Medicine and Health Sciences Commons^™

Effects Of Perceived Fitness Level Of Exercise Partner On Intensity Of Exertion, Thomas G. Plante, Meghan Madden, Sonia Mann, Grace Lee

Psychology

Problem statement: Social comparison theory was used to examine if exercising with a research confederate posing as either high fit or low fit would increase the exertion in exercising. Approach: 91 college students were randomly assigned to one of three conditions: Biking alone, biking with a high fit confederate, or biking with a low fit confederate. All participants were instructed to complete 20 min of exercise at 60-70% of their maximum target heart rate. Results: Results indicated that participants in the high fit condition exercised harder than those in the low fit condition. However, no mood differences emerged between conditions. …

Today - March 31, 2010, Loma Linda University

TODAY

Inside this issue:

-- Lifestyle and chronic diseases discussed at Healthy People 2010
-- Walter's Children's Charity Classic raises $200,000 for pediatric ophthalmology
-- Strengthening Hospital Adventiste d'Haiti
-- Pediatric RN residents celebrate with Drs. Clark and Seuss
-- Public health student speaks at One Young World Summit
-- The renewal of spiritual emphasis at Loma Linda University in the 1970s
-- LLU summer internship and management residency programs continue to shape the Adventist health care, business, and communication leaders of tomorrow
-- LLU prepares county environmental health departments
-- Children's Assessment Center combats the effects of sexual child abuse …

Les Risques De Troubles Musculo-Squelettiques Aux Membres Supérieurs Dans Le Secteur Des Services À L’Automobile : Étude Exploratoire, Denis Marchand, Denis Giguère

Rapports de recherche scientifique

Les troubles musculosquelettiques aux membres supérieurs (TMS-MS) comptaient en moyenne au Québec, entre 1998 et 2002, pour 8,7 % de l’ensemble des lésions compensées du secteur des Services à l’automobile, mais représentaient 14,9 % des jours d’arrêt de travail et 13,8 % des déboursés totaux de compensation. Une analyse de l’activité de travail réalisée sur quatre postes au Québec et dans cinq garages aux États-Unis, ainsi qu’une étude sur les postures dans 42 garages en Europe, faisait état de la présence de plusieurs des facteurs de risque associés à ce type de lésion, dont la répétition des gestes, le travail …

Molecular Cross Talk Between Misfolded Proteins In Animal Models Of Alzheimer's And Prion Diseases, Rodrigo Morales, Lisbell D Estrada, Rodrigo Diaz-Espinoza, Diego Morales-Scheihing, Maria C Jara, Joaquin Castilla, Claudio Soto

Faculty, Staff and Student Publications

The central event in protein misfolding disorders (PMDs) is the accumulation of a misfolded form of a naturally expressed protein. Despite the diversity of clinical symptoms associated with different PMDs, many similarities in their mechanism suggest that distinct pathologies may cross talk at the molecular level. The main goal of this study was to analyze the interaction of the protein misfolding processes implicated in Alzheimer's and prion diseases. For this purpose, we inoculated prions in an Alzheimer's transgenic mouse model that develop typical amyloid plaques and followed the progression of pathological changes over time. Our findings show a dramatic acceleration …

Synthesis, Biological Evaluation, And Molecular Modeling Studies Of 1-Aryl-1h-Pyrazole-Fused Curcumin Analogues As Anticancer Agents, L Curtis, P Datta, X Liu, N Bogdanova, R Heidelberger, R Janz

Faculty, Staff and Student Publications

Ribbon synapses of the vertebrate retina are specialized synapses that release neurotransmitter by synaptic vesicle exocytosis in a manner that is proportional to the level of depolarization of the cell. This release property is different from conventional neurons, in which the release of neurotransmitter occurs as a short-lived burst triggered by an action potential. Synaptic vesicle exocytosis is a calcium regulated process that is dependent on a set of interacting synaptic proteins that form the so-called SNARE (soluble N-ethylmaleimide sensitive factor attachment protein receptor) complex. Syntaxin 3B has been identified as a specialized SNARE molecule in ribbon synapses of the …

Motor Output Evoked By Subsaccadic Stimulation Of Primate Frontal Eye Fields., Brian D Corneil, James K Elsley, Benjamin Nagy, Sharon L Cushing

