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1998

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Full-Text Articles in Medicine and Health Sciences

What's Happening: January 7, 1998, Maine Medical Center Jan 1998

What's Happening: January 7, 1998, Maine Medical Center

What's Happening

No abstract provided.


Oppositional Defiant Disorder And Conduct Disorder : Different Names For The Same Condition?, Daryl L. Hawkins Jan 1998

Oppositional Defiant Disorder And Conduct Disorder : Different Names For The Same Condition?, Daryl L. Hawkins

Graduate Research Papers

The purpose of this paper is to present a review of the literature related to the proposition that oppositional defiant disorder and conduct disorder are, in essence, the same disorder, with varying degrees of severity. The author of this paper believes that it would make more sense diagnostically to combine these two diagnoses into one category.

This paper will cover a variety of areas related to oppositional defiant disorder and conduct disorder. First, a section on the formulation of the diagnostic criteria is presented. Brief definitions and descriptions of the two disorders follow the diagnostic criteria section. In addition to …


Caduceus 1998, Stritch School Of Medicine Jan 1998

Caduceus 1998, Stritch School Of Medicine

Stritch School of Medicine Yearbooks

No abstract provided.


Differences In Lean And Obese Skeletal Muscle Myoblasts Of Adult And Post-Natal La/N (Faf) Rats: A Confocal Description Of The Skeletal Muscle Myoblast, J. Adam Noah Jan 1998

Differences In Lean And Obese Skeletal Muscle Myoblasts Of Adult And Post-Natal La/N (Faf) Rats: A Confocal Description Of The Skeletal Muscle Myoblast, J. Adam Noah

Theses, Dissertations and Capstones

Mutant strains of obese rats are currently being studied to reveal the mechanisms of increased lipid synthesis and decreased lipid oxidation in these rats. It was originally thought that much of the fat production that leads to obesity is the result of metabolic processes in the liver and adipose tissue. Studies by Kahle et al.3 showed that the liver and adipose tissue account for only 22% and 7% respectively, of total fatty acid synthesis. It was also shown that 21 % of total de novo fatty acid was localized in the postural skeletal muscle.

The dry weight of the …


Land Use Patterns In Relation To Lake Water Quality In The Great Pond Watershed, Problems In Environmental Science Course (Biology 493), Colby College, Colby Environmental Assessment Team, Colby College Jan 1998

Land Use Patterns In Relation To Lake Water Quality In The Great Pond Watershed, Problems In Environmental Science Course (Biology 493), Colby College, Colby Environmental Assessment Team, Colby College

Colby College Watershed Study: Great Pond (2012, 2010, 1998)

Lakes are natural resources, which have many effects on the land surrounding them, They support adjacent communities by providing water and regulating temperatures, helping to define the surrounding ecosystem, and serving as sources of drinking water as well as recreation. The prolonged presence of human activity in a watershed can disturb the physical and chemical cycles of the lake and its surrounding ecosystems (Henderson-Sellers and Markland 1987). Over time, lakes undergo a process called eutrophication, a natural aging process during which the nutrient levels increase and dissolved oxygen levels decrease (Smith and Smith 1998). As the lake ages or becomes …


Effects Of Metformin On Spontaneous And Clomiphene-Induced Ovulation In The Polycystic Ovary Syndrome, John E. Nestler , M.D., Daniela J. Jakubowicz , M.D., William S. Evans , M.D., Renato Pasquali , M.D. Jan 1998

Effects Of Metformin On Spontaneous And Clomiphene-Induced Ovulation In The Polycystic Ovary Syndrome, John E. Nestler , M.D., Daniela J. Jakubowicz , M.D., William S. Evans , M.D., Renato Pasquali , M.D.

Obstetrics and Gynecology Publications

ABSTRACT

Background Obese women with the polycystic ovary syndrome are relatively unresponsive to the induction of ovulation by clomiphene. We hypothesized that reducing insulin secretion by administering metformin would increase the ovulatory response to clomiphene.

