Medicine and Health Sciences Commons^™

Library Synthesis Of Anticancer And Antibacterial Agents Via Azide Chemistry, Jianjun Zhang

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Various anticancer and antibacterial agents have been synthesized via azide chemistry by taking advantage of carbohydrate. Starting from the synthesis of 14 glycosyl azides, a library of carbohydrate-oxazolidinone conjugates and a library of carbohydrate-cyclopamine conjugates with biological interests were synthesized based on a highly efficient "click reaction" assisted by sonication. Some of the conjugates have improved solubility and enhanced anticancer activity.

A library of neomycin B derivatives with various modifications at the 5" position has been synthesized. Two leads exhibit prominent activity against both methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). Antibacterial activities were measured when combined with other …

The Hypericum Perforatum Herb As An Antimycobacterial Agent And Its Implications As An Additional Tuberculosis Medication, Trent W. Mortensen

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

An immediate demand exists for new tuberculosis (TB) antibiotics due to the ever-increasing spread of drug-resistant strains. The drug-development process goes through four phases, the first (Phase 0) of which is to demonstrate and investigate drug effectiveness and toxicity. This research investigated the effectiveness of the Hypericum perforatum herb (commonly St. John's wort (SJW)) in its growth inhibition of mycobacteria and its viability effect on human lung cells.

Organic-solvent SJW extracts were effective at inhibiting every nonpathogenic genetically sequenced Mycobacterium isolate currently available (six isolates) in preliminary studies. Quantitative studies of five Mycobacterium isolates showed an order of concentration sensitivity …

Correlation Of Age-Specific Phenylalanine Levels On Intellectual Outcome In Patients With Phenylketonuria, Krista S. Viau

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This study includes data collected from a retrospective chart review of patients with phenylketonuria treated at the University of Utah Metabolic Clinic. Among the
approximately 175 patients treated for phenylketonuria at this clinic, 55 patients (28 female) met the inclusion criteria for the present study. Based on the diagnostic Phe
level, 66.7% were classified as having classic phenylketonuria, 18.5% with moderate phenylketonuria, and 14.8% with mild phenylketonuria.

Subjects’ cognitive status was measured with one of three neuropsychological tests: Wechsler Intelligence Scale for Children third and fourth editions and the Wechsler Adult Intelligence Scale third edition. Due to structural differences among …

The Ecological Influences Of Community Trail Use And Physical Activity Among Female Trail Users, Sarah N. Moulton

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Despite great effort to improve physical activity, little success has come to pass. Due to this, some researchers have shifted from individual approaches to promoting physical activity to multilevel environmental approaches. One of these multifaceted environmental approaches is through community trails. A small body of research has suggested that community trails may be a successful ecological approach to promoting physical activity. However, the research is minimal and inconsistent in supporting effectiveness of community trails for promoting physical activity.

This study sought to examine ecological factors to learn if and how they might influence trail use among women. The ecological factors …

The Effect Of Static Stretching And Order Of Warm-Up On The Isokinetic Peak Torque Of The Knee Extensors, Eric J. Sobolewski

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The purposes of these studies were to determine if an acute static stretch influenced isokinetic peak torque (IPT), and to examine if the order in which the warm up routine was performed affected peak knee extension torque. Twenty trained college male students performed maximal isokinetic knee extensions under four conditions: a control consisting of no stretching, a stretch only trial, jog then stretch, and stretch then jog conditions. Each stretch was held for a total volume of 360 s. Measurements were taken on a Biodex System 3 isokinetic dynamometer at speeds of 60º s^-1 and 300º s^-1. …

Thioester Hydrolysis Reactivity Of Metal Complexes, James Justin Danford

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Glyoxalase II is one of two metalloenzymes found in the glyoxalase pathway and is responsible for catalyzing the hydrolysis of a thioester substrate. Its bimetallic active site is found to contain a variety of metal combinations, including Fe(III)Zn(II). A recent report indicates that human glyoxalase II, while containing a Fe(II)Zn(II) center, is catalytically active as a mononuclear Zn(II) enzyme. Detailed mechanistic studies of glyoxalase II enzymes are limited due to uncertainty in the metal ion content of recombinantly prepared samples. The research presented in this thesis is focused on gaining mechanistic insight into thioester hydrolysis promoted by well-characterized metal complexes …

