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Articles 31 - 48 of 48
Full-Text Articles in Medicine and Health Sciences
Application Of Culture Care Theory For Nurse Administrators And Managers, Ann Hubbert
Application Of Culture Care Theory For Nurse Administrators And Managers, Ann Hubbert
Ann Hubbert
No abstract provided.
Pka-Mediated Erk1/2 Inactivation And Hsp70 Gene Expression Following Exercise, C.W. Melling, Matthew Krause, Earl Noble
Pka-Mediated Erk1/2 Inactivation And Hsp70 Gene Expression Following Exercise, C.W. Melling, Matthew Krause, Earl Noble
Jamie Melling
Exercise induces the expression of the cardioprotective protein, Hsp70, through the activation of its transcription factor HSF1. Recently, we reported that administration of a protein kinase A (PKA) inhibitor suppressed exercise-induced hsp70 gene expression, suggesting a role for PKA in the regulation of HSF1 activation in vivo. While the mechanism by which PKA regulates HSF1 is unclear, studies in vitro have reported that HSF1 is phosphorylated on two serine residues by mitogen activated protein kinases (MAPKs); ERK1/2 (ser307) and JNK/SAPK (ser363). As PKA is a regulator of these protein kinases, the current study examined the role of PKA in their …
Enhanced Neurite Outgrowth In Pc12 Cells Mediated By Connexin Hemichannels And Atp, Daniel Belliveau, M. Bani-Yagoub, R. Mcgirr, C. Naus, W. Rushlow
Enhanced Neurite Outgrowth In Pc12 Cells Mediated By Connexin Hemichannels And Atp, Daniel Belliveau, M. Bani-Yagoub, R. Mcgirr, C. Naus, W. Rushlow
Daniel J. Belliveau
Gap junctions have traditionally been described as transmembrane channels that facilitate intercellular communication via the passage of small molecules. Connexins, the basic building blocks of gap junctions, are expressed in most mammalian tissues including the developing and adult central nervous system. During brain development, connexins are temporally and spatially regulated suggesting they play an important role in the proper formation of the central nervous system. In the current study, connexins 32 and 43 were overexpressed in PC12 cells to determine whether connexins are involved in neuronal differentiation. Both connexin 32 and 43 were appropriately trafficked to the cell membrane following …
Is Pulse Palpation Helpful In Detecting Atrial Fibrillation? A Systematic Review, Georga Cooke, Jenny Doust, Sharon Sanders
Is Pulse Palpation Helpful In Detecting Atrial Fibrillation? A Systematic Review, Georga Cooke, Jenny Doust, Sharon Sanders
Jenny Doust
Background: Atrial fibrillation in the elderly is common and potentially life threatening. The classical sign of atrial fibrillation is an irregularly irregular pulse. Objective: The objective of this research was to determine the accuracy of pulse palpation to detect atrial fibrillation. Methods: We searched Medline, EMBASE, and the reference lists of review articles for studies that compared pulse palpation with the electrocardiogram (ECG) diagnosis of atrial fibrillation. Two reviewers independently assessed the search results to determine the eligibility of studies, extracted data, and assessed the quality of the studies. Results: We identified 3 studies (2385 patients) that compared pulse palpation …
The Role Of Radiation Therapy On Medically Inoperable Clinically Localized Non-Small Cell Lung Patients: London Regional Cancer Program (Lrcp) Clinical Experience, Michael Lee, Edward Yu, Robert Ash, Patricia Tai, Larry Stitt, George Rodrigues, Rashid Dar, Mark Vincent, Richard Inculet, Richard Malthaner
The Role Of Radiation Therapy On Medically Inoperable Clinically Localized Non-Small Cell Lung Patients: London Regional Cancer Program (Lrcp) Clinical Experience, Michael Lee, Edward Yu, Robert Ash, Patricia Tai, Larry Stitt, George Rodrigues, Rashid Dar, Mark Vincent, Richard Inculet, Richard Malthaner
Edward Yu
Lung cancer is the most frequent cause of cancer death in both men and women in North America. In 2006, an estimated 22,700 Canadians will be diagnosed with lung cancer and 19,300 will die of it (Canadian Cancer Statistics 2006). Approximately 15-20% of NSCLC patients present with early or localized disease. Surgical resection of T1-2N0 NSCLC remains the treatment of choice for this population, and results in a 5-year survival rate of 50-70%. Patients deemed medically inoperable have been treated with non-surgical therapies, such as radiation therapy(RT), while some patients have simply been observed without any tumor therapy because of …
Meeting The Health Care Needs Of Miedically Underserved, Uninsured, And Underinsured Appalachians, Ida Slusher, C. Fletcher-Withrow, M. Whitaker
Meeting The Health Care Needs Of Miedically Underserved, Uninsured, And Underinsured Appalachians, Ida Slusher, C. Fletcher-Withrow, M. Whitaker
Ida Slusher
There is the need for critical changes in the United States health care system to meet the rising costs of health care and the massive number of people without health insurance. The Berea Health Ministry Rural Health Clinic (BHMRHC) is a nurse-managed, rural primary health care clinic that was designed to respond to the health care needs of the underserved, uninsured, and underinsured populations in a designated nine county area of Appalachian Kentucky. The process used in the development and implementation of BHMRHC is described as a model to assist in the future development of similar clinics.
