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2005

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Articles 1951 - 1980 of 2796

Full-Text Articles in Medicine and Health Sciences

Effect Of Cirrhosis On Antibiotic Efficacy In A Rat Model Of Pneumococcal Pneumonia, Laurel C. Preheim, Keith M. Olsen, Mei Yue, Mary U. Snitily, Martha J. Gentry-Nielsen Jan 2005

Effect Of Cirrhosis On Antibiotic Efficacy In A Rat Model Of Pneumococcal Pneumonia, Laurel C. Preheim, Keith M. Olsen, Mei Yue, Mary U. Snitily, Martha J. Gentry-Nielsen

United States Public Health Resources

A rat model was used to study the effects of cirrhosis on antibiotic therapy of pneumococcal pneumonia. Cirrhotic and control male Sprague-Dawley rats were infected transtracheally with type 3 Streptococcus pneumonia. Treatment began 18 h later with phosphate-buffered saline (PBS), azithromycin (50 mg/kg), trovafloxacin (50 mg/kg), or ceftriaxone (100 mg/kg) injected subcutaneously twice daily for 5 days. Antibiotic concentrations were measured by high-performance liquid chromatography. Azithromycin, trovafloxacin, and ceftriaxone were all equally effective at preventing mortality in both cirrhotic and normal rats. Free fraction area under the curve to minimum inhibitory concentration ratio (AUC/MIC) and maximum calculated serum concentration …

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Rat Sinusoidal Liver Endothelial Cells (Secs) Produce Pro-Fibrotic Factors In Response To Adducts Formed From The Metabolites Of Ethanol, Geoffrey M. Thiele, Michael J. Duryee, Thomas L. Freeman, Michael F. Sorrell, Monte S. Willis, Dean J. Tuma, Lynell W. Klassen Jan 2005

Rat Sinusoidal Liver Endothelial Cells (Secs) Produce Pro-Fibrotic Factors In Response To Adducts Formed From The Metabolites Of Ethanol, Geoffrey M. Thiele, Michael J. Duryee, Thomas L. Freeman, Michael F. Sorrell, Monte S. Willis, Dean J. Tuma, Lynell W. Klassen

United States Public Health Resources

Previous studies with alcohol-associated malondialdehyde–acetaldehyde (MAA)-modified proteins have demonstrated an increase in the expression of adhesion molecules, and the secretion of pro-inflammatory cytokines/chemokines by rat sinusoidal liver endothelial cells (SECs). However, no studies have been initiated to examine the effects of MAA-modified proteins on the expression of the extracellular matrix (ECM) protein, fibronectin and its isoforms. For these studies, SECs were isolated from the liver of normal rats, and exposed to MAA-modified bovine serum albumin (MAA–Alb). At selected time points, the total plasma and cellular fibronectin were determined by Western blot. Injection of rat liver via the mesenteric vein with …

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Integrating Technology Into The Chemical Dependency Curriculum At The St. Croix Camp Schools, Cory D. Knudtson Jan 2005

Integrating Technology Into The Chemical Dependency Curriculum At The St. Croix Camp Schools, Cory D. Knudtson

Theses and Graduate Projects

The Amherst H. Wilder St. Croix Camps are located 25 miles east of Hinckley, Minnesota. The camps provide rehabilitative programming for both male and female juveniles referred by either social services or probation. One of the programming pieces consists of alcohol, tobacco, and other drug curriculum. During this project, the integration of technology and chemical dependency curriculum was explored. The computer program Alcohol 101 for Hish School provided students attending the on-site public school a new way of learning and exploring alcohol use and consequences. Along with providing students a new learning opportunity, teachers and other staff learned about the …

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Delayed Supramalleolar Flap: An Innovative Technique For Enhanced Viability, Syed Kamran Ahmed, Pervaiz Mehmood Hashmi Jan 2005

Delayed Supramalleolar Flap: An Innovative Technique For Enhanced Viability, Syed Kamran Ahmed, Pervaiz Mehmood Hashmi

