Medicine and Health Sciences Commons^™

Nanomaterials And Block Copolymers For Overcoming Multidrug Resistance In Cancer, Wesley Livingstone

Loma Linda University Electronic Theses, Dissertations & Projects

The development of multidrug resistance in cancer is one of the leading causes for decreased chemotherapy efficacy and is particularly threatening to aggressive cancers such as that of the pancreas. In cancers where chemotherapy is amongst the few treatment options, it is crucial to develop chemotherapeutics that either bypass or control the development of multidrug resistance. Polymeric nanomaterials such as Pluronics® are of current interest due to their ability to perform these functions in addition to enhancing pro-apoptotic mechanisms. Using the respectively known chemosensitive and chemoresistant pancreatic adenocarcinoma cell lines MiaPaCa-2 and PANC-1, an in vitro analysis of the synergistic …

Influence Of Gender And Aerobic Training Background On Exercise-Induced Increase In Adiponectin, Pooja Pratap Mujumdar

Loma Linda University Electronic Theses, Dissertations & Projects

Adipose tissue secretes the adipokine, adiponectin (ADPN), which is insulinsensitizing, anti-inflammatory, and anti-atherogenic. Exercise training improves insulin sensitivity and lowers the risk of cardiovascular complications. As some of the metabolic effects of exercise training and ADPN overlap, exercise training has been proposed to increase ADPN. However, most single bout exercise, or short-term (ï‚£3 months) and constant-effort (fixed session duration, fixed number of sessions/week, and fixed intensity) exercise protocols do not produce increases in ADPN in untrained and trained cohorts. Furthermore, most exercise studies were conducted on male-female mixed gender cohorts or male/female single gender cohorts. As a result, no direct …

Cholera Toxin B Subunit-Diabetes Autoantigen Fusion Proteins Modulate Dendritic Cell Function And T Cell Morphogenesis, Oludare Jeremiah Odumosu

Loma Linda University Electronic Theses, Dissertations & Projects

Type 1 diabetes mellitus is a chronic inflammatory disease in which the insulin and glutamic acid decarboxylase producing β-cells of the pancreatic islets are killed by autoreactive cells of the immune system in response to a loss of tolerance. Early experiments showed that self-tolerance could be partially restored by oral inoculation with small amounts of insulin. Later experiments showed that insulin autoantigen induced immune tolerance could be greatly enhanced by linkage of β-cell autoantigens (Auto Ag) to adjuvant molecules such as the non-toxic cholera enterotoxin B subunit (CTB). To identify mechanisms responsible for CTB-autoantigen fusion protein suppression of diabetes autoimmunity, …

Foundation For Evaluating Injured Firefighters Returning To Work, Deanna Stover

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to establish a foundation for developing an evidence-based assessment guideline to be used by nursing and medical personnel when evaluating a firefighter's ability to return to work after a lower extremity injury. Two on-line survey instruments were used to record the opinions and beliefs of healthcare providers and firefighters. The final samples included 63 California healthcare providers (with and without professional work experience with firefighters) and 312 California firefighters. Most of the healthcare providers with professional work experience with firefighters use the National Fire Protection Association (NFPA) 1582 Standard on Comprehensive Occupational Medical Program …

African Americans With Diabetes: Couples’ Support Program Development Project, Zanetta Fern Carlene Van Putten

Loma Linda University Electronic Theses, Dissertations & Projects

Diabetes is reaching epidemic proportions in the United States with a record 25.8 million diagnosed in 2010 compared to 20.8 million in 2005. African Americans have the highest prevalence of diabetes in the United States. Social support related to medical conditions has been found effective in increasing treatment adherence. The purpose of this study is to gain a clearer understanding of diabetes support within African American couples’ relationships. This study explores the definition of support from the perspective of African American couples when at least one member has been diagnosed with diabetes. Couples were recruited from Riverside and San Bernardino …

Child And Family Responses To Weight Management Programs : A Qualitative Investigation, Andra Lynn Fjone

Loma Linda University Electronic Theses, Dissertations & Projects

Introduction: The purpose of this study is to explore what happens within families in which a child participates in a pediatric weight management program for the treatment of overweight or obesity and identify strategies and processes for successful weight management.

Method: A qualitative approach was used to collect data from seven families. Individual interviews were conducted with parents, target children, and siblings. Data was analyzed within families and compared between families.

