Medicine and Health Sciences Commons^™

Wilms’ Tumor-1 (Wt1) Protein Expression In Glioma Cells Actuates Cellular Invasiveness- Identifying Its Target Genes, Archana Chidambaram

Theses and Dissertations

Previous studies in our laboratory demonstrated the expression of WT1 in a significant number of glioma cells and established its role in promoting tumor cell proliferation. Here, we noted the effect(s) of manipulating WT1 levels on the expression levels of genes that were previously shown to be regulated by WT1. We found no correlation between the expression levels of WT1 and PDGF-A, Snai1 and E-cadherin and a consistent inverse correlation between WT1 and IGF-1R expression in U251-MG cells. To ascertain whether the increased IGF-1R levels resulting from WT1 silencing could account for decreased cellular proliferation, we utilized siRNA mediated knockdown …

Listeners' Ability To Identify The Gender Of Preadolescent Children Across Multiple Linguistic Contexts, Sharalee Ann Blunck

Theses and Dissertations

The purpose of this study was to determine whether 20 listeners could identify the gender of 10 preadolescent children from speech samples. An additional aim was to evaluate whether listeners identified children more accurately when listening to speech samples when more linguistic context was available. The listeners were presented with a total of 190 speech samples in four different categories of linguistic context: segments, words, sentences, and discourse. The listeners were instructed to listen to each speech sample and decide whether the speaker was a male or female. In addition, the listeners were instructed to rate their level of confidence …

Proceedings - Wright State University Boonshoft School Of Medicine Third Annual Medical Student Research Symposium: Celebrating Medical Student Scholarship, Office Of Research Affairs, Boonshoft School Of Medicine

Medical Student Research Symposium Proceedings

The student abstract booklet is a compilation of abstracts from students' oral and poster presentations at Wright State University's Third Annual Boonshoft School of Medicine Medical Student Research Symposium held on April 21, 2011.

Takotsubo Cardiomyopathy Vs Acute Myocardial Infarction: Diagnostic Utility Of Subtle Ecg Differences, Asma Saba Syed, Umair Khalid

Section of Cardiology

The clinical findings of Takatsubo Cardiomyopathy and acute myocardial infarction can be very similar. While Takatsubo cardiomyopathy rarely leads to severe complications, acute myocardial infarction can be life threatening. Treatment of both these conditions is different and so it is imperative for clinicians to have a high index of suspicion for either. Several EKG differences between the two entities have been proposed. This article summarizes the EKG changes most likely seen in Takatsubo cardiomyopathy and compares them to those seen in Acute Myocardial infarction.

Bryant Making Science Its Business, Gina Macris

Bryant REDay (Research and Engagement Day)

No abstract provided.

The Effect Of A Treatment Program Utilizing A Humanoid Robot On Social Engagement Of Two Children With Autism Spectrum Disorder, Margaret Michele Maxfield

Theses and Dissertations

The purpose of this study was to evaluate the use of a robot (Troy) in a low-dose treatment protocol for two children with Autism Spectrum disorder. The efficacy of intervention was measured by comparing social engagement in two contexts: interactions with two adults and interaction with an unfamiliar adult. During the treatment, a robot was included in pseudo-triadic interactions with the clinician and the child. The robot was programmed to perform simple actions that imitated the actions of the clinician in an effort to engage the child. These pseudo-triadic interactions were incorporated into intervention over the course of a 16-session …

A Synergistic Antiproliferation Effect Of Curcumin And Docosahexaenoic Acid In Sk-Br-3 Breast Cancer Cells: Unique Signaling Not Explained By The Effects Of Either Compound Alone., Jeffrey D. Altenburg, Andrew A. Bieberich, Colin Terry, Kevin A. Harvey, Justin F. Vanhorn, Zhidong Xu, Vincent J. Davisson, Rafat A. Siddiqui

Borch Department of Medicinal Chemistry and Molecular Pharmacology Faculty Publications

Background

Breast cancer is a collection of diseases in which molecular phenotypes can act as both indicators and mediators of therapeutic strategy. Therefore, candidate therapeutics must be assessed in the context of multiple cell lines with known molecular phenotypes. Docosahexaenoic acid (DHA) and curcumin (CCM) are dietary compounds known to antagonize breast cancer cell proliferation. We report that these compounds in combination exert a variable antiproliferative effect across multiple breast cell lines, which is synergistic in SK-BR-3 cells and triggers cell signaling events not predicted by the activity of either compound alone.