Section of Orthopaedic Surgery

Background: Delaying flap rotation for 48 to 72 hours leads to opening of choke anastomotic vessels linking adjacent vascular territories. This mechanism enhances flap circulation. Lateral supramalleolar flap with larger dimensions or vascular variations can potentially have survival problems. The purpose of this study is to assess the outcome of delayed lateral supramalleolar flap.
Methods: This descriptive case series was conducted at Aga Khan University Hospital, Karachi from May 1999 to December 2004. Eight cases of delayed lateral supramalleolar flap were identified through medical records maintained through Health Information Management Systems (HIMS). A detailed questionnaire was developed addressing variables of …

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Bacillus Calmette-Guerin (Bcg) Lymphadenitis: Changing Trends And Management, Zafar Nazir, Saqib Hamid Qazi Jan 2005

Bacillus Calmette-Guerin (Bcg) Lymphadenitis: Changing Trends And Management, Zafar Nazir, Saqib Hamid Qazi

Section of Paediatric Surgery

Background: Bacillus Calmette-Guérin (BCG) vaccination is performed as a part of expanded Programme of Immunization (EPI). Suppurative lymphadenitis is the common complication of BCG vaccination. The optimum treatment for this complication is debated.
Methods: All cases of BCG lymphadenitis presenting to pediatric surgical service over a 17-year study period were reviewed to determine the optimum treatment for this problem.
Results: Sixty children were referred for the management of BCG lymphadenitis during the study period. Most patients (n=43) presented during 1988 and 1990. Children were healthy and received BCG (Pasteur strain) vaccination at EPI during first 2 months of life. Initially …

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Spatial Management Of Wildlife Disease, Richard Horan, Christopher Wolf, Eli P. Fenichel, Kenneth H. Mathews, Jr. Jan 2005

Spatial Management Of Wildlife Disease, Richard Horan, Christopher Wolf, Eli P. Fenichel, Kenneth H. Mathews, Jr.

Michigan Bovine Tuberculosis Bibliography and Database

The spread of wildlife diseases is a major threat to livestock, human health, resource-based recreation, and biodiversity conservation (Cleaveland, Laurenson, and Taylor). The development of economically sound wildlife disease-management strategies requires an understanding of the links between ecological functions (e.g., disease transmission and wildlife dispersal) and economic choices, and the associated tradeoffs. Spatial linkages are particularly relevant. Yet while ecologists have long-argued that space is important (Hudson et al.), prior economic work has largely ignored spatial issues.

For instance, Horan and Wolf analyzed a case study of bovine tuberculosis (bTB) in Michigan deer, a problem where the disease appears to …

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Michigan Bovine Tuberculosis Eradication Project: 2005 Activities Report And Conference Proceedings Jan 2005

Michigan Bovine Tuberculosis Eradication Project: 2005 Activities Report And Conference Proceedings

Michigan Bovine Tuberculosis Bibliography and Database

On June 7 and 8, 2005, the State of Michigan and U.S. Department of Agriculture hosted the ninth annual bovine Tuberculosis (TB) meeting of scientists, with the intent to share research information and provide updates on policies, regulations and activities regarding bovine TB.

This document is a thank you to stakeholders and serves as an annual report offering insight into the finer points of this multi-agency project. The year 2005 has been one of milestones. The Upper Peninsula received TB-Free Status; only one TB positive farm was found during routine surveillance testing; and the disease prevalence rate in Deer Management …

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Pelvic Examinations Under Anesthesia: An Important Teaching Tool, Jennifer Goedken Jan 2005

Pelvic Examinations Under Anesthesia: An Important Teaching Tool, Jennifer Goedken

Journal of Health Care Law and Policy

No abstract provided.

