Medicine and Health Sciences Commons^™

Micronutrient Deficiencies As A Result Of Bariatric Surgery, Ashlie Lewis

Food Science and Nutrition

The most effective method of sustainable weight loss in obese patients is bariatric surgery. However, micronutrient deficiencies that can result after bariatric surgery can cause health problems that may outweigh its benefits. Micronutrient deficiencies are most common in patients who undergo Roux-en-Y gastric bypass or biliopancreatic diversion with or without duodenal switch. The majority of vitamin B12 and folate deficiencies studies showed significant prevalence rates in their patient populations. Most concluded that routine oral B12 supplementation was ineffective at resolving deficiency; very high oral doses (> 350 μg) or intramuscular injections of crystalline B12 were typically required. Studies of iron …

Letter By Harris Et Al Regarding Article, "Outcomes Of Patients With Acute Type A Aortic Intramural Hematoma, Jamie M. Pelzel

Articles

We read with interest the report by Song et al1 outlining the management of ascending aortic intramural hematoma (IMH) at the Asan Medical Center in Seoul, South Korea. This series, the largest of this life-threatening condition, demonstrated that at that institution, 84% of patients (n=85) could be treated with initial medical therapy, resulting in a mortality rate of 7.1%. These results are impressive but are observational rather than a randomized comparison of medical and surgical therapy.

Causality Assessment In Drug-Induced Liver Injury Using A Structured Expert Opinion Process: Comparison To The Roussel-Uclaf Causality Assessment Method, James W. Freston

Articles - Patient Care

Drug-induced liver injury (DILI) is largely a diagnosis of exclusion and is therefore challenging. The US Drug-Induced Liver Injury Network (DILIN) prospective study used two methods to assess DILI causality: a structured expert opinion process and the Roussel-Uclaf Causality Assessment Method (RUCAM). Causality assessment focused on detailed clinical and laboratory data from patients with suspected DILI. The adjudication process used standardized numerical and descriptive definitions and scored cases as definite, highly likely, probable, possible, or unlikely. Results of the structured expert opinion procedure were compared with those derived by the RUCAM approach. Among 250 patients with suspected DILI, the expert …

Characterization Of Stem And Progenitor Cells In The Dental Pulp Of Erupted And Unerupted Murine Molars, Anamaria Balic, Hector L. Aguila, Melissa J. Caimano, Victor P. Francone, Mina Mina

UCHC Articles - Research

In the past few years there have been significant advances in the identification of putative stem cells also referred to as “mesenchymal stem cells” (MSC) in dental tissues including the dental pulp. It is thought that MSC in dental pulp share certain similarities with MSC isolated from other tissues. However, cells in dental pulp are still poorly characterized. This study focused on the characterization of progenitor and stem cells in dental pulps of erupted and unerupted mice molars. Our study showed that dental pulps from unerupted molars contain a significant number of cells expressing CD90+/CD45-, CD117+/CD45-, Sca-1+/CD45- and little if …

Effects Of Naltrexone Treatment For Alcohol-Related Disorders On Healthcare Costs In An Insured Population, Henry R. Kranzler

UCHC Articles - Research

Objective To determine the impact of treatment with oral naltrexone on healthcare costs in patients with alcohol-related disorders. Methods Using data from the MarketScan Commercial Claims and Encounters Database for 2000–2004, we identified a Naltrexone Group (with an alcohol-related diagnosis and at least one pharmacy claim for oral naltrexone) and two control groups. Alcohol Controls had an alcohol-related diagnosis and were not prescribed an alcoholism treatment medication. Non-Alcohol Controls had no alcohol-related diagnosis and no prescription for an alcoholism treatment medication. The control groups were matched three to one to the naltrexone group on demographic and other relevant measures. Healthcare …

Mitochondria-Centric Activation Induced Cell Death Of Cytolytic T Lymphocytes And Its Implications For Cancer Immunotherapy, Arvind Chhabra

UCHC Articles - Research

Premature death of the adoptively transferred cytolytic T lymphocytes (CTL) by means of activation induced cell death (AICD) represents one of the major constraints in devising an effective anti-cancer immune intervention strategy. Understanding the mechanism of AICD is, therefore, critical for developing methods to interfere with this death process. Although the existing paradigm on AICD centers around the initiation of the cascade of events originating from the engagement of death receptors leading to the activation of effector caspases and eventually resulting in cell death, recent findings have questioned the universal role of caspases as the cell death executioners. We here …

A Prospective Cohort Study Investigating Factors Associated With Depression During Medical Internship, Grace Chan, Henry R. Kranzler

UCHC Articles - Research

Context

Although the prevalence of depression among medical interns substantially exceeds that of the general population, the specific factors responsible are not well understood. Recent reports of a moderating effect of a genetic polymorphism (5-HTTLPR) in the serotonin transporter protein gene on the likelihood that life stress will precipitate depression may help to understand the development of mood symptoms in medical interns.