Brain and Mind Institute Researchers' Publications

In addition to its role in shifting the line of sight, the oculomotor system is also involved in the covert orienting of visuospatial attention. Causal evidence supporting this premotor theory of attention, or oculomotor readiness hypothesis, comes from the effect of subsaccadic threshold stimulation of the oculomotor system on behavior and neural activity in the absence of evoked saccades, which parallels the effects of covert attention. Here, by recording neck-muscle activity from monkeys and systematically titrating the level of stimulation current delivered to the frontal eye fields (FEF), we show that such subsaccadic stimulation is not divorced from immediate motor …

The Influences Of Matrix Metalloproteinase-1 Expression On Glioblastoma Pathology, Nicholas Pullen

Theses and Dissertations

Glioblastoma multiforme (GBM) is an aggressive central nervous system (CNS) cancer characterized by enhanced tumor cell motility, pernicious invasion into the normal brain, extensive tumor-induced angiogenesis, and adaptive resistance to current therapeutic paradigms. One of the difficulties associated with GBM is the ability of the tumor cells to infiltrate normal CNS tissue. Neurosurgeons can remove the primary tumor mass, but peripheral cells that are inaccessible will ultimately result in a secondary lesion that can lead to death. The matrix metalloproteinases (MMP) are well known for their abilities to facilitate processes of cellular motility and invasion through their clearance of extracellular …

Locus Of Control And The Age Difference In Free Recall From Episodic Memory, Paul Amrhein, Judith K. Bond, Derek Hamilton

Department of Psychology Faculty Scholarship and Creative Works

The authors investigated the relation of locus of control (LOC) to age differences in free-recall memory performance. Older and younger participants completed P. C. Duttweiler's (1984) Internal Control Index (ICI) and subsequently performed free-recall memory tasks. Compared with the younger participants, the older participants exhibited poorer recall with more intrusions and uncorrected repetition errors as well as reduced categorical clustering. For the older participants with less internal LOC, recall proportion and item-pair associative recall clustering were lower than for the older participants with more internal LOC. By contrast, the younger participants did not exhibit any LOC effects in their recall …

Improving Health Outcomes For Children (Ihoc) In Maine Logic Model For Primary Care Practice Improvement, Cutler Institute Of Health And Social Policy

Population Health & Health Policy

Improving Health Outcomes for Children (IHOC) is a 5-year demonstration grant from the Centers for Medicare & Medicaid Services, and authorized by 401 (d) of the Children's Health Insurance Program Reauthorization Act of 2009 (CHIPRA).

IHOC works with doctors' offices, practices and other agencies who want to improve health care in Maine and Vermont to:

• Collect and report on the use of evidenced-based child health quality measures
• Expand the Health Information Technology to improve the flow of child health data
• Promote a collaborative child health learning environment

Who Guidelines For Antimicrobial Treatment In Children Admitted To Hospital In An Area Of Intense Plasmodium Falciparum Transmission: Prospective Study, Behzad Nadjm, Ben Amos, George Mtove, Jan Ostermann, Semkini Chonya, Hannah Wangai, Juma Kimera, Walii Msuya, Frank Mtei, Denise Dekker, Rajabu Malahiyo, Raimos Olomi, John A. Crump, Christopher J. M. Whitty, Hugh Reyburn

Faculty Publications

Objectives To assess the performance of WHO’s “Guidelines for care at the first-referral level in developing countries” in an area of intense malaria transmission and identify bacterial infections in children with and without malaria.

Design Prospective study.

Setting District hospital in Muheza, northeast Tanzania.

Participants Children aged 2 months to 13 years admitted to hospital for febrile illness.

Main outcome measures Sensitivity and specificity of WHO guidelines in diagnosing invasive bacterial disease; susceptibility of isolated organisms to recommended antimicrobials.

Results Over one year, 3639 children were enrolled and 184 (5.1%) died; 2195 (60.3%) were blood slide positive for Plasmodium falciparum …

The State Health Insurance Assistance Program (Ship), Carol O'Shaughnessy

National Health Policy Forum

The State Health Insurance Assistance Program (SHIP), created by section 4360 of the Omnibus Budget Reconciliation Act (OBRA) of 1990 and administered by the Centers for Medicare & Medicaid Services (CMS), supports grants to states and jurisdictions to provide information, counseling, and assistance to Medicare beneficiaries and their families on Medicare and other health insurance questions. This publication describes the program and presents its funding history.

