Medicine and Health Sciences Commons^™

Evaluation Of Glucocorticoid Sensitivity In 697 Pre-B Acute Lymphoblastic Leukemia Cells After Overexpression Or Silencing Of Map Kinase Phosphotase-1, Marc T. Abrams, Noreen Robertson, Gerald Litwack, Eric Wickstrom

Department of Biochemistry and Molecular Biology Faculty Papers

PURPOSE: To determine the effect of reducing MAP kinase phosphatase-1 (MKP-1) levels on cell death induced by glucocorticoid (GC) or hydroxyurea (HU) treatment in the human pre-B acute lymphoblastic leukemia cell line 697.

METHODS: Stable MKP-1 overexpressing transformants of the 697 pre-B ALL cell line were created and tested for sensitivity to the GC triamcinolone acetonide (TA) and HU, and compared to a control 697 cell line containing normal MKP-1 expression levels. Small interfering RNAs (siRNAs) were designed to inhibit MKP-1 expression and evaluated for their effect on GC-mediated cell death.

RESULTS: MKP-1 overexpression caused a phenotype of partial resistance …

Influence Of Cardiorespiratory Fitness On The Association Between C-Reactive Protein And Metabolic Syndrome Prevalence In Racially Diverse Women, Michael J. Lamonte, Barbara E. Ainsworth, J. Larry Durstine

Faculty Publications

No abstract provided.

Health Insurance Coverage For Small Employers, Dawn Gencarelli

National Health Policy Forum

For workers of small employers, access to affordable health insurance coverage is a growing concern. This paper examines the problems these firms and their employees face in obtaining health insurance coverage they can afford. The degree to which these challenges become obstacles varies greatly, depending on, for instance, the size of the employer and the characteristics of its employees. Reviewed here are these challenges to access, as well as some of the efforts made through state and federal reforms to address them, including rules regarding guaranteed issue and guaranteed renewability. This paper also explores some of the more recent initiatives …

The Cns Role Of Toll-Like Receptor 4 In Innate Neuroimmunity And Painful Neuropathy, Flobert Y. Tanga, Nancy Nutile-Mcmenemy, Joyce A. Deleo

Dartmouth Scholarship

Neuropathic pain remains a prevalent and persistent clinical problem because of our incomplete understanding of its pathogenesis. This study demonstrates for the first time, to our knowledge, a critical role for CNS innate immunity by means of microglial Toll-like receptor 4 (TLR4) in the induction phase of behavioral hypersensitivity in a mouse and rat model of neuropathy. We hypothesized that after L5 nerve transection, CNS neuroimmune activation and subsequent cytokine expression are triggered by the stimulation of microglial membrane-bound TLR4. To test this hypothesis, experiments were undertaken to assess tactile and thermal hypersensitivity in genetically altered (i.e., TLR4 knockout and …

Landscaping Laborer Dies When Struck By Bouncing Log, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Tractors/Logging

On March 5, 2004, a 57-year-old male laborer died when a 19 inch wide x 31 inch long log rolled down a mountain hitting him in his head and chest. The laborer had been employed for three days by a landscaping company contracted to clear the tree canopy over a gas line right-of-way. At approximately 2:20 pm, the company owner and five laborers were felling trees and bucking downed trees with chain saws and pole saws to remove the trees and limbs hanging over and growing in the gas line right-of-way. Two of the laborers were working topside at the …

Ada News - 04/18/2005, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Histories Of Childhood Maltreatment In Schizophrenia: Relationships With Premorbid Functioning, Symptomatology, And Cognitive Deficits, Lindsay S. Schenkel, William D. Spaulding, David Dilillo, Steven M. Silverstein

Department of Psychology: Faculty Publications

A number of studies have demonstrated an increased rate of histories of childhood maltreatment among adults with serious mental illness. The present investigation documented the presence of childhood maltreatment in a sample of 40 psychiatric inpatients with schizophrenia spectrum disorders. The type (neglect, physical abuse, sexual abuse), duration, and severity of childhood maltreatment was examined along with measures of premorbid functioning, current symptomatology, and cognitive functioning. Participants with histories of maltreatment were significantly more likely to have poorer peer relationships in childhood, more diffi culty in school, an earlier age at first hospitalization, more previous hospitalizations, elevated symptoms of anxiety, …

Ohio Academy Of Medical History Annual Meeting Program, April 16, 2005, Ohio Academy Of Medical History

Annual Conference Programs

This four page program is from the annual meeting of the Ohio Academy of Medical History held on April 16, 2005 at the Dittrick Medical History Center in Cleveland, Ohio. The program details the events and presentations of the meeting.

