Medicine and Health Sciences Commons^™

Effect Of Indomethacin On Bile Acid-Phospholipid Interactions: Implication For Small Intestinal Injury Induced By Nonsteroidal Anti-Inflammatory Drugs, Yong Zhou, Elizabeth J Dial, Rand Doyen, Lenard M Lichtenberger

Faculty, Staff and Student Publications

The injurious effect of nonsteroidal anti-inflammatory drugs (NSAIDs) in the small intestine was not appreciated until the widespread use of capsule endoscopy. Animal studies found that NSAID-induced small intestinal injury depends on the ability of these drugs to be secreted into the bile. Because the individual toxicity of amphiphilic bile acids and NSAIDs directly correlates with their interactions with phospholipid membranes, we propose that the presence of both NSAIDs and bile acids alters their individual physicochemical properties and enhances the disruptive effect on cell membranes and overall cytotoxicity. We utilized in vitro gastric AGS and intestinal IEC-6 cells and found …

Decision Analytic Model For Evaluation Of Suspected Coronary Disease With Stress Testing And Coronary Ct Angiography., Ethan J Halpern, David Fischman, Michael P Savage, Anish R Koka, Matthew Decaro, David C Levin

Department of Radiology Faculty Papers

RATIONALE AND OBJECTIVES: The aim of this study was to apply a decision analytic model for the evaluation of coronary artery disease (CAD) to define the optimal utilization of coronary computed tomographic angiography (cCTA) and stress testing.

MATERIALS AND METHODS: The model tested in this study assumes that CAD is evaluated with a stress test and/or cCTA and that a patient with positive evaluation results undergoes cardiac catheterization. On the basis of values of sensitivity, specificity, and radiation dose from the published literature and test costs from the Medicare fee schedule, a decision tree model was constructed as a function …

Location And Initiation Of Degenerative Rotator Cuff Tears: An Analysis Of Three Hundred And Sixty Shoulders, H. Mike Kim, Nirvikar Dahiya, Sharlene A. Teefey, William D. Middleton, Georgia Stobbs, Karen Steger-May, Ken Yamaguchi, Jay D. Keener

Open Access Publications

No abstract provided.

The Effect Of Recombinant Human Bone Morphogenetic Protein-2 On The Osseointegration Of Temporary Anchorage Devices, Eden E. Cruz

Master's Theses

Titanium has been widely used for dental implants, and in particular, roughened titanium surfaces have provided a means for increasing bone apposition and strengthening the implant-to-bone interface. Finding a way to further increase osseointegration is important because there is a significant clinical benefit to patients if a stable anchor can be established instead of anchoring orthodontic hardware to the molars. In this study, the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on the ability of temporary anchorage devices (TADs) to osseointegrate was investigated. The temporary anchorage devices (TADs) used in this study were manufactured from commercially pure titanium and …

Osseointegration Of Temporary Anchorage Devices Using Recombinant Human Bone Morphogenetic Protein-2, Erin E. Cruz

Master's Theses

Over the past 5 years, the use of titanium implants as temporary anchorage devices (TADs) has become an important tool in clinical orthodontic practices. The use of TADs have provided orthodontists a way of moving teeth against fixed objects rather than against the surrounding teeth, which tend to counteract desired motion. At present, viable attachment of TADs involves direct insertion through gingival tissue and piercing of the bone. Surface modifications such as sandblasted and acid-etched treatment or bone morphogenetic protein surface treatment, however, can be applied to the TADs to promote enhanced osseointegration, thereby allowing the TADs to serve as …

Tooth Loss, Apolipoprotein E, And Decline In Delayed Word Recall, P. S. Stein, R. J. Kryscio, M. Desrosiers, Sara J. Donegan, M. B. Gibbs

School of Dentistry Faculty Research and Publications

Our previous research suggests an association between a low number of teeth and increased risk of dementia. The aim of the present study was to determine if a low number of teeth is specifically related to memory decline as evidenced by low Delayed Word Recall scores. In addition, we examined the combined effect of a low number of teeth and the apolipoprotein E ϵ4 allele on Delayed Word Recall scores. We hypothesized that the scores of those who had the allele and a low number of teeth (0-9) would decline more rapidly over time than those participants with a greater …