Methods We performed oral glucose-tolerance tests before and after the administration of 500 mg of metformin or placebo three times daily for 35 days in 61 obese women with the polycystic ovary syndrome. Women who did not ovulate spontaneously were then given 50 mg of clomiphene daily for five days while continuing to take metformin or placebo. Serum progesterone was measured on days 14, 28, …


Effects Of Managed Care On The Professional Autonomy Of Board Certified Physical Therapy Specialist's Practice, Cami Diezel Jan 1998

Effects Of Managed Care On The Professional Autonomy Of Board Certified Physical Therapy Specialist's Practice, Cami Diezel

Department of Physical Therapy Student Theses, Dissertations and Capstones

Purpose: Identify perceptions of professional autonomy of Board Certified Physical Therapy Specialists (BCPTS) who practiced in managed care environments.

Guiding questions: Do BCPTS perceive an increase in professional autonomy as a specialist than as a generalist? How do the perceptions of professional autonomy vary among each specialization? What variables affect perceptions of professional autonomy among BCPTS?

Method: Two-hundred BCPTS throughout the country were randomly chosen as participants. One-hundred-eight respondents were used as subjects.

Data analysis: Frequency distributions and Pearson's correlation coefficient statistic were utilized.

Results: Majority of respondents reported no increase in professional autonomy as a specialist. Greater than three-quarters …


Atovaquone Compared With Dapsone For The Prevention Of Pneumocystis Carinii Pneumonia In Patients With Hiv Infection Who Cannot Tolerate Trimethoprim, Sulfonamides, Or Both, Wafaa M. El-Sadr , M.D., M.P.H., Robert L. Murphy , M.D., Teresa Mccabe Yurik , M.S., Roberta Luskin-Hawk , M.D., Tony W. Cheung , M.D., Henry H. Balfour , Jr., M.D., Robert Eng , M.D., Thomas M. Hooton , M.D., Thomas M. Kerkering , M.D., Malte Schutz , M.D., Charles Van Der Horst , M.D., Richard Hafner , M.D. Jan 1998

Atovaquone Compared With Dapsone For The Prevention Of Pneumocystis Carinii Pneumonia In Patients With Hiv Infection Who Cannot Tolerate Trimethoprim, Sulfonamides, Or Both, Wafaa M. El-Sadr , M.D., M.P.H., Robert L. Murphy , M.D., Teresa Mccabe Yurik , M.S., Roberta Luskin-Hawk , M.D., Tony W. Cheung , M.D., Henry H. Balfour , Jr., M.D., Robert Eng , M.D., Thomas M. Hooton , M.D., Thomas M. Kerkering , M.D., Malte Schutz , M.D., Charles Van Der Horst , M.D., Richard Hafner , M.D.

Internal Medicine Publications

BACKGROUND

Although trimethoprim–sulfamethoxazole is the drug of choice for the prevention of Pneumocystis carinii pneumonia, many patients cannot tolerate it and must switch to an alternative agent.

METHODS

We conducted a multicenter, open-label, randomized trial comparing daily atovaquone (1500-mg suspension) with daily dapsone (100 mg) for the prevention of P. carinii pneumonia among patients infected with the human immunodeficiency virus who could not tolerate trimethoprim–sulfamethoxazole. The median follow-up period was 27 months.

RESULTS

Of 1057 patients enrolled, 298 had a history of P. carinii pneumonia.P. cariniipneumonia developed in 122 of 536 patients assigned to atovaquone (15.7 cases per …


Interferon Alfa-2b Alone Or In Combination With Ribavirin As Initial Treatment For Chronic Hepatitis C, John G. Mchutchison , M.D., Stuart C. Gordon , M.D., Eugene R. Schiff , M.D., Mitchell L. Shiffman , M.D., William M. Lee , M.D., Vinod K. Rustgi , M.D., Zachary D. Goodman , M.D., Ph.D., Mei-Hsui Ling , Ph.D., Susannah Cort , M.D., Janice K. Albrecht , Ph.D. Jan 1998