"Miss Tallant...Docteur En Medicine": A Woman Physician In World War I France, Ximena Chrisagis

Annual Conference Presentations, Papers, and Posters

The presentation discusses the life of Alice Weld Tallant, M.D. with a focus on her service during World War I. The presentation was given at the Ohio Academy of Medical History Annual Conference at Dittrick Medical History Center on April 16, 2005.

Reconstructability Analysis And Log-Linear Modeling, Martin Zwick

Complex Systems Faculty Publications and Presentations

Reconstructability Analysis (RA) is a method developed within the systems community for analyzing nominal (or discretized) data. RA both overlaps and extends Log-Linear (LL) modeling, and the purpose of this talk is to introduce RA to researchers unfamiliar with it. Two aspects of RA will be focused on: (1) its use for exploratory, as opposed to confirmatory, modeling – searching for good models in a vast space of possible models, and (2) state-based RA – analyzing data not in terms of relations among variables but in terms of relations among specific states of variables. Examples of applications to social science …

Timing Of Conditioned Responding In A Nicotine Locomotor Conditioning Preparation: Manipulations Of The Temporal Arrangement Between Context Cues And Drug Administration, Rick A. Bevins, Sarah Eurek, Joyce Besheer

Department of Psychology: Faculty Publications

Using a locomotor conditioning preparation, we examined whether manipulating time between exposure to distinct environmental cues and nicotine administration affected conditioned responding. Rats that received nicotine (0.42 mg/kg base) immediately before placement in an environment for 30 min on eight separate occasions displayed hyperactivity relative to controls in a subsequent injection/drug-free test. This conditioned hyperactivity was weaker if nicotine was administered 15 min before environment exposure. Conditioning was not evidenced when nicotine was administered 15 min after placement or upon removal from the environment. In a follow-up experiment, rats received 45 min in the environment; nicotine was administered 15 min …

Ocular Surface Epithelia Contain Abcg2-Dependent Side Population Cells Exhibiting Features Associated With Stem Cells., Murat T Budak, Onder S Alpdogan, Mingyuan Zhou, Robert M Lavker, M A Murat Akinci, J Mario Wolosin

Department of Medical Oncology Faculty Papers

When cell populations are incubated with the DNA-binding dye Hoechst 33342 and subjected to flow cytometry analysis for Hoechst 33342 emissions, active efflux of the dye by the ABCG2/BCRP1 transporter causes certain cells to appear as a segregated cohort, known as a side population (SP). Stem cells from several tissues have been shown to possess the SP phenotype. As the lack of specific surface markers has hindered the isolation and subsequent biochemical characterization of epithelial stem cells this study sought to determine the existence of SP cells and expression of ABCG2 in the epithelia of the ocular surface and evaluate …

Fundamentals Of Underwriting In The Nongroup Health Insurance Market: Access To Coverage And Options For Reform, Mark Merlis

National Health Policy Forum

Although the majority of Americans with health insurance obtain coverage through their employers, many individuals must negotiate the nongroup insurance market alone. Insurers use a process called medical underwriting to identify applicants with current or recent medical problems. Because these applicants are likely to cost the insurer more in claims than a healthier person, insurers may charge them higher premiums or restrict or deny coverage. This background paper reviews the practice of underwriting, state and federal regulation of insurers offering nongroup health coverage, and several proposed options for improving access to coverage for applicants who are in poor health.

Changes In Nursing Student Attitudes Toward Mental Illness, Jared Rogge

Honors Theses

People who suffer from mental illness comprise a highly vulnerable population, and encounter adversity from two directions. Not only do they have to contend with their illness and the management of its symptoms, but they also have to brace themselves against the societal backlash and devaluation produced by the stigma that accompanies mental illness. Stigmatization can drastically alter the life chances of individuals with mental illness and have negative outcomes in regards to employment, income (Markowitz, 1998), social integration(Chan, 2004), self esteem(Blankertz, 2001), health care, insurance, and access to justice (Sayce, 1998.)