Results: Grounded theory analysis revealed three major essential themes: Shared Burden, Family Congruence, and Collaboration. Descriptive analysis was used to identify recommendations for improving family based weight management programs. …

The Association Of Religious Coping On Reports Of Low Back Pain And Inflammatory Markers, Jacqueline D. Bougie

Loma Linda University Electronic Theses, Dissertations & Projects

Chronic pain is the most common cause of disability in the United States with depression, anxiety, and stress often occurring co-morbidly. The purpose of the study was to explore how religion may modulate the frequency of back pain, influence inflammatory markers, influence the use of medications, and impact functional ability.

Participants were from the Biological Manifestations of Religion Study (BioMRS; N= 508) and the Psychological Manifestations of Religion Study (PsyMRS; N = 10,988). All participants completed a 20-page questionnaire and BioMRS participants provided blood, salivary, and urine samples, performance tests, and learning tests all collected within 1 week of …

A High Fiber Diet Versus A Low-Carbohydrate Diet For Weight Loss In Obese Individuals With Or Without Type 2 Diabetes, Neal G. Malik

Loma Linda University Electronic Theses, Dissertations & Projects

In the United States, obesity rates have climbed steadily over the years. Many different diets for weight loss have been proposed and studied, yet no one diet seems to clearly be more beneficial. Among diets that have been promoted are those high in fiber and low in carbohydrates, yet thus far, results of these studies have been mixed.

Using a 2x2 complete factorial design, 173 obese men and women with or without type 2 diabetes were randomized to one of two conditions: (a) a high fiber diet (> 40 grams of fiber per day for women, >50 grams of fiber …

Perceived Barriers And Benefits Of Hiv Voluntary Counseling And Testing Among University Students In Nigeria, Clara Egbealele Omogbai

Loma Linda University Electronic Theses, Dissertations & Projects

Background. Nigeria, the most populous country in Africa is one of the sub- Saharan nations most affected by HIV and AIDS. However, due to stigma most people at risk of infection refuse testing, thereby likely increasing the transmission of HIV. Voluntary counseling and testing (VCT) has been shown to influence behavior change and it is important to explore how to increase rates of VCT in young people who may experiment with sexual activity in this environment that holds increased risks due to nationally elevated rates of HIV.

Purpose. To examine intention to use HIV voluntary counseling and testing (VCT) services …

Marital Experience And Spirituality Among Physician Couples, Elisabeth Vonegen Esmiol

Loma Linda University Electronic Theses, Dissertations & Projects

This study will examine how marital experience and spirituality interact in the lives of physician couples. Physicians’ increasing openness to spiritual issues inherent in treating the ill and suffering (King, 2000; Thorsen, Harris & Oman, 2001), the growing number of women entering the medical profession and becoming physician and dual physician couples (Levinson & Lurie, 2004; Brotherton & Etzel, 2008), and physicians’ work-related stress (Transue, 2004; Wicks, 2006) and the resulting pressures and time constraints on medical marriages (Sotile & Sotile, 2000) make studying this population particularly relevant. Interviews with twenty two married, professional couples, in which at least one …

The Relation Of Fitness Assessment Feedback To Intrinsic Motivation And Physical Activity Among College Students, Laura Chandler

Loma Linda University Electronic Theses, Dissertations & Projects

Physical inactivity is a major public health concern in the United States and is no less of a concern among college students. According to the 2000 National College Health Assessment, as cited by Kilpatrick, Herbert, and Bartholomew (2005), only 38% of college students participate in regular vigorous activity, and only 20% participate in regular moderate activity. This study focused on how fitness assessment results affect intrinsic motivation for physical activity in college students. The specific mechanism examined was that between the constructs of intrinsic motivation, competence and autonomy from the self determination theory (SDT) and cognitive evaluation theory (CET). Approximately …

Relationship Of Vitamin D Levels To Blood Pressure In A Biethnic Cohort, Rosario O. Sakamoto

Loma Linda University Electronic Theses, Dissertations & Projects

Background: Serum hydroxyvitamin D [25(OH)D] has been well-accepted as not an ordinary vitamin but a pro-hormone that has many benefits beyond its well-known effects on bone. Cardiovascular risk factors such as hypertension remain a huge health burden and Blacks have been recognized to have higher prevalence of hypertension compared to non-Hispanic Whites. Despite increasing evidence of the benefits of vitamin D on blood pressure control, there is much more to be learned about the relationship of serum 25(OH)D to blood pressure among different ethnicities.

