Medicine and Health Sciences Commons^™

Cancer Management Is A Multidisciplinary Team Work, Ahmed Nadeem Abbasi

Department of Radiation Oncology

No abstract provided.

Rhinocerebral Zygomycosis In Pakistan: Clinical Spectrum, Management, And Outcome, Mubasher Ikram, Moghira Iqbal, Muhammad Aslam Khan, Erum Khan, Mahnaz Shah, Raymond A., Jr Smego

Section of Otolaryngology, Head & Neck Surgery

OBJECTIVE: To study the disease spectrum and salient management features of 36 patients with histopathologically-confirmed rhinocerebral zygomycosis seen at our academic center over a 16-year period.

METHODS: Retrospective review of patients admitted to the Aga Khan University Hospital in Karachi, Pakistan from January 1991 to December 2006 with histopathologically-confirmed zygomycosis of the head and neck.

RESULTS: Mean patient age was 40 +/- 5.0 years (range, 34-63 years), and 23 (64%) patients were male. Thirty-two (89%) patients were referred from clinical services other than otolaryngology. Underlying predisposing conditions included diabetes mellitus (21 patients), haematologic diseases (9), and renal failure (6). Twenty …

Evaluation Of Kawasaki Disease Risk-Scoring Systems For Intravenous Immunoglobulin Resistance., Lynn A. Sleeper, L Luann Minich, Brian M. Mccrindle, Jennifer S. Li, Wilbert Mason, Steven D. Colan, Andrew M. Atz, Beth F. Printz, Annette Baker, Victoria L. Vetter, Jane W. Newburger, Pediatric Heart Network Investigators, Girish S. Shirali

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVES: To assess the performance of 3 risk scores from Japan that were developed to predict, in children with Kawasaki disease, resistance to intravenous immunoglobulin (IVIG) treatment.

STUDY DESIGN: We used data from a randomized trial of pulsed steroids for primary treatment of Kawasaki disease to assess operating characteristics of the 3 risk scores, and we examined whether steroid therapy lowers the risk of coronary artery abnormalities in patients prospectively classified as IVIG resistant.

RESULTS: For comparability with published cohorts, we analyzed the data of 99 patients who were not treated with steroids (16% IVIG-retreated) and identified male sex, lower …

Use Of Audit, And Measures Of Drinking Frequency And Patterns To Detect Associations Between Alcohol And Sexual Behaviour In Male Sex Workers In Kenya, Stanley Luchters, Scott Geibel, Masila Syengo, Daniel Lango, Nzioki King'ola, Marleen Temmerman, Matthew F. Chersich

Population Health, East Africa

Background: Previous research has linked alcohol use with an increased number of sexual partners, inconsistent condom use and a raised incidence of sexually transmitted infections (STIs). However, alcohol measures have been poorly standardised, with many ill-suited to eliciting, with adequate precision, the relationship between alcohol use and sexual risk behaviour. This study investigates which alcohol indicator - single-item measures of frequency and patterns of drinking ( > = 6 drinks on 1 occasion), or the Alcohol Use Disorders Identification Test (AUDIT) - can detect associations between alcohol use and unsafe sexual behaviour among male sex workers.

Methods: A cross-sectional …

Employment Selections Of Resident And Non-Resident Graduates Of Physical Therapy Programs In Underserved Western States, Trever J. Cornia, Ryan B. Dutot, Jacob T. Parsons, Kathryn D. Swart

UNLV Theses, Dissertations, Professional Papers, and Capstones

Background and Purpose:Physical therapy (PT) is an essential component of the healthcare system in providing a comprehensive treatment plan for patients with functional limitations. The demand for physical therapy services is projected to expand in the next eight years, leading to an increased need for practicing physical therapists. The Mountain States plus Washington State (MSPWS) demonstrate the greatest shortage of therapists and are considered to be medically underserved. The purpose of this study was to determine the retention rates of resident and non-resident physical therapy graduates of public universities in the MSPWS and to determine which factors influenced their …

Effects Of Classwide Self-Management Intervention On Second Grade Students’ Social Skills In Physical Education, Elian Aljadeff-Abergel

UNLV Theses, Dissertations, Professional Papers, and Capstones

Maintaining students' on-task behavior and engagement with learning materials is difficult due to factors such as a large number of students and the increasing occurrences of disruptive behaviors in class. Students' acquisition of appropriate social skills can increase the teacher's ability to effectively teach in class and facilitate students' academic success. Self-management (SM) interventions in which students manage their own behaviors can serve as socially and ecologically-valid strategies for enhancing students' social skills in the classroom. Self-management programs have wide empirical support that demonstrates their merit for students' learning of social and academic skills. In school settings, self-management interventions were …

