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Download Full Pdf Issue Volume1, Issue 2 - Msph Newsletter 2005

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This is the second issue from 2005 and includes student thesis topics, reminders, updates, and upcoming events.

Psychometrically Equivalent Digital Recordings For Speech Audiometry Testing In Mandarin Chinese: Standard Mandarin Dialect, Lara-Jill Jennings

Theses and Dissertations

The development of digitally recorded speech audiometry materials in Mandarin Chinese has been limited to date. High quality materials proliferate in the English language and have been developed for other languages such as Brazilian Portuguese, Spanish, Japanese, Korean, French, Italian, Polish, and Russian. The aims of this study were to develop, digitally record, evaluate, and equate words and word lists in Mandarin Chinese to use for speech reception threshold testing and for speech discrimination testing. The words that were evaluated were chosen from a Chinese frequency usage dictionary. One native male and one native female talker recorded the words onto …

Intimate Partner Violence And Disabilities Among Women Attending Family Practice Clinics, Ann L. Coker, Paige H. Smith, Mary Kay Fadden

CRVAW Faculty Journal Articles

Purpose: To estimate the frequency and type of disabilities preventing work among those experiencing intimate partner violence (IPV) compared with those never experiencing IPV.

Methods: We used a large cross-sectional survey of women, ages 18–65, attending family practice clinics from 1997 through 1998. Participation included a 5–10-minute in-clinic survey assessing IPV experience and a longer telephone survey assessing health status and chronic disabilities that prevented work outside the home or housework.

Results: Of 1,152 eligible women surveyed, 54% experienced some type of IPV, and 24% were currently in a violent relationship. Women who had ever experienced IPV …

Seventeen Amino Acid Peptide (Peptide P) For Treating Ischemia And Reperfusion Injury, Peter R. Oeltgen, Mark S. Kindy

Molecular and Cellular Biochemistry Faculty Patents

Peptide P, having the amino acid sequence Tyr-D-Ala-Phe-Ala-Asp-Val-Ala-Ser-Thr-Ile-Gly-Asp-Phe-His-Ser-Ile-NH2-SEQ ID NO:1, is useful to treat ischemia.

Mammalian Micrornas: A Small World For Fine-Tuning Gene Expression, Cinzia Sevignani, George A. Calin, Linda D. Siracusa, Carlo M. Croce

Department of Microbiology and Immunology Faculty Papers

The basis of eukaryotic complexity is an intricate genetic architecture where parallel systems are involved in tuning gene expression, via RNA-DNA, RNA-RNA and RNA-protein and DNA-protein interactions. In higher organisms, about 97% of the transcriptional output is represented by non-coding RNA (ncRNA) encompassing not only rRNA, tRNA, introns, 5’ and 3’-untranslated regions, transposable elements and intergenic regions, but also a large rapidly emerging family, named microRNAs. MicroRNAs are short 20-22 nucleotide RNA molecules that have been shown to regulate the expression of other genes in a variety of eukaryotic systems. MicroRNAs are formed from larger transcripts that fold to produce …

Ada News - 11/21/2005, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Growth Factor–Induced Shedding Of Syndecan-1 Confers Glypican-1 Dependence On Mitogenic Responses Of Cancer Cells, Kan Ding, Martha Lopez-Burks, José A. Sánchez-Duran, Murray Korc, Arthur D. Lander

Dartmouth Scholarship

The cell surface heparan sulfate proteoglycan (HSPG) glypican-1 is up-regulated by pancreatic and breast cancer cells, and its removal renders such cells insensitive to many growth factors. We sought to explain why the cell surface HSPG syndecan-1, which is also up-regulated by these cells and is a known growth factor coreceptor, does not compensate for glypican-1 loss. We show that the initial responses of these cells to the growth factor FGF2 are not glypican dependent, but they become so over time as FGF2 induces shedding of syndecan-1. Manipulations that retain syndecan-1 on the cell surface make long-term FGF2 responses glypican …

Loss Of Editing Activity During The Evolution Of Mitochondrial Phenylalanyl-Trna Synthetase, Hervé Roy, Jiqiang Ling, Juan D. Alfonzo, Michael Ibba