Methods

Dose response curves for CCM and DHA …

Identification Of A Phytase Gene In Barley (Hordeum Vulgare L.), Fei Dai, Long Qiu, Lingzhen Ye, Dezhi Wu, Meixue Zhou, Guoping Zhang

Publications

BACKGROUND: Endogenous phytase plays a crucial role in phytate degradation and is thus closely related to nutrient efficiency in barley products. The understanding of genetic information of phytase in barley can provide a useful tool for breeding new barley varieties with high phytase activity. METHODOLOGY/PRINCIPAL FINDINGS: Quantitative trait loci (QTL) analysis for phytase activity was conducted using a doubled haploid population. Phytase protein was purified and identified by the LC-ESI MS/MS Shotgun method. Purple acid phosphatase (PAP) gene was sequenced and the position was compared with the QTL controlling phytase activity. A major QTL for phytase activity was mapped to …

Characterization Of A Blast Wave Device And Blast Wave Induced Traumatic Brain Injury In A Rat Model By Magnetic Resonance Imaging And Spectroscopy, Frank Corwin

Theses and Dissertations

Blast wave induced traumatic brain injury (bTBI) is a modality of injury that has come into prominence at the current time due to the large number of military and civilian personnel who have experienced the localized shock wave produced by explosive devices. The shock wave will travel concentrically outward from the explosive center, being absorbed and transmitted thru soft objects, such as tissue, and reflecting off stationary obstructions. Transmission and absorption in tissues can result in a number of physiological measureable injuries, the most common of which being what is frequently called “blast lung”. Blast lung involves the spalling effect …

Clark County Mental Health Court: An Outcomes-Based Evaluation Model Of Residential And Treatment Programs Beyond Recidivism, Mark J. Nichols

Graduate Research Symposium (2010 - 2017)

The number of America’s mental health courts has grown significantly over the course of the past 15 years. Mental health courts can be seen as a form of therapeutic jurisprudence where the court implements therapeutic interventions, case management and treatment (Palermo, 2010). A mental health court was established in Clark County during 2003. Its mission is to promote engagement in treatment, improve quality of life, decrease recidivism, and increase community safety and awareness (Glass, 2008).

The focus of the evaluation of the Clark County Mental Health Court, limited to performance measures related to the decreased recidivism by its clients and …

Attachment And Couple Sexual Functioning, Kathryn Z. Devis, Melissa A. Louder, Kara L. Thompson, Katherine M. Hertlein

Graduate Research Symposium (2010 - 2017)

Within the last several years, there has been a surge in the publications that focus on attachment within the couple relationships, including how it pertains to infidelity treatment. Despite the interest in couple relationships and attachment, however, a limited amount of literature focuses on how varying styles of attachment manifest in a couple's level of sexual functioning. This study is a response to the need to explore the literature and related gaps in literature.

Bryant University Research And Engagement Day Program

Bryant REDay (Research and Engagement Day)

No abstract provided.

The Medical Essay As An Invitation For Interdisciplinary Exploration, Edwin Stieve

Quadrivium: A Journal of Multidisciplinary Scholarship

No abstract provided.

Medicare's Accountable Care Organization Regulations: How Will Medicare Beneficiaries Who Reside In Medically Underserved Communities Fare?, Sara J. Rosenbaum, Peter Shin

Geiger Gibson/RCHN Community Health Foundation Research Collaborative

On March 31, 2011, the Centers for Medicare and Medicaid Services (CMS) released proposed regulations implementing the Medicare Shared Savings Program (MSSP). The thrust of the MSSP is to promote savings to Medicare as well as the greater clinical integration of health care through incentive payments to accountable care organizations (ACOs) that meet Medicare standards for structure, performance, and health care outcomes. The effort to spur greater clinical integration through the MSSP was part of a broader set of reforms contained in the Affordable Care Act (ACA) whose aim was to improve health care quality and efficiency. Among these reforms …

Semi Truck Driver Falls Asleep While Driving, Crashes And Dies, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Motor Vehicle

A 56 year-old male long-haul semi-truck driver fell asleep while driving. It was approximately 4:15 AM and the driver was hauling a load of canned tomatoes. He was approximately 225 miles away from his destination driving in the right hand lane, on a four lane interstate traveling south, when he fell asleep. Upon falling asleep, the unit travelled to the right, across the rumble strip and the emergency lane, behind a guardrail, down an embankment and crashed into a grove of trees. A man driving a car behind the semi truck saw dust rise from the crash, stopped, called emergency …

Opinions About Anti-Tobacco Marketing Strategies From The Undergraduate Student Perspective, Kara Jachcinski, Meranda Block, Caitlin Berry, Lauren Paczkowski, Emily Bernhard, Nathan Matejczyk

Symposium on Research and Creative Expression (SORCE)

The purpose of this project was to assess undergraduate college students’ opinions of anti-tobacco marketing strategies. The college environment offers an excellent setting for implementation of smoking abstinence interventions for young adults. Freshmen students at Valparaiso University were invited to join group sessions in the residence halls to evaluate anti-tobacco YouTube videos, print materials, and Quit Kit materials. Undergraduate nursing students functioned as group session facilitators. Participants (N = 39) included: 59% males, 87% non-smokers, and 92% who chose to attend for CORE credit. YouTube videos were found to be effective if a dramatic, age appropriate, simple message was connected …