Interferon Alfa-2b Alone Or In Combination With Ribavirin As Initial Treatment For Chronic Hepatitis C, John G. Mchutchison , M.D., Stuart C. Gordon , M.D., Eugene R. Schiff , M.D., Mitchell L. Shiffman , M.D., William M. Lee , M.D., Vinod K. Rustgi , M.D., Zachary D. Goodman , M.D., Ph.D., Mei-Hsui Ling , Ph.D., Susannah Cort , M.D., Janice K. Albrecht , Ph.D.

Internal Medicine Publications

BACKGROUND

Only 15 to 20 percent of patients with chronic hepatitis C have a sustained virologic response to interferon therapy. We compared the efficacy and safety of recombinant interferon alfa-2b alone with those of a combination of interferon alfa-2b and ribavirin for the initial treatment of patients with chronic hepatitis C.

METHODS

We randomly assigned 912 patients with chronic hepatitis C to receive standard-dose interferon alfa-2b alone or in combination with ribavirin (1000 or 1200 mg orally per day, depending on body weight) for 24 or 48 weeks. Efficacy was assessed by measurements of serum hepatitis C virus (HCV) RNA …


Quality Of Life And Clinical Outcomes In Elderly Patients Treated With Ventricular Pacing As Compared With Dual-Chamber Pacing, Gervasio A. Lamas , M.D., E. John Orav , Ph.D., Bruce S. Stambler , M.D., Kenneth A. Ellenbogen , M.D., Elena B. Sgarbossa , M.D., Shoei K. Stephen Huang , M.D., Roger A. Marinchak , M.D., N.A. Mark Estes , M.D., Gary F. Mitchell , M.D., Eric H. Lieberman , M.D., Carol M. Mangione , M.D., Lee Goldman , M.D., John J. Griffin, James D. Maloney, Carlos Rizo-Patrón, Ferdinand J. Venditti, Bruce L. Wilkoff Jan 1998

Quality Of Life And Clinical Outcomes In Elderly Patients Treated With Ventricular Pacing As Compared With Dual-Chamber Pacing, Gervasio A. Lamas , M.D., E. John Orav , Ph.D., Bruce S. Stambler , M.D., Kenneth A. Ellenbogen , M.D., Elena B. Sgarbossa , M.D., Shoei K. Stephen Huang , M.D., Roger A. Marinchak , M.D., N.A. Mark Estes , M.D., Gary F. Mitchell , M.D., Eric H. Lieberman , M.D., Carol M. Mangione , M.D., Lee Goldman , M.D., John J. Griffin, James D. Maloney, Carlos Rizo-Patrón, Ferdinand J. Venditti, Bruce L. Wilkoff

Internal Medicine Publications

ABSTRACT

Background Standard clinical practice permits the use of either single-chamber ventricular pacemakers or dual-chamber pacemakers for most patients who require cardiac pacing. Ventricular pacemakers are less expensive, but dual-chamber pacemakers are believed to be more physiologic. However, it is not known whether either type of pacemaker results in superior clinical outcomes.

Methods The Pacemaker Selection in the Elderly study was a 30-month, single-blind, randomized, controlled comparison of ventricular pacing and dualchamber pacing in 407 patients 65 years of age or older in 29 centers. Patients received a dual-chamber pacemaker that had been randomly programmed to either ventricular pacing or …


Interferon Alfa-2b Alone Or In Combination With Ribavirin For The Treatment Of Relapse Of Chronic Hepatitis C, Gary L. Davis , M.D., Rafael Esteban-Mur , M.D., Vinod Rustgi , M.D., John Hoefs , M.D., Stuart C. Gordon , M.D., Christian Trepo , M.D., Mitchell L. Shiffman , M.D., Stefan Zeuzem , M.D., Antonio Craxi , M.D., Mei-Hsui Ling , Ph.D., Janice Albrecht , Ph.D. Jan 1998

Interferon Alfa-2b Alone Or In Combination With Ribavirin For The Treatment Of Relapse Of Chronic Hepatitis C, Gary L. Davis , M.D., Rafael Esteban-Mur , M.D., Vinod Rustgi , M.D., John Hoefs , M.D., Stuart C. Gordon , M.D., Christian Trepo , M.D., Mitchell L. Shiffman , M.D., Stefan Zeuzem , M.D., Antonio Craxi , M.D., Mei-Hsui Ling , Ph.D., Janice Albrecht , Ph.D.