Causal Inference In Longitudinal Studies With History-Restricted Marginal Structural Models, Romain Neugebauer, Mark J. Van Der Laan, Ira B. Tager

U.C. Berkeley Division of Biostatistics Working Paper Series

Causal Inference based on Marginal Structural Models (MSMs) is particularly attractive to subject-matter investigators because MSM parameters provide explicit representations of causal effects. We introduce History-Restricted Marginal Structural Models (HRMSMs) for longitudinal data for the purpose of defining causal parameters which may often be better suited for Public Health research. This new class of MSMs allows investigators to analyze the causal effect of a treatment on an outcome based on a fixed, shorter and user-specified history of exposure compared to MSMs. By default, the latter represents the treatment causal effect of interest based on a treatment history defined by the …

Health Savings Accounts: The Fundamentals, Beth Fuchs, Julie A. James

National Health Policy Forum

This paper explores the fundamentals of health savings accounts (HSAs). While not intended to be an exhaustive review of these accounts, it describes their intellectual and legislative origins and the mechanics of how they work, explores the early returns on how they are faring in the insurance market, and identifies major issues and controversies that they raise. The paper looks specifically at the basic rules for HSAs and the requirements for health insurance that qualifies as a high-deductible health plan (HDHP) for HSA purposes. Also considered are issues related to provider payments under HSAs and the administration of the benefit …

Recognition And Treatment Of Anaphylaxis By Day Care Providers, Michele Trach Glood

Theses and Graduate Projects

BACKGROUND: Anaphylaxis is a severe, potentially life-threatening allergic reaction. Foods, medications, insect venom and latex are the four most common anaphylactic agents. Of these, foods account for most anaphylactic reactions in children. Delayed treatment with epinephrine is the critical factor between anaphylaxis and death. Research has shown that recognition and treatment of anaphylaxis in schools and other child care settings is inadequate. This study was designed to determine if day care providers received severe allergy and anaphylaxis training and if they were confident in recognizing and treating anaphylaxis' METHODS: Sixty licensed home day care providers and 60 employees of licensed …

Current Mood And Food Choices: The Relation Between Positive Affect And Dietary Behavior, Kristi E. White, Amy M. Humke, Marc T. Kiviniemi

Department of Psychology: Faculty Publications

Colloquially, much is made of the relation between food and mood. For example, “comfort foods” are eaten in the service of affect regulation. Affect can influence behavioral choices in a number of ways. We investigated whether college students’ mood when making dietary choices influenced the nutritional value of the foods chosen. Sixty-five participants completed a questionnaire immediately prior to eating a meal in a college dining hall. The questionnaire included a measure of current positive affect. Following the meal, participants reported what they ate for dinner. Using nutritional data from the college dining services, we used participants’ self reported food …

Should I Diet? What Should I Eat? Different Decision Making Factors Predict Dieting Intentions Versus Actual Dietary Behavior, Marc T. Kiviniemi, Kristi E. White, Amy M. Humke

Department of Psychology: Faculty Publications

Many individuals diet to lose weight. Most attempts are not successful—weight is either not lost or is quickly regained.We investigated decision making factors influencing dieting intentions versus those influencing actual behavior. Prior to eating in a university cafeteria, 65 participants reported their cost-benefit beliefs about low fat foods and fruits/vegetables, affective associations with both food categories, and whether they were currently dieting to lose weight. After the meal, participants reported what they ate. Using these reports and nutritional data from the college dining service, we computed the calories, total and saturated fat, sodium, and cholesterol consumed. Cost-benefit beliefs and affective …

2005 - The Tenth Annual Symposium Of Student Scholars

Symposium of Student Scholars Program Books

The full program book from the Tenth Annual Symposium of Student Scholars, held on April 8, 2005. Includes abstracts from the presentations and posters.

Documentation Des Risques Dans Les Centres De Transfert Des Matières Dangereuses, Brigitte Roberge, Marc Baril, Claude Bariteau

Rapports de recherche scientifique

No abstract provided.

Proopiomelanocortin Neurons In Nucleus Tractus Solitarius Are Activated By Visceral Afferents: Regulation By Cholecystokinin And Opioids, Suzanne M. Appleyard, Timothy W. Bailey, Mark W. Doyle, Young-Ho Jin, James L. Smart, Malcolm J. Low, Michael C. Andresen

Faculty Publications - Department of Biological & Molecular Science

The nucleustractus solitarius (NTS) receives dense terminations from cranial visceral afferents, including those from the gastrointestinal (GI) system. Although the NTS integrates peripheral satiety signals and relays this signal to central feeding centers, little is known about which NTS neurons are involved or what mechanisms are responsible. Proopiomelanocortin (POMC) neurons are good candidates for GI integration, because disruption of the POMC gene leads to severe obesity and hyperphagia. Here, we used POMC– enhanced green fluorescent protein (EGFP) transgenic mice to identify NTS POMC neurons. Intraperitoneal administration of cholecystokinin (CCK) induced c-fos gene expression in NTS POMC–EGFP neurons, suggesting that they …