Beyond The Volcanoes: A Community Partnership For Health In Rural Nicaragua, Chelsea Zeman, Cathy Wingstrom

Symposium on Research and Creative Expression (SORCE)

Background: Health inequities related to gender, ethnicity, socioeconomic status, and geography exist in rural Nicaragua due in part to lack of access to health services. The purpose of this ongoing project is to improve health equity in rural Nicaragua through social transformation using community-based participatory action research. Bronfenbrenner’s ecological model of human development, school health, and primary health care theories provided the framework for this research. Methods: Community-based participatory action research involves six phases: partnership, assessment, planning, implementation, evaluation, and dissemination. In the implementation phase, the goal was to build stoves that would remove smoke from the homes and in …

Crossing The Border: Improving Therapeutic Relationships Between First Generation Mexican Americans And Western Health Providers, Meg Petron

Symposium on Research and Creative Expression (SORCE)

In health care, the needs of the patient are always first and determine the course of patient care. Due to the strong presence of Mexican Americans in the United States, and consequently the nation's hospitals, their expectations may be influenced by cultural norms. The aim of this presentation is to give health care providers the information they need to deal with Mexican cultural norms, traditional Mexican folk remedies, and general preexisting notions about Western health care. This information is necessary to create patient-client trust and, subsequently, a therapeutic relationship between patient and practitioner.

Best Practice For Insomnia Patients At A Sleep Center, Jennifer Bronnenberg, Rachshun Hampton, Kelli Martin, Rachael Mckay, Jessica Sneed

Symposium on Research and Creative Expression (SORCE)

Sleep disorders affect millions of people worldwide. The purpose of this project was to determine if individuals with sleep disorders can achieve better outcomes with treatment that includes education classes and cognitive therapy than with current treatments which utilize medication and equipment. Seven articles, obtained from a search of CINAHL, JBI, Medline, and Psych Info, were reviewed and critiqued. Studies contained samples of men and women with sleep disorders, reviews of previous studies, and reviews of effective alternative treatments. Designs included systematic reviews, meta-analysis, randomized control, longitudinal two group pre-test posttest, and a narrative review. Findings showed that when traditional …

Relationship Between Health Literacy And Educational Materials, Jacqueline O'Reiley, Jennifer Bronnenberg, Brittany O'Reiley, Jennifer Sechrist, Katherine Jankauski, Carole Pepa, Constance Lemley

Symposium on Research and Creative Expression (SORCE)

No abstract provided.

Hydrophobicity As A Driver Of Mhc Class I Antigen Processing., Lan Huang, Matthew C Kuhls, Laurence C. Eisenlohr

Department of Microbiology and Immunology Faculty Papers

The forces that drive conversion of nascent protein to major histocompatibility complex (MHC) class I-restricted peptides remain unknown. We explored the fundamental property of overt hydrophobicity as such a driver. Relocation of a membrane glycoprotein to the cytosol via signal sequence ablation resulted in rapid processing of nascent protein not because of the misfolded luminal domain but because of the unembedded transmembrane (TM) domain, which serves as a dose-dependent degradation motif. Dislocation of the TM domain during the natural process of endoplasmic reticulum-associated degradation (ERAD) similarly accelerated peptide production, but in the context of markedly prolonged processing that included nonnascent …

Effectiveness Of Bite Charts In Behavioral Feeding Intervention, Natalie Gray, Melissa Council

2011 Awards for Excellence in Student Research & Creative Activity - Documents

This study evaluated the effectiveness of a bite chart as a method of positive reinforcement in behavioral feeding intervention. The bite chart was used to increase bite acceptance. Using a BAB research design, the researchers found the bite chart effective for two subjects with differing diagnoses, ages, environments, and therapists.

Dental Plan Performance With Medicaid Reform In Virginia, James Reed

Theses and Dissertations

Purpose: To assess the effect of dental Medicaid reforms in the state of Virginia on dental plan performance. Methods: This project is a retrospective cohort study of 825,000 dental claims obtained from the Virginia Department of Medical Assistance Services. This cohort includes dental claims for children enrolled in Virginia’s Medicaid program from July 1, 2002 through June 30, 2008. The independent variable was enrollment pre or post policy reform with July 1, 2005 as the period dividing date. The dependent variable was dental benefit utilization measured as the average number of restorative, preventative, and total procedures. Statistical methods include Welch’s …

Fracture In Teeth—A Diagnostic For Inferring Bite Force And Tooth Function, Paul J. Constantino, Brian R. Lawn, James J.-W. Lee, Peter W. Lucas