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Pathogenesis Of Intracranial Aneurysms, Brian Vala Nahed Jan 2005

Pathogenesis Of Intracranial Aneurysms, Brian Vala Nahed

Yale Medicine Thesis Digital Library

Introduction: Intracranial aneurysms (IA) are a common neurological problem, the rupture of which frequently constitutes a catastrophic neurological event. While the pathogenesis is largely unknown, it is believed that both genetic and environmental factors work in concert to some degree within patients. Our goal was to take a comprehensive approach to understanding the pathogenesis of IA by identifying factors leading to the formation, growth and rupture of IA. Methods: Since 1994, we have recruited patients and families with IA into the Yale Brain Aneurysm Database. Information regarding aneurysm characteristics (size, location, number), patient characteristics (age, medical, and social history), and …

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Reducing The Transmission Of Hiv And Sexually Transmitted Infections In A Mining Community: Findings From The Carletonville Mothusimpilo Intervention Project: 1998 To 2001, Lewis Ndhlovu, Catherine Searle, Johannes Van Dam, Yodwa Mzaidume, Bareng Rasego, Solly Moema Jan 2005

Reducing The Transmission Of Hiv And Sexually Transmitted Infections In A Mining Community: Findings From The Carletonville Mothusimpilo Intervention Project: 1998 To 2001, Lewis Ndhlovu, Catherine Searle, Johannes Van Dam, Yodwa Mzaidume, Bareng Rasego, Solly Moema

HIV and AIDS

The Horizons program, in collaboration with the Center for Scientific and Industrial Research, the South African Institute for Medical Research, and the London School of Economics, conducted an intervention study in the mining town of Carletonville, South Africa to examine the social determinants of the HIV epidemic, and to assess the impact of a targeted program of HIV and STI prevention and service delivery. The project did not reduce STI prevalence or HIV prevalence, as changing sexual behavior is far more complex than educating individuals about HIV. The report recommends interventions to support behavioral change education, STI treatment, the role …

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Human Rights And Bioethics: Formulating A Universal Right To Health, Health Care, Or Health Protection?, George P. Smith Ii Jan 2005

Human Rights And Bioethics: Formulating A Universal Right To Health, Health Care, Or Health Protection?, George P. Smith Ii

Scholarly Articles

Codifying, and then implementing, an international right to health, health care, or protection is beset with serious roadblocks - foremost among them being contentious issues of indeterminacy, justiciability, and progressive realization. Although advanced - and to some degree recognized under the rubric of a social or cultural entitlement within the law of human rights and, more particularly, the U.S. Declaration on Human Rights, together with International Covenant on Economic, Social and Cultural Rights (ICESCR), the International Covenant on Civil and Political Rights, the European Convention on Human Rights, and presently UNESCO's Draft Declaration on Universal Norms on Bioethics - attainment …

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Dinámica De Seroconversión En Hembras Bovinas Post Eliminación De Animales Portadores Del Virus De La Diarrea Viral Bovina., Jayashi Cesar F., Gavidia Cesar C., Mariluz Araínga, Alberto Manchego, Hermelinda G. Rivera Jan 2005

Dinámica De Seroconversión En Hembras Bovinas Post Eliminación De Animales Portadores Del Virus De La Diarrea Viral Bovina., Jayashi Cesar F., Gavidia Cesar C., Mariluz Araínga, Alberto Manchego, Hermelinda G. Rivera

Journal Articles: Pharmacology & Experimental Neuroscience

A study was conducted to determine the effect of culling BVDV carrier animals on the seroconversion against BVDV in the new generation of heifers from a dairy herd located in Arequipa, Peru. Blood samples were collected from 6-12 month old females in four sampling periods: January (n = 73), June (n = 48), October 2003 (n = 48), and January 2004 (n = 35) to evaluate their serological against BVDV status and to screen for carrier animals using the virus neutralization and antigen-capture ELISA tests, respectively. The prevalence of BVDV was 80.8 ± 9.0, 56.3 ± 14.0, 50.0 ± 14.2 …

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Changes In Beliefs Identify Unblinding In Randomized Controlled Trials: A Method To Meet Consort Guidelines, Judy R. Rees, Timothy J. Wade, Deborah A. Levy, John M. Colford, Joan F. Hilton Jan 2005

Changes In Beliefs Identify Unblinding In Randomized Controlled Trials: A Method To Meet Consort Guidelines, Judy R. Rees, Timothy J. Wade, Deborah A. Levy, John M. Colford, Joan F. Hilton

