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Full-Text Articles in Medicine and Health Sciences

Examining The Correlation Between The Competing Values Framework And Other Scales Of Measure, Jesina Mistry Dec 2025

Examining The Correlation Between The Competing Values Framework And Other Scales Of Measure, Jesina Mistry

The Plymouth Student Scientist

Organisational culture is widely acknowledged as a critical determinant of performance and employee engagement, yet debates persist regarding how best to conceptualise and measure it. This study examines the construct validity of two widely used diagnostic tools: the Competing Values Framework (CVF) and the Organisational Culture Inventory (OCI). While the CVF has achieved broad application across sectors, questions remain regarding its empirical grounding and cross-cultural relevance. Using a quantitative, cross-sectional design, this research investigates the degree of convergence between CVF and OCI dimensions within a diverse UK-based sample spanning multiple industries and job levels. In addition, it incorporates three underexplored …


The Lived Experience Of Uk Students Transitioning To University With Type 1 Diabetes Mellitus, Emelia C. Steel Dec 2025

The Lived Experience Of Uk Students Transitioning To University With Type 1 Diabetes Mellitus, Emelia C. Steel

The Plymouth Student Scientist

Transitioning from secondary school to university is a high-risk period for managing type 1 diabetes among UK students. Canadian research identified limited systemic support during this period. However, there is a lack of qualitative insight into how students navigate this transition in the UK, where healthcare and education systems differ. This study addressed that gap through semi-structured interviews to understand what makes this transition particularly challenging and what support students would find most helpful. A purposive sample comprised seven participants aged 19–29 from four UK universities. Thematic analysis, guided by Braun and Clarke’s (2022) six-phase framework, identified three superordinate themes: …


Investigating Deception-Related Moral Conflict Using Electroencephalography (Eeg) Hyperscanning, Madie Ades Dec 2025

Investigating Deception-Related Moral Conflict Using Electroencephalography (Eeg) Hyperscanning, Madie Ades

The Plymouth Student Scientist

Amplitudes of the early Bereitschaftspotential (BP) and deceptive behaviour have been theorised to be modulated by moral conflict experienced when making deceptive decisions, as the decision to lie can depend upon our moral perceptions of what is right and wrong (Panasiti et al., 2014). However, most Electroencephalography (EEG) deception paradigms lack ecological validity by utilising instructed lying and failing to incorporate genuine social interaction (Ganis & Keenan, 2009) and therefore may fail to elicit genuine moral conflict. The present study combined hyperscanning EEG with a competitive two-player social game, where participants freely chose to respond accurately or deceptively for …


The Spoon Theory & Autoimmune Diseases, Karen Davis Rdh, Bsdh Dec 2025

The Spoon Theory & Autoimmune Diseases, Karen Davis Rdh, Bsdh

Metro Denver Dental Society Articulator Magazine

In this article, Karen Davis, RDH, BSDH, uses the Spoon Theory to illustrate how the hidden challenges of living with an autoimmune disease or chronic illness can impact oral health, treatment tolerance and daily hygiene routines. She offers practical strategies for dental teams to better support “Spoonie” patients with compassionate, customized care.


Oral Health Is Still The World’S #1 Disease. Here’S How We Fix That, Kami Hoss Dds Dec 2025

Oral Health Is Still The World’S #1 Disease. Here’S How We Fix That, Kami Hoss Dds

Metro Denver Dental Society Articulator Magazine

Dr. Kami Hoss explores how outdated products, one-size-fits-all routines and microbiome-disrupting ingredients are failing patients, and why a more personalized, science-driven approach is urgently needed. His message is clear: it’s time to reinvent oral care for the 21st century.


Intentional Ai: Preserving Skills, Judgment And Humanity Dec 2025

Intentional Ai: Preserving Skills, Judgment And Humanity

Metro Denver Dental Society Articulator Magazine

Dr. Amisha Singh explores the rapid rise of AI across dentistry, highlighting both its transformative potential and the ethical, cognitive and professional risks that come with overreliance. She emphasizes the need for intentional use, critical thinking and boundaries that preserve core clinical and human skills. Her reflection offers a roadmap for using AI as an amplifier of expertise rather than a replacement for it.