Polycystic Ovary Syndrome (Pcos) In Urban India, Heidi A. Manlove

UNLV Theses, Dissertations, Professional Papers, and Capstones

This thesis research focuses on urban women in India diagnosed with polycystic ovary syndrome (PCOS). PCOS is a complex metabolic, endocrine and reproductive disorder affecting approximately 5-10% of the female population in developed countries. The prevalence of PCOS is on the rise in developing nations like India, which are undergoing rapid nutritional transitions due to Westernized diets and lifestyle. However, less appreciated in the literature are the developmental psychosocial impacts for women diagnosed with PCOS, especially in developing countries. Thus, the goal of my thesis research was to contribute to the small but growing literature by investigating psychosocial dimensions of …

Different Means To The Same End: A Comparative Contingency Analyses Of Singapore And China’S Management Of The Severe Acute Respiratory Syndrome (Sars) Crisis, Yan Jin, Augustine Pang, Glen T. Cameron

Research Collection Lee Kong Chian School Of Business

For months in 2003, the world lay under siege by a strain of virus that masqueraded as pneumonia but inflicted a far more lethal effect. By all accounts, the mystery of how the severe respiratory acute syndrome (SARS) virus came to be has remained largely unsolved (Bradsher & Altman 2003). What began as routine fever and cough in a Chinese physician, later identified as a super-carrier, rapidly spread to people who had cursory contacts with him, spiralling into a worldwide crisis that spanned Asia and the North Americas (Rosenthal 2003).

Forebrain Origins Of Glutamatergic Innervation To The Rat Paraventricular Nucleus Of The Hypothalamus: Differential Inputs To The Anterior Versus Posterior Subregions, Yvonne M. Ulrich-Lai, Kenneth R. Jones, Dana R. Ziegler, William E. Cullinan, James P. Herman

Biomedical Sciences Faculty Research and Publications

The hypothalamic paraventricular nucleus (PVN) regulates numerous homeostatic systems and functions largely under the influence of forebrain inputs. Glutamate is a major neurotransmitter in forebrain, and glutamate neurosignaling in the PVN is known to mediate many of its functions. Previous work showed that vesicular glutamate transporters (VGluTs; specific markers for glutamatergic neurons) are expressed in forebrain sites that project to the PVN; however, the extent of this presumed glutamatergic innervation to the PVN is not clear. In the present study retrograde FluoroGold (FG) labeling of PVN-projecting neurons was combined with in situ hybridization for VGluT1 and VGluT2 mRNAs to identify …

Case Studies In Working With Loving-Kindness Meditation And Art Therapy For Those Suffering From Chronic Pain, Jessica N. Ropars

EVMS School of Health Professions Theses & Dissertations

This study combined the use of Loving-Kindness meditation with art therapy for three women suffering from different types of chronic pain. These women ranged in age from 26 to 62 years and were from a variety of backgrounds; two of the women were Caucasian and one woman was originally from Barbados. The participants were recruited from the Department of Physical Medicine and Rehabilitation at Eastern Virginia Medical School. Four sessions were scheduled. During each session there was time for Loving-Kindness meditation followed by an art therapy intervention. The West Haven-Yale Multidimensional Pain Inventory was used to measure pain. In order …

Giant Mandibular Condyle Osteoma, Luis Eduardo Almeida, Marco Antonio De Oliveira Filho

School of Dentistry Faculty Research and Publications

Osteomas are benign tumors composed of mature compact or cancellous bone. They represent an uncommon lesion that occurs mainly in craniofacial complex bones. In jaws, they can appear on the bone surface as a polypoid or sessile mass, characterizing a peripheral osteoma (PO), or can be a lesion in the medullar space, then it is called central osteoma. In view of the scarcely reported cases about POs, this article presents a case of PO of the maxillofacial area that was surgically resected using hemicoronal approach.

Primary Care Providers’ Perceptions Of Mental And Behavioral Health Problems In Frontier Areas Of Idaho, Alexander A. Theiler

Boise State University Theses and Dissertations

Depression and other significant mental and behavioral health (MBH) problems have not been well documented in frontier areas of Idaho. It has been suggested that residents of frontier areas access their primary care provider (PCP) for most of their general health and MBH needs. To determine PCPs’ perceptions of MBH issues in frontier areas of Idaho, surveys were sent to all 252 PCPs with a registered practice location in one of Idaho’s 26 frontier counties. The survey asked questions regarding the PCPs’ practice history, the percentage of their patients who have an MBH problem and what those MBH problems are, …

Ultrasound Imaging Of Lumbar Multifidus Immediately Following Three Physical Therapy Techniques In Asymptomatic Individuals, Victoria Byers, Steven Lim, Kathryn Rice

UNLV Theses, Dissertations, Professional Papers, and Capstones

Study Design

Randomized, blinded, cohort, within subjects design.