Examining The Neuroscience Evidence For Sensory-Driven Neuroplasticity: Implications For Sensory-Based Occupational Therapy For Children And Adolescents., Shelly J. Lane, Roseann C. Schaaf

Department of Occupational Therapy Faculty Papers

When Ayres first presented the theory of sensory integration (SI), she grounded it in the neuroscience literature. Neuroplasticity was then, and is today, considered to be at the heart of this theory. This evidence-based review sought to critically examine the basic science literature to specifically identify evidence for the assumptions and tenets of Ayres' theory of SI. We reviewed literature between 1964 and 2005, within psychological, physiological, and biomedical areas, addressing neuroplasticity. The review focused on sensorimotor-based neuroplasticity; explored the data that addressed the links among sensory input, brain function, and behavior; and evaluated its relevance in terms of supporting …

Emerging Parasitic Infection Mimicking Functional Bowel Disease, Javed Yakoob, Wasim Jafri, Mohammad Asim Beg, Z Abbas, Shagufta Naz,, Muhammad Islam, A. B. Khalid, Rustam Khan, Zubair Ahmad

Section of Gastroenterology

No abstract provided.

Cocaine And The Heart., Suraj Maraj, Vincent M. Figueredo, M.D., D Lynn Morris

Division of Cardiology Faculty Papers

The use of cocaine may be associated with either acute or chronic toxicity, and approximately 5% to 10% of emergency department visits in the United States are believed to be secondary to cocaine usage. Chest pain is the most common cocaine-related medical problem, leading to the evaluation of approximately 64,000 patients annually for possible myocardial infarction, of which approximately 57% are admitted to the hospital, resulting in an annual cost greater than $83 million. There is a plethora of cocaine-related cardiovascular complications, including acute myocardial ischemia and infarction, arrhythmias, sudden death, myocarditis, cardiomyopathy, hypertension, aortic ruptures, and endocarditis. There is …

Nursing Compliance With Standard Fall Prevention Protocol Among Acute Care Hospital Nurses, Anuradha Thirumalai

UNLV Theses, Dissertations, Professional Papers, and Capstones

The purpose of the study was to determine the level of nursing compliance in implementing Fall Prevention Protocol (FPP) in an acute care hospital in a high fall risk patient population and to identify the barriers in complying. This study is important because falls are considered one of the nursing-sensitive quality indicators. The AACN Synergy model for patient care was used as the organizing framework for this study. A total of 24 nurses participated in the study, and a total of 29 high fall risk patients were assessed. The degree of compliance among nursing staff was measured using the modified …

An Evaluation Of Lead In Imported Candies Within Clark County, Nevada, Usa, Lee Reuben Ibarra

UNLV Theses, Dissertations, Professional Papers, and Capstones

Imported candies from Latin America pose a danger to children because of the potential for those candies to contain harmful levels of lead. This study sought to identify characteristics of imported candies that typically display higher concentrations of lead. This study also explored the Integrated Exposure Uptake Biokinetic model developed by the EPA. Using lead exposure data specific to Clark County, Nevada, the IEUBK model was used to estimate the amounts of candy a child would have to consume in order to raise his blood lead level to over 10µg/dL (the federal allowable limit).

The results showed that candies with …

Cultural Competence Of Rn To Bsn Students, Dierdre Michelle Riley

UNLV Theses, Dissertations, Professional Papers, and Capstones

The purpose of this exploratory research study was to examine the cultural competence of registered nurses returning to school for an RN to BSN program in Nevada. Campinha-Bacote's model, The Process of Cultural Competence in the Delivery of Healthcare Services, was used as a theoretical framework for the study. A secondary analysis of data collected as part of a Health Resources and Services Administration (HRSA) Grant was completed. Fifty-three RN to BSN students voluntarily completed the Inventory for Assessing the Process of Cultural Competency Among Healthcare Professionals- Revised (IAPCC-R) electronically in the learning management system of the first nursing course …

Solid-Organ Transplant Recipients And Breastfeeding While On Immunosuppression, Schweta Arakali, Faith Carlin, Lisa A. Coscia, Carolyn H. Mcgrory, Dawn Armenti, Vincent T. Armenti

Department of Surgery Faculty Papers

Conclusions:

The relatively small amount of drug transferred in breast milk and the lack of reported adverse effects along with the known benefits of breastfeeding may outweigh the risk of drug exposures in the transplant population.