Relationship Between Cognitive Reserve And Rate Of Decline In Alzheimer’S Disease: A Population Study, Katherine Treiber

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

According to the theory of cognitive reserve, cognitively enriching aspects of life experience (e.g., education, occupation, and leisure activity) foster the development of more efficient neural networks and cognitive strategies, enabling individuals to cope more effectively with the pathology of dementia. Using extant data from a population-based study, we examined: (1) the effect of reserve accrued through middle life on course of neuropsychological decline; and (2) the role of ongoing engagement in mentally stimulating leisure activities in rate of general cognitive and functional deterioration.

In linear mixed models, level of occupational attainment did not affect rate of cognitive or functional …

The Effects Of Cellular Theta Breathing Meditation On Cell Mediated Immune Response: A Controlled, Randomized Investigation Of Altered Consciousness And Health, Marjorie D. Hardgrave

UNLV Theses, Dissertations, Professional Papers, and Capstones

Medical anthropology is well positioned to make contributions to consciousness research based on biocultural approaches that integrate methodologies from the biological, behavioral and social sciences to explore aspects of human health. The ubiquity and perseverance of health related activities involving altered states of consciousness (ASC) across cultures past and present suggest that these potentials are deeply rooted in human sociocultural evolution. Analyzing the relationship between immune function and meditative ASC represents an effort to empirically investigate the adaptive value of these human potentials.

A controlled, randomized investigation of two meditation practices was conducted at the University of Nevada, Las Vegas …

Implementation Of The Wiegand Sun Safety Program Into Physicians’ Offices In Southern Nevada, Breanne Eddington

UNLV Theses, Dissertations, Professional Papers, and Capstones

In this study Nevada Cancer Institute’s Wiegand Sun Safety Program was implemented in 14 clinics in Southern Nevada as a pilot run to increase awareness in children and their guardians through educational materials in pediatricians’ and family physicians’ offices. It was hypothesized that the increased display of information regarding sun safety and skin cancer in physicians’ offices would increase patient and guardian awareness of the subject and increase the likelihood of patients and/or guardians asking their physician questions about skin cancer and sun safety, resulting in an increase in preventive actions by guardians to protect their children from damaging rays …

Use Of An Animal Model To Explore Prenatal Predictors Of Insulin And Glucose Metabolism In Southwestern Alaskan Yupiit, Julie Jo Kachinski

UNLV Theses, Dissertations, Professional Papers, and Capstones

Compared to other North American indigenous populations, Southwest Alaskan Yupiit exhibit very low rates of type 2 diabetes despite the occurrence of common risk factors. Contemporary Yupiit obtain a substantial portion of their calories from traditional foods, which contain high amounts of omega-3 polyunsaturated fatty acids. Epidemiological and experimental animal research has linked glucose and insulin homeostasis with a diet high in omega-3s. This study used an experimental animal model to explore potential diabetes protective effects (for adult offspring) of prenatal maternal nutrition modeled on traditional locally-obtained Yupiit diets. The results of this study showed that the adult offspring whose …

Oral Cancer In Nevada: A Public Health Perspective, Karl Kingsley

UNLV Theses, Dissertations, Professional Papers, and Capstones

Cancer is the second leading cause of death in the United States, and oral cancer remains the eighth leading cause of cancer death among US males. Although previous epidemiologic studies have found that overall rates of cancer, including oral cancer, have declined in the US in recent decades – these declines are neither uniform nor consistent within this population. Anecdotal evidence has suggested that rates of oral cancer in Nevada are relatively high, although no evidence was available to support these assertions.

Oral Cancer Epidemiology: Based upon this information, a detailed and thorough epidemiologic examination of oral cancer rates in …

Self-Efficacy And The Predictors For Nclex-Rn® Success For Baccalaureate Nursing Students, Linda Anne Silvestri

UNLV Theses, Dissertations, Professional Papers, and Capstones

The National Council Licensure Examination for Registered Nurses (NCLEX) is the examination that nursing graduates must pass to attain the title of registered nurse and practice professionally. Each year a substantial number of nursing graduates are unable to enter the nursing profession because of failure on the NCLEX. Failure on this examination is a concern, especially since this country desperately needs nurses. Currently, the United States (U.S.) is faced with a nursing shortage. This shortage significantly impacts the U.S. health care system and requires urgent attention so that the health care needs of the people in this country are met. …