Letter From The President, Marcia M. Ditmyer Dec 2025

Letter From The President, Marcia M. Ditmyer

Michigan Journal of Public Health

No abstract provided.


Letter From The Editor, Sarah J. Nechuta Dec 2025

Letter From The Editor, Sarah J. Nechuta

Michigan Journal of Public Health

No abstract provided.


Deficiencies In Non-Emergency Medical Transportation For Aging Rural Residents Of Iosco County, Michigan, Richard L. Douglass, Donald Stansloski, James Mortimer, Sam Purdy, Dale Evilsizer, Scott Rice Dec 2025

Deficiencies In Non-Emergency Medical Transportation For Aging Rural Residents Of Iosco County, Michigan, Richard L. Douglass, Donald Stansloski, James Mortimer, Sam Purdy, Dale Evilsizer, Scott Rice

Michigan Journal of Public Health

Introduction: The rural aging population in Michigan struggles to access medical care often available only at significant distances due to limited health system resources and provider shortages. Access to routine care is challenged by lack of non-emergency medical transportation (NEMT). The Iosco County Commission on Aging provides home-delivered meals to eligible county residents. The Rural Health Group investigated the needs of home-delivered meal recipients (aged ≥60 years) for healthcare transportation access. Utilizing data from this investigation, we examined if medical care needs were hindered by problems with transportation in rural Iosco County, Michigan.

Methods: We conducted a cross-sectional survey with …


Fostering Dialogue, Learning, And Reflection: The Role Of Book Discussions For Public Health Professionals, Naomi E. Ervin, Belinda Aberle, Katherine Balint, Lynn Mcdaniels, Paula Tomczak Dec 2025

Fostering Dialogue, Learning, And Reflection: The Role Of Book Discussions For Public Health Professionals, Naomi E. Ervin, Belinda Aberle, Katherine Balint, Lynn Mcdaniels, Paula Tomczak

Michigan Journal of Public Health

Background: The Public Health Nursing (PHN) Section of the Michigan Public Health Association (MPHA) works to improve public health and public health nursing practice in Michigan. In 2021, the PHN Section initiated virtual book discussions to engage public health professionals in meaningful discussion about topics of critical importance to public health and public health nursing; provide continuing education contact hours; and recruit new section members. Methods: The discussions are conducted virtually four times per year. A moderator introduces each book and leads the one-hour discussion. As an added incentive to read the books, the PHN Section sends a limited number …


A Community-Based After-School Wellness Camp’S Effect On Healthy Habit Beliefs, Staci A. O'Brien, Ranelle Brew, Madeline Krawciw, Jodie Seese, Tess Scheidel Dec 2025

A Community-Based After-School Wellness Camp’S Effect On Healthy Habit Beliefs, Staci A. O'Brien, Ranelle Brew, Madeline Krawciw, Jodie Seese, Tess Scheidel

Michigan Journal of Public Health

Introduction: Children in the United States face declining physical activity, poor nutrition, and increasing mental health concerns. As school time for wellness declines, out-of-school programs offer an alternative to promote healthy habits to students. A community-driven, multi-component after-school wellness camp was developed in response to a small-town needs assessment and implemented at a local elementary school to determine whether it would change participants’ beliefs held towards healthy habits.