Internal Medicine Publications

BACKGROUND

Interferon alfa is the only effective treatment for patients with chronic hepatitis C. Forty percent of patients have an initial response to this therapy, but most subsequently relapse. We compared the effect of interferon alone with that of interferon plus oral ribavirin for relapses of chronic hepatitis C.

METHODS

We studied 345 patients with chronic hepatitis C who relapsed after interferon treatment. A total of 173 patients were randomly assigned to receive standard-dose recombinant interferon alfa-2b concurrently with ribavirin (1000 to 1200 mg orally per day, depending on body weight) for six months, and 172 patients were assigned to …


A Comparison Of Four Treatments For Generalized Convulsive Status Epilepticus, David M. Treiman , M.D., Patti D. Meyers , M.P.A., Nancy Y. Walton , Ph.D., Joseph F. Collins , Sc.D., Cindy Colling , R.Ph., M.S., A. James Rowan , M.D., Adrian Handforth , M.D., Edward Faught , M.D., Vincent P. Calabrese , M.D., Basim M. Uthman , M.D., R. Eugene Ramsay , M.D., Meenal B. Mamdani , M.D., Pratap Yagnik , M.D., John C. Jones , M.D., Elizabeth Barry , M.D., Jane G. Boggs , M.D., Andres M. Kanner , M.D. Jan 1998

A Comparison Of Four Treatments For Generalized Convulsive Status Epilepticus, David M. Treiman , M.D., Patti D. Meyers , M.P.A., Nancy Y. Walton , Ph.D., Joseph F. Collins , Sc.D., Cindy Colling , R.Ph., M.S., A. James Rowan , M.D., Adrian Handforth , M.D., Edward Faught , M.D., Vincent P. Calabrese , M.D., Basim M. Uthman , M.D., R. Eugene Ramsay , M.D., Meenal B. Mamdani , M.D., Pratap Yagnik , M.D., John C. Jones , M.D., Elizabeth Barry , M.D., Jane G. Boggs , M.D., Andres M. Kanner , M.D.

VCU Health Publications

ABSTRACT

Background and Methods Although generalized convulsive status epilepticus is a life-threatening emergency, the best initial drug treatment is uncertain. We conducted a five-year randomized, doubleblind, multicenter trial of four intravenous regimens: diazepam (0.15 mg per kilogram of body weight) followed by phenytoin (18 mg per kilogram), lorazepam (0.1 mg per kilogram), phenobarbital (15 mg per kilogram), and phenytoin (18 mg per kilogram). Patients were classified as having either overt generalized status epilepticus (defined as easily visible generalized convulsions) or subtle status epilepticus (indicated by coma and ictal discharges on the electroencephalogram, with or without subtle convulsive movements such as …


Preventing The Unnecessary Losses Of Alzheimer's Disease, Lin E. Noyes Jan 1998

Preventing The Unnecessary Losses Of Alzheimer's Disease, Lin E. Noyes

Case Studies from Age in Action

Educational Objectives

1. To state the importance of early detection and diagnosis of Alzheimer's disease.

2. To describe common concerns of people in the early stages of Alzheimer's disease.

3. To describe interventions to help people who have recently been diagnosed with Alzheimer's disease or other dementias.


