Hosts 25th Anniversary BEAR Reunion

• Next Week's DSS - Dr. M. Celeste Simon

Management Of Permanent Pacing Wires During Tricuspid Valve Repair, Luke Sheen, Daniel L. Cherkassky, Faculty Advisor, Virna L. Sales, Md, Faculty Advisor, Richard Lee, Md, Mba, Faculty Advisor, Brittany Lapin, Mph, Faculty Advisor, Edward Wang, Phd, Faculty Advisor, Patrick M. Mccarthy, Md, Faculty Advisor

John Wesley Powell Student Research Conference

No abstract provided.

Complete 2011 Program, John Wesley Powell Conference

John Wesley Powell Student Research Conference

No abstract provided.

Coal Mining, Masculinity And Meth: The Development Of Appalachia And Its Modern Crisis, Kerry Hobson '11

Honor Scholar Theses

The central Appalachian region, encompassing West Virginia and most of Eastern Kentucky and Tennessee, is a region filled with contradictions. It has one of the richest endowments of natural resources, yet twenty percent of families live in poverty. Safe drinking water is an issue in Appalachia, and one-fifth of Appalachian counties do not even have a hospital. Furthermore, the very identity of the Appalachian people has been continuously misrepresented and oversimplified. Throughout the twentieth century, the image of a toothless, uneducated hillbilly has persisted as the typical Appalachian. Stereotypes can certainly be a useful way to categorize information and understand …

Sensory Modulation Disorder And Schizophrenia: Linking Behavioral Measures, Linda Olson

Theses and Dissertations

Schizophrenia is a devastating disorder affecting millions of people in the United States. Studies leading to new understanding of and intervention for this disorder are essential, as current interventions are minimally effective. The end result is high rates of re-hospitalization, impaired occupational performance and decreased community reintegration. According to the Diagnostic and Statistical Manual of Mental Disorders, symptoms of schizophrenia are categorized as positive or negative, with both types of symptoms impacting successful occupational engagement. Based on behavioral observations occupational therapists have hypothesized that this population may also experience sensory modulation disorder (SMD). Although electrophysiological studies support the presence of …

Epignetics And Allergic Disease, Jacob Sweeney '11

Honor Scholar Theses

In this thesis I will propose a novel framework for understanding allergy. I will argue that exposure to certain early-life environments lead to life-long allergic disease through epigenetic mechanisms. Although my argument currently exists as an unsubstantiated hypothesis, I will review indirect evidence that I have gathered throughout the immunologic and epigenetic literature to support my claim. | will then propose a set of experiments which will test my hypothesis. This thesis will address current scientific “hot topics” and their implications will challenge fundamental tenants of biology. Rather than jumping straight into the argument I will begin with some background …

Avian Community Ecology And The Shifting Baseline In Sugarcreek Metropark, Jennifer Lynne Hays, Thomas P. Rooney, Jeffrey L. Peters

Biological Sciences Faculty Publications

No abstract provided.

Abundance And Trends Of Woodpecker Populations In The Wright State Biology Preserve, Brittany Damron, Thomas P. Rooney

Biological Sciences Faculty Publications

No abstract provided.

Carbon Sequestration In Soils Of The Wright State University Biology Preserve, Laurie Wissler, Thomas P. Rooney

Biological Sciences Faculty Publications

No abstract provided.

Wright State University Celebration Of Research, Scholarship And Creative Activities Book Of Abstracts Friday, April 8, 2011, Wright State University Office Of Undergraduate Research And Stemm Activities

Celebration of Undergraduate & Graduate Research, Scholarship, and Creative Activities Materials

The student abstract booklet is a compilation of abstracts from students' oral and poster presentations at Wright State University's second annual Celebration of Research, Scholarship and Creative Activities on April 8, 2011.

Roles Of Three Transporters, Cbcxwv, Bett1, And Bett3, In Pseudomonas Aeruginosa Choline Uptake For Catabolism, Adel A. Malek, Chiliang Chen, Matthew J. Wargo, Gwyn A. Beattie, Deborah A. Hogan

Dartmouth Scholarship

Pseudomonas aeruginosa uses the quaternary amine choline as a carbon source, osmoprotectant, and macromolecular precursor. The importance of choline in P. aeruginosa physiology is highlighted by the presence of multiple known and putative choline transporters encoded within its genome. This report describes the relative roles of three choline transporters, the ABC transporter CbcXWV and two symporters, BetT1 and BetT3, in P. aeruginosa growth on choline under osmotic conditions that are physiologically relevant to eukaryotic hosts. The increased lag phases exhibited by the ΔbetT1 and ΔbetT1 ΔbetT3 mutants relative to the wild type upon transfer to medium with …

Hormonal Consequences Of Epilepsy And Its Treatment In Men., Kartik Sivaraaman, Scott Mintzer

Department of Neurology Faculty Papers

PURPOSE OF REVIEW: Epilepsy and anticonvulsant medications may substantially alter endocrine homeostasis, including the male reproductive hormonal system.

RECENT FINDINGS: Seizures in medial temporal lobe structures, through their connectivity to the hypothalamus, alter the secretion of gonadotropins. Levels of circulating bioavailable testosterone are affected by changes in the level of binding proteins, which in turn may be affected by seizure medications. The use of older generation medications that induce the cytochrome P450 system is associated with an increase in sex hormone-binding globulin and lower bioactive testosterone. Sexual dysfunction, including decreased libido and decreased potency, and infertility, is seen commonly in …

Intégration D’Une Culture De Prévention Durable Des Tms. Étape 1 : Portrait Systémique D’Une Grande Entreprise Manufacturière, Marie St-Vincent, Daniel Imbeau, Maud Gonella, Marie-Ève Chiasson, Marie-Andrée Lorange, Geslie Lassy

Rapports de recherche scientifique

Cette étude s’insère dans une séquence de projets, dont le but est d’implanter une culture de prévention durable des troubles musculo-squelettiques (TMS) dans une grande entreprise manufacturière. Cette première étape consistait à dresser un portrait systémique de l’entreprise. Les auteurs ont noté une prévalence de TMS très élevée; 78 % des travailleurs ont déclaré avoir eu des douleurs assez souvent ou tout le temps à au moins une région du corps au cours des 12 derniers mois. Par ailleurs, près de 70 % des travailleurs se sont dits ouverts à la rotation des postes, une forme d’organisation que la direction …

Run Like A Kenyan: How To Be An Elite Athlete The Kenyan Way, Becca Blubaugh

Undergraduate Research Conference

By observation and statistics, research shows that one dominating elite group in running is the Kenyan distance runners, specifically the Kalenjinethnic group. Many aspects of the Kenyan life were found to contribute to their efficiency and success. Analyzing Kenyan aspects of environment, altitude, society, diet, transportation, motives, and training may reveal possible ways American runners can improve their running.

Acceptance Of The Human Papillomavirus Vaccine Amount College Age Adults: Survey Research, Emily Pippo

Honors Capstones

Capstone submitted as a graduation requirement for BSU Honors Program.