Oral Health Checkup: Progress In Tough Fiscal Times?, Cynthia Shirk

National Health Policy Forum

Almost ten years after the surgeon general’s report designating dental disease as the “silent epidemic,” the nation continues to struggle with adequate access to and utilization of dental services. This is particularly true for low-income individuals, who experience more than twice the amount of untreated dental disease as their higher-income peers. This issue brief reviews sources of dental coverage for low-income children and adults and the challenges these programs face. It highlights some examples of state Medicaid initiatives to improve access and utilization for children and the progress of these initiatives. Finally, it examines the potential effects of the economy …

Medical School Watercooler Newsletter - March 28, 2010, Lindsey Lyle

Watercooler Newsletter

This is the March 28, 2010 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• USA Physicians Group To Implement EMR System
• U.S. Army Honors COM Alum
• Upcoming Professional Conferences In April
• Scientific Foundations for Future Physicians: Report of the AAMC-HHMI Committee

School Food Services And Childhood Obesity: Is There A Link?, Christine M. Spiker

Florida Public Health Review

Childhood overweight and obesity have increased three-fold since 1980, and there is minimal evidence of any leveling off. Research has found that many school food programs are not sufficiently providing adequate nutrients and providing far too many calories and fat. Competitive foods are widely available in many schools which may possibly contribute to increased weight and body mass index (BMI) in students. This has put school food programs under scrutiny as a contributor to the childhood obesity crisis being faced. Schools can promote healthier eating by improving school meals, but most are forced to sell competitive foods to support their …

Application Of A Leadership Approach To Address Suicide Among Gay, Lesbian And Bisexual Youth, Katherine Davis

Florida Public Health Review

Suicide, esepcially among youth, is a significant public health issue, ranking as the third leading cause of death among youth and young adults between the ages of 10 and 24. Suicide attempts and successful suicides are more frequent occurrences in the gay, lesbian,and bisexual (GLB) population. Despite this heightened risk, sexual orientation is omitted from important documents that detail suicide risk factors. Moreover, few schools have programs that address the unique needs of GLB youth that could create a more receptive or tolerant, and less threatening environment for them. In this paper, Kotter’s eight-stage framework for leadership is explored for …

Hiv Prevention And Education: Leadership And Implications For African-American Churches, Khaliah F. Fleming

Florida Public Health Review

This paper illustrates use of John Kotter’s eight-stage process for creating change through leadership its potential for aiding African-American churches in addressing rising HIV/AIDS rates. The focus is on churches due to their large influence on the African-American community. Knowing that there are multiple influences surrounding HIV/AIDS, it is useful to highlight how certain ideological and theological factors are contributing to the current state of African-American churches work to increase HIV/AIDS awareness, prevention, and education.

Leadership, Leadership Paradigms, And Leadership Training In 2010 And Beyond, Robert J. Mcdermott

Florida Public Health Review

Since 2008, the Florida Public Health Review (FPHR) has published student essays that attempt to illustrate how the application of specific leadership paradigms might, in theory, be applied to address some nagging and ongoing problems in public health and related endeavors. The current volume of the FPHR continues that tradition. Other public health students, faculty, and practitioners from around the state are invited to contribute ideas that foster leadership skills and the development of dynamic leaders.

Predictors Of Retention In Physical Therapy: Client-, Disease-, And Treatment-Related Factors, Marc A. Silva

Counselor Education and Counseling Psychology Research Exchange Conference

OBJECTIVES: The objectives of the study are to (1) document the incidence of veterans who prematurely terminate physical therapy before medically indicated, and (2) identify reliable predictors of treatment retention and attrition. The potential benefit of this study is the identification of reliable variables that predict who is at risk for terminating physical therapy prematurely, which may lead to targeted interventions designed to increase treatment retention. RESEARCH DESIGN: This study will be a retrospective design involving a review of medical records of veterans receiving referral to physical therapy. METHODOLOGY: Multinomial logistic regression (MLR) will be used to examine the effects …

Client-Treatment Matching In Substance Use Disorder Treatment: A Delphi Study, Noah Elijah Adrians

Counselor Education and Counseling Psychology Research Exchange Conference

Client-treatment matching (CTM) practices have been identified as important in enhancing substance use disorder (SUD) treatment outcomes while also minimizing the investment of time and resources necessary to achieve such outcomes. Despite strong positive effects associated with CTM, many questions remain regarding how CTM is implemented in treatment settings. This dissertation examines expert perspectives on how CTM practices are implemented in real world treatment settings, how to improve upon current practices, barriers to improvement, strategies for overcoming barriers, and consequensces of existing treatment system flaws. In this study, qualitative and quantitative data will be collected and analyzed through an iterative …