Reducing Medication Mismanagement In Adult Care Residences, Mary Ann F. Kirkpatrick Jan 1998

Reducing Medication Mismanagement In Adult Care Residences, Mary Ann F. Kirkpatrick

Case Studies from Age in Action

Educational Objectives

1. Describe the prevalence of medication mismanagement in adult care facilities in Virginia.

2. Explain the significance of selected medication management errors.

3. Recommend practices to improve medication management task performance in adult care facilities.


State Regulation Of Assisted Living Facilities, Sonya A. Sterbenz Jan 1998

State Regulation Of Assisted Living Facilities, Sonya A. Sterbenz

Case Studies from Age in Action

Educational Objectives

1. To define the role of assisted living facilities in the continuum of long-term care options for older adults.

2. To present the various arguments concerning the regulation of the assisted living industry.


Medications And Falls, Patricia W. Slattum Jan 1998

Medications And Falls, Patricia W. Slattum

Case Studies from Age in Action

Educational Objectives:

1. To describe potential causes of falls and ways to prevent them.

2. To illustrate how medications can contribute to an increased risk of falls and recommend strategies for reducing this risk.


The Beat Newsletter, College Of Medicine Jan 1998

The Beat Newsletter, College Of Medicine

The Beat Newsletter

This is the January, 1998 edition of the Frederick P. Whiddon College of Medicine's newsletter - The Beat.

Contents include:

  • Battling brittle bones
  • Medical sciences building addition near completion
  • New Ph.D. graduates in basic medical sciences
  • DR. AUBREY E. TAYLOR received heart association award
  • Learning resources renamed media production services
  • FDA proposes rule on women in clinical trails
  • CME office received accreditation
  • The NIH'S new criteria for assessing grant proposals
  • DR. REGINA BENJAMIN receives national honor
  • Congratulations
  • New web service for faculty
  • National primary care day
  • LEDOUX receives career development award
  • DR. STEVEN PITTLER appointed to NIH study Section
  • HHS …


Union Wages, Rents, And Skills In Health Care Labor Markets, Barry T. Hirsch, Edward J. Schumacher Jan 1998

Union Wages, Rents, And Skills In Health Care Labor Markets, Barry T. Hirsch, Edward J. Schumacher

Health Care Administration Faculty Research

We examine the effect of unions on the earnings of health care workers, with emphasis on the measurement and sources of union wage premiums. Using data constructed from the 1973 though 1994 Current Population Surveys, standard union premium estimates are found to be substantially lower among workers in health care than in other sectors of the economy, and to be smaller among higher skill than among lower skill occupational groups. Longitudinal analysis of workers switching union status, which controls for worker-specific skills, indicates a small impact of unions on earnings within both high and low skilled health care occupations. Evidence …


The Effect Of Tape And Neoprene Ankle Supports On Balance In Athletes With Injured Ankles, Tara Michelle Gerlach Jan 1998

The Effect Of Tape And Neoprene Ankle Supports On Balance In Athletes With Injured Ankles, Tara Michelle Gerlach

Theses, Dissertations and Capstones

Injuries to the ankle joint are among the most common in athletics (Feuerbach et al., 1994; Gross, 1987). As clinicians, it is important to investigate various factors which could potentially reduce the occurrence of ankle injuries. One such actors is an improvement in proprioception (Cox et al., 1993; Glencross & Thornton, 1994). A suggested method for improving proprioception in the ankle is application of an external support, such as tape or a brace (Feuerbach et al. , 1994; Karlsson & Andreasson, 1992 ) . This study compared the proprioceptive abilities of the ankle under three conditions: unsupported, taped, and using …


Progestin Stimulation Of The Protooncogene C-̲M̲Y̲C In T47d Human Breast Cancer Cells, Kristy Ann Blankenship Jan 1998

Progestin Stimulation Of The Protooncogene C-̲M̲Y̲C In T47d Human Breast Cancer Cells, Kristy Ann Blankenship