The threshold for determining the level of exposure of an immunosuppressive agent that is acceptable is not known at present.

Continued study and follow-up of all breast-fed transplant recipient offspring is warranted.

Centers are encouraged to report all pregnancies in transplant recipients to the NTRR.

Pregnancy Outcomes In Female Lung Transplant Recipients, Julie Shaner, Faith Carlin, Lisa A. Coscia, Carolyn H. Mcgrory, Dawn Armenti, Vincent T. Armenti

Department of Surgery Faculty Papers

Conclusions:

Female lung recipients appear to face higher risks related to pregnancy when compared to other solid organ transplant recipients.

Although successful pregnancies have been reported in female lung recipients, analyses of larger numbers of cases may help to identify pre-pregnancy factors predictive of adverse outcomes.

Centers are encouraged to report all pregnancies in transplant recipients to the NTPR.

Pregnancy Outcomes With Exposure To The Mycophenolic Acid Products (Mpa), To Dung K. Nguyen, Faith Carlin, Lisa A. Coscia, Dawn Armenti, Vincent T. Armenti

Department of Surgery Faculty Papers

Conclusions:

Reports to NTPR to date continue to reveal an increased incidence of birth defects in transplant recipients maintained on MPA products during gestation compared to those not maintained on these agents.

Structural birth defects consisting of microtia (ear deformity) and facial defects suggest a pattern of malformations.

Evaluation of the higher incidence of non-viable outcomes requires further study in this cohort.

Centers are encouraged to report all pregnancy exposures in transplant recipients to the NTPR.

Pregnancy Outcomes In Pancreas-Kidney Vs. Kidney-Alone Diabetic Female Transplant Recipients, Lyuba Gitman, Faith Carlin, Lisa A. Coscia, Carolyn H. Mcgrory, Dawn Armenti, Vincent T. Armenti

Department of Surgery Faculty Papers

Conclusions:

The high incidences of hypertension, preeclampsia, and infection during pregnancy underscore the high-risk nature of pregnancy in both pancreas-kidney and kidney alone recipients.

Although overall offspring outcomes are similar in both PK and K groups, pregnancy in PK recipients may be associated with higher incidences of maternal infections and overall graft loss.

Centers are encouraged to report all pregnancies in transplant recipients to the NTPR.

Immunosuppressive Therapy For Autoimmune Disease And Pregnancy Outcomes, Karolina Paziana, Faith Carlin, Lisa A. Corcia, Carolyn H. Mcgrory, Dawn Armenti, Vincent T. Armenti

Department of Surgery Faculty Papers

Conclusions:

Cyclosporine exposure during pregnancy in the transplant population does appear to be associated with premature delivery and low infant birthweight.

Data from the NPR show that cyclosporine exposure during pregnancy in women with psoriasis does not appear to be associated with low gestational age or low infant birthweight.

Maternal comorbidities or other factors, such as multiple drug regimens, likely play a role in the higher rates of premature delivery and low birthweight infants in the kidney transplant population.

Further investigation is warranted to evaluate the impact of comorbidities and other factors on pregnancy outcomes of women taking Neoral®.

The Type 1 Insulin-Like Growth Factor Receptor In Hepatocellular Carcinoma Cell Lines, Zhengyu Wei, Phd, Tiziana Deangelis, M.S., Reginald Hurtt, B.S., Renato Baserga, M.D., Cataldo Doria, M.D., Ph.D

Department of Surgery Faculty Papers

Summary:

1. Human HCC cells have higher expression levels of IGF-1R, IRS1, and c-Met.

2. IRS1 interacts with c-Met. The role of IGF-1R in human HCC should be revisited.

3. Lentivirus-mediated shRNA delivery system targeting IGF-1R showed significant suppressive effects on HCC cell growth, promising a potential therapeutic treatment for human HCC.