Latino Family Variables And Sexual Activity In Latino Adolescents, Brittany Nicole Barber

Counselor Education and Counseling Psychology Research Exchange Conference

Researchers’ focused examination of Latino adolescents’ cultural values and sexual activity has yielded questions regarding the cultural- and gender-specific attitudes and practices of these youth (Deardorff, Tschann, & Flores, 2008). Cultural values include family-related variables such as different aspects of familism, parent-adolescent communication, and parental monitoring, which have been found to decrease adolescents’ engagement in other negative activities such as aggressive behavior, (Dishion & McMahon, 1998), substance use (Estrada, Rabow, & Watts, 1982), and delinquency (Clark & Shields, 1997). Research investigating these risk behaviors has often implicated Latino adolescents’ level of assimilation to White, mainstream society as a potential risk …

Language Outcome After Left Anterior Temporal Lobectomy In Patients With Discordant Functional Magnetic Resonance Imaging And Intracarotid Sodium Amobarbital Testing Results, Julie K. Janecek

Counselor Education and Counseling Psychology Research Exchange Conference

Language Outcome after Left Temporal Anterior Lobectomy in Patients with Discordant Functional Magnetic Resonance Imaging and Intracarotid Sodium Amobarbital Testing Results Rationale: Previous research has examined concordance rates between Wada and fMRI language lateralization indices (LIs) and has yielded variable results with limited post-surgical language outcome data. Therefore, additional evidence of the concurrent and predictive validity of fMRI LIs is needed. We will calculate Wada/fMRI LI concordance rates in the largest sample to date, investigate predictors of discordance and examine the ability of each procedure to predict language outcome in discordant cases. Methods: A consecutive series of 229 presurgical epilepsy …

Seeking Safety Group Proposal For Posttraumatic Stress Disorder And Co-Occurring Substance Use Disorder, Caryn P. Brakenridge

Counselor Education and Counseling Psychology Research Exchange Conference

Reports on rates of PTSD among women receiving treatment for substance use disorders (SUDs) ranges from 20% to as much as 59%. Research however has shown that fewer than half of women with SUDs will receive treatment that addresses their PTSD symptoms. Research over the past three decades has shown an increased interest in individuals diagnosed with posttraumatic stress disorder (PTSD) using group psychotherapy. However, group psychotherapy approaches for co-occurring PTSD and substance use disorders are not as well developed. This proposal suggests the creation of a psychotherapy group for women suffering from SUDs with co-occurring PTSD symptoms. The group …

Nurses Of 2010: The Dichotomy Between Continuity Of Patient Care And Nursing Fatigue As Related To Shift Length, Christy Kurtz

Capstone Research Projects

Nursing shift lengths are widely debated, and the implications on both nurse and patient safety are quite large. This work seeks to present a current review of literature describing the current work schedules of nurses in comparison to the Institute of Medicine’s 2004 recommendations and both the positive and negative effects that these schedules have on nurses and their patients. Eleven studies from the past five years (2004-2009) are included, with particular emphasis on those studies that address the dispute between continuity of care and nursing fatigue. Results show that nurses are regularly working longer than is recommended, and this …

Neuropilin 1 Directly Interacts With Fer Kinase To Mediate Semaphorin3a-Induced Death Of Cortical Neurons, Susan X. Jiang, Shawn N. Whitehead, Amy Aylsworth, Bogdan Zurakowski, Kenneth Chan, Jianjun Li, Sheng T. Hou

Anatomy and Cell Biology Publications

Neuropilins (NRPs) are receptors for the major chemorepulsive axonal guidance cue semaphorins (Sema). The interaction of Sema3A/NRP1 during development leads to the collapse of growth cones. Here we show that Sema3A also induces death of cultured cortical neurons through NRP1. A specific NRP1 inhibitory peptide ameliorated Sema3A-evoked cortical axonal retraction and neuronal death. Moreover, Sema3A was also involved in cerebral ischemia-induced neuronal death. Expression levels of Sema3A and NRP1, but not NRP2, were significantly increased early during brain reperfusion following transient focal cerebral ischemia. NRP1 inhibitory peptide delivered to the ischemic brain was potently neuroprotective and prevented the loss of …

