Medicine and Health Sciences Commons^™

Rapid Assessment Of Hib Disease Burden In Vietnam, Batunkh Nyambat, Duc Anh Dang, Hien Anh Nguyen, Trin Quynh Mai, Manju Rani, Mary Pe Slack, Paul E. Kilgore

Department of Pharmacy Practice

Background: Several countries have applied the Haemophilus influenzae type b (Hib) rapid assessment tool (RAT) to estimate the burden of Hib disease where resources for hospital- or population-based surveillance are limited. In Vietnam, we used the Hib RAT to estimate the burden of Hib pneumonia and meningitis prior to Hib vaccine introduction.

Methods: Laboratory, hospitalization and mortality data were collected for the period January 2004 through December 2005 from five representative hospitals. Based on the WHO Hib RAT protocol, standardized MS Excel spreadsheets were completed to generate meningitis and pneumonia case and death figures.

Results: We found 35 to 77 …

The Effect Of Training On Motoneuron Survival In Amyotrophic Lateral Sclerosis: Which Motoneuron Type Is Saved?, Sherif M. Elbasiouny, Jenna E. Schuster

Neuroscience, Cell Biology & Physiology Faculty Publications

Amyotrophic lateral sclerosis (ALS) is characterized by selective and progressive degeneration of motoneurons (MNs). Although the etiology of the disease is unknown, glutamate toxicity and reactive oxygen species toxicity have been strongly implicated in ALS pathophysiology, Training exercise has been proposed to provide a beneficial therapy during the early or late stages of ALS; however, some studies showed deleterious effects of exercise on survival in ALS.

Lingkungan Fisik Dan Angka Kuman Udara Ruangan Di Rumah Sakit Umum Haji Makassar, Sulawesi Selatan, M. Tahir Abdullah, Buraerah Abdul Hakim

Kesmas

Udara merupakan salah satu media lingkungan tempat bakteri, virus, dan fungi hidup dan berkembang. Oleh karena mikroorganisme tersebut memerlukan berbagai persyaratan untuk tumbuh dan berkembang, faktor-faktor lingkungan fisik udara tertentu dapat berhubungan dengan angka kuman. Untuk menentukan hubungan ini, telah dilakukan studi potong lintang di ruang rawat inap pasien Rumah Sakit Umum Haji Makasar. Kualitas faktor-faktor lingkungan fisik (pencahayaan, suhu, kelembaban relatif, dan kepadatan ruangan) dan angka kepadatan kuman dalam 5 ruang rawat inap (pavilion, kelas 1, kelas 2, kelas 3, dan recovery room) diukur 3 kali (pagi, siang, dan sebelum matahari terbenam) pada 3 titik pengukuran berbeda setiap ruang. …

Adam10 Exacerbation Of Allergic Disease Is Potentially Explained By Its Role In Cd23 Exosomal Sorting., Joel Mathews

Theses and Dissertations

CD23, the natural negative regulator of IgE, has been shown to be involved in asthma progression through its regulation of IgE. To investigate if its sheddase, ADAM10, is also involved in asthma progression, three mouse models were utilized; an IgE/mast cell dependent model, an IgE dependent, mast cell independent model and a mast cell and IgE independent model. Experimental asthma was then induced in mice which were selectively deficient for ADAM10 in B cells (ADAM10-/-) and compared to WT controls. The ADAM-/- mice had decreased signs of asthma, including eosinophilia, AHR and IgE synthesis in the IgE dependent model compared …

The Effects Of Sdf-1Α Treatment On The Migration Of Neural Stem/Progenitor Cells After Traumatic Brain Injury, Corey Evans

Theses and Dissertations

Traumatic Brain Injury (TBI) is one of the leading causes of death and disability among young adults and has been a significant field in medical research over the past decades. Intensive studies focusing on how to repair tissue damage resulting from head injuries have discovered that the central nervous system (CNS) retains a regenerative capacity throughout life due to the persistent presence of neural stem/progenitor cells (NS/NPCs) in the neurogenic regions. In the normal brain, cells generated in the subventricular zone (SVZ) migrate along the rostral migratory stream (RMS) to the olfactory bulb and cells in the subgranular zone (SGZ) …

Profil Lipid, Peroksidasi Lipid, Dan Status Inflamatif Wanita Penderita Sindrom Metabolik, Hery Winarsi, Siwi P.M. Wijayanti, Agus Purwanto

Kesmas

Prevalensi sindrom metabolik (SM) di Indonesia (13,13%) tergolong tinggi dengan kecenderungan terus meningkat. Salah satu akibat SM adalah disfungsi endotel, sebagai awal penyakit kardiovaskuler yang diinduksi oleh stres oksidatif dan inflamatif. Penelitian ini bertujuan untuk mengeksplorasi profil lipid, peroksidasi lipid, dan marker inflamasi pada wanita penderita SM di Purwokerto. Sebanyak 30 wanita dengan kadar gula darah di atas normal, obesitas body mass index (BMI) > 25 kg/m2, dan berusia 40-65 tahun dilibatkan sebagai responden yang dipilih melalui survei di Poliklinik Penyakit Dalam Rumah Sakit Margono Soekarjo. Kadar kolesterol total, trigliserida, high density lipoprotein, low density lipoprotein, malondialdehid, dan plasma C-reactive protein …