Methods: Third to fifth graders at a local elementary school in Lowell, Michigan, participated in an after-school wellness camp for four weeks through education and hands-on activities focused on physical …


Physical Therapy Direct Access To Unrestricted Access In The State Of Michigan- Is Michigan Ready To Embrace Change? A Policy Analysis, Erica M. Fernandes, Mary D. Lagerwey, Kieran Fogarty Dec 2025

Physical Therapy Direct Access To Unrestricted Access In The State Of Michigan- Is Michigan Ready To Embrace Change? A Policy Analysis, Erica M. Fernandes, Mary D. Lagerwey, Kieran Fogarty

Michigan Journal of Public Health

Michigan’s Direct Access Provision of 2015 (Enrolled Senate Bill No. 690, 201), which aimed to increase patient access to physical therapy and reduce waiting times, has created hurdles for patient access and for physical therapy as an autonomous profession. The purposes of this policy analysis were: 1) to analyze the Direct Access (DA) policy including examining existing challenges resulting from implementation, 2) provide recommendations for implementing an alternative policy, and 3) outline the benefits of the alternative policy. The DA policy with provisions was examined using the Patton and Sawicki (1993) framework, which provides a basic approach that …


Promoting Self-Reflection And Implicit Bias Awareness In Nursing: A Mixed-Method Study Advancing Practice And Fostering Healthcare Equality, Diane S. Kramer, Victoria Y. Mccue, Anshul Saxena, Jeanette B. Deniz, Nicole Burks, Patricia Russell Dec 2025

Promoting Self-Reflection And Implicit Bias Awareness In Nursing: A Mixed-Method Study Advancing Practice And Fostering Healthcare Equality, Diane S. Kramer, Victoria Y. Mccue, Anshul Saxena, Jeanette B. Deniz, Nicole Burks, Patricia Russell

Nursing & Health Sciences Research Journal

Background: Implicit biases influence how nurses perceive and interact with patients and shape clinical practice. Awareness is crucial because implicit biases are difficult to detect. Our study evaluated how educational sessions impacted awareness and understanding of implicit bias. In our study, we sought to mitigate effects of these biases on patient care to promote equitable healthcare outcomes.

Methods: The research involved registered nurses from all levels employed at nine hospitals. Data were collected anonymously through voluntary participation to ensure confidentiality. A mixed-methods approach with a quasi-experimental prepost design was utilized to measure the effectiveness of the educational session. Descriptive statistics …


Pilot Testing The Reliability And Validity Of The Modified Obstetric Fall Risk Assessment System, Geraldine F. Lamoglia, Ashley H. Hurtado, Yasmin Solis, Deborah Pol, Natalie Bermudez Dec 2025

Pilot Testing The Reliability And Validity Of The Modified Obstetric Fall Risk Assessment System, Geraldine F. Lamoglia, Ashley H. Hurtado, Yasmin Solis, Deborah Pol, Natalie Bermudez

Nursing & Health Sciences Research Journal

No abstract provided.


The Effect Of Simulation On Nurses’ Confidence With Providing Post-Fetal Death Support To Bereaved Parents, Monique Scholine, Shannon Zalewski, Erin M. Franklin, Sandria Jamieson, Janelle Diaz, Donna Davis, Kristi Vargo, Nicole Adokou, Kettia Antoine, Natalie Bermudez Dec 2025

The Effect Of Simulation On Nurses’ Confidence With Providing Post-Fetal Death Support To Bereaved Parents, Monique Scholine, Shannon Zalewski, Erin M. Franklin, Sandria Jamieson, Janelle Diaz, Donna Davis, Kristi Vargo, Nicole Adokou, Kettia Antoine, Natalie Bermudez

Nursing & Health Sciences Research Journal

Introduction: Fetal death (FD) affects one in 10 women worldwide and is associated with negative sequelae such as complicated grief. The negative effects of FD may potentially be mitigated through provision of bereavement support (BS) by trained healthcare workers.

Purpose: The purpose of this study was to explore the effect of simulation on registered nurses’ (RN) confidence in providing BS following FD.