Radiotherapy For Merkel Cell Carcinoma Of The Skin, Patricia Tai, Edward Yu, Juan Pacella
Radiotherapy For Merkel Cell Carcinoma Of The Skin, Patricia Tai, Edward Yu, Juan Pacella
Edward Yu
We examine the impact of radiotherapy in the treatment of Merkel cell carcinoma (MCC) of the skin. Data at two Canadian institutions (Allan Blair Cancer Centre and London Regional Cancer Program) were collected and charts were retrieved from the registry of 1987 to 2005. A total of 79 patients with definite MCC were studied. All except three had a primary skin lesion. Six patients presented with nodal metastases and three patients with distant metastases. Fourteen patients were referred to the cancer centers at the time of recurrence: 2/14 with local recurrence, 8/14 with nodal recurrence, 2/14 with both local and …
Evidence Based Answers - Is Salmeterol Safe In Asthma?, Geoffrey Spurling, Jenny Doust
Evidence Based Answers - Is Salmeterol Safe In Asthma?, Geoffrey Spurling, Jenny Doust
Jenny Doust
Case history SW, 21 years of age, presented for a prescription for her salbutamol puffer. She had a long history of chronic persistent asthma usually exacerbated by upper respiratory tract infections (URTIs). These exacerbations had occasionally landed her in hospital but never in intensive care. After a friend died of an asthma attack, SW adhered rigorously to her asthma plan and always used a spacer for her preventer, fluticasone. It therefore surprised me when I noticed that she had had no URTIs yet had been prescribed salbutamol by another general practitioner in the practice only 2 weeks previously. In response …
The Balm Of Gilead: Is The Provision Of Treatment To Those Who Seroconvert In Hiv Prevention Trials A Matter Of Moral Obligation Or Moral Negotiation?, Charles Weijer, Guy Leblanc
The Balm Of Gilead: Is The Provision Of Treatment To Those Who Seroconvert In Hiv Prevention Trials A Matter Of Moral Obligation Or Moral Negotiation?, Charles Weijer, Guy Leblanc
Charles Weijer
Must treatment be provided to subjects who acquire HIV during the course of a prevention study? An analysis of ethical foundation, regulation, and recent argumentation provides no basis for the obligation. We outline an alternative approach to the problem based on moral negotiation.
Access To Death Certificates: What Should Research Ethics Committees Require For Approval?, Tore Nilstun, Colleen Cartwright, Rurik Lofmark, L Deliens, Susanne Fischer, Guido Miccinesi, Michael Norup, Agnes Van Der Heide
Access To Death Certificates: What Should Research Ethics Committees Require For Approval?, Tore Nilstun, Colleen Cartwright, Rurik Lofmark, L Deliens, Susanne Fischer, Guido Miccinesi, Michael Norup, Agnes Van Der Heide
Professor Colleen M Cartwright
Purpose: To present and discuss the reactions of research ethics committees (RECs) in a number of countries when asked for approval of a study requiring access to death certificates to identify the physicians signing the certificates and to send them a four-page questionnaire about medical decisions made at the patient's end-of-life that could possibly have hastened death. Methods: A simple questionnaire were sent to the responsible national investigator in an international study (Australia, Belgium, Denmark, Italy, the Netherlands, Sweden, Switzerland) asking about the interactions between the national research group and the national/regional REC(s). Results: Different laws or guidelines were used …
Lactobacillus Vaginal Microbiota Of Women Attending A Reproductive Health Care Service In Benin City, Nigeria., Kingsley Anukam, Emmanuel Osazuwa, Ijeoma Ahonkhai, Gregor Reid
Lactobacillus Vaginal Microbiota Of Women Attending A Reproductive Health Care Service In Benin City, Nigeria., Kingsley Anukam, Emmanuel Osazuwa, Ijeoma Ahonkhai, Gregor Reid
Kingsley C Anukam
OBJECTIVE: The objective of this study was to determine whether Lactobacillus species found in African women differ substantially to those of Caucasian decent, described in previous studies. The vaginal microbiota play an important role in female health, and when the naturally dominant lactobacilli are displaced resulting in bacterial vaginosis (BV), the host is more at risk of acquiring sexually transmitted diseases, including HIV. METHODS: Vaginal samples were collected from 241 healthy, pre-menopausal Nigerian women, which were then Gram stained for Nugent scoring. Microbial DNA was extracted, amplified using PCR and Lactobacillus primers, and processed by Denaturing Gradient Gel Electrophoresis (DGGE). …