Theses, Dissertations and Capstones

Moore and co-workers have previously demonstrated that progestins stimulate the growth of T47D human breast cancer cells. We now investigate the possibility that progestins might transactivate the protooncogcne c-myc as part of the mechanism for growth stimulation. Treatment of T47D cells with the synthetic progestin R5020 results in a rapid, dose-dependent increase in c-myc mRNA. This stimulation is evident as early as 5 minutes, increases up to 4-fold at 1 hour, and then returns toward basal levels. The optimal concentration of R5020 for induction of c-myc gene expression is 10 nM, which is within the physiologically relevant range of hormone …


Characterization Of The Promoter And Upstream Activation Sequences Of Sporulation-Specific Genes Spr1 (Ssg1) And Spr2 In Saccharomyces Cerevisiae, Sharmini S. Soosaithasan Jan 1998

Characterization Of The Promoter And Upstream Activation Sequences Of Sporulation-Specific Genes Spr1 (Ssg1) And Spr2 In Saccharomyces Cerevisiae, Sharmini S. Soosaithasan

Theses, Dissertations and Capstones

Sporulation is a developmental process in which temporally distinct sets of genes regulate the processes of meiosis and ascospore formation. Sporulation-specific genes are classified into early, middle, and late genes based on their peak time of expression during sporulation. Regulation of two late genes, SPR1 and SPR2, was studied. The function of SPR2 is unknown. Its regulatory region contains two Mid Sporulation Elements (MSE) repeated in tandem that are sufficient to confer sporulation-specific regulation to a CYCl-lacZ reporter. These sequences have UAS (upstream activation sequence) properties, as each 14 base pair element is sufficient to confer sporulation-specific regulation …


Adolescent Depression: The Influence Of Self-Esteem, Self-Consciousness And Gender, Kevin W. Adams Jan 1998

Adolescent Depression: The Influence Of Self-Esteem, Self-Consciousness And Gender, Kevin W. Adams

Theses, Dissertations and Capstones

This study explored gender differences in reports of depressive symptoms among adolescents. Self-esteem was examined for its relationship to reports of depressive symptoms and self-consciousness was examined to determine its influence on self-esteem and depression. One hundred four 10th grade students were involved in the study. The Beck Depression Inventory-II, the Imaginary Audience Scale, and the Rosenberg Self-Esteem Inventory were used in the analysis. A hierarchical multiple regression analysis was used to analyze the data. Alpha was set at .05. A positive relationship was found between gender and the variables of depression, abiding self-consciousness, transient self-consciousness, and self-esteem. Females scored …


Integrating Christian Caring In Nursing Curriculum: One School’S Experience, Charlotte Stephenson, Charlotte Ann Thayer Wood, Mary Ann Henriques, Tina L. Magers, Kaye Wilson-Anderson Jan 1998

Integrating Christian Caring In Nursing Curriculum: One School’S Experience, Charlotte Stephenson, Charlotte Ann Thayer Wood, Mary Ann Henriques, Tina L. Magers, Kaye Wilson-Anderson

Faculty Publications - College of Nursing

The link between caring and nursing has been evident since the days of Florence Nightingale. She referred to nursing as an act of charity or "God's work." Nursing within the Judea-Christian tradition was viewed as a mission, ministry or call from God to serve others. Those entering nursing fulfilled a commitment to God through service and care for others. Over time the focus in nursing shifted from the Christian perspective of being "called to be a nurse" to technical and physio­logical reasons for helping people. Virginia Henderson defined nursing as "that service to an individual that helps him to attain …


Voices From The Floor - A Pcom Anthology (Winter 1998), Pcom Jan 1998

Voices From The Floor - A Pcom Anthology (Winter 1998), Pcom

Voices from the Floor

The Winter 1998 issue includes:

  • "One Day at at Time with Michael" by Mary DeJoseph, DO and Paul DeJoseph, DO,
  • "The Bloodless Medical Care Option" by Ronald C. Morgan
  • "Going Home" by By Maria J. Hoertz, MPH, MSIII
  • "The Humors in Uniform" by Susan Entwistle Marshall, MSII


Articulations 1998, Som School Of Osteopathic Medicine, Umdnj University Of Medicine And Dentistry Of Nj Jan 1998

Articulations 1998, Som School Of Osteopathic Medicine, Umdnj University Of Medicine And Dentistry Of Nj

Yearbooks

University of Medicine and Dentistry of New Jersey (UMDNJ) School of Osteopathic Medicine yearbook for the class of 1998. 120 pages.