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Accurate selection of amino acids is essential for faithful translation of the genetic code. Errors during amino acid selection are usually corrected by the editing activity of aminoacyl-tRNA synthetases such as phenylalanyl-tRNA synthetases (PheRS), which edit misactivated tyrosine. Comparison of cytosolic and mitochondrial PheRS from the yeast Saccharomyces cerevisiae suggested that the organellar protein might lack the editing activity. Yeast cytosolic PheRS was found to contain an editing site, which upon disruption abolished both cis and trans editing of Tyr-tRNA^Phe. Wild-type mitochondrial PheRS lacked cis and trans editing and could synthesize Tyr-tRNA^Phe, an activity enhanced in …

Ua61/1 Advisory Committee Meeting Minutes, Wku Nursing

WKU Administration Documents

Minutes of the WKU Nursing Advisory Committee meeting.

Human Immunodeficiency Virus Type 1-Induced Macrophage Gene Expression Includes The P21 Gene, A Target For Viral Regulation, Nancy Vazquez, Teresa Greenwell-Wild, Nancy J. Marinos, William D. Swaim, Salvador Nares, David E. Ott, Ulrich Schubert, Peter Henklein, Jan M. Orenstein, Michael B. Sporn, Sharon M. Wahl

Dartmouth Scholarship

In contrast to CD4⁺ T cells, human immunodeficiency virus type 1 (HIV-1)-infected macrophages typically resist cell death, support viral replication, and consequently, may facilitate HIV-1 transmission. To elucidate how the virus commandeers the macrophage's intracellular machinery for its benefit, we analyzed HIV-1-infected human macrophages for virus-induced gene transcription by using multiple parameters, including cDNA expression arrays. HIV-1 infection induced the transcriptional regulation of genes associated with host defense, signal transduction, apoptosis, and the cell cycle, among which the cyclin-dependent kinase inhibitor 1A (CDKN1A/p21) gene was the most prominent. p21 mRNA and protein expression followed a bimodal pattern which was …

Effect Of Cytokine Gene Polymorphism On Histological Activity Index, Viral Load And Response To Treatment In Patients With Chronic Hepatitis C Genotype 3, Zaigham Abbas, Tariq Moatter, Akber Hussainy, Wasim Jafri

Section of Gastroenterology

AIM: To investigate the association between cytokine gene polymorphism and disease status in chronic hepatitis C genotype 3 by liver biopsy, ALT, HCV RNA levels and response to treatment.Methods: Patients with chronic hepatitis C genotype 3 were analyzed for single nucleotide polymorphisms of interleukin (IL)-10, IL-1 beta, interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta (TGF-beta) by polymerase chain reaction using sequence-specific oligonucleotide primers. Liver biopsies were assessed by modified histological activity index (HAI) scoring system using a scale of 0-18 for grading the necro-inflammatory activity and 0-6 for staging the fibrosis. HCV RNA levels were determined by …

Hispanic Physicians' Tobacco Intervention Practices: A Cross-Sectional Survey Study, Francisco G. Soto Mas, Richard L. Papenfuss, Holly E. Jacobson, Chiehwen E. Hsu, William M. Kane

Faculty, Staff and Student Publications

Background U.S. Hispanic physicians constitute a considerable professional collective, and they may be most suited to attend to the health education needs of the growing U.S. Hispanic population. These educational needs include tobacco use prevention and smoking cessation. However, there is a lack of information on Hispanic physicians' tobacco intervention practices, their level of awareness and use of cessation protocols, and the type of programs that would best address their tobacco training needs. The purpose of this study was to assess the tobacco intervention practices and training needs of Hispanic physicians.

Methods Data was collected through a validated survey instrument …

Medicare Advantage Snps: A New Opportunity For Integrated Care?, Christie Provost Peters

National Health Policy Forum

Medicare Advantage special needs plans (SNPs) are a new type of coordinated care plan established by the Medicare Prescription Drug, Improvement and Modernization Act. SNPs were created to encourage greater access to Medicare managed care for certain special needs populations: the institutionalized, persons dually eligible for Medicare and Medicaid, and the chronically ill. Some view SNPs as a new opportunity to integrate acute and long-term care services as well as Medicare and Medicaid financing. Others, however, question the degree to which full integration will become a widespread reality. This issue brief examines the SNP option and the promises and challenges …

Continuous Asl Perfusion Fmri Investigation Of Higher Cognition: Quantification Of Tonic Cbf Changes During Sustained Attention And Working Memory Tasks, Junghoon Kim, John Whyte, Jiongjiong Wang, Hengyi Rao, Kathy Z. Tang, John A. Detre

