Medicine and Health Sciences Commons^™

Dad, Could You Get Hd?', Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

4 Wikis + 4 Blogs + 70 Third Year Medical School Students = Improved Students’ Confidence In Practicing Ebm. A Pilot Project Using Blogs And Wikis For A Collaborative Ebm Assignment In A 3rd Year Internal Medicine Clerkship., Jessica Salt, Md Facp, Anthony J. Frisby, Phd, Margy Grasberger, Ms, Gary Kaplan, Ms, Daniel G. Kipnis, Msi, Karen Krasznavolgyi, Mls, Jon Veloski, Ms

Academic Commons and Scott Memorial Library Staff Papers and Presentations

PowerPoint presented at national Medical Library Association conference in Washington DC on May 25, 2010, 2:00 PM - 3:30 PM Section Program: Beyond Cool: Reflecting on Web 2.0 Adventures and Misadventures.

Narrative Reflection In The Family Medicine Clerkship-Cultural Competence In The Third Year Required Clerkships, Donna Elliott, Pamela Schaff, Theresa Woehrle, Anne Walsh, Janet Trial

Physician Assistant Studies Faculty Articles and Research

This resource cultivates effective cross-cultural communication skills, which requires an understanding of culture that includes both the physician's and the patient's perspectives. Building on a foundation of cultural awareness, knowledge, and skills students have acquired during the preclinical curriculum, this exercise provides an opportunity for students to continue to refine their narrative reflection skills as they interact with patients in the clinical setting. During the family medicine clerkship, students participate in learning activities that provide the opportunity to explore the rich opportunities of thoughtful reflection and narrative practice. Students also participate in a formative narrative reflection exercise during the clerkship …

Organic Cation Transporter Preferentially Expressed In Hematopoietic Cells And Leukemias And Uses Thereof, Jeffrey A. Moscow, Xin Lu, Craig Jordan

Markey Cancer Center Faculty Patents

A novel organic cation transporter (OCT) gene, OCT 6, and use thereof is described. The OCT6 gene is preferentially expressed in human hematopoietic tissues, including CD34+ cells and leukemia cells. Its narrow tissue distribution, substrate specificity, and close homology to other cell membrane transporters make OCT6 an attractive target for the treatment of myeloid diseases.

Intravenous Ibuprofen: The First Injectable Product For The Treatment Of Pain And Fever, P Brandon Bookstaver, April D. Miller, Celeste N. Rudisill, Leann B. Norris

Faculty Publications

This paper reviews the current data on the use of the first approved intravenous ibuprofen product for the management of post-operative pain and fever in the United States. The management of acute and post-operative pain and fever with nonsteroidal anti-inflammatory agents (NSAIDs) is well documented. A search in Medline and International Pharmaceutical Abstracts of articles until the end of November 2009 and references of all citations were conducted. Available manufacturer data on file were also analyzed for this report. Several randomized controlled studies have demonstrated the opioid-sparing and analgesic effects of 400 and 800 mg doses of intravenous ibuprofen in …

Cardiovascular Risk Assessment - From Individual Risk Prediction To Estimation Of Global Risk And Change In Risk In The Population, John A. Batsis, Francisco Lopez-Jimenez

Dartmouth Scholarship

Cardiovascular disease is the most common cause of death and risk prediction formulae such as the Framingham Risk Score have been developed to easily identify patients at high risk that may require therapeutic interventions. Using cardiovascular risk formulae at a population level to estimate and compare average cardiovascular risk among groups has been recently proposed as a way to facilitate surveillance of net cardiovascular risk and target public health interventions. Risk prediction formulas may help to compare interventions that cause effects of different magnitudes and directions in several cardiovascular risk factors, because these formulas assess the net change in risk …

Good Publication Practice: Maintaining The Integrity Of Scientific Communications, Jackie Mayne Msc

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

7th Annual Interclerkship Day: Improving Patient Safety

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Young Journalists Deliver Public Health Message, Marian Uhlman, Moriah Zimmerman Mph

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Health Policy Forum: Future Implications And The Role Of The Physician Advocate

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Health Policy Forum: Achieving Cultural Competency: Using A Case-Based Approach For Teaching And Learning

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Creating Our Future Leaders: Amsa 2nd Annual Patient Safety And Quality Leadership Institute, Justin Abraham

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Partnerships For Health In Rwandan Genocide Survivers Village: The Rwanda Health And Healing Project And Barefoot Artists, James Plumb Md, Mph