Journal Articles: Epidemiology

Double-blinded trials are often considered the gold standard for research, but significant bias may result from unblinding of participants and investigators. Although the CONSORT guidelines discuss the importance of reporting "evidence that blinding was successful", it is unclear what constitutes appropriate evidence. Among studies reporting methods to evaluate blinding effectiveness, many have compared groups with respect to the proportions correctly identifying their intervention at the end of the trial. Instead, we reasoned that participants' beliefs, and not their correctness, are more directly associated with potential bias, especially in relation to self-reported health outcomes. During the Water Evaluation Trial performed in …

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Introduction, Melanie Santiago Jan 2005

Introduction, Melanie Santiago

Journal of Health Care Law and Policy

No abstract provided.

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The 800 Pound Gorilla Sleeps: The Federal Government's Lackadaisical Liability And Compensation Policies In The Context Of Pre-Event Vaccine Immunization Programs, Michael Greenberger Jan 2005

The 800 Pound Gorilla Sleeps: The Federal Government's Lackadaisical Liability And Compensation Policies In The Context Of Pre-Event Vaccine Immunization Programs, Michael Greenberger

Journal of Health Care Law and Policy

No abstract provided.

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Old Legacies And New Paradigms: Confusing "Research" And "Treatment" And Its Consequences In Responding To Emergent Health Threats, Gail H. Javitt Jan 2005

Old Legacies And New Paradigms: Confusing "Research" And "Treatment" And Its Consequences In Responding To Emergent Health Threats, Gail H. Javitt

Journal of Health Care Law and Policy

No abstract provided.

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Inoculation Inventions: The Interplay Of Infringement And Immunity In The Development Of Biodefense Vaccines, Cynthia M. Ho Jan 2005

Inoculation Inventions: The Interplay Of Infringement And Immunity In The Development Of Biodefense Vaccines, Cynthia M. Ho

Journal of Health Care Law and Policy

No abstract provided.

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Some Right Jabs And Back In The Ring: Lessons Learned From The Phase I Civilian Smallpox Program, Elin Gursky, Avani Parikh Jan 2005

Some Right Jabs And Back In The Ring: Lessons Learned From The Phase I Civilian Smallpox Program, Elin Gursky, Avani Parikh

Journal of Health Care Law and Policy

No abstract provided.

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Introduction: Use Of Patients For Teaching Purposes Without Their Knowledge Or Consent, Michelle Oberman Jan 2005

Introduction: Use Of Patients For Teaching Purposes Without Their Knowledge Or Consent, Michelle Oberman

Journal of Health Care Law and Policy

No abstract provided.

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Teaching Without Harming The Living: Performing Minimally Invasive Procedures On The Newly Dead, Kenneth V. Iserson Jan 2005

Teaching Without Harming The Living: Performing Minimally Invasive Procedures On The Newly Dead, Kenneth V. Iserson

Journal of Health Care Law and Policy

No abstract provided.

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Autonomy Suspended: Using Female Patients To Teach Intimate Exams Without Their Knowledge Or Consent, Robin Fretwell Wilson Jan 2005

Autonomy Suspended: Using Female Patients To Teach Intimate Exams Without Their Knowledge Or Consent, Robin Fretwell Wilson

Journal of Health Care Law and Policy

No abstract provided.

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Research Involving Children: Regulations, Review Board, And Reform, Rupali Gandhi Jan 2005

Research Involving Children: Regulations, Review Board, And Reform, Rupali Gandhi

Journal of Health Care Law and Policy

No abstract provided.

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Do Pregnant Women Have (Living) Will?, Daniel Sperling Jan 2005

Do Pregnant Women Have (Living) Will?, Daniel Sperling

Journal of Health Care Law and Policy

No abstract provided.

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Faster, Higher, Stronger? Federal Efforts To Criminalize Anabolic Steroids And Steroid Precursors, Adrian Wilairat Jan 2005

Faster, Higher, Stronger? Federal Efforts To Criminalize Anabolic Steroids And Steroid Precursors, Adrian Wilairat

Journal of Health Care Law and Policy

No abstract provided.