Department of Rehabilitation Medicine Faculty Papers

Arterial spin labeling (ASL) perfusion fMRI is an emerging method in clinical neuroimaging. Its non-invasiveness, absence of low frequency noise, and ability to quantify the absolute level of cerebral blood flow (CBF) make the method ideal for longitudinal designs or low frequency paradigms. Despite the usefulness in the study of cognitive dysfunctions in clinical populations, perfusion activation studies to date have been conducted for simple sensorimotor paradigms or with single-slice acquisition, mainly due to technical challenges. Using our recently developed amplitude-modulated continuous ASL (CASL) perfusion fMRI protocol, we assessed the feasibility of a higher level cognitive activation study in twelve …

Modélisation De L'Exposition Au Monoxyde De Carbone, Andrea Scarino, Robert Tardif

Rapports de recherche scientifique

No abstract provided.

Download The Pdf Of The Full Issue

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Events And Opportunities

Population Health Matters (Formerly Health Policy Newsletter)

No abstract available.

Motorcycle Helmets Are Good Medicine, Douglas Mcgee

Population Health Matters (Formerly Health Policy Newsletter)

No abstract available.

Montreal Gp Successfully Challenges Canada's Ban On Parallel Private Healthcare Insurance, David Woods

Population Health Matters (Formerly Health Policy Newsletter)

No abstract available.

Harvest Health: Chronic Disease Self-Management Program For Older African-Americans, Nancy L. Chernett, Laura N. Gitlin

Population Health Matters (Formerly Health Policy Newsletter)

No abstract available.

The 2005 Disease Management Colloquium A Success

Population Health Matters (Formerly Health Policy Newsletter)

The 2005 Disease Management Colloquium was heald at Jefferson Medical College in Philadelphia on June 21-24, 2005. The Colloquium's goal is to better educate government agencies, the healthcare industry, employers, and the general public about the important role disease management programs play in improving healthcare quality and outcomes for persons subject to chronic conditions. The following are highlights from a number of the morning keynote presentations.

New Publications From The Department Of Health Policy

Population Health Matters (Formerly Health Policy Newsletter)

No abstract available.

Demonstrating The Value Of Data Warehouses

Population Health Matters (Formerly Health Policy Newsletter)

The Department of Health Policy hosted a Professional Collaboration Day on June 14, 2005. The following is a summary of the morning session, hosted by GE Healthcare, which focused on Demonstrating the Value of Data Warehouses.

Promoting Research In Cognitive Neuroscience And Cognitive Rehabilitation, John Whyte

Population Health Matters (Formerly Health Policy Newsletter)

No abstract available.

Letter To The Editor: Health Literacy, Bob Marquis

Population Health Matters (Formerly Health Policy Newsletter)

No abstract available.

Letter To The Editor: On The Trilogy Of Woe, Bruce A. Boissonnault

Population Health Matters (Formerly Health Policy Newsletter)

No abstract available.

Letter To The Editor: Trilogy Of Woe, Mark Linzer

Population Health Matters (Formerly Health Policy Newsletter)

No abstract available.

From The Editor: Hips And Knees, David B. Nash

Population Health Matters (Formerly Health Policy Newsletter)

No abstract available.

Event Related Potentials: A Study Of The Processing Of Gapping Structures In Adolescents, Michelle Miller Nishida

Theses and Dissertations

Many questions remain unanswered regarding the intricacies of the human brain, especially with regard to the complexities of language processing. One essential component of human sentence processing is the ability to detect, decipher, and recover from errors in the interpretation of both verbal and written language. This process of repair of ungrammatical sentences and revision or reinterpretation of ambiguous sentences has been studied extensively in recent years. A variety of tools have been developed, including the use of event-related potentials (ERPs) in order to assess how language is processed and developed, and to help better identify the nature of these …

Social Security Reform: What Are The Options?, Greg Shaw, Susan Swanlund, Tari Renner

Roundtables

Recorded in 2005, this Roundtable set the social security issue in the context of public opinion, strategies of the political parties, and changes in the Medicare program. The goal of the discussion was to help citizens understand the political and economic challenges confronting the efforts to reform social security.

A transcript of this discussion is available at the download link above and to the right of this page.