Can Student Reflection Predict Academic Success And Clinical Performance In A Physical Therapist Education Program?, Jeanne L. Cook

Department of Educational Administration: Dissertations, Theses, and Student Research

The purpose of this retrospective study was to determine if a predictive relationship existed between student reflection and student academic and clinical success as determined by student performance on the National Physical Therapy Examination (NPTE) and the Clinical Performance Instrument (CPI). Secondary questions included whether higher and lower reflection scores would correspond with higher and lower NPTE and CPI scores respectively, and whether students’ reflection scores would increase between the first and fourth clinical internships. Journal entries were submitted by students from a physical therapist education program at a large North Central Region university over the course of two clinical …

Allred Scoring For Er Reporting And It's Impact In Clearly Distinguishing Er Negative From Er Positive Breast Cancers, Asim Qureshi, Shahid Pervez

Department of Pathology and Laboratory Medicine

Objective: To determine the scoring of Estrogen Receptor (ER) status in carcinoma breast by Allred method that is essentially bimodal and to compare the results with a conventional scoring system.
Materials and Methods: A retrospective, comparative study carried out at Aga Khan University Hospital Section of Histopathology over a period of 18 months i.e. Jan 2005 to June 2006. Anti ER antibody (clone D07) was used for all IHC stains using envision detection system. ER stains of 860 consecutive breast cancer cases were reviewed and rescored by both conventional and Allred method of ER scoring.
Results: Comparison of results showed …

Extraskeletal Osteosarcoma: Clinico-Pathologic Features And Results Of Multimodal Management, Nicola Fabbri, Akshay Tiwari, Masood Umer

Department of Radiology

. Extraskeletal Osteosarcoma: Clinico-pathologic Features and Results of Multimodal
Management N. Fabbri, A. Tiwari, M. Umer, D. Vanel, M. Alberghini, P. Ruggieri, S. Ferrari, P.
Picci, M. Mercuri Department of Musculoskeletal Oncology Istituto Ortopedico Rizzoli, Bologna,
Italy 23rd EMSOS Meeting Birmingham, UK 5th-7th May 2010 Page 2. Extraskeletal Osteosarcoma
Background .About 1% of all soft tissue sarcomas .First described by Wilson in 1941 .Few large
series then reported .Older individuals & usually worse survival

Surgical Interventions For Malignant Middle Cerebral Infarction--Saving Lives And Functionality Or Increasing Disabled Survivors?, Maria Khan, Ayeesha Kamran Kamal

Section of Neurology

No abstract provided.

Performance Of A Metarhizium Anisopliae-Treated Semiochemical-Baited Trap In Reducing Amblyomma Variegatum Populations In The Field, F. Nchu, N. K. Maniania, A. Hassanali, J. N. Eloff

All Peer-Reviewed Publications

Experiments were carried out to evaluate the efficacy of Metarhizium anisopliae (Metsch.) Sorok. (Ascomycota: Hypocreales)-treated semiochemical-baited traps for control of Amblyomma variegatum Fabriscius (Acari: Ixodidae) under field conditions. Unfed A. variegatum adults (118) were seeded in each 100-m plot and allowed to acclimatise for 3 days. On the fourth day (Day 4), an emulsifiable formulation of M. anisopliae (consisting of 49.5% sterile distilled water, fungal conidia, 49.5% corn oil and 1% Tween 80) titrated at 109conidiaml-1 was applied in semiochemical-baited traps (900cm2) which were placed at five spots within the plot. The control and fungal treatments were repeated after 14 …

Severity Of Acute Hepatitis And Its Outcome In Patients With Dengue Fever In A Tertiary Care Hospital Karachi, Pakistan (South Asia), Om Parkash, Aysha Almas, Wasim Jafri, Saeed Hamid, J. Akhter, Syed H Shah

Department of Medicine

Background: Liver injury due to dengue viral infection is not uncommon. Acute liver injury is a severe complicating factor in dengue, predisposing to life-threatening hemorrhage, Disseminated Intravascular Coagulation (DIC) and encephalopathy. Therefore we sought to determine the frequency of hepatitis in dengue infection and to compare the outcome (length of stay, in hospital mortality, complications) between patients of Dengue who have mild/moderate (ALT 23-300 IU/L) v/s severe acute hepatitis (ALT > 300 IU/L).