Microsomal Prostaglandin E Synthase-1: The Inducible Synthase For Prostaglandin E2, Annaleise V. Sampey, Seetha Monrad, Leslie J. Crofford

Internal Medicine Faculty Publications

Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible enzyme that catalyzes the conversion of prostaglandin (PG)H2 to PGE2. Proinflammatory stimuli markedly increase levels of mPGES-1 expression both in vivo and in vitro. mPGES-1 knockout studies and animal models of inflammatory arthritis also provide a strong basis for the contribution of mPGES-1 in the increased local production of PGE2 observed in inflammatory arthritis. The focus of this article is to review some recent advances in our understanding of mechanisms specific to the regulation of inducible mPGES-1 in inflammatory arthritis.

History-Adjusted Marginal Structural Models: Time-Varying Effect Modification, Maya L. Petersen, Mark J. Van Der Laan

U.C. Berkeley Division of Biostatistics Working Paper Series

Marginal structural models (MSM) provide a powerful tool for estimating the causal effect of a treatment, particularly in the context of longitudinal data structures. These models, introduced by Robins, model the marginal distributions of treatment-specific counterfactual outcomes, possibly conditional on a subset of the baseline covariates. However, standard MSM cannot incorporate modification of treatment effects by time-varying covariates. In the context of clinical decision- making such time-varying effect modifiers are often of considerable interest, as they are used in practice to guide treatment decisions for an individual. In this article we introduce a generalization of marginal structural models, which we …

History-Adjusted Marginal Structural Models: Optimal Treatment Strategies, Maya L. Petersen, Mark J. Van Der Laan

U.C. Berkeley Division of Biostatistics Working Paper Series

Much of clinical medicine involves choosing a future treatment plan that is expected to optimize a patient's long-term outcome, and modifying this treatment plan over time in response to changes in patient characteristics. However, dynamic treatment regimens, or decision rules for altering treatment in response to time-varying covariates, are rarely estimated based on observational data. In a companion paper, we introduced a generalization of Marginal Structural Models, named History-Adjusted Marginal Structural Models, that estimate modification of causal effects by time-varying covariates. Here, we illustrate how History-Adjusted Marginal Structural Models can be used to identify a specific type of optimal dynamic …

The Sensitivity And Specificity Of Markers For Event Times, Tianxi Cai, Margaret S. Pepe, Thomas Lumley, Yingye Zheng, Nancy Swords Jenny

Harvard University Biostatistics Working Paper Series

No abstract provided.

Method For Treating Cytokine Mediated Hepatic Injury, Peter R. Oeltgen, Paul D. Bishop, Craig J. Mcclain, Shirish Barve

Graduate Center for Nutritional Sciences Faculty Patents

A method of modulating cytokine mediated hepatic injury by administering compound-D SEQ ID NO:1 to a mammal. A concentration of the compound in the range of about 0.5 mg/kg to about 20 mg/kg in a physiologically acceptable formulation blocks a cytokine cascade. A therapeutic method of modulating cytokine mediated acute inflammatory, trauma induced and toxin induced hepatic injury, particularly via tumor necrosis factor modulation, is thus disclosed.

Ada News - 04/04/2005, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Addressing The Marion County Health Department’S Need For A Comprehensive Resource Detailing Florida Medicare’S Medical Necessity Policies

Florida Public Health Review

No abstract provided.

Molecular And Clinical Analyses Of Greig Cephalopolysyndactyly And Pallister-Hall Syndromes: Robust Phenotype Prediction From The Type And Position Of Gli3 Mutations, Jennifer J. Johnston, Isabelle Olivos-Glander, Christina Killoran, David Tilstra Md

Articles

Mutations in the GLI3 zinc-finger transcription factor gene cause Greig cephalopolysyndactyly syndrome (GCPS) and Pallister-Hall syndrome (PHS), which are variable but distinct clinical entities. We hypothesized that GLI3 mutations that predict a truncated functional repressor protein cause PHS and that functional haploinsufficiency of GLI3 causes GCPS. To test these hypotheses, we screened patients with PHS and GCPS for GLI3 mutations. The patient group consisted of 135 individuals: 89 patients with GCPS and 46 patients with PHS. We detected 47 pathological mutations (among 60 probands); when these were combined with previously published mutations, two genotype-phenotype correlations were evident. First, GCPS was …