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Identification Of Neuronal Enhancers Of The Proopiomelanocortin Gene By Transgenic Mouse Analysis And Phylogenetic Footprinting, Flavio S. J. De Souza, Andrea M. Santangelo, Viviana Bumaschny, Marıa Elena Avale, James L. Smart, Malcolm J. Low, Marcelo Rubinstein Jan 2005

Identification Of Neuronal Enhancers Of The Proopiomelanocortin Gene By Transgenic Mouse Analysis And Phylogenetic Footprinting, Flavio S. J. De Souza, Andrea M. Santangelo, Viviana Bumaschny, Marıa Elena Avale, James L. Smart, Malcolm J. Low, Marcelo Rubinstein

Faculty Publications - Department of Biological & Molecular Science

The proopiomelanocortin (POMC) gene is expressed in the pituitary and arcuate neurons of the hypothalamus. POMC arcuate neurons play a central role in the control of energy homeostasis, and rare loss of function mutations in POMC cause obesity. Moreover, POMC is the prime candidate gene within a highly significant quantitative trait locus on chromosome 2 associated with obesity traits in several human populations. Here, we identify two phylogenetically conserved neuronal POMC enhancers designated nPE1 (600 bp) and nPE2 (150 bp) located approximately 10 to 12 kb upstream of mammalian POMC transcriptional units. We show that mouse or human genomic regions …

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Smoking Prevalence, Knowledge And Attitudes Among Medical Students In Karachi, Pakistan, F M. Khan, S J. Husain, A Laeeq, A Awais, S F. Hussain, J A. Khan Jan 2005

Smoking Prevalence, Knowledge And Attitudes Among Medical Students In Karachi, Pakistan, F M. Khan, S J. Husain, A Laeeq, A Awais, S F. Hussain, J A. Khan

Section of Pulmonary & Critical Care

A survey of smoking prevalence and attitudes was made among medical students randomly selected from classes at the Aga Khan University, Karachi, Pakistan. Of 271 respondents, 14.4% were current smokers (22.0% male and 3.8% females) and 3.3% ex-smokers. A majority of students recognized the dangers associated with active as well as passive smoking although only 55% of current smokers planned to quit in the near future. Most smokers (96%) believed that they as well as other health professionals needed training on smoking cessation and 95% of all students believed that doctors should play a role model in smoking cessation by …

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Department Of Radiology-Annual Executive Summary Report-July 1, 2004 To June 30, 2005, Vijay M. Rao M.D. Jan 2005

Department Of Radiology-Annual Executive Summary Report-July 1, 2004 To June 30, 2005, Vijay M. Rao M.D.

Department of Radiology Administrative Documents and Reports

88 page Department of Radiology Annual Executive Summary Report, July 1, 2004 to June 30, 2005, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States.

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Health Professions Division Catalog 2005-2006, Nova Southeastern University Jan 2005

Health Professions Division Catalog 2005-2006, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

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College Of Optometry Student Handbook 2005-2006, Nova Southeastern University Jan 2005

College Of Optometry Student Handbook 2005-2006, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

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Implementing Computerized Physician Order Entry In Community Hospitals: Vendor Perspectives For Success, Todd D. Ellis Jan 2005

Implementing Computerized Physician Order Entry In Community Hospitals: Vendor Perspectives For Success, Todd D. Ellis

MUSC Theses and Dissertations

The purpose of this study was to understand vendor perspectives for successful implementation of Computerized Physician Order Entry (CPOE) in community hospitals. The methodology followed was based on grounded theory with an aim of generating a descriptive and explanatory theory of the likely success factors for CPOE implementations in community hospitals. The primary source of data came from telephone, face-to-face focus group interviews with CPOE vendor implementation specialists who possessed two or more years of CPOE implementation experience in community hospital settings. The interviews involved semi-structured open-ended questions that were intended to elicit views and opinions from the study participants. …

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