Methods: A Cohort study of inpatients with dengue viral infection done at Aga Khan University Hospital Karachi. All patients (≥ 14 yrs age) admitted with diagnosis of Dengue …

Empirical Testing Of The Neuman Systems Nursing Education Model: Exploring The Created Environment Of Registered Nursing Students In Nevada’S Colleges And Universities, Diane H. Elmore

UNLV Theses, Dissertations, Professional Papers, and Capstones

The purposes of this paper are to: (a) present the strategies and rationale for creation of a middle range nursing theory that is specific to nursing education, (b) to determine if propositions of the model are valid and appropriate to support further research based on the student-centered education model, and (c) to conduct initial research on the created environment of nursing students, which is one of two the primary constructs of the nursing education model. Use of the Neumans Systems Nursing Education Model (NSNEM), a student centered educational model, which is consistent with the Neumans System Model (NSM) provided the …

Opportunities For Intervention: Characteristics Of Alcohol Related Visits To United States Emergency Departments, 2003 - 2007, Jonathon Lavalley

UNLV Theses, Dissertations, Professional Papers, and Capstones

The cycle of alcohol intoxicated patients passing through United States (US) emergency departments (ED) and repeated inpatient detoxification for alcohol inebriates is costly, as these patients are continually exposed to injury and other health and legal consequences of their continued at risk alcohol use. The high proportion of ED resources used by these alcohol intoxicated patients has contributed to increased patient wait times, increased ambulance diversions, forced closures of US EDs, increased numbers of patients leaving without being seen, and an overall reduction in the quality of medical services provided in the ED. In order to contribute to efforts towards …

The Effects Of Aquatic Exercise On Physiological And Biomechanical Responses, Matthew M. Denning

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Due to recent advances in aquatic research, technology, and facilities, many modes of aquatic therapy now exist. These aquatic modes assist individuals (e.g., osteoarthritis patients) in the performance of activities that may be too difficult to complete on land. However, the biomechanical requirements of each aquatic therapy mode may elicit different physiological and functional responses. Therefore, the purpose of this thesis was to: (a) provide a review of the physiological and biomechanical differences between aquatic and land based exercises, and (b) examine the acute effects of underwater and land treadmill exercise on oxygen consumption (VO₂), rating of perceived …

Arterial Oxygen Saturation As A Predictor Of Acute Mountain Sickness And Summit Success Among Mountianeers, Jonathan R. Knott

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The purpose of this study was to determine if arterial oxygen saturation (SaO₂), as measured by a finger pulse oximeter upon rapid arrival to 4260 m, could be predictive of acute mountain sickness (AMS) or summit success on a climb to 5640 m. In total 73 climbers volunteered to participate in the study. After excluding those taking drugs to counteract the effects of AMS and those with missing data, 48 participants (45 male, 3 female) remained. Climbers were transported from 2650 m to the Piedra Grande hut at 4260 m on Pico de Orizaba within 2 hr. After …

Effects Of Underwater Treadmill Exercise On Mobility Of People With Knee Osteoarthritis, Jaimie Roper

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Gait, pain, and self-efficacy alterations in osteoarthritis (OA) patients may be precursors for pathological alterations and are important variables to examine in an aquatic therapy study aimed at improving mobility. A greater understanding of these alterations will be useful for the treatment of OA and the prevention of OA progression. The purpose of this thesis was twofold: to review the effects of certain land and aquatic therapies on gait kinematics and mobility of people with osteoarthritis, and to examine the effects of short-term aquatic treadmill exercise on gait kinematics, perception of pain, and mobility in OA patients. A direct comparison …

Static Versus Dynamic Stretching Effect On Agility Performance, Patrick Troumbley

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The purpose of this study was to compare effects of static and dynamic stretching on explosive agility movements, and to examine the effect of the interaction of dynamic and static stretching prior to explosive agility movements. Fourteen men and 10 women performed the different warm-up protocols, including no warm-up (NWU), static stretching (SS), dynamic stretching (DS), and dynamic stretching with static stretching (DS+SS). The T-Drill was used to assess agility. The results indicated no difference between the NWU and SS conditions (effect size = 0.40, p = 0.06), as well as no significant difference between the NWU and DS+SS conditions …