A Grounded Theory Approach To Faculty’S Perspective And Patterns Of Online Social Presence, Rebecca A. Cox-Davenport

UNLV Theses, Dissertations, Professional Papers, and Capstones

The purpose of this research study was to generate a grounded theory regarding the patterns and perceptions of nursing faculty in the formation of social processes in an online course. Employing a grounded theory approach, this researcher built upon the theoretical concepts of the Community of Inquiry (CoI) model (Garrison, Anderson, & Archer, 2000). The CoI model illustrates the inner workings of the educational experience. The model consists of three main components: social presence, teaching presence, and cognitive presence. These three elements overlap to demonstrate how each factor influences the other forms of presence. This study sought to better understand …

Relative Deprivation, Relative Gratification, Status, And Health, Samuel A. Holland

UNLV Theses, Dissertations, Professional Papers, and Capstones

The role of perceived inequity in health was assessed and compared to other social constructs predicted to be relevant in the relationship between inequity and health. Four studies were conducted that demonstrated that a social comparison-based measure of relative deprivation (RD) and relative gratification (RG) can predict health and continues to do so even after accounting for perceived stress, personal income, perceived control, and social participation. A measure of RD/RG was developed that was based on prominent social comparisons and objects of comparison. This measure was reliable and predictive of health in two samplings of different populations. Comparisons of the …

Association Of Body Mass Index, Fruit And Vegetable Intake, And Acculturation In A Sample Las Vegas Hispanic Population, Anne L. Bolstad

UNLV Theses, Dissertations, Professional Papers, and Capstones

The U.S. is experiencing a rising prevalence of overweightedness that has been identified as the second leading cause for chronic health conditions threatening public health. Overweightedness has grown disproportionately among ethnic sub-groups. In the fastest going minority population in the U.S., Hispanic Americans are observed with disparately high body mass index, placing them at heightened risk for poor health outcomes. Research suggests five servings of fruit and vegetables, in any combination, provides a sound nutritional base for healthful living and helps to maintain normal body weight.

Americans are known to have poor eating habits while foreign-born populations have well balanced …

Lead Risk Hazards In Pre-1978 Childcare Facilities Located In Clark County, Nevada, Usa, Jessica Marie Newberry

UNLV Theses, Dissertations, Professional Papers, and Capstones

The harmful health effects of lead exposure have been known for centuries, yet lead is still produced and utilized in a variety of ways. There have been many movements to rid the environment of this toxic metal in hope to reduce the number of individuals who are and who may potentially be exposed. Lead exposure is responsible for a myriad of negative health effects most notably lowering IQ scores in children. Extensive amounts of data have been collected from areas of the country with known lead hazards, hazards that have been identified through hundreds of thousands of elevated blood lead …

The Role Of Visual, Vestibular, And Somatosensory Systems In Postural Balance, Mary Grace Gaerlan

UNLV Theses, Dissertations, Professional Papers, and Capstones

The integration of visual, vestibular, and somatosensory components are used to maintain one's postural balance. Postural control changes over time and body sway increases with age. The different sensory systems begin to develop and refine starting when children are young, while in older adults it begins to decline. Hence, it is important to study the changes that occur in postural balance. There is very little known about balance of younger adults. If balance issues are identified early in adult life it is possible to prevent exacerbation of balance decline as one ages. If nurse practitioners are aware of what dominant …

Health Care Access Disparities Among Children Entering Kindergarten In Nevada, Nadia Deashinta

UNLV Theses, Dissertations, Professional Papers, and Capstones

Access to health care is an important factor for the well-being of America's children. The principal goal of this study was examine the 2008-2009 Kindergarten Health Survey data to advance understanding and appreciation of the health status of children in addition to their discrepancies in accessing health care in the state of Nevada (n = 11,073). This dataset serves as a secondary data source to determine whether socio-demographic and medical factors are associated with disparity in accessing health care for children entering kindergarten. This study looked at both independent and combined effects of annual household income, race/ethnicity, primary language spoken …

Enhanced Food Marketing To Children On The Internet: A Content Analysis, Sarah A. Ochsner