Objective

To identify psychological, demographic and residency program factors that associate with depression among interns and use medical internship as a model to study the moderating effects of this polymorphism using a prospective, within-subject design that addresses the …

A Pilot Study Examining Exercise Self-Efficacy As A Mediator For Walking Behavior In College-Age Women, Lynne L. Ornes, Lynda B. Ransdell

Kinesiology Faculty Publications and Presentations

Since mechanisms of behavior change are not always evaluated in physical activity interventions, current interventions are limited until these mechanisms are better understood (Bauman, Sallis, Dzewaltowski, & Owen, 2002). Therefore, studies are needed that examine mediating variables, derived from theory, in the design, implementation, and evaluation of interventions. A mediator is a variable that must be included in an intervention in order for a specific change in a dependent variable or outcome to occur (MacKinnon, 2008). MacKinnon (2008) describes several methods of identifying mediators using statistical procedures, including the causal inference approach, difference in coefficients, product of coefficients, structural equation …

A Comparison Of 1978 And 2006 Peak Pollen Seasons And Sampling Methods In Missoula, Montana, Kelly L. Crispen, Donald N. Gillespie, Emily C. Weiler, Curtis W. Noonan, Raymond F. Hamilton, Tony Ward

Public and Community Health Sciences Faculty Publications

A study was conducted in Missoula, Montana to compare local pollen counts from 1978 with those measured nearly 30 years later in 2006 using two different measurement techniques (Durham gravimetric sampler and a Burkard volumetric sampler). Trends in peak pollen times measured during the spring, summer and autumn, respectively, were compared between the two years by Pearson’s correlation and frequency of occurrence of plant genus. Meteorological conditions were also examined during each of the two study periods.

In comparing the two years, there was a statistically significant linear association between the different counts for the months of April through August, …

Urinary Levoglucosan As A Biomarker For Wood Smoke: Results Of Human Exposure Studies, Megan Ann Bergauff, Tony Ward, Curtis W. Noonan, Christopher T. Migliaccio, Christopher D. Simpson, Ashley R. Evanoski, Christopher P. Palmer

Public and Community Health Sciences Faculty Publications

Urinary levoglucosan was investigated as a potential biomarker for wood smoke exposure in two different controlled experimental settings. Nine subjects were exposed to smoke from a campfire in a controlled setting and four were exposed to smoke from an older model wood stove. All subjects were asked to provide urine samples before and after exposure, and to wear personal PM_2.5 monitors during the exposure. Urinary levoglucosan measurements from both studies showed no consistent response to the smoke exposure. A third experiment was conducted to assess the contribution of dietary factors to urinary levoglucosan levels. Nine subjects were asked to …

Relationship Between Muscle Strength, Power And Stiffness And Running Economy In Trained Male Runners, Charles Dumke, Christopher M. Pfaffenroth, Jeffrey M. Mcbride, Grant O. Mccauley

Integrative Physiology and Athletic Training Faculty Publications

Purpose: In this study, a comparison was made between muscle strength, power and muscle and tendon (k(m), and k(t) respectively) stiffness of the triceps surae muscle group and running economy (RE) in trained male runners. Methods: Twelve well-trained male runners (age = 21 +/- 2.7 y, height = 178.1 +/- 7.1 cm, body mass = 66.7 +/- 3.2 kg, VO(2)max = 68.3 +/- 4.3 mL.kg(-1).min(-1), 5000-m time = 15:04 min:s) undement passive stiffness testing using a free oscillation method. Muscle strength was determined via a maximal isometric squat test and power determined via a maximal countermovement jump (CMJ). On a …

Chhs June Enewsletter, Dr. John Bonaguro, Dean, Vashon S. Wells, Editor, Wku College Of Health & Human Services

College of Health & Human Services Publications

No abstract provided.

Psychological Adjustment: Are Adopted Adolescents At Greater Risk For Negative Outcomes?, Caroline Tozzi Reppold, Aida Hutz, Claudio Simon Hutz

Counselor Education Faculty Publications and Presentations

During the last decades several authors have indicated that being an adopted child resulted in a higher risk of psychological maladjustment. The objective of this research was to investigate the changes in perception of parental styles in adopted and no-adopted adolescents Brazilians. The sample comprised 524 adolescents (68 were adopted and 456 were raised by their biological parents). The instruments used were a demographic questionnaire and the Responsiveness Scales and Parental Demands. The findings indicated that adoptive parents are significantly more indulgent than biological parents. In comparison, the adolescents described their biological parents as more negligent. The findings corroborated the …