Pengaruh Perawatan Metode Kanguru Terhadap Respons Fisiologis Bayi Prematur, Deswita Deswita, Besral Besral, Yeni Rustina

Kesmas

Saat ini, perawatan metode kanguru mulai dianjurkan bagi bayi prematur karena kelahiran prematur dan bayi dengan berat badan lahir rendah merupakan salah satu penyebab kematian bayi terbesar. Tujuan penelitian ini adalah untuk mengetahui pengaruh perawatan metode kanguru terhadap respons fisiologis bayi prematur. Desain quasi experiment one group pre and post-test dilakukan di 2 rumah sakit di Jakarta. Sebanyak 16 bayi prematur yang memenuhi kriteria inklusi dipilih sebagai sampel. Hasil penelitian menunjukkan bahwa terdapat pengaruh yang bermakna dari perawatan metode kanguru terhadap respons fisiologis bayi prematur seperti peningkatan suhu tubuh ke arah suhu normal (p value = 0,000), peningkatan frekuensi denyut …

Tuberkulosis Paru Di Palembang, Sumatera Selatan, Hery Unita Versitaria, Haryoto Kusnoputranto

Kesmas

Indonesia tercatat memiliki 304.787 penderita tuberkulosis yang menempatkannya pada peringkat ketiga terbanyak di dunia. Penyakit tuberkulosis merupakan penyebab kematian nomor 3 setelah penyakit kardiovaskuler dan penyakit saluran pernafasan pada semua kelompok usia serta nomor 1 dari golongan penyakit infeksi. Angka kepadatan hunian rumah di Kota Palembang 5,84 lebih tinggi daripada angka ideal kepadatan hunian rumah. Penelitian ini bertujuan mengetahui hubungan antara sumber penular serumah, faktor lingkungan dalam rumah, dan karakteristik individu terhadap kejadian tuberkulosis paru basil tahan asam (BTA) (+) di Kota Palembang. Penelitian yang menggunakan desain kasus kontrol ini membandingkan kelompok kasus (BTA(+)) dan kelompok kontrol (BTA (-)) yang …

Analysis Of Current And Potential Treatments For Chronic Lymphocytic Leukemia, Angelica M. Atkins

Senior Honors Theses

Chronic Lymphocytic Leukemia (CLL) is one of the most common forms of adult leukemia in North Americans.  However, it has been shown through the analysis of clinical studies and synopses of medical research that no current treatment indefinitely cures CLL or prolongs the life of CLL patients.  Current CLL therapies are either symptomatic treatments (chemotherapy and  immunotherapy) that do not improve complete remission rates or effective treatments that target the actual cancer but have excessive morbidity and toxicity rates (stem cell transplants).  Conventional CLL treatments are inadequate according to the results of clinical trials and research of field experts.  Potential …

Contextual Factors And Reproductive Control In U.S. Women, Brianna Magnusson

Theses and Dissertations

Introduction: Access to family planning services is a major public health issue. State policies and funding for family planning services may increase access to contraceptive services and help women avoid unintended pregnancies. Study Design: We identified sexually active, fertile women participants of the National Survey of Family Growth (2006-2008). Women were categorized as consistent or inconsistent users of contraceptives based on self-report. States were classified based on 2006 Medicaid family planning waiver status (income expansions, limited expansions, or no Medicaid family planning expansions), 2006 public funding for family planning in dollars per woman, and insurance coverage of contraceptive mandate status …

Radiation Therapy Treatment Plan Optimization Accounting For Random And Systematic Patient Setup Uncertainties, Joseph Moore

Theses and Dissertations

External-beam radiotherapy is one of the primary methods for treating cancer. Typically a radiotherapy treatment course consists of radiation delivered to the patient in multiple daily treatment fractions over 6-8 weeks. Each fraction requires the patient to be aligned with the image acquired before the treatment course used in treatment planning. Unfortunately, patient alignment is not perfect and results in residual errors in patient setup. The standard technique for dealing with errors in patient setup is to expand the volume of the target by some margin to ensure the target receives the planned dose in the presence of setup errors. …

The Diary Of A Huntington's Disease Activist, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Medical School Watercooler Newsletter - April 24, 2011, Lindsey Lyle

Watercooler Newsletter

This is the April 124, 2011 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler