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

The Adventure Of Helping Abroad: Experiences Providing Health Care In Ethiopia. Interview With Jeffrey Panzer, Md, And Erin Mc Carville, Mph

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Moving Forward: Jsph To Launch Online Courses

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

American Medical Association - Medical Student Section Region Vi Conference, Zein Nakhoda

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Wii-Hab: Using The Wii Video Game System As An Occupational Therapy Intervention With Patients In The Hospital Setting, Kimberly Gargin Otr/L, Lauren Pizzi Otr/L

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

The Future Health Care Workforce Of Older Americans, Richard G. Stefanacci Do, Mgh, Mba, Christine A. Arenson Md, Barney S. Spivack Md, Facp, Agsf, Cmd

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

One Book, One School, Kathyrn Kash Phd, David B. Nash Md, Mba

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Hp Newsletter March 2010 Dowload Full Pdf

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Inhibition Of Abcb1 (Mdr1) Expression By An Sirna Nanoparticulate Delivery System To Overcome Drug Resistance In Osteosarcoma, Michiro Susa, Arun K. Iyer, Keinosuke Ryu, Edwin Choy, Francis J. Hornicek, Henry Mankin, Lara Milane, Mansoor M. Amiji, Zhenfeng Duan

Pharmaceutical Sciences Faculty Publications

Background: The use of neo-adjuvant chemotherapy in treating osteosarcoma has improved patients’ average 5 year survival rate from 20% to 70% in the past 30 years. However, for patients who progress after chemotherapy, its effectiveness diminishes due to the emergence of multi-drug resistance (MDR) after prolonged therapy.

Methodology/Principal Findings: In order to overcome both the dose-limiting side effects of conventional chemotherapeutic agents and the therapeutic failure resulting from MDR, we designed and evaluated a novel drug delivery system for MDR1 siRNA delivery. Novel biocompatible, lipid-modified dextran-based polymeric nanoparticles were used as the platform for MDR1 siRNA delivery; and the efficacy …

Estimated Birth Weight And Adult Cardiovascular Risk Factors In A Developing Southern Chinese Population: A Cross Sectional Study, C. Mary Schooling, C. Q. Jiang, T. H. Lam, B. J. Cowling, S. L. Yeung, W. S. Zhang, K. K. Cheng, G. M. Leung

Publications and Research

Background: Birth weight is negatively associated with cardiovascular diseases and diabetes, but the associations are less well-established in developing populations where birth weight is often unavailable. We studied the association of birth weight and cardiovascular risk, using birth rank as an instrumental variable, in Southern China.

Methods: We used published data on birth weight by birth rank from an appropriate population and baseline data from the Guangzhou Biobank Cohort Study phases 2 & 3 (2005-8) to examine the adjusted associations, using instrumental variable analysis, of birth weight with clinically measured cardiovascular risk factors and the metabolic syndrome in older …

Epistatic Relationships Between Sara And Agr In Staphylococcus Aureus Biofilm Formation, Karen E. Beenken, Lara N. Mrak, Linda M. Griffin, Agnieszka K. Zielinska, Lindsey N. Shaw, Kelly C. Rice, Alexander R. Horswill, Kenneth W. Bayles, Mark S. Smeltzer

Molecular Biosciences Faculty Publications

Background: The accessory gene regulator (agr) and staphylococcal accessory regulator (sarA) play opposing roles in Staphylococcus aureus biofilm formation. There is mounting evidence to suggest that these opposing roles are therapeutically relevant in that mutation of agr results in increased biofilm formation and decreased antibiotic susceptibility while mutation of sarA has the opposite effect. To the extent that induction of agr or inhibition of sarA could potentially be used to limit biofilm formation, this makes it important to understand the epistatic relationships between these two loci.

Methodology/Principal Findings: We generated isogenic sarA and agr mutants in clinical isolates of S. …

Cd4 T-Cell Suppression By Cells From Toxoplasma Gondii-Infected Retinas Is Mediated By Surface Protein Pd-L1, Elizabeth Charles, Sunil Joshi, John D. Ash, Barbara A. Fox

Dartmouth Scholarship

In the inflamed retina, CD4(+) T cells can cause retinal damage when they are not properly regulated. Since tissue expression of major histocompatibility complex (MHC) class II and costimulatory molecules is a key mechanism for regulating effector T cells, we tested the hypothesis that upregulation of these proteins in the retina contributes to the regulation of CD4 T cells. Here we report that in retinas infected with the protozoan parasite Toxoplasma gondii, MHC class II is upregulated on infiltrating leukocytes as well as on resident retinal cells, including photoreceptors. Flow cytometric analysis indicated that B7 costimulatory family members (CD80, CD86, …