Background and Objective

The effects of different manual therapy (MT) techniques on lumbar multifidus (LM) thickness have been investigated in subjects with low back pain (LBP) but have not been investigated in asymptomatic subjects. The objective of this study was to examine the immediate effects of mobilization and manipulation on contraction thickness of LM in healthy individuals.

Methods and Measures

Forty-two healthy individuals participated in the study. Ultrasound imaging techniques were used to record LM thickness (L4-5 level) at rest, during an abdominal drawing in maneuver (ADIM), and during a prone upper …

The Relationship Of Child Maltreatment Potential And Mothers’ Satisfaction With Their Neglected Children, Kelsey M. Bradshaw

UNLV Theses, Dissertations, Professional Papers, and Capstones

Parental satisfaction refers to the extent to which parents are satisfied with their children in relation to parent-child interactions and child behavior. The relationship between parental satisfaction and child behavior problems has been demonstrated extensively in the literature. Children who exhibit increased behavior problems appear to be at increased risk of parental aggression. Maltreating parents evidence greater levels of parental dissatisfaction as compared to caregivers of children who are not maltreated. Thus, low parental satisfaction is a suspected risk-factor for child maltreatment. Previous studies have shown that parental substance abuse is also strongly related to occurrence of child maltreatment. This …

To Consult Or Not To Consult? Investigating Barriers To Dysparenia Treatment-Seeking In Young Women, Robyn L. Donaldson

UNLV Theses, Dissertations, Professional Papers, and Capstones

Little is known about mediators of treatment-seeking in dyspareunia. The general health belief literature as well as some existing qualitative data specific to dyspareunia, however, suggests a number of potentially significant barriers that may delay or prevent women from enlisting the aid of health care professionals. The aim of this study was to investigate influences on dyspareunia treatment-seeking behavior in young women, for whom the consequences of treatment avoidance are hypothesized to be the greatest. Given the lack of standardized health behavior measures relevant to intercourse pain, we constructed a measure assessing potential barriers to dyspareunia treatment-seeking. An exploratory principal …

The Effect Of Acute Exercise-Induced Fatigue On Pistol Shooting Performance In Police Officers, Melissa Jean Brown

UNLV Theses, Dissertations, Professional Papers, and Capstones

Duties of police officers include apprehending suspects, which may involve foot pursuit and firing a weapon at a suspect. Previous studies in biathletes and soldiers suggest that shooting performance is compromised when fatigue is present. Purpose: To investigate the effects of exercise-induced fatigue on shooting performance in police officers. Methods: Nine police officers fired five rapid-fire shots at three targets each with a fifteen second rest period in between each trail. Officers then exercised on a cycle ergometer to 85% maximum heart rate or voluntary fatigue. The pretest shooting was repeated post-exercise. Distances of 4 shots from the center of …

The Variable Presentations Of Anaplastic Spindle Cell Squamous Carcinoma Associated With Tall Cell Variant Of Papillary Thyroid Carcinoma., Pallavi P Gopal, Kathleen T Montone, Zubair Baloch, Madalina Tuluc, Virginia Livolsi

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

BACKGROUND: In 1976, Hawk and Hazard described the tall cell variant (TCV) of papillary thyroid carcinoma (PTC). While the lesions they described had cytologic features of papillary carcinoma, they showed more aggressive behavior with a greater propensity for extrathyroid extension and lymphovascular invasion than classic PTC. In 1991, Bronner and LiVolsi described a series of patients with TCV that progressed to spindle cell squamous carcinoma (SCSC), a unique form of anaplastic thyroid carcinoma. This study describes the variable clinical and pathologic presentations in 31 patients with anaplastic SCSC arising in association with TCV.