Methods: This was a quasi-experimental study conducted within a South Florida community hospital. Nurses were recruited via email/flyers. Participation in the study entailed attending a post-FD simulation session, and completion of the Perinatal Bereavement Care Confidence Scale (PBCCS) …


A Descriptive Study Of Non-Pharmacological Interventions In Early Labor In Nulliparous Term Singleton Vertex (Ntsv) Women, Candida R. Bell, Acklin Gordon, Dianna Hill, Elba Rivera, Heather R. Cowherd, Ivette Ramos, Martha Valdes, Maureen Gordon, Silvia Foltan, Silvia Medina, Catherina C. Chang Martinez Dec 2025

A Descriptive Study Of Non-Pharmacological Interventions In Early Labor In Nulliparous Term Singleton Vertex (Ntsv) Women, Candida R. Bell, Acklin Gordon, Dianna Hill, Elba Rivera, Heather R. Cowherd, Ivette Ramos, Martha Valdes, Maureen Gordon, Silvia Foltan, Silvia Medina, Catherina C. Chang Martinez

Nursing & Health Sciences Research Journal

Introduction: Positional changes may contribute to progression of labor in nulliparous women. We investigated the use of non-invasive, non-pharmacological interventions during the first stage of labor in nulliparous, term, singleton, vertex (NTSV) women at a community hospital in the U.S. Another aim was to compare the times from the first intervention to completion of the first stage of labor across three interventions.

Methods: Ours was a descriptive, retrospective study of 98 NTSV women from January to June 2025. Descriptive and inferential statistics were analyzed using Statistical Package for Social Sciences version 27.

Results: Most women were Hispanic (71%), averaging 31 …


Letter From The Editors: The Value Of Research, Quality Improvement And Evidence-Based Practice Projects, And Innovations In Clinical Practice, Nohemi Sadule Rios, Stephen Breazeale Dec 2025

Letter From The Editors: The Value Of Research, Quality Improvement And Evidence-Based Practice Projects, And Innovations In Clinical Practice, Nohemi Sadule Rios, Stephen Breazeale

Nursing & Health Sciences Research Journal

No abstract provided.


Promoting Healthy Diet Adherence Using A Multisensory Approach For Post-Stroke Patients: A Pilot Randomized Controlled Trial, Stacey Myers, Yuki Asakura Strempek, Sarah Kaster, Clare Hall Dec 2025

Promoting Healthy Diet Adherence Using A Multisensory Approach For Post-Stroke Patients: A Pilot Randomized Controlled Trial, Stacey Myers, Yuki Asakura Strempek, Sarah Kaster, Clare Hall

Nursing & Health Sciences Research Journal

Introduction: Evidence supports a healthy diet for secondary stroke prevention; however, programs to implement nutrition education remain inconsistent. This study assessed the feasibility and efficacy of using a multisensory approach called the “Hands-on Training” program (HOT) to improve healthy diet adherence among patients rehabilitating after stroke.

Methods: This pilot randomized controlled study was conducted at an inpatient rehabilitation facility. Stroke patients were randomly assigned to either an experimental group who received HOT or a control group who received conventional education. The HOT group received real-time meal choice coaching, a healthy meal preparation experience, and additional written education. The Mediterranean Eating …


Harnessing The Communities Of Resilience And Excellence Framework To Advance Population Health: The Healthy West Kendall Experience, Cristina Brito, Simone Cheong, Stephanie Norling, Michelle Mejia, Sandra R. Mclean, Carlos E. Hernandez, Lourdes Boue, Zuanel Diaz, Javier Hernandez-Lichtl Dec 2025

Harnessing The Communities Of Resilience And Excellence Framework To Advance Population Health: The Healthy West Kendall Experience, Cristina Brito, Simone Cheong, Stephanie Norling, Michelle Mejia, Sandra R. Mclean, Carlos E. Hernandez, Lourdes Boue, Zuanel Diaz, Javier Hernandez-Lichtl

Nursing & Health Sciences Research Journal

Introduction: Fragmented community efforts often dilute health‐improvement initiatives. The Communities of Resilience and Excellence (C.O.R.E) Guide offers a Baldrige-based systems approach that aligns cross‐sector partners around shared metrics and continuous improvement cycles for collective impact. West Kendall, an unincorporated area of Miami-Dade County with over 340,000 residents, adopted the framework in response to rising chronic disease burden and socioeconomic disparities.

