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Full-Text Articles in Medicine and Health Sciences
The Effect Of Timing Of Radiotherapy After Breast-Conserving Surgery In Patients With Positive Or Close Resection Margins, Young Age, And Node-Negative Disease, With Long Term Follow-Up, Olga Vujovic, Anil Cherian, Edward Yu, A. Dar, Larry Stitt, Francisco Perera
The Effect Of Timing Of Radiotherapy After Breast-Conserving Surgery In Patients With Positive Or Close Resection Margins, Young Age, And Node-Negative Disease, With Long Term Follow-Up, Olga Vujovic, Anil Cherian, Edward Yu, A. Dar, Larry Stitt, Francisco Perera
Edward Yu
Purpose: The aim of this study was to determine the effect of timing of radiotherapy after conservative breast surgery on local recurrence in women with positive resection margins and young age, treated without systemic therapy. Methods and materials: A total of 568 patients with T1 and T2, N0 breast cancer were treated with breast-conserving surgery and breast irradiation, between January 1, 1985, and December 31, 1992, at the London Regional Cancer Centre. 63 patients (11.1%) had positive/close resection margins (< 2 mm) and 48 patients (8.4%) were age < or = 40 years. For patients with positive resection margins, the time intervals from breast surgery to breast irradiation used for analysis were, 0 to 8 weeks, > 8 to 12 weeks and > 12 weeks. For patients < or = 40 years, the intervals used for analysis were 0 to 8 weeks and > 8 weeks. Results: Median follow up was 11.2 years. For patients …
Syndrome Of Inappropriate Antidiuretic Hormone Secretion (Siadh) In Patients With Limited Stage Small Cell Lung Cancer, Patricia Tai, Edward Yu, Kurian Jones, Evgeny Sadikov, Shazia Mahmood, Jon Tonita
Syndrome Of Inappropriate Antidiuretic Hormone Secretion (Siadh) In Patients With Limited Stage Small Cell Lung Cancer, Patricia Tai, Edward Yu, Kurian Jones, Evgeny Sadikov, Shazia Mahmood, Jon Tonita
Edward Yu
A few series in the literature were published before 1987 on syndrome of inappropriate antidiuretic hormone secretion (SIADH) in small cell lung cancer (SCLC). This study examines the outcome in more recent era. From 1981-1998, there were 1417 new cases of SCLC diagnosed in the provincial registry, of which 244 were of limited stage (LS). A chart review and statistical analyses were performed using Mann-Whitney test, chi-square test and Kaplan-Meier method. Fourteen LS patients (group A) had SIADH at presentation. Group B consisted of 230 LS patients without SIADH. There were more patients with poorer performance status (ECOG 2-4) in …
The Role Of Radiation Therapy In Malignant Pleural Mesothelioma: A Systematic Review, Yee Ung, Edward Yu, Conrad Falkson, Adam Haynes, Denise Stys-Norman, William Evans
The Role Of Radiation Therapy In Malignant Pleural Mesothelioma: A Systematic Review, Yee Ung, Edward Yu, Conrad Falkson, Adam Haynes, Denise Stys-Norman, William Evans
Edward Yu
Introduction: Radiation therapy may offer patients presenting with malignant pleural mesothelioma (MPM) symptom palliation and improvements in quality of life. This systematic review will address the role of radiation therapy in the management of MPM. Methods: A thorough systematic search of the literature was conducted for published articles and conference proceedings for applicable abstracts. Relevant trials were selected and assessed. Results: Three small randomized controlled trials compared prophylactic external beam radiation therapy to no radiation therapy for patients with thoracic tracts caused by drainage tubes or diagnostic procedures. None of those trials reported any serious adverse effects. A pooled analysis …
Eleven-Year Follow-Up Results In The Delay Of Breast Irradiation After Conservative Breast Surgery In Node-Negative Breast Cancer Patients, Olga Vujovic, Edward Yu, Anil Cherian, A. Dar, Larry Stitt, Francisco Perera
Eleven-Year Follow-Up Results In The Delay Of Breast Irradiation After Conservative Breast Surgery In Node-Negative Breast Cancer Patients, Olga Vujovic, Edward Yu, Anil Cherian, A. Dar, Larry Stitt, Francisco Perera
Edward Yu
Purpose: This retrospective review was conducted to determine if delay in the start of radiotherapy after conservative breast surgery had any detrimental effect on local recurrence or disease-free survival in node-negative breast cancer patients. Methods and materials: A total of 568 patients with T1 and T2, N0 breast cancer were treated with breast-conserving surgery and breast irradiation, without adjuvant systemic therapy, between January 1, 1985 and December 31, 1992 at the London Regional Cancer Centre. The time intervals from definitive breast surgery to breast irradiation used for analysis were 0 to 8 weeks (201 patients), greater than 8 to 12 …
Comparative Planning Evaluation Of Intensity-Modulated Radiotherapy Techniques For Complex Lung Cancer Cases, Slav Yartsev, Jeff Chen, Edward Yu, Tomas Kron, George Rodrigues, Terry Coad, Kristina Trenka, Eugene Wong, Glenn Bauman, Jake Van Dyk
Comparative Planning Evaluation Of Intensity-Modulated Radiotherapy Techniques For Complex Lung Cancer Cases, Slav Yartsev, Jeff Chen, Edward Yu, Tomas Kron, George Rodrigues, Terry Coad, Kristina Trenka, Eugene Wong, Glenn Bauman, Jake Van Dyk
Edward Yu
Background and purpose: Lung cancer treatment can be one of the most challenging fields in radiotherapy. The aim of the present study was to compare different modalities of radiation delivery based on a balanced scoring scheme for target coverage and normal tissue avoidance. Patients and methods: Treatment plans were developed for 15 patients with stage III inoperable non-small cell lung cancer using 3D conformal technique and intensity-modulated radiotherapy (IMRT). Elective nodal irradiation was included for all cases to create the most challenging scenarios with large target volumes. A 2 cm margin was used around the gross tumour volume (GTV) to …