A Biological Global Positioning System: Considerations For Tracking Stem Cell Behaviors In The Whole Body., Shengwen Calvin Li, Lisa May Ling Tachiki, Jane Luo, Brent A Dethlefs, Zhongping Chen, William G Loudon

Department of Stem Cell Biology and Regenerative Medicine Faculty Papers & Presentations

Many recent research studies have proposed stem cell therapy as a treatment for cancer, spinal cord injuries, brain damage, cardiovascular disease, and other conditions. Some of these experimental therapies have been tested in small animals and, in rare cases, in humans. Medical researchers anticipate extensive clinical applications of stem cell therapy in the future. The lack of basic knowledge concerning basic stem cell biology-survival, migration, differentiation, integration in a real time manner when transplanted into damaged CNS remains an absolute bottleneck for attempt to design stem cell therapies for CNS diseases. A major challenge to the development of clinical applied …

Teaching The Resistance Training Class: A Circuit Training Course Design For The Strength And Conditioning Coach, Shawn R. Simonson

Kinesiology Faculty Publications and Presentations

Strength and conditioning coaches in high schools and small colleges are asked to perform duties beyond working with athletes, including teaching resistance training courses. Many have not had teacher preparation. This article will address guidelines for physical activity and provide a course description and rationale for a circuit training program.

An Evaluation Of The Motivations And Implications Of Participating In High School Athletics While Injured, Trevor M. Bateson

Recreation, Parks, and Tourism Administration

No abstract provided.

Trial And Budget Analysis Of Two Synchronized Artificial Insemination Breeding Programs For Beef First Calf Heifers, John Nino

Agribusiness

This study was designed to compare the benefits and costs of two different synchronized artificial insemination programs on two groups of beef first calf heifers. A financial budget was developed that would include cost of synchronized insemination per animal and the added value of a bred heifer compared to an open one.

The two synchronized programs were called controlled internal drug release (CIDR) and Ovsynch. They used a specific timeline and drugs to complete the synchronization process. A single low birth weight high calving ease bull was used for both groups to enforce conformity between the groups. Costs of all …

Polyheart: Cardiovascular Disease Risk Assessment, Katherine Vaughan

Kinesiology and Public Health

Cardiovascular disease (CVD) is the leading cause of death in ‘Western Civilization.’ Lifestyle modification (ie regular exercise and healthy diet) greatly reduces the risk for CVD. It is unclear whether faculty at Cal Poly, who are exposed to positive benefits of lifestyle modification are at risk for CVD. The purpose of this study was to assess Cal Poly’s faculties’ cardiovascular health status, as specified by the American College of Sports Medicine’s (ACSM) seven cardiovascular disease risk factors. Both the researchers and participants benefit from this study because awareness of CVD risk factors may help prevent progression of risk factors and …

Notch1 Functions As A Tumor Suppressor In A Model Of K-Ras–Induced Pancreatic Ductal Adenocarcinoma, Linda Hanlon, Jacqueline L Avila, Renée M Demarest, Scott Troutman, Megan Allen, Francesca Ratti, Anil K Rustgi, Ben Z Stanger, Fred Radtke, Volkan Adsay, Fenella Long, Anthony J Capobianco, Joseph L Kissil

Rowan-Virtua School of Osteopathic Medicine Departmental Research

K-ras is the most commonly mutated oncogene in pancreatic cancer and its activation in murine models is sufficient to recapitulate the spectrum of lesions seen in human pancreatic ductal adenocarcinoma (PDAC). Recent studies suggest that Notch receptor signaling becomes reactivated in a subset of PDACs, leading to the hypothesis that Notch1 functions as an oncogene in this setting. To determine whether Notch1 is required for K-ras-induced tumorigenesis, we used a mouse model in which an oncogenic allele of K-ras is activated and Notch1 is deleted simultaneously in the pancreas. Unexpectedly, the loss of Notch1 in this model resulted in increased …

Preliminary Biochemical Characterization Of The Novel, Non-At1, Non-At2 Angiotensin Binding Site From The Rat Brain, Vardan T. Karamyan, Jason Arsenault, Emanuel Escher, Robert C. Speth

HPD Articles

A novel binding site for angiotensins II and III was recently discovered in brain membranes in the presence of the sulfhydryl reactive angiotensinase inhibitor parachloromercuribenzoate. This binding site is distinctly different from the other known receptors for angiotensins: AT₁, AT₂, AT₄, and mas oncogene protein (Ang 1-7 receptor). Preliminary biochemical characterization studies have been done on this protein by crosslinking it with (125)I-labeled photoaffinity probes and solubilizing the radiolabeled binding site. Polyacrylamide gel electrophoresis studies and isoelectric focusing indicate that this membrane bound binding site is a protein with a molecular weight of 70-85 kDa and an isoelectric point of …

Management Of Devastating Ocular Trauma--Experience Of Maxillofacial Surgeons Deployed To A Forward Field Hospital, M. J. Ansell, J. Breeze, Vivian C. Mcalister, M. D. Williams

Surgery Publications

Combat-related eye injuries continue to increase in frequency and are generally secondary to Improvised Explosive Devices. Many ocular injuries are potentially preventable by the wearing of ballistic eye protection. The management of penetrating eye trauma is normally outside the routine practice of maxillofacial surgeons in the UK. The aim of this paper is to describe the surgical techniques used in the modern management of devastating ocular trauma including selected case examples managed by British military maxillofacial surgeons deployed to Afghanistan.