Methods: West Kendall Baptist Hospital served as the backbone organization that aligned multi-sector partners, implemented evidence-based interventions, and tracked community-level outcomes. We conducted a cross-sectional evaluation of the Healthy West Kendall initiative's impact across various regions in Miami-Dade County and …


Exploring The Lived Experience Of Nursing Faculty In Preparing For The Next Generation Nclex: A Qualitative Study, Mary Granoff, Missilia Gilbert, Marjorie Lima, Erika Nusbaum, Natalie Bermudez Dec 2025

Exploring The Lived Experience Of Nursing Faculty In Preparing For The Next Generation Nclex: A Qualitative Study, Mary Granoff, Missilia Gilbert, Marjorie Lima, Erika Nusbaum, Natalie Bermudez

Nursing & Health Sciences Research Journal

Introduction: According to the Nursing Council of State Boards of Nursing (NCSBN), more than half of all errors among new graduate registered nurses are related to a lack of clinical judgment, a critical component of nursing practice. Considering the Next Generation National Council Licensure Examination (NCLEX) focuses on clinical judgment, a greater understanding of faculty’s Next Generation NCLEX (NGN) teaching preparedness is needed. The purpose of this study was to explore nursing faculty’s lived experience preparing students for the NGN.

Methods: This was a qualitative descriptive study. Data were collected via 15-minute individual interviews. Participants were pre-licensure nursing faculty from …


Retrospectively Examining The Probability Of Acute Skin Failure Among Hospitalized Patients With Hospital-Acquired Pressure Injuries, Tori C. Hatch, Jeanine M. Salamone, Pierna F. Vaughner, Natalie Bermudez Dec 2025

Retrospectively Examining The Probability Of Acute Skin Failure Among Hospitalized Patients With Hospital-Acquired Pressure Injuries, Tori C. Hatch, Jeanine M. Salamone, Pierna F. Vaughner, Natalie Bermudez

Nursing & Health Sciences Research Journal

Introduction: Acute skin failure (ASF) in hospitalized patients is a growing concern and a product of multisystem organ failure. Unlike hospital-acquired pressure injuries (HAPIs), ASF is not preventable despite prevention measures. The Skin Failure Clinical Indicator Scale (SFCIS) was recently developed to assess the probability of ASF. The purpose of this study was to retrospectively examine the probability of and factors associated with ASF in hospitalized individuals with HAPIs.

Methods: Data were collected from the electronic health records of in-patients with stage 3 or greater HAPIs over two years. Collection included demographics, comorbidities, COVID status, wound staging, injury location, SFCIS, …


Evaluating The Role Of Covid-19 On Delay In Cancer Care And Health Disparities Of Women With Breast Cancer: A Retrospective, Multi-Site Study, Nohemi Sadule Rios, Morgan Nestingen, Mukesh Roy, Lucy Morales, Andrew Salner, Margaret Barton-Burke, Natalie Bermudez, Annmarie Mazzella, Muni Rubens, Muhammad A. Rizvi, Morgan Horton, Suresh G. Nair Md, Tania Silva Santos, Patricia Shearburn, Melissa Kratz, Morgan Hume, Kerry Kluska, Nayla Cepero, Wanli Xu, Wu Weizi, Batool Almasri Dec 2025

Evaluating The Role Of Covid-19 On Delay In Cancer Care And Health Disparities Of Women With Breast Cancer: A Retrospective, Multi-Site Study, Nohemi Sadule Rios, Morgan Nestingen, Mukesh Roy, Lucy Morales, Andrew Salner, Margaret Barton-Burke, Natalie Bermudez, Annmarie Mazzella, Muni Rubens, Muhammad A. Rizvi, Morgan Horton, Suresh G. Nair Md, Tania Silva Santos, Patricia Shearburn, Melissa Kratz, Morgan Hume, Kerry Kluska, Nayla Cepero, Wanli Xu, Wu Weizi, Batool Almasri

Nursing & Health Sciences Research Journal

Introduction: COVID-19 had a profound impact on cancer screening, diagnosis, and treatment worldwide. The purpose of this study was to examine the role that the COVID-19 pandemic had on delays in breast cancer screening, diagnosis, treatment, and other related variables, including cancer staging and oncology measures of performance (ECOG Performance Status), in the inpatient and ambulatory oncology settings.