End-Of-Life Decision Making In Europe And Australia: A Physician Survey, Bregje Onwuteaka-Philipsen, Susanne Fischer, Colleen Cartwright, L Deliens, Guido Miccinesi, Michael Norup, Tore Nilstun, Agnes Van Der Heide, Gerrit Van Der Wal
End-Of-Life Decision Making In Europe And Australia: A Physician Survey, Bregje Onwuteaka-Philipsen, Susanne Fischer, Colleen Cartwright, L Deliens, Guido Miccinesi, Michael Norup, Tore Nilstun, Agnes Van Der Heide, Gerrit Van Der Wal
Professor Colleen M Cartwright
Background: The frequencies with which physicians make different medical end-of-life decisions (ELDs) may differ between countries, but comparison between countries has been difficult owing to the use of dissimilar research methods. Methods: A written questionnaire was sent to a random sample of physicians from 9 specialties in 6 European countries and Australia to investigate possible differences in the frequencies of physicians' willingness to perform ELDs and to identify predicting factors. Response rates ranged from 39% to 68% (N = 10 139). Using hypothetical cases, physicians were asked whether they would (probably) make each of 4 ELDs. Results: In all the …
Fiduciary Obligation In Clinical Research, Paul Miller, Charles Weijer
Fiduciary Obligation In Clinical Research, Paul Miller, Charles Weijer
Charles Weijer
Heated debate surrounds the question whether the relationship between physician-researcher and patient-subject is governed by a duty of care. Miller and Weijer argue that fiduciary law provides a strong legal foundation for this duty, and for articulating the terms of the relationship between physician-researcher and patient-subject.
An Empirical Investigation Of Psychopathy In A Noninstitutionalized And Noncriminal Sample, David Dematteo, Kirk Heilbrun, Geoffrey Marczyk
An Empirical Investigation Of Psychopathy In A Noninstitutionalized And Noncriminal Sample, David Dematteo, Kirk Heilbrun, Geoffrey Marczyk
David DeMatteo
No abstract provided.
Non-Pharmacological Management Of Hypokinetic Dysarthria In Parkinson’S Disease, Andrew Johnson, S. Adams
Non-Pharmacological Management Of Hypokinetic Dysarthria In Parkinson’S Disease, Andrew Johnson, S. Adams
Andrew M. Johnson
No abstract provided.
The Prevalence And Characteristics Of Intimate Partner Violence In A Community Study Of Chinese American Women., Madelyn Hicks
The Prevalence And Characteristics Of Intimate Partner Violence In A Community Study Of Chinese American Women., Madelyn Hicks
Madelyn Hsiao-Rei Hicks
No abstract provided.
Mortality After The 2003 Invasion Of Iraq: Were Valid And Ethical Field Methods Used In This Survey?, M Hicks
Mortality After The 2003 Invasion Of Iraq: Were Valid And Ethical Field Methods Used In This Survey?, M Hicks
Madelyn Hsiao-Rei Hicks
No abstract provided.
Cardiorespiratory Fitness And Acute Aerobic Exercise Effects On Neuroelectric And Behavioral Measures Of Action Monitoring, Jason R. Themanson, Charles H. Hillman
Cardiorespiratory Fitness And Acute Aerobic Exercise Effects On Neuroelectric And Behavioral Measures Of Action Monitoring, Jason R. Themanson, Charles H. Hillman
Jason R. Themanson, Ph.D
Cardiorespiratory fitness and acute aerobic exercise effects on cognitive function were assessed for 28 higher- and lower-fit adults during a flanker task by comparing behavioral and neuroelectric indices of action monitoring. The error-related negativity, error positivity, and N2 components, as well as behavioral measures of response speed, accuracy, and post-error slowing were measured following a 30-minute acute bout of treadmill exercise or following 30-minutes of rest. A graded maximal exercise test was used to measure cardiorespiratory fitness by assessing maximal oxygen uptake. Results indicated that higher-fit adults exhibited reduced error-related negativity amplitude, increased error positivity amplitude, and increased post-error response …