Purpose: The goal of this study was to determine whether vitamin D serum 25(OH)D levels were …

Predicting Mammography Screening And Breast Self-Examination Among Hispanic And Non-Hispanic White Women In Orange County, California, Sanam Kazemi

Loma Linda University Electronic Theses, Dissertations & Projects

Background and Purpose. Breast cancer is the second leading cause of cancer deaths among Hispanic/Latina women who are one of the fastest growing ethnic groups in the United States. Although Hispanic women have a lower incidence of breast cancer when compared to non-Hispanic White women, they are more likely to develop breast cancer at an advanced stage. In California, Hispanic women have the lowest rate of insurance coverage compared to other ethnic groups.

Method. The study was a cross-sectional observational study among Hispanic/Latino and non-Hispanic White women, ages 30-64 years. I examined intention to obtain a mammogram or breast self-exam …

Success With Compassion: Peripheral Intravenous Cannulation In The Pediatric Population, Joanne Dinatale Bsn, Rn, Oncc, Marcia Summers Msn, Rn, April Saboe Bsn, Rn.

Patient Care Services / Nursing

No abstract provided.

Evaluation Of Prevalence Of Low And High Level Mupirocin Resistance In Methicillin Resistant Staphylococcus Aureus Isolates At A Tertiary Care Hospital, Summiya Nizamuddin, Seema Irfan, Afia Zafar

Department of Pathology and Laboratory Medicine

OBJECTIVE: To evaluate the trend of mupirocin resistance in MRSA, isolated at the Clinical Microbiology Laboratory of a tertiary care hospital.

METHODS: A total of 200 MRSA strains recovered over a 2 year period from various body sites were tested using the 5 and 200 microg discs of mupirocin to detect its resistance.

RESULTS: High level and low level mupirocin resistance were detected in zero and 1% of MRSA strains, respectively. Resistance to other non beta lactam antibiotics was also high. No MRSA strains were found to be resistant to vancomycin and tegicycline.

CONCLUSION: Mupirocin resistance was found to be …

Analysis Of Vertical Ground Reaction Force Variables During A Sit To Stand Task In Participants Recovering From A Hip Fracture, Jeff R. Houck, Janet Kneiss, Susan V. Bukata, J. Edward Puzas

Faculty Publications - College of Physical Therapy

Background: A Sit to Stand task following a hip fracture may be achieved through compensations (e.g. bilateral arms and uninvolved lower extremity), not restoration of movement strategies of the involved lower extremity. The primary purpose was to compare upper and lower extremity movement strategies using the vertical ground reaction force during a Sit to Stand task in participants recovering from a hip fracture to control participants. The secondary purpose was to evaluate the correlation between vertical ground reaction force variables and validated functional measures.

Methods: Twenty eight community dwelling older adults, 14 who had a hip fracture and 14 control …

Developing Interprofessional Collaboration: An Action Research Approach To Change In Residential Care, Denise F. O Leary

Theses

This thesis presents a study which aimed to develop interprofessional teams to drive organisational change at residential care facilities in order to gain insight into the processes involved, as well as the factors influencing them. It is unrealistic to create a team and expect team members to immediately act in a collaborative way to address team goals, yet the development process has been largely overlooked in the literature. This thesis addresses this gap. Healthcare providers at three residential care facilities for older people were invited to become involved in the study and teams were successfully set up at two facilities. …

Editorial, Alok Kumar

Indian Journal of Research in Homoeopathy

No abstract provided.