Contents Include

• Tornado Relief Effort: How You Can Help
• Med School Café - Expert Advice for the Community
• COM Dean Honored With Alumni Achievement Award
• Dr. Rutecki Interviewed By Baltimore Sun
• USA Orthopaedic Rehabilitation Center Celebrates Anniversary at New Location
• Next Week's DSS - Dr. Joseph Brewer
• RSVP Today Online - 2011 Oncology Outlook

Identification And Engineering Of Human Variable Regions That Allow Expression Of Stable Single-Chain T Cell Receptors, David H. Aggen, Adam S. Chervin, Francis K. Insaidoo, Kurt H. Piepenbrink, Brian M. Baker, David M. Kranz

Food for Health: Publications

Single-chain antibody fragments (scFv), consisting of two linked variable regions (V_H and V_L), are a versatile format for engineering and as potential antigen-specific therapeutics. Although the analogous format for T cell receptors (TCRs), consisting of two linked V regions (Vα and Vβ; referred to here as scTv), could provide similar opportunities, all wild-type scTv proteins examined to date are unstable. This obstacle has prevented scTv fragments from being widely used for engineering or therapeutics. To further explore whether some stable human scTv fragments could be expressed, we used a yeast system in which display of properly folded …

Service, Education, And Advocacy Within A Student-Run Pharmacy: An Evaluation Of The Butler University Community Outreach Pharmacy, Eliza Anne Dy

Undergraduate Honors Thesis Collection

Objective To investigate three domains of the student-run Butler University Community Outreach Pharmacy’s (BUCOP) mission statement. Methods This multi-phase, survey-based study evaluated the execution of BUCOP’s mission statement in the areas of service, education, and advocacy. Results The service survey found that the majority (~78%) of patients were satisfied with most aspects of BUCOP’s care; however, patients were most displeased with hours of operation and wait time. The education survey results demonstrated BUCOP’s role as an early confidence-building experience; however, noteworthy clinical interactions with medical students were limited. The advocacy survey revealed that 96% of community members interviewed were unaware …

Undergraduate Nursing Students' Perceptions Of Preparedness As They Prepare To Graduate, Julie Simmons

Nursing Masters

Background: Nursing students in their final semester before graduation often have feelings of anxiety as they face unique challenges that come with the transition from a protective educational environment to the roles and responsibilities of a new graduate staff nurse. Factors such as increasing responsibility and clinical workload and the continuing development of clinical and time management skills may contribute to feelings of anxiety and insecurity. New graduate nurses are recognized as a valuable resource due to the chronic and increasing shortage of registered nurses as seasoned nurses approach retirement, baby boomers age, and the need for health care grows. …

Book Review: Nudge: Improving Decisions About Health, Wealth, And Happiness, Etienne Phipps Phd

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Main Line Health Offers Unique Educational Model For Outreach To Community Youth: The Annenberg High School Science Symposium, Joel Port, Nan Myers

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Health Policy Forum: Public Health Law Research, Making The Care For Laws To Improve Health

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Health Policy Forum: Transformative Technology Applications In Health Care

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

New Global Health Fellowship Links Jefferson And Sierra Leone, Bon S. Ku Md, Harsh P. Sule Md

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Use Of Archival Data To Inform Health Policy, Shana Stites Ma, Ms

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

8th Annual Interclerkship Day: Improving Patient Safety

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

The Jefferson Scale Of Empathy (Jse): An Update, Mohammedreza Hojat Phd, Daniel Z. Louis Ms, Kay Maxwell Bs, Joseph S. Gonnella Md

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Pitfalls And Problems Abound: A Medical Student Shares A Family Experience With The Health Care System, Cole Zanetti

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Amsa's 3rd Annual Patient Safety And Quality Leadership Institute, Boris Rozenfeld, Marina Zeltser

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Health Reform: Will It Improve Our Nation's Health?, Rob Simmons Drph,Mph,Mches,Cph

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Health Policy Newsletter Spring 2011 Download Full Text Pdf

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Regulation Of Sterol Transport By Dietary Phytosterol Esters, Trevor J. Carden

Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research

LDL cholesterol is associated with the development of atherosclerosis and is therefore considered an important target for intervention to prevent cardiovascular diseases. The inhibition of cholesterol absorption in the small intestine is an attractive approach to lowering plasma cholesterol, one that is exploited by drug therapy as well as dietary supplementation with plant sterols. The mechanism of action of plant sterol esters (PSE) is still incompletely understood, therefore this study was conducted to test the hypothesis that hydrolysis of plant sterol esters is necessary for their cholesterol-lowering effects to be realized.

Male Syrian hamsters were fed diets containing no PSE, …

An Exploration Of Pharmacognosy And Its Potential In The Multi-Faceted Solution Required To Address Hiv/Aids In Sub-Saharan Africa, Alexandra Sassi

Pell Scholars and Senior Theses

This work has both both biological and anthropoligcal foci. It addresses research done on the medicinal properties of plants and how this research could make positive contributions to the current social and biological issues surrounding the HIV/AIDS epidemic in sub-Saharan Africa.