Epistatic Relationships Between Sara And Agr In Staphylococcus Aureus Biofilm Formation., Karen E. Beenken, Lara N. Mrak, Linda M. Griffin, Agnieszka K. Zielinska, Lindsey N. Shaw, Kelly C. Rice, Alexander R. Horswill, Kenneth W. Bayles, Mark S. Smeltzer

Journal Articles: Pathology and Microbiology

BACKGROUND: The accessory gene regulator (agr) and staphylococcal accessory regulator (sarA) play opposing roles in Staphylococcus aureus biofilm formation. There is mounting evidence to suggest that these opposing roles are therapeutically relevant in that mutation of agr results in increased biofilm formation and decreased antibiotic susceptibility while mutation of sarA has the opposite effect. To the extent that induction of agr or inhibition of sarA could potentially be used to limit biofilm formation, this makes it important to understand the epistatic relationships between these two loci.

METHODOLOGY/PRINCIPAL FINDINGS: We generated isogenic sarA and agr mutants in clinical isolates of S. …

Medical School Watercooler Newsletter - May 23, 2010, Lindsey Lyle

Watercooler Newsletter

This is the May 23, 2010 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• Peter Harris Distinguished Scientist Award Presented to USA Physiologist
• Dr. William Richards to Give Community Lecture on Bariatric Surgery
• USA Students Travel to Honduras for Medical Mission Trip
• USA Researchers Present Work at ATS 2010 Conference

Commencement, Georgia (2010), Philadelphia College Of Osteopathic Medicine

Commencements

Georgia Campus Commencement program, Class of 2010. Degrees include Doctorate in Osteopathic Medicine and Master of Science in Biomedical Sciences.

Today - May 21, 2010, Loma Linda University

TODAY

Inside this issue:

-- University prepares for 2010 commencement ceremonies
-- LLU public relations video ream receives three Emmy nominations
-- Silent teachers honored at the willed body program memorial service
-- Children's Hospital staffers run for the money (or was it the kids?)
-- Dubious activities cloud LLU School of Medicine event
-- School of Dentistry alumna and faculty member receives Golden Key Award
-- MBA students successfully compete in annual HCE bowl
-- Interviews for Orientation for Leadership taking place in May
-- Laughter may boost appetite, Loma Linda University researchers find
-- School of Religion hosts first …

Reduction Of Sympathetic Activity Via Adrenal-Targeted Grk2 Gene Deletion Attenuates Heart Failure Progression And Improves Cardiac Function After Myocardial Infarction., Anastasios Lymperopoulos, Giuseppe Rengo, Erhe Gao, Steven N. Ebert, Gerald W. Dorn, Walter J. Koch

Department of Medicine Faculty Papers

Chronic heart failure (HF) is characterized by sympathetic overactivity and enhanced circulating catecholamines (CAs), which significantly increase HF morbidity and mortality. We recently reported that adrenal G protein-coupled receptor kinase 2 (GRK2) is up-regulated in chronic HF, leading to enhanced CA release via desensitization/down-regulation of the chromaffin cell alpha(2)-adrenergic receptors that normally inhibit CA secretion. We also showed that adrenal GRK2 inhibition decreases circulating CAs and improves cardiac inotropic reserve and function. Herein, we hypothesized that adrenal-targeted GRK2 gene deletion before the onset of HF might be beneficial by reducing sympathetic activation. To specifically delete GRK2 in the chromaffin cells …

Effect Of Calcium Supplements On Risk Of Myocardial Infarction And Cardiovascular Events: Meta-Analysis, Mark J. Bolland, Allison Avenell, John A. Baron, A. Grey

Dartmouth Scholarship

Objective: To investigate whether calcium supplements increase the risk of cardiovascular events.

Osteoporosis is a major cause of morbidity and mortality in older people. Calcium supplements margin- ally reduce the risk of fracture, and most guidelines recommend adequate calcium intake as an integral part of the prevention or treatment of osteoporosis. Consequently, calcium supplements are commonly used by people over the age of 50. Observational stu- dies suggest that high calcium intake might protect against vascular disease, and the findings are consis- tent with those of interventional studies of calcium sup- plements thatshow improvementin some vascular risk factors. In contrast, …