Putative Protective Effect Of Cadmium Chloride High Diluted Solution On Llc-Pk1 Cell Intoxicated By High Concentration Of This Same Metal: An Isopathic In Vitro Assay, Roberta Ghilosso-Bortolini, Leoni Bonamin, Carla Holandino

Indian Journal of Research in Homoeopathy

Cadmium is an important toxic environmental heavy metal. Several studies have demonstrated that a major site of cadmium toxicity in humans and in other animals is the proximal tubule of the kidney. A well established model for nephrotoxicity is the use of in vitro technique with proximal tubule epithelial cell lines, as LLC-PK1. Herein, we have the intention to study the possible protective effect of high diluted CdCl2 solutions. In a blinding way, LLC-PK1 cells were pre-treated with high diluted Cadmium chloride in the potencies 10cH, 15cH and 20cH. After 4 days, these cells have received CdCl2 in a pre-determined …

Standardisation Of Homoeopathic Drug - Aquilegia Vulgaris L, H Gupta, P Subramanian, P Rao, J Raj, Santosh Sharma

Indian Journal of Research in Homoeopathy

In this present investigation, drug standardization studies are undertaken for quality assurance of a homoeopathic drug Aquilegia vulgaris. In Homoeopathy, it has been reported to have clinical indications for clavus hystericus and globus hystericus in women, sleeplessness and dysmenorrhoea. To establish the drug in the system, the standardization studies are mandatory and the useful parts of the plant drug are analyzed according to the standards of Homoeopathic Pharmacopoeia of India. The pharmacognostic and physico-chemical studies of the leaf and petiole are undertaken in present study. The diagnostic macro and microscopical characters of leaf and petiole, moisture content, ash and extractive …

A Case Of Colloidal Nodular Goiter, Bindu Sharma

Indian Journal of Research in Homoeopathy

Most thyroid nodules are asymptomatic. Visible nodules are of great concern to the patient because of the cosmetic embarrassment they cause. Affected patients are euthyroid i.e. serum T3, T4 & TSH are normal. A case of colloidal nodular goiter presented at Regional Research Institute (RRI) (H), Shimla. Her thyroid profile was within normal range and Fine Needle Aspiration Cytology was clearly suggestive of colloidal nodular goiter. Partial thyroidectomy was advised due to cosmetic reasons. The fear of surgery brought the patient to RRI (H), Shimla for treatment. She was treated with homoeopathic medicines following holistic concepts of Homoeopathy and the …

Mediator Influences Telomeric Silencing And Cellular Life Span, Xuefeng Zhu, Beidong Liu, Jonas O. P. Carlsten, Jenny Beve, Thomas Nyström, Lawrence C. Myers, Claes M. Gustafsson

Dartmouth Scholarship

The Mediator complex is required for the regulated transcription of nearly all RNA polymerase II-dependent genes. Here we demonstrate a new role for Mediator which appears to be separate from its function as a transcriptional coactivator. Mediator associates directly with heterochromatin at telomeres and influences the exact boundary between active and inactive chromatin. Loss of the Mediator Med5 subunit or mutations in Med7 cause a depletion of the complex from regions located near subtelomeric X elements, which leads to a change in the balance between the Sir2 and Sas2 proteins. These changes in turn result in increased levels of H4K16 …

System-Wide Deployment Of Color Coded Pediatric Resuscitation Carts Supported By In Situ Simulation, Deborah Arnold Msn, Rn, Cmsrn, Jayne Febbraro Msn Rn Crnp, William Bond Md, Ms, Michele Dunstan, Margaret J. Chorazak, Melissa B. Walsh Bs, K Walker, T Dietz

Department of Education

No abstract provided.

Obesity And Other Predictors Of Absenteeism In Philadelphia School Children., Elizabeth B Rappaport, Constantine Daskalakis, Jocelyn Andrel

Department of Family & Community Medicine Faculty Papers

BACKGROUND: Limited data indicate that obese children are absent from school more than their normal-weight peers. We analyzed administrative data from a large urban school district to investigate the association of obesity and student sociodemographic characteristics with absenteeism.

METHODS: We analyzed 291,040 records, representing 165,056 unique students (grades 1-12). Obesity status was classified according to Centers for Disease Control and Prevention age- and sex-specific percentiles for body mass index (BMI) and analyses were based on negative binomial regression.