UNLV Theses, Dissertations, Professional Papers, and Capstones

In light of the continuing epidemic of childhood obesity, aggressive food marketing strategies have come under increased scrutiny as a possible contributing factor. It has been acknowledged in numerous studies, that poor nutrient quality of food and beverages dominate children's programming. The growth in child-specific media envoys has further increased favorable opportunities to market food and beverages to children, notably less regulated and parentally unsupervised. According to the U.S. Census Bureau, 65% of children aged 6-11 have home access to the Internet; and today, the majority of food manufacturers operate websites appealing to children. The Institute of Medicine issued a …

Latin America And The Caribbean: Assessment Of The Advances In Public Health For The Achievement Of The Millennium Development Goals, Amal K. Mitra, Gisela Rodriguez-Fernandez

Faculty Publications

To improve health and economy of the world population, the United Nations has set up eight international goals, known as Millennium Development Goals (MDGs), that 192 United Nations member states and at least 23 international organizations have agreed to achieve by the year 2015. The goals include: (1) eradicating extreme poverty and hunger; (2) achieving universal primary education; (3) promoting gender equality; (4) reducing child mortality; (5) improving maternal health; (6) combating HIV/AIDS, malaria and other diseases; (7) ensuring environmental sustainability; and (8) developing a global partnership for development. Having been in the midway from the 2015 deadline, the UN …

Grade Point Average As A Predictor Of Timely Graduation From Associate Degree Registered Nursing Programs, Delores J. Jackson

Dissertations

The purpose of this study was to determine if admission selection strategies that utilize cumulative and/or pre-requisite GPA are predictive of timely graduation for associate degree nursing (RN-AD) students. Data were obtained from de-identified records of 437 associate degree nursing students enrolled in three Midwest community colleges from 2003-2006. Of the total sample, only 44% of the students graduated on time (i.e., in four semesters or two years). Although a statistically significant difference was found for timely graduation rates between colleges (ranging from 29% in College B to 54% in College A), no relationship was found for cumulative GPA, pre-requisite …

The Abortion Attitudes Of Counselor, Social Worker, And Nursing Trainees, Mary J. Ball

Dissertations

This study examined the similarities and dissimilarities in abortion attitudes among counselors (CTs, n = 51), social workers (SWTs, n = 42), and nurses in training (NTs, n = 78), based on profession, age, race, gender, and religion. Data were analyzed using analysis of variance and standard multiple regression. It was predicted that profession, religion, age, gender, and race would predict the abortion attitudes of CTs, SWTs, and NTs in training. It was also predicted that the attitudes of CTs and SWTs would be most similar, and that both of these groups would hold more positive abortion attitudes than NTs. …

Experimental Analysis Of Gambling Using A Concurrent-Schedules Procedure, Andrew Ellis Brandt

Dissertations

Gambling has been experimentally investigated using various types of gambling simulations designed to mimic the contingencies found in real-world games of chance. Findings from past risky choice research suggest that certain procedures used in existing gambling simulations may systematically increase levels of gambling. Two of these characteristics, the use of a participant stake and the type of options available during gambling, were tested in four experiments in which participants had the opportunity to gamble using tokens exchangeable for entries into a $50 lottery. Experiments 1 and 2 tested persistence on a gamble option when either a single-option or a concurrent …

Impacts On Maternal Diet In A Transitional Community In Rural Costa Rica: Potential Implications For The Developmental Origins Of Obesity-Related Disorders, Allison Cantor

UNLV Theses, Dissertations, Professional Papers, and Capstones

This thesis examines maternal diet in a rural, transitional community in Costa Rica. Using cross-cultural categories recognized in the ethnographic literature (i.e. dietary taboos, dietary prescriptions, food cravings and the acknowledgment of a special post-partum period diet), maternal dietary practices were identified in the local community through surveys (n=45) and participant-observation (n=5), and to reflect the actual consumption patterns of pregnant and nursing women in the area, 24-hour diet recalls were administered to 5 pregnant or nursing women. In light of the recent changes that increased tourism has brought to the Monteverde Zone, focus groups were employed to determine impacts …

Attitudes Of Young Adults About Breastfeeding And The Association Of Breastfeeding Exposure, Cheryl Lynn Darby-Carlberg