METHODS: The surgical pathology archives as well …

Youth At The Nexus: Ideology In Hiv Prevention In Nairobi, Kenya, Zohra Ahmed

Scholarly Works

In the fight against HIV/AIDS, the Behavior Change Communication (BCC) model stands as international best practice in preventive education. Ideally, a BCC intervention aims to changes behaviors and attitudes by facilitating group negotiation and introspection, with a resultant improvement in health. However, introducing this best practice model to a group of youth in Nairobi resulted in suboptimal outcomes: they were unaccustomed to expressing themselves in the ways prescribed by the class. To explain this failure, I examine how local discourses produced by parents and teachers communicate agency, sexuality and health, and highlight the diverging practices invoked at home, school and …

Mother-Son Connectedness, Substance Use, And Young Men's Criminal Justice System Involvement, Kim L. Moreno Phd

Dissertations

The relationship between a mother and her son and its influence on health and risk behaviors as a boy becomes a man has had little exploration. The purpose of this study was to examine the relationships between mother-son connectedness, substance use, serious delinquency, violent delinquency, and criminal justice system involvement in young men. This study uses data from The National Longitudinal Study of Adolescent Health (ADD Health), a school-based study of students in grades 7–12 in the United States. Multiple regression, ANOVA, and logistic regression were used to analyze independent and dependent variables. Results show a perception of connectedness, which …

A Study Of Life Experiences Influencing Art Therapy As A Career Choice, Raleigh Ann Spires King

EVMS School of Health Professions Theses & Dissertations

Many factors contribute to one’s decision when choosing a career. Literature has stated that personal traits and demographics, chance encounters with influential people, and significant life events play important roles in the choice to enter a career in the helping professions. This study creates a descriptive summary of the life experiences that motivate an individual to choose art therapy as a career.

Using face-to-face interviews, the researcher gathered information regarding career choice from six art therapists each of whom had five or more years of experience. Although the art therapists disclosed personal experiences, unique to their lives, similar topics emerged …

Insights Into P53-Dependent Apoptotic Signaling And Cell Fate Vis-A-Vis Functional Cooperation Among Bcl-Xl, Cytoplasmic P53, And Puma, John C. Fisher

Theses and Dissertations (ETD)

Following DNA damage, nuclear p53 induces the expression of PUMA (p53 upregulated modulator of apoptosis), a BH3‑only protein that binds and inhibits the anti‑apoptotic BCL‑2 repertoire, including BCL‑xL. Structural investigations of PUMA and the BCL‑xL×PUMA BH3 domain complex by X‑ray crystallography and nuclear magnetic resonance (NMR) spectroscopy reveal a novel, PUMA‑induced, domain‑swapped dimerization of BCL‑xL that requires a π‑stacking interaction between PUMA W71 and BCL‑xL H113. PUMA is an intrinsically disordered protein, but upon interaction with BCL‑xL, PUMA W71 and the PUMA BH3 domain residues fold into an alpha helix and subtly remodel BCL‑xL to trigger its dimerization. Wild type …

Inhibition Of Monocyte Chemotaxis And Chemokine Macrophage Inflammatory Protein-1 Alpha, And Interleukin-8 Secretion By Lipopolysaccharide Isolated From Periodontal Pathogens, Andrew Karl Gray

Theses and Dissertations (ETD)

The vast majority of periodontal pathogens are classified as gram negative bacteria. These bacteria have an outermost membrane consisting of lipopolysaccharide (LPS), a molecule that can act as an endotoxin and elicit an immune response. The lipopolysaccharide structure consists of three major regions: oligosaccharide, core, and lipid A. Oligosaccharide is exposed on the cell surface, and lipid A anchors LPS in the outer membrane. LPS has been known to hinder certain defensive mechanisms of the immune system by secreting products that interfere with signals that promote chemotaxis of leukocytes enabling the pathogens to go unrestricted. When LPS binds to the …

The Design And Synthesis Of Autotaxin Inhibitors And Analogs Of Lysophosphatidic Acid, Renuka Niranjan Gupte

Theses and Dissertations (ETD)

Lysophosphatidic acid (LPA) is a naturally occurring bioactive phospholipid. It has a wide array of biological effects like cell proliferation, survival, migration, apoptosis invasion, wound healing and angiogenesis. Autotaxin (ATX) was identified as an autocrine tumor cell motility factor from A2058 melanoma conditioned medium. ATX has lysophospholipase D enzyme activity and is responsible for the cleavage of lysophophatidylcholine (LPC) leading to the generation of LPA. Antagonists of Autotaxin would have a potential therapeutic application in cancer research. Chapter 1 is an introduction of LPA and autotaxin. It provides the background and significance of the research. Chapter 2 explores the synthesis …

The Long-Term Stability Of Class Ii Cases Treated In A Private Practice Using A Straightwire Appliance: A Dental Cast Analysis, Lina K. Kulkarni

Theses and Dissertations (ETD)

Achieving long-term stability after orthodontic treatment is a major challenge for orthodontists. The previous literature shows that relapse occurs at a considerable magnitude. The purpose of the present study was to determine the amount and type of long-term, posttreatment relapse that occurs in a homogeneous group of patients treated by a single experienced orthodontist in a private practice setting. Dental casts from a sample of 30 Class II division 1 Caucasian females treated without extractions were evaluated at pretreatment (mean age = 13.1 years), posttreatment (mean age = 15.9 years) and recall (mean age = 28.3 years) to determine the …