Contact Point, Arthur A. Dugoni School Of Dentistry

Contact Point

No abstract provided.

What's Happening: June, 2010, Maine Medical Center

What's Happening

No abstract provided.

Initiating A Faith Community Nurse Program In The Latino Community: Addressing The Health Care Disparity Of Increased Obesity And Type 2 Diabetes, Helen Jones

Theses and Graduate Projects

There are several related health concerns in the Latino community. These concerns include increased rates of obesity and Type 2 Diabetes. The [MDH] Minnesota Department of Health reports some startling statistics regarding the costs to the community as well as the cost of care. A review of the literature reveals that the costs are staggering, and that several approaches can be helpful in addressing the health care disparity of increased rates of obesity and Type 2 diabetes in the Latino population. Some approaches include the promotore model, a collaborative approach, and education of clergy and lay boards regarding the [FCN] …

Promoting Motivation Towards Community Health Care: A Qualitative Study From Nurses In Pakistan, Saleema A. Gulzar, Muhammad Shahid Shamim, Ali Khan Khuwaja

School of Nursing & Midwifery

Based on the extensive health care needs of Pakistani population, the idea of Community Health Nursing was introduced in 1985. The educational nursing institutes adopted nursing curriculum in order to produce competent nurses to meet the rising demands of society. However, very few numbers of nurses choose community health nursing as their career pathway in Pakistan. Based on the current observation, enhancing motivation among graduate nurses has always been viewed as a great challenge for the academic nursing institutions. This study was intended to explore motivating and de motivating factors in nurses towards community Health Nursing. By utilizing self concept …

Serious Mental Illness In Florida Nursing Homes: A Study Of Resident, Facility And Cost Characteristics, Marion Becker, Shabnam Mehra

Mental Health Law & Policy Faculty Publications

No abstract provided.

Early Childhood Professional Development: A Synthesis Of Recent Research, Allyson Dean

Children, Youth, & Families

This literature review explores the current status of research on the impacts of investments in different types of professional development in early child care settings.

Sizing Up Pharmacotherapy For Obesity., Michael A. Valentino, Andre Terzic, Scott A. Waldman

Department of Pharmacology and Experimental Therapeutics Faculty Papers

Obesity has increased over the last 20 years, from a condition affecting only a small portion of populations in developed countries, into a global pandemic. The impact of obesity can be appreciated in the context of the populations at risk, and it is estimated that >1 billion adults worldwide are overweight (BMI >25 kg/m2), 300 million of whom are clinically obese (BMI >30 kg/m2). In the United States, 65% of adults are overweight, and 32.2% of them are obese, a prevalence that has doubled over 20 years. In industrialized countries, obesity rates have tripled, coinciding with adoption of a Western …

Workers Killed While Collecting Solid Waste, Kentucky Injury Prevention And Research Center

Kentucky Haz Alerts--Motor Vehicle

To prevent solid waste collection injuries:

• An applicable worker safety program should be established
• Before the solid waste truck is moved, visible hand signal communication between the driver and tipper should be established
• A standard operating procedure (SOP) should be established for stacking dumpsters as a result of a job hazard analysis
• A drug testing program should be incorporated in a worker safety program
• Pre-trip and post-trip vehicle inspections should be performed
• An ANSI ISEA 107-1999 safety vest should be worn at all times when on duty
• Do not ride on the steps if the truck is going faster than …

Neural Substrates Of Reliability-Weighted Visual-Tactile Multisensory Integration, Michael S. Beauchamp, Siavash Pasalar, Tony Ro

Publications and Research

As sensory systems deteriorate in aging or disease, the brain must relearn the appropriate weights to assign each modality during multisensory integration. Using blood-oxygen level dependent functional magnetic resonance imaging of human subjects, we tested a model for the neural mechanisms of sensory weighting, termed “weighted connections.” This model holds that the connection weights between early and late areas vary depending on the reliability of the modality, independent of the level of early sensory cortex activity. When subjects detected viewed and felt touches to the hand, a network of brain areas was active, including visual areas in lateral occipital cortex, …