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Regulation Of Contraction-Induced Fa Uptake And Oxidation By Ampk And Erk1/2 Is Intensity Dependent In Rodent Muscle, Marcella Raney, Lorraine Turcotte
Regulation Of Contraction-Induced Fa Uptake And Oxidation By Ampk And Erk1/2 Is Intensity Dependent In Rodent Muscle, Marcella Raney, Lorraine Turcotte
Marcella Raney
Muscle contraction activates AMP-activated protein kinase (AMPK) and extracellular signal-regulated kinase (ERK1/2), two signaling molecules involved in the regulation of muscle metabolism. The purpose of this study was to determine whether activation of AMPK and/or ERK1/2 contributes to the regulation of muscle fatty acid (FA) uptake and oxidation in contracting muscle. Rat hindquarters were perfused during rest (R) or electrical stimulation (E) of increasing intensity by manipulating train duration (E1 = 25 ms, E2 = 50 ms, E3 = 100 ms, E4 = 200 ms). For matched FA delivery, FA uptake was significantly greater than R during E1, E2, and …