RESULTS: Overall rates of overweight and obesity were 17% and 20%, respectively, and the estimated absence rate was 17 absences per 180 …

Andrographis Paniculata - A Multicentric, Randomized, Double-Blind Homoeopathic Pathogenetic Trial, Rajpal Rajpal, Vinay Singh, B Dutta, S Das, P Mal, A Bhakat, R Roy, C Chaudhary

Indian Journal of Research in Homoeopathy

Objective: To elicit the pathogenetic response of the drug Andrographis paniculata in homoeopathic potencies on healthy human beings. Methodology: Drug Andrographis paniculata was proved by the Central Council for Research in Homoeopathy through double-blind, randomized, placebo-controlled method. The study was conducted at three centers. The drug was proved in two potencies (6C and 30C) on 39 apparently healthy volunteers who were selected after conducting pre-trial medical examination by the medical specialists and routine laboratory investigations. In the first phase volunteers were given 56 doses (04 doses per day for 14 days) of placebo. In the next two phases 56 doses …

Cassia Fistula - A Multicentric Clinical Verification Study, P Chakraborty, Subhash Kaushik, R Ray, R Yadav, M Rai, Darshan Singh, A Bhakat, V Singh, John

Indian Journal of Research in Homoeopathy

Objectives: The primary objective was to clinically verify the symptomatology of Cassia fistula as observed during its proving conducted by the Council earlier. The secondary objective was to ascertain the clinical symptoms. Methods: In this multicentre study, a total of 129 patients from all age groups and of both sexes were drawn from the OPDs of respective institutes and units of the Council, following the inclusion and exclusion criteria as per protocol and obtaining the written consent from the patients. Their presenting signs and symptoms were recorded in a predefined case recording proforma. Special attention was paid to the circumstances …

A Multicentre Observational Study To Ascertain The Role Of Homoeopathic Therapy In Urolithiasis, V Siddiqui, Hari Singh, Jaya Gupta, C Nayak, Vikram Singh, M Sinha, A Gupta, Paul Sumithran, M Rai

Indian Journal of Research in Homoeopathy

Study was aimed to ascertain the role of homoeopathic medicines in Urolithiasis. A prospective, multicentre observational study was conducted by Central Council for Research in Homoeopathy (CCRH) from October 2005 to January 2010 to find the usefulness of homoeopathic medicines in cases of Urolithiasis. 901 cases were screened, out of which 311 cases were enrolled and 220 cases were analyzed in this study. The symptoms pertaining to urolithiasis were assessed before and after treatment. Pain, Dysuria and Haematuria were graded from 0-3 as per severity of complaints. Calculi were graded as per Number, Size and Position of calculi. The difference …

Stem Cells And Tissue Engineering In Dentistry — A Myth Or Reality, Farhan Raza Khan, Tashfeen Ahmad, Nurrudin Badruddin

Section of Dental-Oral Maxillofacial Surgery

No abstract provided.

Immune Evasion Of Porcine Reproductive And Respiratory Syndrome Virus Through Glycan Shielding Involves Both Glycoprotein 5 As Well As Glycoprotein 3, Hiep Vu, Byungjoon Kwon, Kyoung-Jin Yoon, William W. Laegreid, Asit K. Pattnaik, Fernando A. Osorio

School of Veterinary and Biomedical Sciences: Faculty Publications

Passive administration of porcine reproductive and respiratory syndrome virus (PRRSV) neutralizing antibodies (NAbs) can effectively protect pigs against PRRSV infection. However, after PRRSV infection, pigs typically develop a weak and deferred NAb response. One major reason for such a meager NAb response is the phenomenon of glycan shielding involving GP5, a major glycoprotein carrying one major neutralizing epitope. We describe here a type II PRRSV field isolate (PRRSV-01) that is highly susceptible to neutralization and induces an atypically rapid, robust NAb response in vivo. Sequence analysis shows that PRRSV-01 lacks two N-glycosylation sites, normally present in wild-type (wt) PRRSV strains, …

The Risk Factor Profile Of Women With Secondary Infertility: An Unmatched Case-Control Study In Kigali, Rwanda, Nathalie Dhont, Stanley Luchters, Claude Muvunyi, Joseph Vyankandondera, Ludwig De Naeyer, Marleen Temmerman, Janneke Van De Wijgert

Population Health, East Africa

Background: Secondary infertility is a common, preventable but neglected reproductive health problem in resource-poor countries. This study examines the association of past sexually transmitted infections (STIs) including HIV, bacterial vaginosis (BV) and factors in the obstetric history with secondary infertility and their relative contributions to secondary infertility.

Methods: Between November 2007 and May 2009 a research infertility clinic was set up at the Kigali University Teaching Hospital in Rwanda. Cases were defined as sexually-active women aged 21-45 years presenting with secondary infertility (n = 177), and controls as multiparous women in the same age groups who recently delivered …