Contents: Dedication p. 1, UMDNJ-SOM Campus p. 2, University Affiliated Medical Centers p. 3, Dean's Message p. 4, Administration p. 5, Faculty p. 7, Staff p. 16, Candids p. 17, Graduates p. 34, Osteopathic Oath p.105, Convocation and Graduation p. 106, Editor's Page p. 112.

The yearbook production staff was not identified by name.


Managing The Iatrogenic Risks Of Risk Management, Jonathan Baert Wiener Jan 1998

Managing The Iatrogenic Risks Of Risk Management, Jonathan Baert Wiener

RISK: Health, Safety & Environment (1990-2002)

Analogizing to concerns that led the practice of medicine to shift from a specialist to a team-based approach, Dr. Wiener suggests that public and environmental health objectives would be better served if, e.g., regulatory jurisdiction were less atomized.


An Environmental History Of Fairfield/Wagner Point, Philip Diamond Jan 1998

An Environmental History Of Fairfield/Wagner Point, Philip Diamond

Legal History Publications

This paper traces the history of the Fairfield/Wagner Point peninsula from the beginning of the European settlement to the present, observing the ambitions and dreams of developers and industrial entrepeneurs, the significant contribution the area made to our nation's wartime production in World War II, the rise and fall of the tight-knit workers' communities, the struggles of outside activists and community leaders to better the living conditions of these neighborhoods, and the environmental devastation of the area followed by the attempt to redevelop the area with “green" industry. A 'central strand in this complex and contradictory story will be the …


College Of Dental Medicine-For The 1998 Entering Class, Nova Southeastern University Jan 1998

College Of Dental Medicine-For The 1998 Entering Class, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.


Neurotransmitter Transport: Models In Flux, Michael Kavanaugh Jan 1998

Neurotransmitter Transport: Models In Flux, Michael Kavanaugh

Biomedical and Pharmaceutical Sciences Faculty Publications

Physiologists say that ions and neutral solutes can cross biological membranes via “transporters” and “channels.” We tend to think about the difference between transporters and channels in terms of gating mechanisms. Ion channels exhibit a wide range of selectivity properties and permeation rates, but their gating at the most basic level can be thought of in terms of a single barrier or gate acting as a switch. When the gate is closed, ions can’t permeate; when the gate is opened, a permeation pathway for ions allows flux, often at very high rates (up to 108/sec). Transporters and ion …


Excitatory Amino Acid Transporters Of The Salamander Retina: Identification, Localization, And Function, Scott Eliasof, Jeffrey L. Arriza, Barbara H. Leighton, Michael Kavanaugh, Susan G. Amara Jan 1998

Excitatory Amino Acid Transporters Of The Salamander Retina: Identification, Localization, And Function, Scott Eliasof, Jeffrey L. Arriza, Barbara H. Leighton, Michael Kavanaugh, Susan G. Amara

Biomedical and Pharmaceutical Sciences Faculty Publications

The rapid re-uptake of extracellular glutamate mediated by a family of high-affinity glutamate transporter proteins is essential to continued glutamatergic signaling and neuronal viability, but the contributions of individual transporter subtypes toward cellular physiology are poorly understood. Because the physiology of glutamate transport in the salamander retina has been well described, we have examined the expression and function of glutamate transporter subtypes in this preparation. cDNAs encoding five distinct salamander excitatory amino acid transporter (sEAAT) subtypes were isolated, and their molecular properties and distributions of expression were compared. We report evidence that at least four distinct sEAAT subtypes are expressed …