Methods: This was a multi-site, interdisciplinary retrospective review study including 1,514 participants. Four cancer centers collaborated, submitting de-identified data in accordance with their policies and procedures.

Results: Our study's results showed significantly higher delays in screening mammogram appointments (p < .001) during the COVID-19 pandemic (N=142) than before the COVID-19 pandemic (N=56), with a 52% higher likelihood of canceling screening mammogram appointments during COVID-19. Our findings also revealed a statistically significant difference (p < .001) in the time from diagnosis to the first recommended treatment for scheduled initially appointments, with an increase of 18 days, suggesting delays in cancer treatment during the COVID-19 pandemic.

Discussion: Our findings …


Assessment Of Stroke Priority Status On Door-To-Reversal Time And Outcomes In Anticoagulant Associated Intracranial Hemorrhage, Kayla Mitzel, Jonathan Kline, Thomas J. Wolfel, Erika Dittmar, Nina Cruz, Felipe De Los Rios La Rosa, Heidi Clarke Dec 2025

Assessment Of Stroke Priority Status On Door-To-Reversal Time And Outcomes In Anticoagulant Associated Intracranial Hemorrhage, Kayla Mitzel, Jonathan Kline, Thomas J. Wolfel, Erika Dittmar, Nina Cruz, Felipe De Los Rios La Rosa, Heidi Clarke

Nursing & Health Sciences Research Journal

Background: The emergent reversal of anticoagulation in the setting of intracranial hemorrhage (ICH) is critical, and it is essential that comprehensive stroke centers adhere to the American Heart Association (AHA) metrics for door-to-reversal within the designated 90 minutes. The objective of this review is to evaluate individuals classified as stroke alert priority 1 and non-stroke alert and compare AHA metrics for door-to-reversal times and clinical outcomes when diagnosed with ICH.

Methods: Single-center observational, retrospective review that compared stroke alert priority 1 individuals to non-stroke alert individuals who were diagnosed with an ICH and taking an anticoagulant prior to admission. The …


Genetic Variations In Extracellular Matrix Degradation Pathways Linking To Major Depressive Disorder: Evidence From A Large-Scale Genetic Association Study, Halliru Zailani, Daniel Tzu-Li Chen, Sheng-Che Lin, Jia-Hau Lee, Mei-Ling Li, Jane Pei-Chen Chang, Kuan-Pin Su Nov 2025

Genetic Variations In Extracellular Matrix Degradation Pathways Linking To Major Depressive Disorder: Evidence From A Large-Scale Genetic Association Study, Halliru Zailani, Daniel Tzu-Li Chen, Sheng-Che Lin, Jia-Hau Lee, Mei-Ling Li, Jane Pei-Chen Chang, Kuan-Pin Su

BioMedicine

Dysregulation of extracellular matrix (ECM) degradation pathways has been increasingly implicated in major depressive disorder (MDD), yet its genetic basis remains unclear. This study investigated the relationship between ECM-related genetic polymorphisms and MDD susceptibility. In a case-control study, we analyzed 317 MDD patients and 1,268 sexmatched controls from the Taiwan Biobank (TWB). Genomic DNA was analyzed using the Affymetrix TWB array, targeting single nucleotide polymorphisms (SNPs) in 140 ECM degradation genes (Reactome database). Full-model association tests identified significant SNPs, validated with 5,000 max(T) permutations and adjusted via logistic regression for age, body mass index, education level, and marital status. We …


Neuroprotection Of Paeoniflorin As Antidepressant Candidate, Yuh-Fung Chen, Yi-Jui Chen, Jai-Sing Yang, Min-Min Lee, Huei-Yann Tsai Nov 2025