Isoform-Specific Regulation And Localization Of The Coxsackie And Adenovirus Receptor In Human Airway Epithelia, Katherine J.D.A. Excoffon, Nicholas D. Gansemer, Matthew E. Mobily, Philip H. Karp, Kalpaj R. Parekh, Joseph Zabner

Biological Sciences Faculty Publications

Adenovirus is an important respiratory pathogen. Adenovirus fiber from most serotypes co-opts the Coxsackie-Adenovirus Receptor (CAR) to bind and enter cells. However, CAR is a cell adhesion molecule localized on the basolateral membrane of polarized epithelia. Separation from the lumen of the airways by tight junctions renders airway epithelia resistant to inhaled adenovirus infection. Although a role for CAR in viral spread and egress has been established, the mechanism of initial respiratory infection remains controversial. CAR exists in several protein isoforms including two transmembrane isoforms that differ only at the carboxy-terminus (CAR^Ex7 and CAR^Ex8). We found low-level …

Virus-Triggered Ubiquitination Of Traf3/6 By Ciap1/2 Is Essential For Induction Of Interferon- &Beta (Ifn-&Beta) And Cellular Antiviral Response, Ai-Ping Mao, Shu Li, Bo Zhong, Ying Li, Jie Yan, Qi Li, Chengwen Teng Pharm.D.. Ph.D, Hong-Bing Shu

Faculty Publications

Viral infection causes activation of transcription factors NF-κB and IRF3, which collaborate to induce type I interferons (IFNs) and cellular antiviral response. Here we show that knockdown of the E3 ubiquitin ligases cIAP1 and cIAP2 markedly inhibited virus-triggered activation of IRF3 and NF-κB as well as IFN-β induction. Knockdown of cIAP1 and cIAP2 also inhibited cytoplasmic dsRNA-triggered cellular antiviral response. Endogenous coimmunoprecipitation experiments indicated that viral infection caused recruitment of cIAP1 and cIAP2 to TRAF3, TRAF6, and VISA. Furthermore, we demonstrated that cIAP1- and cIAP2-mediated virus-triggered ubiquitination of TRAF3 and TRAF6. These findings suggest that virus-triggered ubiquitination of TRAF3 and …

Good-Bye, Pre-Existing Conditions!, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Is Uncompensated Care Affecting Quality Assurance Of Rural Hospitals?, Doohee Lee, Chris Dixon, Paul Kruszynski, Alberto Coustasse

Management Faculty Research

Healthcare disparities in rural areas remain significant in the U.S. healthcare industry. Uncompensated care makes healthcare disparities in rural areas worse and rural hospitals are unfavorably positioned to compete with urban hospitals in the economic downturn marketplace. How uncompensated care affects quality care among rural hospitals has been lightly investigated. As many rural residents experience difficulty accessing high quality care and the importance of establishing quality care practice standards in a rural setting, we conducted a systematic literature review to identify some quality care barriers and opportunities, suggested strategies to strengthen the position of rural hospitals in response to uncompensated …

A Matter Of Trust: The Impact Of Transcultural Communication Between Culturally Diverse Nursing Staff, Patricia Reed

Theses and Graduate Projects

The diversity in the U.S. population is increasing. Nurse Managers today are challenged by not only a changing health care system but also one that is more culturally diverse than ever. It is also important to recognize the influence culture has on personal relationships, productivity and performance. Expectations about work styles, communication patterns, role relationships, taking initiative and concepts of time are all examples of factors that are influenced by culture. The purpose of this project is to help nursing staff (registered nurses and patient care assistants) come to understand their cultural differences and how these differences impact their communication …

Omega-3 Fatty Acids: Potential Role In The Management Of Early Alzheimer's Disease, Gregory A. Jicha, William R. Markesbery

Sanders-Brown Center on Aging Faculty Publications

Omega-3 fatty acids are essential for brain growth and development. They play an important role throughout life, as critical modulators of neuronal function and regulation of oxidative stress mechanisms, in brain health and disease. Docosahexanoic acid (DHA), the major omega-3 fatty acid found in neurons, has taken on a central role as a target for therapeutic intervention in Alzheimer's disease (AD). A plethora of in vitro, animal model, and human data, gathered over the past decade, highlight the important role DHA may play in the development of a variety of neurological and psychiatric disorders, including AD. Cross sectional and prospective …