Temporal And Aerodynamic Aspects Of Velopharyngeal Coarticulation: Effects Of Age, Gender And Vowel Height, Fadwa Khwaileh

Theses and Dissertations (ETD)

Previous studies on the normal patterns of velopharyngeal coarticulation did not provide a multidimensional description of the phenomenon. The primary objective of this study was to determine the effects of age, gender and vowel height on the temporal and aerodynamic aspects of nasal airflow segments related to velar coarticulation in the normal speech of children and adults. A secondary objective was to determine the within speaker variability of the segments.

Speakers consisted of 20 children between the ages of 5 and 7 years, 20 children between 9 and 11 years and 20 adult speakers 18 years or older. Nasal and …

Rna Interference For Improving The Outcome Of Islet Transplantation And Polymeric Micelle‑Based Nanomedicine For Cancer Therapy, Feng Li

Theses and Dissertations (ETD)

Ex vivo gene transfer has been used to improve the outcome of islet transplantation for treating type I diabetes. RNA interference is an effective approach for reducing gene expressions at the mRNA level. The application of RNA interference to improve the outcome of islet transplantation was reviewed in Chapter 2, where I summarized biological obstacles to islet transplantation, various types of RNAi techniques, combinatorial RNAi in islet transplantation, and different delivery strategies.

Upregulation of inducible nitric oxide synthase (iNOS) and subsequent product of radical nitric oxide (NO) impair islet β cell function. Therefore, we hypothesized that iNOS gene silencing could …

Application Of A High‑Resolution Computed Radiography System In Detecting An Iodinated X‑Ray Contrast Agent: Small Animal Phantom Study, Anobel Maghsoodpour

Theses and Dissertations (ETD)

Tumor angiogenesis, the creation of new blood vessels, is the characteristic of solid tumors and crucial for their development. Iodinated contrast agents are used to increase the X‑ray detectability of zone of angiogenesis, and thus providing a means for tracking tumor growth.

The overall objective of this project was to evaluate the performance of Kodak CR 7400, a high‑resolution compact computed radiography (CR) system in detection of Omnipaque‑240, an iodinated contrast agent, in a phantom mimicking small animal tumor model.

The first phase of the project was dedicated to a comprehensive assessment of CR image quality by measuring presampled Modulation …

Biomechanical Comparison Of Traditional Laminectomy And Minimally‑Invasive Facetectomies, Karen Sedacki

Theses and Dissertations (ETD)

The facet joints of the lumbar spine are one of the sources of low‑back pain that affects a great portion of the population. Minimally‑invasive (MI) procedures have been becoming more popular in the surgical decompression of the spine because they offer shorter recovery time and involve removal of smaller amounts of important structures. With these features, it is believed that MI procedures lead to less clinical instability, and the functionality of the segment is maintained. Another important factor is how the facet angle in the lumbar segments affects the biomechanical instability. In spite of all this interest in MI procedures, …

Emergency Physicians' Perspectives On The Usability Of Health Information Exchange, Shirley A. Thorn

Theses and Dissertations (ETD)

Emergency physicians are key users of health information exchanges (HIE). Understanding their perspectives on the usability of HIE is important if the full potential of the HIE is to be achieved. The literature identified that emergency physician experiences with HIEs are unexplored areas requiring further studies. The purpose of this study using grounded theory methods was to understand the perspectives of emergency physicians concerning the usability of HIEs. The fundamental question was how do emergency physicians use the HIE in making clinical decisions?

Rich and thick data were collected from 15 emergency physicians in four urban hospitals in the mid-south …

Pharmacokinetic And Pharmacodynamic Studies Of A Novel Spectinamide Series Of Antituberculosis Agents, V. N. R. Pavan Kumar Vaddady

Theses and Dissertations (ETD)

Spectinamides are novel amide derivatives of the antibiotic spectinomycin that have emerged as a new class of agents to treat tuberculosis. These agents showed potent in vitro activity against Mycobacterium tuberculosis (MTB) compared to spectinomycin and in a preliminary in vivo study in interferon gamma (IFN‑γ) knockout mice, spectinamide Lee1329 reduced the lung bacillary load of TB comparable to streptomycin. We hypothesized that the application of an iterative pharmacokinetics and pharmacodynamics (PK/PD) guided approach would facilitate the optimization of these lead compounds suitable for further development.

A series of in vitro experiments including parallel artificial membrane permeability assay (PAMPA), microsomal …