Neuroprotection Of Paeoniflorin As Antidepressant Candidate, Yuh-Fung Chen, Yi-Jui Chen, Jai-Sing Yang, Min-Min Lee, Huei-Yann Tsai

BioMedicine

Background: Depression is one of the common mental disorders worldwide, and currently used antidepressants have undesirable effects; therefore, the development of new antidepressants without side effects is urgently needed. Paeoniflorin (PF) exhibits various pharmacological activities, including anti-inflammatory, antioxidant, and neuroprotective effects. NMDA receptors in the hippocampus play a vital role in the pathophysiology of depression. Due to the scarcity of reports on the neuroprotection of PF on NMDA-induced excitotoxicity in the hippocampus, the present study aims to investigate the effects of PF on NMDA-mediated EPSP and calcium influx in the hippocampus to evaluate the potential of PF as an antidepressant. …


Prophylactic Effect Of Omega-3 Polyunsaturated Fatty Acids Monotherapy In Preventing Recurrent Major Depressive Disorder: A Randomized Controlled Trial, Ikbal Andrian Malau, Cheng-Ho Chang, Wei-Jen Chen, Wen-Chun Liu, Halliru Zailani, Hsien-Feng Liao, Jane Pei-Chen Chang, Wei-Che Chiu, Kuan-Pin Su Nov 2025

Prophylactic Effect Of Omega-3 Polyunsaturated Fatty Acids Monotherapy In Preventing Recurrent Major Depressive Disorder: A Randomized Controlled Trial, Ikbal Andrian Malau, Cheng-Ho Chang, Wei-Jen Chen, Wen-Chun Liu, Halliru Zailani, Hsien-Feng Liao, Jane Pei-Chen Chang, Wei-Che Chiu, Kuan-Pin Su

BioMedicine

Background: Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have demonstrated efficacy as adjunctive treatment for MDD. In fact, fewer studies assessed the prophylactic properties of n-3 PUFAs as monotherapy on the recurrence of MDD.

Aims: This study aimed to assess the prophylactic effect of n-3 PUFAs monotherapy against recurrent MDD.

Methods: We conducted a 6-month randomized controlled trial to assess the prophylactic effect of n-3 in preventing recurrent MDD. We assigned 60 remitted MDD patients to the n-3 group (n = 30) and placebo (n = 30). Furthermore, we assessed the difference in depression severity and MDD recurrence based on the …


Tai Chi For Cardiovascular Wellness: Integrating An Ancient Practice Into Modern Therapeutic Approaches, Chun-Han Cheng, Wen-Rui Hao, Huan-Yuan Chen, Po-Yuan Chen, Ju-Chi Liu, Tzu-Hurng Cheng Nov 2025

Tai Chi For Cardiovascular Wellness: Integrating An Ancient Practice Into Modern Therapeutic Approaches, Chun-Han Cheng, Wen-Rui Hao, Huan-Yuan Chen, Po-Yuan Chen, Ju-Chi Liu, Tzu-Hurng Cheng

BioMedicine

Tai Chi, a traditional Chinese martial art characterized by gentle, fluid movements and deep breathing, has gained increasing recognition for its cardiovascular health benefits. This study investigated the integration of Tai Chi into contemporary cardiovascular health practices, focusing on its physiological and psychological effects. The slow, controlled movements characteristic of Tai Chi contribute to enhanced cardiovascular fitness, decreased blood pressure, and improved vascular function, while simultaneously alleviating stress and fostering emotional well-being. Through a review of clinical studies and trials, this study underscores the efficacy of Tai Chi in cardiovascular rehabilitation programs and its accessibility as a community-based intervention. Additionally, …


Circadian Rhythms And Neuroendocrine Dysregulation In Adhd: Therapeutic Insights From Omega-3 Fatty Acids, Ayesha Zafar Iqbal, Patricia Marest Suwindi, Sunny Yin-Shan Chen, Lindsay Liang-Tien Cho, Kuan-Pin Su, Jane Pei-Chen Chang Nov 2025