Biological Sciences Faculty Research

Teeth are brittle and highly susceptible to cracking. We propose that observations of such cracking can be used as a diagnostic tool for predicting bite force and inferring tooth function in living and fossil mammals. Laboratory tests on model tooth structures and extracted human teeth in simulated biting identify the principal fracture modes in enamel. Examination of museum specimens reveals the presence of similar fractures in a wide range of vertebrates, suggesting that cracks extended during ingestion or mastication. The use of ‘fracture mechanics’ from materials engineering provides elegant relations for quantifying critical bite forces in terms of characteristic tooth …

Astrocytes From The Contused Spinal Cord Inhibit Oligodendrocyte Differentiation Of Adult Oligodendrocyte Precursor Cells By Increasing The Expression Of Bone Morphogenetic Proteins, Yaping Wang, Xiaoxin Cheng, Qian He, Yiyan Zheng, Dong H Kim, Scott R Whittemore, Qilin L Cao

Faculty, Staff and Student Publications

Promotion of remyelination is an important therapeutic strategy to facilitate functional recovery after traumatic spinal cord injury (SCI). Transplantation of neural stem cells (NSCs) or oligodendrocyte precursor cells (OPCs) has been used to enhance remyelination after SCI. However, the microenvironment in the injured spinal cord is inhibitory for oligodendrocyte (OL) differentiation of NSCs or OPCs. Identifying the signaling pathways that inhibit OL differentiation in the injured spinal cord could lead to new therapeutic strategies to enhance remyelination and functional recovery after SCI. In the present study, we show that reactive astrocytes from the injured rat spinal cord or their conditioned …

Managing Stress In The Orthopaedic Family: Avoiding Burnout, Achieving Resilience, M. Catherine Sargent, Wayne Sotile, Mary O. Sotile, Harry Rubash, Peter S. Vezeridis, Larry Harmon, Robert L. Barrack

Open Access Publications

No abstract provided.

Evaluating Dental Surgery Post-Operative Pain In Children Following Treatment Under General Anesthesia, Malinda Husson

Theses and Dissertations

Purpose: The purpose of this pilot study was to determine if there is a difference in post-operative pain experience for children following dental restorations and/or extractions under general anesthesia (GA), with and without local anesthetic (LA). The alternative hypothesis is that children will experience less post-operative discomfort and soft tissue trauma when using intra-ligamental local anesthetic during the intra-operative time period. Methods: Patients were recruited for this single blind, randomized, prospective cohort study with the following inclusion criteria, children age 2-6 years requiring general anesthesia for dental treatment. Patients were randomized into categories of either receiving a standardized local anesthetic …

Elevated Expression Of Squamous Cell Carcinoma Antigen (Scca) Is Associated With Human Breast Carcinoma, Joseph M. Catanzaro, Jennifer L. Guerriero, Jingxuan Liu, Namratha Sheshadri, John J. Chen, Wei-Xing Zhong

Department of Molecular Genetics and Microbiology Faculty Publications

Squamous cell carcinoma antigen (SCCA) belongs to the serine protease inhibitor (Serpin) family of proteins. Elevated expression of SCCA has been used as a biomarker for aggressive squamous cell carcinoma (SCC) in cancers of the cervix, lung, head and neck, and liver. However, SCCA expression in breast cancer has not been investigated. Immunohistochemical analysis of SCCA expression was performed on tissue microarrays containing breast tumor tissues (n = 1,360) and normal breast epithelium (n = 124). SCCA expression was scored on a tiered scale (0-3) independently by two evaluators blind to the patient's clinical status. SCCA expression was observed in …

Methods And Animal Model For Analyzing Age-Related Macular Degeneration, Jayakrishna Ambati

Ophthalmology and Visual Science Faculty Patents

Methods for testing candidate drugs for treatment of age-related macular degeneration are provided. Ccl2-deficient, and Ccr2-deficient mice are used to determine the effect of candidate drugs and treatments on development of age-related macular degeneration. Also provided is a Ccl2-deficient, Ccr2-deficient dual knockout mouse, which is a useful animal model for age-related macular degeneration.

Exploring Student Perceptions To Explain The Relationship Between Physical Activity And Academic Achievement In Adolescents: A Mixed Methods Study, Megan J. Hylok

College of Education and Human Sciences: Dissertations, Theses, and Student Research

A nationwide survey conducted by the Center for Disease Control in 2007 reported 65% of high school students did not meet the recommendation that youth participate in at least 60 minutes of physical activity most days of the week (CDC, 2008). While research has focused its attention primarily on bodily health, growing evidence supports the benefits of physical activity on brain health (Ratey & Hagerman, 2008). Physical activity is important and many adolescents are not meeting the recommendation, therefore, it is important to explore the adolescent perceptions to understand which factors influence physical activity participation. The significance of this study …