UNLV Theses, Dissertations, Professional Papers, and Capstones

This study was conducted to determine the attitudes of young adults in Clark County, Nevada about breastfeeding and was a replication of part of a study by Marrone, Vogeltanz-Holm, and Holm (2008). The theory for reasoned action was used as the framework to guide the study. This theory explains deliberate behavior and how specific behaviors, such as breastfeeding, are affected by individual attitudes and social support. The research is a cross-sectional correlational study and sought to test two null hypotheses: (1) There is no association between previous exposure to breastfeeding and positive attitudes toward breastfeeding, and (2) There is no …

The Interim Window: Women’S Experiences During In Vitro Fertilization Leading To Maternal Embryo Attachment, Tammy Mackinnon Lampley

UNLV Theses, Dissertations, Professional Papers, and Capstones

Infertility affects about 7.3 million women and their partners in the U.S., about 12% of the reproductive-age population. In vitro fertilization (IVF) has been used successfully in the United States since 1981. The number of women seeking artificial reproductive techniques (ART) has increased dramatically and the number of ART cycles performed in the United States has more than doubled, from 64,681 in 1996 to 134,260 in 2005 and 99% of these are IVF. Studies indicated that women rank waiting for the outcome of and IVF treatment and a negative pregnancy result as the most stressful events during their treatment. Although …

Factors Associated With Blood Lead Levels Of Children In Southern Nevada, Mackenzie Suzanne Burns

UNLV Theses, Dissertations, Professional Papers, and Capstones

Exposure to lead continues to be a public health concern, particularly for young children. The Centers for Disease Control and Prevention report that approximately 250,000 children currently have blood lead levels (BLLs) above the level at which adverse health effects are apparent and intervention is recommended (10μg/dL). National surveillance data on childhood lead exposure has been collected for children under the age of 6 years old since 1995. However, not until 2006 did a program begin in Nevada (limited to Clark County); therefore, statewide data about childhood lead exposure in Nevada remains limited. The goal of this study was to …

The Relationship Of A Long-Term Exercise Program And Selected Coronary Risk Factors, Maryse Wells

UNLV Theses, Dissertations, Professional Papers, and Capstones

The purpose of this study was to investigate body composition and blood pressure as potential risk factors for coronary artery disease after 3 years of participation in a structured exercise program. The sample group was comprised of 21 male participants (66%) and 11 (34%) female participants with a mean age of 55 years who attended the exercise program and completed health and fitness testing annually. Participants did cardiovascular, strength, and flexibility training 5 days a week with an average attendance of 70%. After 3 years, BMI, waist circumference, and percent body fat increased significantly (p < .01); blood pressure levels did not change significantly (p > .05). Low control of diet …

Experienced Clinician’S Understanding And Approach To Treatment With Male Survivors Of Child Sexual Abuse, Blendine Perreire Hawkins

UNLV Theses, Dissertations, Professional Papers, and Capstones

The number of males abused sexually as children are significant and while the awareness of the needs of this population has increased, the process in treatment has not been sufficiently examined. The purpose of this study was to explore experienced clinicians' approach and understanding within treatment with adult male survivors of child sexual abuse. A qualitative research design was utilized, using purposeful expert sampling procedures. In this study, data was collected from phone interviews with five participants who were identified as highly experienced clinicians in the area of male survivors of child sexual abuse treatment. Using qualitative methods within phenomenological …

Effects Of Obesity On The Biomechanics Of Children’S Gait At Different Speeds, Philana-Lee Gouws

UNLV Theses, Dissertations, Professional Papers, and Capstones

The purpose of the study was to investigate the relationship between body mass index (BMI) and spatio-temporal gait characteristics of overweight/obese and non-obese school-aged children (12-14 years) at two different walking speeds. Eighty-four overweight/obese (n=28; age: 13.96 ± 0.79 yrs; mass: 74.8 ± 18.21 kg; height: 159.2 ± 7.1 cm and BMI: 29.28 ± 5.64 kg/m2) and non-obese students (n=56; age: 13.72 ± 0.79 yrs; mass: 51.7 ± 10.2 kg; height: 157.8 ± 8.3 cm and BMI: 20.69 ± 2.74 kg/m2) with no present injuries were recruited. Participants were instructed to walk across an electronic walkway in each of two …