Circadian Rhythms And Neuroendocrine Dysregulation In Adhd: Therapeutic Insights From Omega-3 Fatty Acids, Ayesha Zafar Iqbal, Patricia Marest Suwindi, Sunny Yin-Shan Chen, Lindsay Liang-Tien Cho, Kuan-Pin Su, Jane Pei-Chen Chang

BioMedicine

Attention-deficit hyperactivity disorder (ADHD) is a common neurodevelopmental condition often accompanied by circadian rhythm disturbances, particularly delayed sleep phase. These involve superchiasmatic nucleus (SCN) dysregulation, altered melatonin secretion, and hypothalamic–pituitary–adrenal (HPA) axis activity, which may be exacerbated by artificial light exposure. Genetic studies further implicate circadian mechanisms, linking ADHD with polymorphisms in clock genes such as PER and CLOCK.

Nutraceuticals, particularly omega-3 polyunsaturated fatty acids (n-3 PUFAs), have been proposed as modulators of circadian rhythms. N-3 PUFAs are essential for brain health and may influence melatonin synthesis and sleep–wake regulation. Preclinical and clinical findings suggest that supplementation can improve cognitive …


The Integrative Role Of Melatonin In Psychiatric Disorders: A Systematic Review Of Evidence From Circadian Biology, Lifestyle Medicine, And Psychoneuroimmunology, Ho Bao Chau Le, Kollawat Somsri, Thansita Bhunyakarnjanarat, Nattiya Hirankarn, Asada Leelahavanichkul Nov 2025

The Integrative Role Of Melatonin In Psychiatric Disorders: A Systematic Review Of Evidence From Circadian Biology, Lifestyle Medicine, And Psychoneuroimmunology, Ho Bao Chau Le, Kollawat Somsri, Thansita Bhunyakarnjanarat, Nattiya Hirankarn, Asada Leelahavanichkul

BioMedicine

Melatonin, a hormone produced by the pineal gland, is known for regulating circadian rhythms and has emerging therapeutic potential in psychiatric disorders. This systematic review examines evidence from clinical and preclinical studies to assess melatonin’s efficacy in the following conditions: depression, anxiety, bipolar disorder, and schizophrenia. Beyond its role in circadian regulation, melatonin exhibits antioxidative, anti-inflammatory, and immunomodulatory properties, which intersect with nutrition, lifestyle medicine, and psychoneuroimmunology (PNI).

The review finds that melatonin improves sleep quality, restores circadian balance, and modulates stress-related neuroimmune pathways. It also supports neuroplasticity and reduces oxidative stress, contributing to resilience against psychosocial and environmental stressors. …


From Rhythm To Resilience: The Interplay Of Circadian Rhythm, Melatonin, Lifestyle, Nutrition In Psychoneuroimmunology (Pni), Jane Pei-Chen Chang, Kuan-Pin Su Nov 2025

From Rhythm To Resilience: The Interplay Of Circadian Rhythm, Melatonin, Lifestyle, Nutrition In Psychoneuroimmunology (Pni), Jane Pei-Chen Chang, Kuan-Pin Su

BioMedicine

Emerging evidence reveals that circadian rhythm, melatonin signaling, nutrition, and inflammation are intricately intertwined in shaping both mental and physical health. Circadian disruptions and lifestyle imbalances contribute to neuroinflammation, mood dysregulation, and cardiometabolic dysfunction, as seen in attention-deficit/hyperactivity disorder (ADHD), major depressive disorder (MDD), metabolic syndrome,and cardiovascular diseases. This special issue highlights interdisciplinary research that integrates circadian biology, nutrition, and psychoneuroimmunology (PNI) toward personalized and preventive psychiatry. Featured studies explore circadian and melatonin mechanisms in ADHD and MDD, the therapeutic and prophylactic potential of omega-3 polyunsaturated fatty acids (n-3 PUFAs), the neuroprotective potentical of paeoniflorin, and the role of extracellular …